SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8A6_LEIDO

TriTrypDb:

LdBPK_343290.1 , LdCL_340041800 , LDHU3_34.5470

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X8A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.655
CLV_C14_Caspase3-7	165	169	PF00656	0.643
CLV_NRD_NRD_1	12	14	PF00675	0.599
CLV_NRD_NRD_1	209	211	PF00675	0.437
CLV_NRD_NRD_1	290	292	PF00675	0.506
CLV_NRD_NRD_1	46	48	PF00675	0.504
CLV_NRD_NRD_1	99	101	PF00675	0.622
CLV_PCSK_KEX2_1	12	14	PF00082	0.597
CLV_PCSK_KEX2_1	209	211	PF00082	0.431
CLV_PCSK_KEX2_1	290	292	PF00082	0.506
CLV_PCSK_KEX2_1	46	48	PF00082	0.535
CLV_PCSK_PC7_1	42	48	PF00082	0.529
CLV_PCSK_SKI1_1	290	294	PF00082	0.513
CLV_PCSK_SKI1_1	306	310	PF00082	0.421
DEG_APCC_DBOX_1	129	137	PF00400	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.715
DOC_CYCLIN_RxL_1	286	297	PF00134	0.473
DOC_MAPK_gen_1	290	301	PF00069	0.464
DOC_PP1_RVXF_1	196	202	PF00149	0.424
DOC_PP1_RVXF_1	270	277	PF00149	0.649
DOC_USP7_MATH_1	172	176	PF00917	0.679
DOC_USP7_MATH_1	219	223	PF00917	0.404
DOC_USP7_MATH_1	277	281	PF00917	0.627
DOC_WW_Pin1_4	124	129	PF00397	0.511
DOC_WW_Pin1_4	59	64	PF00397	0.640
DOC_WW_Pin1_4	93	98	PF00397	0.621
LIG_14-3-3_CanoR_1	107	114	PF00244	0.487
LIG_14-3-3_CanoR_1	159	163	PF00244	0.362
LIG_14-3-3_CanoR_1	306	316	PF00244	0.457
LIG_14-3-3_CanoR_1	81	87	PF00244	0.410
LIG_Actin_WH2_2	280	296	PF00022	0.534
LIG_BIR_III_4	238	242	PF00653	0.501
LIG_deltaCOP1_diTrp_1	315	321	PF00928	0.370
LIG_eIF4E_1	24	30	PF01652	0.557
LIG_FHA_1	142	148	PF00498	0.640
LIG_FHA_1	287	293	PF00498	0.483
LIG_FHA_1	72	78	PF00498	0.443
LIG_FHA_2	308	314	PF00498	0.466
LIG_LIR_Apic_2	21	27	PF02991	0.581
LIG_LIR_Gen_1	112	122	PF02991	0.509
LIG_LIR_Gen_1	19	30	PF02991	0.557
LIG_LIR_Gen_1	200	207	PF02991	0.417
LIG_LIR_Gen_1	258	268	PF02991	0.580
LIG_LIR_Nem_3	112	117	PF02991	0.434
LIG_LIR_Nem_3	19	25	PF02991	0.522
LIG_LIR_Nem_3	200	204	PF02991	0.417
LIG_LIR_Nem_3	243	248	PF02991	0.403
LIG_LIR_Nem_3	258	263	PF02991	0.401
LIG_LYPXL_S_1	244	248	PF13949	0.374
LIG_LYPXL_yS_3	245	248	PF13949	0.375
LIG_Pex14_1	26	30	PF04695	0.470
LIG_Pex14_1	317	321	PF04695	0.490
LIG_SH2_NCK_1	157	161	PF00017	0.597
LIG_SH2_PTP2	260	263	PF00017	0.573
LIG_SH2_PTP2	323	326	PF00017	0.298
LIG_SH2_STAT5	132	135	PF00017	0.406
LIG_SH2_STAT5	22	25	PF00017	0.533
LIG_SH2_STAT5	260	263	PF00017	0.553
LIG_SH2_STAT5	28	31	PF00017	0.447
