Amidinotransferase_putative/GeneDB:LmjF.34.3470

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8B2_LEIDO

TriTrypDb:

LdBPK_343250.1 , LdCL_340041400 , LDHU3_34.5430

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8B2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016740	transferase activity	2	3
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.399
CLV_NRD_NRD_1	320	322	PF00675	0.305
CLV_PCSK_KEX2_1	320	322	PF00082	0.305
CLV_PCSK_SKI1_1	197	201	PF00082	0.253
CLV_PCSK_SKI1_1	298	302	PF00082	0.341
CLV_Separin_Metazoa	350	354	PF03568	0.435
DOC_CYCLIN_RxL_1	295	303	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	265	271	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.422
DOC_MAPK_gen_1	67	76	PF00069	0.529
DOC_MAPK_JIP1_4	186	192	PF00069	0.327
DOC_PP2B_LxvP_1	190	193	PF13499	0.268
DOC_PP2B_LxvP_1	265	268	PF13499	0.327
DOC_USP7_MATH_1	223	227	PF00917	0.473
DOC_USP7_MATH_1	341	345	PF00917	0.613
DOC_WW_Pin1_4	159	164	PF00397	0.359
LIG_14-3-3_CanoR_1	321	327	PF00244	0.338
LIG_14-3-3_CanoR_1	73	77	PF00244	0.464
LIG_APCC_ABBA_1	143	148	PF00400	0.327
LIG_BRCT_BRCA1_1	157	161	PF00533	0.422
LIG_BRCT_BRCA1_1	225	229	PF00533	0.417
LIG_EH_1	111	115	PF12763	0.207
LIG_FHA_1	207	213	PF00498	0.262
LIG_FHA_1	346	352	PF00498	0.466
LIG_FHA_1	58	64	PF00498	0.404
LIG_FHA_2	44	50	PF00498	0.475
LIG_FHA_2	73	79	PF00498	0.314
LIG_LIR_Gen_1	243	252	PF02991	0.332
LIG_LIR_Nem_3	243	249	PF02991	0.318
LIG_LIR_Nem_3	312	317	PF02991	0.413
LIG_LIR_Nem_3	49	54	PF02991	0.489
LIG_REV1ctd_RIR_1	49	57	PF16727	0.388
LIG_SH2_CRK	169	173	PF00017	0.290
LIG_SH2_CRK	246	250	PF00017	0.290
LIG_SH2_NCK_1	169	173	PF00017	0.261
LIG_SH2_PTP2	281	284	PF00017	0.327
LIG_SH2_SRC	152	155	PF00017	0.369
LIG_SH2_STAP1	246	250	PF00017	0.301
LIG_SH2_STAT5	152	155	PF00017	0.377
LIG_SH2_STAT5	167	170	PF00017	0.382
LIG_SH2_STAT5	281	284	PF00017	0.457
LIG_SH2_STAT5	334	337	PF00017	0.490
LIG_SH3_2	110	115	PF14604	0.335
LIG_SH3_3	104	110	PF00018	0.339
LIG_SH3_3	265	271	PF00018	0.426
LIG_SH3_3	337	343	PF00018	0.493
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.409
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.427
LIG_SUMO_SIM_par_1	247	254	PF11976	0.417
LIG_SUMO_SIM_par_1	281	288	PF11976	0.327
LIG_TRAF2_1	131	134	PF00917	0.478
LIG_TRAF2_1	145	148	PF00917	0.266
LIG_TRAF2_1	75	78	PF00917	0.436
LIG_TYR_ITSM	310	317	PF00017	0.464
LIG_WRC_WIRS_1	310	315	PF05994	0.409
LIG_WRC_WIRS_1	48	53	PF05994	0.369
LIG_WW_2	340	343	PF00397	0.420
MOD_CDK_SPxxK_3	159	166	PF00069	0.369
MOD_CK1_1	173	179	PF00069	0.278
MOD_CK1_1	325	331	PF00069	0.373
MOD_CK1_1	344	350	PF00069	0.320
MOD_CK2_1	250	256	PF00069	0.365
MOD_CK2_1	260	266	PF00069	0.323
MOD_CK2_1	344	350	PF00069	0.482
MOD_CK2_1	43	49	PF00069	0.378
MOD_CK2_1	72	78	PF00069	0.398
MOD_GlcNHglycan	154	158	PF01048	0.407
MOD_GlcNHglycan	242	245	PF01048	0.462
MOD_GlcNHglycan	262	265	PF01048	0.395
MOD_GlcNHglycan	272	275	PF01048	0.350
MOD_GSK3_1	155	162	PF00069	0.435
MOD_GSK3_1	240	247	PF00069	0.305
MOD_GSK3_1	321	328	PF00069	0.403
MOD_GSK3_1	341	348	PF00069	0.262
MOD_GSK3_1	43	50	PF00069	0.338
MOD_NEK2_1	153	158	PF00069	0.341
MOD_NEK2_1	23	28	PF00069	0.480
MOD_NEK2_1	260	265	PF00069	0.327
MOD_NEK2_1	36	41	PF00069	0.441
MOD_NEK2_1	52	57	PF00069	0.382
MOD_OFUCOSY	322	329	PF10250	0.356
MOD_PIKK_1	170	176	PF00454	0.351
MOD_PIKK_1	341	347	PF00454	0.545
MOD_PIKK_1	36	42	PF00454	0.385
MOD_PK_1	79	85	PF00069	0.460
MOD_PKA_2	72	78	PF00069	0.409
MOD_Plk_1	36	42	PF00069	0.437
MOD_Plk_4	155	161	PF00069	0.417
MOD_Plk_4	223	229	PF00069	0.457
MOD_Plk_4	309	315	PF00069	0.435
MOD_Plk_4	47	53	PF00069	0.426
MOD_ProDKin_1	159	165	PF00069	0.359
MOD_SUMO_rev_2	147	153	PF00179	0.369
MOD_SUMO_rev_2	66	71	PF00179	0.462
TRG_DiLeu_BaEn_1	195	200	PF01217	0.340
TRG_DiLeu_BaEn_4	148	154	PF01217	0.390
TRG_ENDOCYTIC_2	169	172	PF00928	0.284
TRG_ENDOCYTIC_2	239	242	PF00928	0.315
TRG_ENDOCYTIC_2	246	249	PF00928	0.210
TRG_ENDOCYTIC_2	281	284	PF00928	0.388
TRG_ENDOCYTIC_2	314	317	PF00928	0.435
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q5	Leptomonas seymouri	66%	100%
A0A0N1IKG5	Leptomonas seymouri	38%	99%
A0A0S4JAZ5	Bodo saltans	27%	93%
A0A1X0PAA5	Trypanosomatidae	38%	95%
A0A3R7KYJ2	Trypanosoma rangeli	37%	95%
A4HB65	Leishmania braziliensis	84%	100%
A4IAB3	Leishmania infantum	100%	100%
C9ZLY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	96%
E9B5D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2J7	Leishmania major	95%	100%
V5B5E2	Trypanosoma cruzi	37%	95%