Metallo-beta-lactamase superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X8A7_LEIDO

TriTrypDb:

LdBPK_343200.1 , LdCL_340040900 , LDHU3_34.5360

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3S7X8A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8A7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004416	hydroxyacylglutathione hydrolase activity	5	3
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016790	thiolester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	421	425	PF00656	0.611
CLV_C14_Caspase3-7	435	439	PF00656	0.662
CLV_NRD_NRD_1	508	510	PF00675	0.400
CLV_PCSK_KEX2_1	507	509	PF00082	0.379
CLV_PCSK_SKI1_1	123	127	PF00082	0.631
DOC_CYCLIN_yClb3_PxF_3	63	71	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.533
DOC_MAPK_DCC_7	155	164	PF00069	0.516
DOC_MAPK_gen_1	448	455	PF00069	0.722
DOC_MAPK_MEF2A_6	155	164	PF00069	0.501
DOC_MAPK_MEF2A_6	200	209	PF00069	0.533
DOC_MAPK_MEF2A_6	448	455	PF00069	0.708
DOC_MAPK_MEF2A_6	468	476	PF00069	0.472
DOC_PP1_RVXF_1	256	262	PF00149	0.496
DOC_PP2B_LxvP_1	203	206	PF13499	0.533
DOC_USP7_MATH_1	492	496	PF00917	0.646
DOC_USP7_MATH_2	340	346	PF00917	0.593
DOC_USP7_UBL2_3	485	489	PF12436	0.607
DOC_WW_Pin1_4	115	120	PF00397	0.416
DOC_WW_Pin1_4	277	282	PF00397	0.522
DOC_WW_Pin1_4	317	322	PF00397	0.653
DOC_WW_Pin1_4	403	408	PF00397	0.711
LIG_14-3-3_CanoR_1	353	357	PF00244	0.548
LIG_14-3-3_CanoR_1	399	407	PF00244	0.689
LIG_Actin_WH2_2	107	125	PF00022	0.414
LIG_Actin_WH2_2	469	487	PF00022	0.561
LIG_APCC_ABBA_1	162	167	PF00400	0.567
LIG_APCC_ABBA_1	238	243	PF00400	0.533
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BIR_III_2	278	282	PF00653	0.552
LIG_BRCT_BRCA1_1	279	283	PF00533	0.533
LIG_BRCT_BRCA1_1	303	307	PF00533	0.447
LIG_BRCT_BRCA1_1	66	70	PF00533	0.622
LIG_BRCT_BRCA1_1	71	75	PF00533	0.597
LIG_Clathr_ClatBox_1	473	477	PF01394	0.570
LIG_EH_1	61	65	PF12763	0.629
LIG_FHA_1	148	154	PF00498	0.569
LIG_FHA_1	176	182	PF00498	0.492
LIG_FHA_1	208	214	PF00498	0.463
LIG_FHA_1	341	347	PF00498	0.557
LIG_FHA_1	384	390	PF00498	0.523
LIG_FHA_2	353	359	PF00498	0.531
LIG_FHA_2	366	372	PF00498	0.627
LIG_FHA_2	404	410	PF00498	0.699
LIG_FHA_2	429	435	PF00498	0.669
LIG_FHA_2	473	479	PF00498	0.572
LIG_LIR_Apic_2	35	40	PF02991	0.461
LIG_LIR_Apic_2	6	10	PF02991	0.552
LIG_LIR_Gen_1	167	176	PF02991	0.448
LIG_LIR_Gen_1	280	290	PF02991	0.553
LIG_LIR_Nem_3	167	172	PF02991	0.467
LIG_LIR_Nem_3	43	49	PF02991	0.375
LIG_LIR_Nem_3	72	78	PF02991	0.476
LIG_LIR_Nem_3	86	92	PF02991	0.232
LIG_MYND_1	253	257	PF01753	0.552
LIG_Pex14_2	132	136	PF04695	0.412
LIG_Pex14_2	64	68	PF04695	0.595
LIG_SH2_CRK	169	173	PF00017	0.488
LIG_SH2_CRK	46	50	PF00017	0.404
LIG_SH2_CRK	89	93	PF00017	0.386
LIG_SH2_NCK_1	137	141	PF00017	0.446
LIG_SH2_SRC	171	174	PF00017	0.530
LIG_SH2_SRC	19	22	PF00017	0.446
LIG_SH2_STAP1	169	173	PF00017	0.456
LIG_SH2_STAP1	19	23	PF00017	0.381
LIG_SH2_STAP1	385	389	PF00017	0.501
LIG_SH2_STAT5	171	174	PF00017	0.447
LIG_SH2_STAT5	380	383	PF00017	0.477
LIG_SH2_STAT5	385	388	PF00017	0.504
LIG_SH2_STAT5	415	418	PF00017	0.561
LIG_SH2_STAT5	46	49	PF00017	0.371
LIG_SH2_STAT5	503	506	PF00017	0.540
LIG_SH2_STAT5	82	85	PF00017	0.353
