Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X8A1_LEIDO

TriTrypDb:

LdBPK_343020.1 , LdCL_340039000 , LDHU3_34.5140

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X8A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X8A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	471	475	PF00656	0.385
CLV_NRD_NRD_1	502	504	PF00675	0.351
CLV_NRD_NRD_1	526	528	PF00675	0.290
CLV_PCSK_KEX2_1	279	281	PF00082	0.366
CLV_PCSK_KEX2_1	502	504	PF00082	0.351
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.366
CLV_PCSK_SKI1_1	502	506	PF00082	0.349
CLV_PCSK_SKI1_1	79	83	PF00082	0.544
CLV_Separin_Metazoa	190	194	PF03568	0.366
DEG_APCC_DBOX_1	74	82	PF00400	0.361
DEG_Nend_UBRbox_2	1	3	PF02207	0.678
DOC_CDC14_PxL_1	26	34	PF14671	0.538
DOC_CKS1_1	152	157	PF01111	0.363
DOC_CKS1_1	337	342	PF01111	0.408
DOC_CYCLIN_RxL_1	591	600	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	337	343	PF00134	0.408
DOC_MAPK_gen_1	527	536	PF00069	0.487
DOC_MAPK_MEF2A_6	125	132	PF00069	0.537
DOC_PP1_RVXF_1	446	452	PF00149	0.388
DOC_PP1_RVXF_1	507	513	PF00149	0.614
DOC_PP1_RVXF_1	84	90	PF00149	0.271
DOC_PP2B_LxvP_1	417	420	PF13499	0.515
DOC_PP2B_LxvP_1	596	599	PF13499	0.614
DOC_PP2B_PxIxI_1	600	606	PF00149	0.550
DOC_USP7_MATH_1	462	466	PF00917	0.399
DOC_USP7_MATH_1	609	613	PF00917	0.642
DOC_WW_Pin1_4	12	17	PF00397	0.620
DOC_WW_Pin1_4	151	156	PF00397	0.363
DOC_WW_Pin1_4	3	8	PF00397	0.731
DOC_WW_Pin1_4	336	341	PF00397	0.408
DOC_WW_Pin1_4	518	523	PF00397	0.520
LIG_14-3-3_CanoR_1	177	185	PF00244	0.350
LIG_14-3-3_CanoR_1	249	258	PF00244	0.405
LIG_14-3-3_CanoR_1	298	308	PF00244	0.521
LIG_14-3-3_CanoR_1	502	510	PF00244	0.653
LIG_14-3-3_CanoR_1	75	79	PF00244	0.363
LIG_14-3-3_CanoR_1	86	92	PF00244	0.236
LIG_Actin_WH2_2	410	427	PF00022	0.424
LIG_Actin_WH2_2	437	455	PF00022	0.415
LIG_APCC_ABBA_1	319	324	PF00400	0.399
LIG_BRCT_BRCA1_1	373	377	PF00533	0.408
LIG_BRCT_BRCA1_1	632	636	PF00533	0.709
LIG_BRCT_BRCA1_1	8	12	PF00533	0.589
LIG_CaM_NSCaTE_8	112	119	PF13499	0.474
LIG_Clathr_ClatBox_1	602	606	PF01394	0.607
LIG_CSL_BTD_1	337	340	PF09270	0.276
LIG_deltaCOP1_diTrp_1	254	258	PF00928	0.261
LIG_FHA_1	181	187	PF00498	0.352
LIG_FHA_1	288	294	PF00498	0.549
LIG_FHA_1	337	343	PF00498	0.305
LIG_FHA_1	393	399	PF00498	0.554
LIG_FHA_1	444	450	PF00498	0.401
LIG_FHA_1	519	525	PF00498	0.508
LIG_FHA_1	52	58	PF00498	0.469
LIG_FHA_1	530	536	PF00498	0.440
LIG_FHA_1	556	562	PF00498	0.425
LIG_FHA_1	82	88	PF00498	0.441
LIG_FHA_2	469	475	PF00498	0.423
LIG_FHA_2	80	86	PF00498	0.398
LIG_GBD_Chelix_1	52	60	PF00786	0.425
LIG_LIR_Gen_1	256	266	PF02991	0.293
LIG_LIR_Gen_1	348	358	PF02991	0.536
LIG_LIR_Gen_1	401	410	PF02991	0.434
LIG_LIR_Gen_1	476	487	PF02991	0.314
LIG_LIR_Gen_1	54	60	PF02991	0.404
LIG_LIR_LC3C_4	54	58	PF02991	0.377
LIG_LIR_Nem_3	256	261	PF02991	0.341
LIG_LIR_Nem_3	348	353	PF02991	0.516
LIG_LIR_Nem_3	374	380	PF02991	0.315
LIG_LIR_Nem_3	457	461	PF02991	0.395
LIG_LIR_Nem_3	476	482	PF02991	0.213
LIG_LIR_Nem_3	54	58	PF02991	0.438
LIG_PCNA_yPIPBox_3	48	56	PF02747	0.408
LIG_Pex14_1	263	267	PF04695	0.408
LIG_Pex14_1	70	74	PF04695	0.327
LIG_Pex14_2	382	386	PF04695	0.338
LIG_PTB_Apo_2	269	276	PF02174	0.276
LIG_PTB_Phospho_1	269	275	PF10480	0.408
LIG_RPA_C_Fungi	498	510	PF08784	0.467
LIG_SH2_CRK	33	37	PF00017	0.319
LIG_SH2_PTP2	552	555	PF00017	0.518
LIG_SH2_SRC	273	276	PF00017	0.417
LIG_SH2_STAT3	195	198	PF00017	0.348
LIG_SH2_STAT5	18	21	PF00017	0.388