LIG_SH2_STAT5	323	326	PF00017	0.436
LIG_SH2_STAT5	70	73	PF00017	0.505
LIG_SH3_2	125	130	PF14604	0.548
LIG_SH3_3	122	128	PF00018	0.514
LIG_SH3_3	70	76	PF00018	0.508
LIG_SH3_3	91	97	PF00018	0.549
MOD_CDC14_SPxK_1	127	130	PF00782	0.501
MOD_CDK_SPxK_1	124	130	PF00069	0.517
MOD_CDK_SPxxK_3	93	100	PF00069	0.541
MOD_CK1_1	93	99	PF00069	0.526
MOD_CK2_1	106	112	PF00069	0.488
MOD_CK2_1	139	145	PF00069	0.483
MOD_CK2_1	276	282	PF00069	0.652
MOD_CK2_1	92	98	PF00069	0.495
MOD_GlcNHglycan	108	111	PF01048	0.526
MOD_GlcNHglycan	141	144	PF01048	0.551
MOD_GlcNHglycan	193	196	PF01048	0.529
MOD_GlcNHglycan	256	260	PF01048	0.451
MOD_GlcNHglycan	278	282	PF01048	0.598
MOD_GSK3_1	141	148	PF00069	0.593
MOD_GSK3_1	225	232	PF00069	0.377
MOD_GSK3_1	251	258	PF00069	0.398
MOD_GSK3_1	4	11	PF00069	0.712
MOD_GSK3_1	88	95	PF00069	0.474
MOD_GSK3_1	96	103	PF00069	0.583
MOD_NEK2_1	139	144	PF00069	0.511
MOD_NEK2_1	229	234	PF00069	0.387
MOD_NEK2_1	4	9	PF00069	0.718
MOD_NEK2_1	71	76	PF00069	0.464
MOD_NEK2_1	90	95	PF00069	0.445
MOD_PIKK_1	193	199	PF00454	0.411
MOD_PKA_1	100	106	PF00069	0.609
MOD_PKA_2	106	112	PF00069	0.468
MOD_PKA_2	158	164	PF00069	0.382
MOD_PKA_2	8	14	PF00069	0.657
MOD_Plk_1	18	24	PF00069	0.574
MOD_Plk_4	100	106	PF00069	0.570
MOD_Plk_4	158	164	PF00069	0.375
MOD_Plk_4	18	24	PF00069	0.609
MOD_Plk_4	240	246	PF00069	0.412
MOD_ProDKin_1	124	130	PF00069	0.514
MOD_ProDKin_1	59	65	PF00069	0.633
MOD_ProDKin_1	93	99	PF00069	0.631
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.444
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.479
TRG_ENDOCYTIC_2	108	111	PF00928	0.505
TRG_ENDOCYTIC_2	132	135	PF00928	0.404
TRG_ENDOCYTIC_2	22	25	PF00928	0.513
TRG_ENDOCYTIC_2	245	248	PF00928	0.366
TRG_ENDOCYTIC_2	260	263	PF00928	0.435
TRG_ENDOCYTIC_2	323	326	PF00928	0.348
TRG_ENDOCYTIC_2	70	73	PF00928	0.505
TRG_ER_diArg_1	12	14	PF00400	0.584
TRG_ER_diArg_1	209	211	PF00400	0.467
TRG_ER_diArg_1	290	292	PF00400	0.526
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T7	Leptomonas seymouri	72%	97%
A0A0S4KKV6	Bodo saltans	33%	95%
A0A1X0PAA6	Trypanosomatidae	44%	100%
A0A3S5IR23	Trypanosoma rangeli	49%	100%
A4HB69	Leishmania braziliensis	86%	100%
A4IAB7	Leishmania infantum	99%	100%
C9ZLX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9B5E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2J3	Leishmania major	95%	100%
V5BV68	Trypanosoma cruzi	50%	95%