DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X894_LEIDO

TriTrypDb:

LdBPK_343050.1 , LdCL_340039400 , LDHU3_34.5190

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X894

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X894

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.499
CLV_PCSK_FUR_1	172	176	PF00082	0.565
CLV_PCSK_KEX2_1	114	116	PF00082	0.344
CLV_PCSK_KEX2_1	174	176	PF00082	0.576
CLV_PCSK_KEX2_1	56	58	PF00082	0.502
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.344
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.576
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.502
DEG_Nend_UBRbox_3	1	3	PF02207	0.509
DOC_CKS1_1	31	36	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.604
DOC_MAPK_gen_1	172	181	PF00069	0.566
DOC_MAPK_gen_1	36	44	PF00069	0.497
DOC_MAPK_gen_1	47	54	PF00069	0.461
DOC_USP7_MATH_1	15	19	PF00917	0.619
DOC_WW_Pin1_4	30	35	PF00397	0.628
LIG_14-3-3_CanoR_1	102	112	PF00244	0.406
LIG_14-3-3_CanoR_1	11	19	PF00244	0.651
LIG_14-3-3_CanoR_1	172	181	PF00244	0.662
LIG_14-3-3_CanoR_1	36	44	PF00244	0.497
LIG_APCC_ABBA_1	82	87	PF00400	0.369
LIG_BRCT_BRCA1_1	132	136	PF00533	0.540
LIG_FHA_1	174	180	PF00498	0.611
LIG_FHA_1	39	45	PF00498	0.559
LIG_LIR_Apic_2	90	96	PF02991	0.393
LIG_LYPXL_S_1	84	88	PF13949	0.344
LIG_LYPXL_yS_3	85	88	PF13949	0.344
LIG_MAD2	115	123	PF02301	0.344
LIG_SH2_CRK	58	62	PF00017	0.523
LIG_SH3_3	158	164	PF00018	0.651
LIG_SH3_3	16	22	PF00018	0.533
LIG_SH3_3	63	69	PF00018	0.575
LIG_TRAF2_1	164	167	PF00917	0.653
LIG_UBA3_1	178	184	PF00899	0.554
MOD_CDK_SPxK_1	30	36	PF00069	0.609
MOD_Cter_Amidation	54	57	PF01082	0.507
MOD_GlcNHglycan	13	16	PF01048	0.700
MOD_GlcNHglycan	144	147	PF01048	0.678
MOD_GlcNHglycan	156	159	PF01048	0.513
MOD_GlcNHglycan	19	22	PF01048	0.541
MOD_GSK3_1	104	111	PF00069	0.349
MOD_GSK3_1	6	13	PF00069	0.598
MOD_N-GLC_1	167	172	PF02516	0.654
MOD_NEK2_1	130	135	PF00069	0.529
MOD_NEK2_1	23	28	PF00069	0.582
MOD_NEK2_2	6	11	PF00069	0.637
MOD_PKA_1	174	180	PF00069	0.667
MOD_PKA_2	10	16	PF00069	0.599
MOD_PKA_2	174	180	PF00069	0.667
MOD_Plk_1	167	173	PF00069	0.655
MOD_Plk_1	23	29	PF00069	0.609
MOD_Plk_4	174	180	PF00069	0.662
MOD_ProDKin_1	30	36	PF00069	0.629
TRG_DiLeu_BaEn_4	166	172	PF01217	0.597
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.660
TRG_ENDOCYTIC_2	85	88	PF00928	0.344
TRG_ER_diArg_1	63	66	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU88	Leptomonas seymouri	68%	92%
A0A1X0PA15	Trypanosomatidae	54%	100%
A0A3R7NSK5	Trypanosoma rangeli	56%	100%
A4HB45	Leishmania braziliensis	75%	100%
A4IA94	Leishmania infantum	99%	100%
C9ZM00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B5B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2L7	Leishmania major	91%	99%