LIG_SH3_1	234	240	PF00018	0.537
LIG_SH3_3	157	163	PF00018	0.467
LIG_SH3_3	183	189	PF00018	0.452
LIG_SH3_3	233	239	PF00018	0.515
LIG_SH3_3	247	253	PF00018	0.434
LIG_SH3_3	404	410	PF00018	0.705
LIG_SH3_3	450	456	PF00018	0.678
LIG_SH3_3	466	472	PF00018	0.379
LIG_SH3_3	57	63	PF00018	0.601
LIG_SH3_3	88	94	PF00018	0.529
LIG_SH3_3	97	103	PF00018	0.403
LIG_SH3_5	103	107	PF00018	0.290
LIG_SUMO_SIM_anti_2	392	398	PF11976	0.567
LIG_SUMO_SIM_par_1	392	398	PF11976	0.594
LIG_SUMO_SIM_par_1	472	479	PF11976	0.536
LIG_TRAF2_1	240	243	PF00917	0.496
LIG_TRAF2_1	311	314	PF00917	0.631
LIG_TRAF2_1	368	371	PF00917	0.664
LIG_TYR_ITIM	44	49	PF00017	0.446
LIG_TYR_ITIM	87	92	PF00017	0.420
LIG_UBA3_1	172	180	PF00899	0.533
LIG_UBA3_1	227	234	PF00899	0.493
LIG_UBA3_1	74	80	PF00899	0.420
LIG_WRC_WIRS_1	65	70	PF05994	0.652
MOD_CDC14_SPxK_1	118	121	PF00782	0.452
MOD_CDK_SPxK_1	115	121	PF00069	0.445
MOD_CDK_SPxK_1	317	323	PF00069	0.642
MOD_CK1_1	175	181	PF00069	0.447
MOD_CK1_1	277	283	PF00069	0.542
MOD_CK2_1	229	235	PF00069	0.491
MOD_CK2_1	308	314	PF00069	0.611
MOD_CK2_1	352	358	PF00069	0.523
MOD_CK2_1	365	371	PF00069	0.645
MOD_DYRK1A_RPxSP_1	403	407	PF00069	0.665
MOD_GlcNHglycan	26	29	PF01048	0.641
MOD_GlcNHglycan	310	313	PF01048	0.370
MOD_GlcNHglycan	32	35	PF01048	0.667
MOD_GlcNHglycan	512	515	PF01048	0.527
MOD_GlcNHglycan	55	58	PF01048	0.356
MOD_GSK3_1	207	214	PF00069	0.449
MOD_GSK3_1	395	402	PF00069	0.618
MOD_GSK3_1	430	437	PF00069	0.662
MOD_GSK3_1	456	463	PF00069	0.523
MOD_GSK3_1	9	16	PF00069	0.347
MOD_NEK2_1	172	177	PF00069	0.451
MOD_NEK2_1	227	232	PF00069	0.464
MOD_NEK2_1	81	86	PF00069	0.300
MOD_NEK2_2	40	45	PF00069	0.463
MOD_PKA_2	352	358	PF00069	0.584
MOD_PKA_2	398	404	PF00069	0.657
MOD_PKB_1	403	411	PF00069	0.618
MOD_Plk_4	149	155	PF00069	0.607
MOD_Plk_4	188	194	PF00069	0.440
MOD_Plk_4	3	9	PF00069	0.609
MOD_Plk_4	301	307	PF00069	0.445
MOD_Plk_4	328	334	PF00069	0.533
MOD_Plk_4	352	358	PF00069	0.571
MOD_Plk_4	392	398	PF00069	0.605
MOD_Plk_4	64	70	PF00069	0.639
MOD_ProDKin_1	115	121	PF00069	0.424
MOD_ProDKin_1	277	283	PF00069	0.522
MOD_ProDKin_1	317	323	PF00069	0.643
MOD_ProDKin_1	403	409	PF00069	0.701
TRG_DiLeu_BaEn_1	374	379	PF01217	0.566
TRG_DiLeu_BaEn_1	392	397	PF01217	0.624
TRG_DiLeu_BaEn_4	265	271	PF01217	0.482
TRG_DiLeu_BaEn_4	374	380	PF01217	0.557
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.552
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.548
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.499
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.533
TRG_ENDOCYTIC_2	169	172	PF00928	0.488
TRG_ENDOCYTIC_2	46	49	PF00928	0.420
TRG_ENDOCYTIC_2	89	92	PF00928	0.394
TRG_ER_diArg_1	360	363	PF00400	0.635
TRG_ER_diArg_1	507	509	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD83	Leptomonas seymouri	66%	99%
A0A0S4IM37	Bodo saltans	35%	100%
A0A1X0PA00	Trypanosomatidae	37%	100%
A0A3R7K9K9	Trypanosoma rangeli	40%	100%
A4HB60	Leishmania braziliensis	82%	100%
A4IAA8	Leishmania infantum	100%	100%
C9ZLY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B5D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2K2	Leishmania major	92%	100%
Q8N490	Homo sapiens	29%	100%
V5B5D7	Trypanosoma cruzi	42%	100%