LIG_SH2_STAT5	195	198	PF00017	0.348
LIG_SH2_STAT5	247	250	PF00017	0.497
LIG_SH2_STAT5	273	276	PF00017	0.447
LIG_SH2_STAT5	403	406	PF00017	0.408
LIG_SH2_STAT5	552	555	PF00017	0.518
LIG_SH2_STAT5	589	592	PF00017	0.393
LIG_SH3_3	258	264	PF00018	0.219
LIG_SUMO_SIM_anti_2	311	316	PF11976	0.308
LIG_SUMO_SIM_anti_2	323	329	PF11976	0.241
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.263
LIG_SUMO_SIM_anti_2	532	537	PF11976	0.355
LIG_SUMO_SIM_par_1	317	324	PF11976	0.494
LIG_SUMO_SIM_par_1	600	606	PF11976	0.429
LIG_UBA3_1	560	567	PF00899	0.408
LIG_WW_1	30	33	PF00397	0.520
MOD_CK1_1	6	12	PF00069	0.657
MOD_CK1_1	617	623	PF00069	0.648
MOD_CK1_1	63	69	PF00069	0.408
MOD_CK2_1	317	323	PF00069	0.498
MOD_CK2_1	426	432	PF00069	0.566
MOD_CK2_1	79	85	PF00069	0.395
MOD_CMANNOS	252	255	PF00535	0.538
MOD_CMANNOS	412	415	PF00535	0.408
MOD_GlcNHglycan	373	376	PF01048	0.219
MOD_GlcNHglycan	428	431	PF01048	0.554
MOD_GlcNHglycan	518	521	PF01048	0.546
MOD_GlcNHglycan	541	544	PF01048	0.301
MOD_GlcNHglycan	617	620	PF01048	0.635
MOD_GlcNHglycan	8	11	PF01048	0.579
MOD_GSK3_1	176	183	PF00069	0.608
MOD_GSK3_1	283	290	PF00069	0.504
MOD_GSK3_1	367	374	PF00069	0.369
MOD_GSK3_1	404	411	PF00069	0.362
MOD_GSK3_1	584	591	PF00069	0.550
MOD_GSK3_1	59	66	PF00069	0.444
MOD_GSK3_1	614	621	PF00069	0.670
MOD_GSK3_1	8	15	PF00069	0.554
MOD_N-GLC_1	392	397	PF02516	0.370
MOD_NEK2_1	287	292	PF00069	0.437
MOD_NEK2_1	308	313	PF00069	0.314
MOD_NEK2_1	317	322	PF00069	0.321
MOD_NEK2_1	330	335	PF00069	0.276
MOD_NEK2_1	398	403	PF00069	0.377
MOD_NEK2_1	413	418	PF00069	0.271
MOD_NEK2_1	529	534	PF00069	0.381
MOD_NEK2_1	568	573	PF00069	0.356
MOD_NEK2_1	584	589	PF00069	0.419
MOD_NEK2_1	60	65	PF00069	0.442
MOD_NEK2_1	615	620	PF00069	0.605
MOD_NEK2_1	8	13	PF00069	0.667
MOD_NEK2_1	87	92	PF00069	0.305
MOD_NEK2_2	392	397	PF00069	0.331
MOD_NEK2_2	74	79	PF00069	0.410
MOD_PIKK_1	468	474	PF00454	0.452
MOD_PIKK_1	555	561	PF00454	0.568
MOD_PKA_1	502	508	PF00069	0.429
MOD_PKA_2	176	182	PF00069	0.453
MOD_PKA_2	502	508	PF00069	0.593
MOD_PKA_2	74	80	PF00069	0.334
MOD_Plk_1	253	259	PF00069	0.402
MOD_Plk_1	392	398	PF00069	0.341
MOD_Plk_4	280	286	PF00069	0.537
MOD_Plk_4	308	314	PF00069	0.317
MOD_Plk_4	330	336	PF00069	0.334
MOD_Plk_4	367	373	PF00069	0.487
MOD_Plk_4	386	392	PF00069	0.179
MOD_Plk_4	408	414	PF00069	0.300
MOD_Plk_4	462	468	PF00069	0.434
MOD_Plk_4	51	57	PF00069	0.611
MOD_Plk_4	573	579	PF00069	0.318
MOD_Plk_4	584	590	PF00069	0.417
MOD_ProDKin_1	12	18	PF00069	0.520
MOD_ProDKin_1	151	157	PF00069	0.442
MOD_ProDKin_1	3	9	PF00069	0.682
MOD_ProDKin_1	336	342	PF00069	0.408
MOD_ProDKin_1	518	524	PF00069	0.385
MOD_SUMO_rev_2	621	630	PF00179	0.769
TRG_DiLeu_BaEn_1	323	328	PF01217	0.408
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.466
TRG_ENDOCYTIC_2	213	216	PF00928	0.380
TRG_ENDOCYTIC_2	33	36	PF00928	0.433
TRG_ENDOCYTIC_2	350	353	PF00928	0.408
TRG_ENDOCYTIC_2	403	406	PF00928	0.297
TRG_ER_diArg_1	502	504	PF00400	0.458
TRG_ER_diArg_1	512	515	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ84	Leptomonas seymouri	62%	100%
A0A1X0PA84	Trypanosomatidae	36%	97%
A0A3R7KG27	Trypanosoma rangeli	34%	100%
A4HB42	Leishmania braziliensis	78%	100%
A4IA91	Leishmania infantum	100%	100%
C9ZM03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B5B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q2M0	Leishmania major	94%	100%
V5DLY6	Trypanosoma cruzi	34%	100%