Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8B4_LEIDO

TriTrypDb:

LdBPK_343260.1 , LdCL_340041500 , LDHU3_34.5440

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A0A3S7X8B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8B4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.430
CLV_NRD_NRD_1	16	18	PF00675	0.586
CLV_NRD_NRD_1	216	218	PF00675	0.403
CLV_NRD_NRD_1	48	50	PF00675	0.337
CLV_PCSK_KEX2_1	16	18	PF00082	0.576
CLV_PCSK_KEX2_1	216	218	PF00082	0.404
CLV_PCSK_KEX2_1	48	50	PF00082	0.337
CLV_PCSK_PC7_1	12	18	PF00082	0.552
CLV_PCSK_SKI1_1	12	16	PF00082	0.557
CLV_PCSK_SKI1_1	192	196	PF00082	0.344
CLV_PCSK_SKI1_1	96	100	PF00082	0.559
DOC_CYCLIN_RxL_1	114	124	PF00134	0.492
DOC_CYCLIN_RxL_1	9	18	PF00134	0.561
DOC_MAPK_MEF2A_6	128	136	PF00069	0.330
DOC_PP1_RVXF_1	115	122	PF00149	0.482
DOC_PP1_RVXF_1	126	132	PF00149	0.308
DOC_USP7_MATH_1	103	107	PF00917	0.516
DOC_USP7_MATH_1	233	237	PF00917	0.683
DOC_USP7_MATH_1	37	41	PF00917	0.493
DOC_USP7_MATH_1	65	69	PF00917	0.605
DOC_WW_Pin1_4	194	199	PF00397	0.411
DOC_WW_Pin1_4	227	232	PF00397	0.535
DOC_WW_Pin1_4	35	40	PF00397	0.447
LIG_14-3-3_CanoR_1	16	26	PF00244	0.533
LIG_14-3-3_CanoR_1	192	198	PF00244	0.463
LIG_14-3-3_CanoR_1	66	70	PF00244	0.634
LIG_14-3-3_CanoR_1	96	101	PF00244	0.512
LIG_Actin_WH2_2	38	56	PF00022	0.355
LIG_BRCT_BRCA1_1	19	23	PF00533	0.466
LIG_CSL_BTD_1	130	133	PF09270	0.387
LIG_FHA_1	213	219	PF00498	0.431
LIG_FHA_1	9	15	PF00498	0.624
LIG_FHA_2	1	7	PF00498	0.635
LIG_FHA_2	135	141	PF00498	0.434
LIG_GBD_Chelix_1	158	166	PF00786	0.396
LIG_LIR_Gen_1	40	51	PF02991	0.422
LIG_LIR_Gen_1	73	81	PF02991	0.381
LIG_LIR_Nem_3	20	26	PF02991	0.475
LIG_LIR_Nem_3	40	46	PF02991	0.467
LIG_LIR_Nem_3	73	78	PF02991	0.442
LIG_LIR_Nem_3	87	93	PF02991	0.413
LIG_NRBOX	157	163	PF00104	0.312
LIG_Pex14_1	131	135	PF04695	0.380
LIG_SH2_CRK	43	47	PF00017	0.372
LIG_SH2_CRK	97	101	PF00017	0.425
LIG_SH2_NCK_1	97	101	PF00017	0.425
LIG_SH2_PTP2	50	53	PF00017	0.404
LIG_SH2_STAP1	43	47	PF00017	0.415
LIG_SH2_STAT5	125	128	PF00017	0.379
LIG_SH2_STAT5	50	53	PF00017	0.461
LIG_SH2_STAT5	75	78	PF00017	0.395
LIG_SH2_STAT5	90	93	PF00017	0.483
LIG_SH3_3	36	42	PF00018	0.480
LIG_SUMO_SIM_anti_2	155	163	PF11976	0.411
LIG_SUMO_SIM_par_1	23	29	PF11976	0.542
LIG_TRAF2_1	2	5	PF00917	0.685
LIG_TYR_ITIM	41	46	PF00017	0.425
LIG_UBA3_1	190	195	PF00899	0.337
MOD_CK1_1	196	202	PF00069	0.411
MOD_GlcNHglycan	105	108	PF01048	0.496
MOD_GlcNHglycan	149	152	PF01048	0.305
MOD_GlcNHglycan	176	180	PF01048	0.406
MOD_GlcNHglycan	207	210	PF01048	0.331
MOD_GlcNHglycan	61	64	PF01048	0.616
MOD_GSK3_1	143	150	PF00069	0.428
MOD_GSK3_1	194	201	PF00069	0.404
MOD_GSK3_1	229	236	PF00069	0.616
MOD_GSK3_1	31	38	PF00069	0.525
MOD_NEK2_1	143	148	PF00069	0.432
MOD_NEK2_1	15	20	PF00069	0.538
MOD_NEK2_1	162	167	PF00069	0.263
MOD_NEK2_1	175	180	PF00069	0.497
MOD_NEK2_1	193	198	PF00069	0.238
MOD_PIKK_1	198	204	PF00454	0.412
MOD_PKA_2	15	21	PF00069	0.535
MOD_PKA_2	65	71	PF00069	0.621
MOD_Plk_4	121	127	PF00069	0.444
MOD_Plk_4	71	77	PF00069	0.541
MOD_ProDKin_1	194	200	PF00069	0.405
MOD_ProDKin_1	227	233	PF00069	0.543
MOD_ProDKin_1	35	41	PF00069	0.429
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.555
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.548
TRG_ENDOCYTIC_2	43	46	PF00928	0.458
TRG_ENDOCYTIC_2	50	53	PF00928	0.454
TRG_ENDOCYTIC_2	75	78	PF00928	0.424
TRG_ENDOCYTIC_2	97	100	PF00928	0.486
TRG_ER_diArg_1	15	17	PF00400	0.583
TRG_ER_diArg_1	216	218	PF00400	0.377
TRG_ER_diArg_1	47	49	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9Z0	Trypanosomatidae	31%	100%
A4HB66	Leishmania braziliensis	75%	100%
A4IAB4	Leishmania infantum	100%	100%
C9ZLY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2J6	Leishmania major	92%	100%
V5BQJ6	Trypanosoma cruzi	32%	100%