Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X898_LEIDO

TriTrypDb:

LdBPK_342930.1 , LdCL_340038100 , LDHU3_34.5050

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X898

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X898

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.395
CLV_NRD_NRD_1	12	14	PF00675	0.685
CLV_NRD_NRD_1	304	306	PF00675	0.619
CLV_PCSK_KEX2_1	12	14	PF00082	0.685
CLV_PCSK_KEX2_1	145	147	PF00082	0.638
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.638
CLV_PCSK_SKI1_1	168	172	PF00082	0.730
CLV_PCSK_SKI1_1	226	230	PF00082	0.594
CLV_PCSK_SKI1_1	264	268	PF00082	0.580
CLV_PCSK_SKI1_1	307	311	PF00082	0.607
DEG_Nend_UBRbox_2	1	3	PF02207	0.494
DOC_MAPK_FxFP_2	187	190	PF00069	0.331
DOC_MAPK_gen_1	196	205	PF00069	0.434
DOC_MAPK_gen_1	226	236	PF00069	0.377
DOC_MAPK_gen_1	303	311	PF00069	0.400
DOC_MAPK_gen_1	376	384	PF00069	0.378
DOC_MAPK_MEF2A_6	196	205	PF00069	0.381
DOC_MAPK_MEF2A_6	281	290	PF00069	0.392
DOC_PP2B_PxIxI_1	174	180	PF00149	0.326
DOC_PP4_FxxP_1	187	190	PF00568	0.331
DOC_USP7_MATH_1	166	170	PF00917	0.494
DOC_USP7_MATH_1	250	254	PF00917	0.616
DOC_WW_Pin1_4	171	176	PF00397	0.406
DOC_WW_Pin1_4	269	274	PF00397	0.312
DOC_WW_Pin1_4	315	320	PF00397	0.358
DOC_WW_Pin1_4	339	344	PF00397	0.349
DOC_WW_Pin1_4	5	10	PF00397	0.458
LIG_14-3-3_CanoR_1	136	142	PF00244	0.377
LIG_14-3-3_CanoR_1	168	177	PF00244	0.358
LIG_14-3-3_CanoR_1	226	236	PF00244	0.377
LIG_14-3-3_CanoR_1	281	288	PF00244	0.323
LIG_14-3-3_CanoR_1	305	310	PF00244	0.388
LIG_14-3-3_CanoR_1	67	73	PF00244	0.487
LIG_14-3-3_CanoR_1	94	99	PF00244	0.370
LIG_BRCT_BRCA1_1	398	402	PF00533	0.276
LIG_eIF4E_1	204	210	PF01652	0.373
LIG_FHA_1	229	235	PF00498	0.399
LIG_FHA_1	391	397	PF00498	0.418
LIG_FHA_1	418	424	PF00498	0.457
LIG_FHA_2	159	165	PF00498	0.467
LIG_FHA_2	39	45	PF00498	0.520
LIG_GBD_Chelix_1	409	417	PF00786	0.295
LIG_LIR_Apic_2	314	319	PF02991	0.372
LIG_LIR_Gen_1	378	389	PF02991	0.365
LIG_LIR_Nem_3	104	109	PF02991	0.340
LIG_LIR_Nem_3	265	271	PF02991	0.334
LIG_LIR_Nem_3	289	295	PF02991	0.366
LIG_LIR_Nem_3	310	316	PF02991	0.371
LIG_LIR_Nem_3	378	384	PF02991	0.386
LIG_NRBOX	384	390	PF00104	0.299
LIG_NRBOX	413	419	PF00104	0.329
LIG_PDZ_Class_2	420	425	PF00595	0.573
LIG_Pex14_1	184	188	PF04695	0.324
LIG_Pex14_1	263	267	PF04695	0.392
LIG_Pex14_2	383	387	PF04695	0.288
LIG_PTB_Apo_2	256	263	PF02174	0.375
LIG_PTB_Phospho_1	256	262	PF10480	0.380
LIG_SH2_CRK	20	24	PF00017	0.455
LIG_SH2_CRK	316	320	PF00017	0.373
LIG_SH2_CRK	33	37	PF00017	0.407
LIG_SH2_PTP2	381	384	PF00017	0.337
LIG_SH2_STAT3	141	144	PF00017	0.384
LIG_SH2_STAT5	154	157	PF00017	0.419
LIG_SH2_STAT5	185	188	PF00017	0.311
LIG_SH2_STAT5	204	207	PF00017	0.267
LIG_SH2_STAT5	269	272	PF00017	0.330
LIG_SH2_STAT5	316	319	PF00017	0.374
LIG_SH2_STAT5	381	384	PF00017	0.328
LIG_SH3_1	316	322	PF00018	0.364
LIG_SH3_3	12	18	PF00018	0.454
LIG_SH3_3	231	237	PF00018	0.464
