Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8B1_LEIDO

TriTrypDb:

LdBPK_342990.1 , LdCL_340038700 , LDHU3_34.5110

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.570
CLV_NRD_NRD_1	88	90	PF00675	0.509
CLV_PCSK_KEX2_1	88	90	PF00082	0.519
CLV_PCSK_SKI1_1	101	105	PF00082	0.346
CLV_PCSK_SKI1_1	124	128	PF00082	0.512
CLV_PCSK_SKI1_1	59	63	PF00082	0.537
CLV_Separin_Metazoa	85	89	PF03568	0.377
DEG_SPOP_SBC_1	37	41	PF00917	0.369
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.397
DOC_PP1_RVXF_1	99	105	PF00149	0.453
DOC_USP7_MATH_1	10	14	PF00917	0.582
DOC_USP7_MATH_1	17	21	PF00917	0.574
DOC_USP7_MATH_1	35	39	PF00917	0.476
DOC_WW_Pin1_4	109	114	PF00397	0.393
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BIR_III_4	204	208	PF00653	0.615
LIG_BRCT_BRCA1_1	38	42	PF00533	0.560
LIG_FHA_2	160	166	PF00498	0.442
LIG_FHA_2	199	205	PF00498	0.443
LIG_FHA_2	38	44	PF00498	0.451
LIG_LIR_Apic_2	144	149	PF02991	0.316
LIG_LIR_Gen_1	177	185	PF02991	0.311
LIG_LIR_Gen_1	192	200	PF02991	0.448
LIG_LIR_Gen_1	28	37	PF02991	0.556
LIG_LIR_Gen_1	39	50	PF02991	0.367
LIG_LIR_Nem_3	177	182	PF02991	0.312
LIG_LIR_Nem_3	190	194	PF02991	0.423
LIG_LIR_Nem_3	28	34	PF02991	0.599
LIG_LIR_Nem_3	39	45	PF02991	0.403
LIG_LIR_Nem_3	47	53	PF02991	0.354
LIG_REV1ctd_RIR_1	102	112	PF16727	0.509
LIG_SH2_CRK	146	150	PF00017	0.302
LIG_SH2_NCK_1	146	150	PF00017	0.362
LIG_SH2_PTP2	33	36	PF00017	0.478
LIG_SH2_STAP1	194	198	PF00017	0.499
LIG_SH2_STAT3	49	52	PF00017	0.297
LIG_SH2_STAT5	146	149	PF00017	0.487
LIG_SH2_STAT5	179	182	PF00017	0.320
LIG_SH2_STAT5	33	36	PF00017	0.508
LIG_SH2_STAT5	44	47	PF00017	0.325
LIG_SH3_3	31	37	PF00018	0.551
MOD_CK1_1	141	147	PF00069	0.379
MOD_CK1_1	38	44	PF00069	0.407
MOD_CK1_1	8	14	PF00069	0.670
MOD_CK2_1	159	165	PF00069	0.432
MOD_CK2_1	189	195	PF00069	0.566
MOD_Cter_Amidation	119	122	PF01082	0.440
MOD_GlcNHglycan	12	15	PF01048	0.611
MOD_GlcNHglycan	18	22	PF01048	0.482
MOD_GlcNHglycan	190	194	PF01048	0.440
MOD_GSK3_1	130	137	PF00069	0.519
MOD_GSK3_1	25	32	PF00069	0.512
MOD_N-GLC_1	130	135	PF02516	0.441
MOD_N-GLC_1	159	164	PF02516	0.423
MOD_N-GLC_1	29	34	PF02516	0.375
MOD_N-GLC_2	64	66	PF02516	0.306
MOD_NEK2_1	159	164	PF00069	0.408
MOD_NEK2_1	5	10	PF00069	0.649
MOD_NEK2_1	69	74	PF00069	0.308
MOD_PK_1	134	140	PF00069	0.284
MOD_Plk_1	144	150	PF00069	0.429
MOD_Plk_1	159	165	PF00069	0.452
MOD_Plk_1	29	35	PF00069	0.562
MOD_Plk_4	134	140	PF00069	0.346
MOD_Plk_4	159	165	PF00069	0.330
MOD_ProDKin_1	109	115	PF00069	0.398
MOD_SUMO_rev_2	54	61	PF00179	0.420
TRG_ENDOCYTIC_2	179	182	PF00928	0.320
TRG_ENDOCYTIC_2	194	197	PF00928	0.392
TRG_ENDOCYTIC_2	33	36	PF00928	0.563
TRG_ENDOCYTIC_2	50	53	PF00928	0.398
TRG_ER_diArg_1	87	89	PF00400	0.415
TRG_NLS_MonoCore_2	120	125	PF00514	0.427
TRG_NLS_MonoExtN_4	121	126	PF00514	0.415
TRG_NLS_MonoExtN_4	56	63	PF00514	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J2	Leptomonas seymouri	71%	100%
A0A0S4ILQ4	Bodo saltans	39%	98%
A0A1X0PA68	Trypanosomatidae	51%	100%
A0A422NNR6	Trypanosoma rangeli	48%	100%
A4HB40	Leishmania braziliensis	84%	100%
A4IAM9	Leishmania infantum	100%	100%
C9ZM07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B5B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q1LU93	Danio rerio	29%	100%
Q28G67	Xenopus tropicalis	32%	100%
Q29S16	Bos taurus	31%	100%
Q4Q2M3	Leishmania major	93%	100%
Q54TD9	Dictyostelium discoideum	31%	100%
Q5RFS0	Pongo abelii	32%	100%
Q5ZHW7	Gallus gallus	32%	100%
Q6GR35	Xenopus laevis	31%	100%
Q80ZQ9	Mus musculus	32%	100%
Q9NX38	Homo sapiens	32%	100%
Q9VFR1	Drosophila melanogaster	32%	99%