LIG_SH3_3	267	273	PF00018	0.335
LIG_SH3_3	316	322	PF00018	0.335
LIG_SH3_3	337	343	PF00018	0.326
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.289
LIG_TYR_ITIM	266	271	PF00017	0.338
LIG_UBA3_1	413	421	PF00899	0.337
MOD_CDK_SPK_2	315	320	PF00069	0.371
MOD_CDK_SPxxK_3	171	178	PF00069	0.393
MOD_CDK_SPxxK_3	5	12	PF00069	0.434
MOD_CK1_1	253	259	PF00069	0.543
MOD_CK1_1	353	359	PF00069	0.382
MOD_CK1_1	40	46	PF00069	0.476
MOD_CK1_1	5	11	PF00069	0.472
MOD_CK2_1	107	113	PF00069	0.410
MOD_CK2_1	158	164	PF00069	0.464
MOD_CK2_1	166	172	PF00069	0.418
MOD_CK2_1	47	53	PF00069	0.486
MOD_GlcNHglycan	168	171	PF01048	0.687
MOD_GlcNHglycan	25	28	PF01048	0.563
MOD_GlcNHglycan	256	259	PF01048	0.663
MOD_GlcNHglycan	282	285	PF01048	0.583
MOD_GlcNHglycan	397	401	PF01048	0.578
MOD_GlcNHglycan	4	7	PF01048	0.664
MOD_GlcNHglycan	49	52	PF01048	0.699
MOD_GlcNHglycan	53	57	PF01048	0.799
MOD_GlcNHglycan	59	62	PF01048	0.717
MOD_GlcNHglycan	79	82	PF01048	0.670
MOD_GSK3_1	166	173	PF00069	0.463
MOD_GSK3_1	246	253	PF00069	0.605
MOD_GSK3_1	307	314	PF00069	0.435
MOD_GSK3_1	34	41	PF00069	0.463
MOD_GSK3_1	371	378	PF00069	0.400
MOD_GSK3_1	57	64	PF00069	0.593
MOD_N-GLC_2	131	133	PF02516	0.591
MOD_NEK2_1	228	233	PF00069	0.426
MOD_NEK2_1	244	249	PF00069	0.499
MOD_NEK2_1	291	296	PF00069	0.398
MOD_NEK2_1	311	316	PF00069	0.346
MOD_NEK2_1	396	401	PF00069	0.480
MOD_NEK2_1	93	98	PF00069	0.368
MOD_NEK2_2	262	267	PF00069	0.323
MOD_PIKK_1	123	129	PF00454	0.351
MOD_PIKK_1	34	40	PF00454	0.369
MOD_PK_1	305	311	PF00069	0.313
MOD_PKA_1	145	151	PF00069	0.388
MOD_PKA_1	305	311	PF00069	0.313
MOD_PKA_2	137	143	PF00069	0.363
MOD_PKA_2	145	151	PF00069	0.442
MOD_PKA_2	156	162	PF00069	0.364
MOD_PKA_2	280	286	PF00069	0.428
MOD_PKA_2	375	381	PF00069	0.397
MOD_PKA_2	66	72	PF00069	0.476
MOD_PKA_2	93	99	PF00069	0.382
MOD_PKB_1	303	311	PF00069	0.360
MOD_PKB_1	45	53	PF00069	0.447
MOD_Plk_4	262	268	PF00069	0.399
MOD_Plk_4	286	292	PF00069	0.331
MOD_Plk_4	307	313	PF00069	0.388
MOD_Plk_4	94	100	PF00069	0.459
MOD_ProDKin_1	171	177	PF00069	0.395
MOD_ProDKin_1	269	275	PF00069	0.316
MOD_ProDKin_1	315	321	PF00069	0.353
MOD_ProDKin_1	339	345	PF00069	0.349
MOD_ProDKin_1	5	11	PF00069	0.459
MOD_SUMO_rev_2	342	349	PF00179	0.429
MOD_SUMO_rev_2	365	372	PF00179	0.459
TRG_DiLeu_LyEn_5	172	177	PF01217	0.357
TRG_ENDOCYTIC_2	185	188	PF00928	0.324
TRG_ENDOCYTIC_2	268	271	PF00928	0.330
TRG_ENDOCYTIC_2	381	384	PF00928	0.406
TRG_ER_diArg_1	12	14	PF00400	0.605
TRG_ER_diArg_1	135	138	PF00400	0.329
TRG_ER_diArg_1	29	32	PF00400	0.308
TRG_ER_diArg_1	336	339	PF00400	0.360
TRG_NLS_MonoExtN_4	303	309	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK0	Leptomonas seymouri	47%	96%
A4HB34	Leishmania braziliensis	71%	100%
A4IAN5	Leishmania infantum	99%	100%
E9B5A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2M9	Leishmania major	86%	100%
V5BQG2	Trypanosoma cruzi	23%	100%