CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X890_LEIDO

TriTrypDb:

LdBPK_342920.1 , LdCL_340038000 , LDHU3_34.5040

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X890

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X890

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.788
CLV_C14_Caspase3-7	232	236	PF00656	0.728
CLV_NRD_NRD_1	13	15	PF00675	0.690
CLV_NRD_NRD_1	16	18	PF00675	0.697
CLV_NRD_NRD_1	9	11	PF00675	0.686
CLV_PCSK_FUR_1	14	18	PF00082	0.751
CLV_PCSK_KEX2_1	13	15	PF00082	0.681
CLV_PCSK_KEX2_1	16	18	PF00082	0.684
CLV_PCSK_KEX2_1	9	11	PF00082	0.694
CLV_PCSK_PC7_1	5	11	PF00082	0.747
DEG_SCF_TRCP1_1	198	204	PF00400	0.584
DEG_SPOP_SBC_1	223	227	PF00917	0.597
DOC_PP4_FxxP_1	131	134	PF00568	0.522
DOC_USP7_MATH_1	223	227	PF00917	0.655
DOC_WW_Pin1_4	219	224	PF00397	0.597
DOC_WW_Pin1_4	45	50	PF00397	0.556
LIG_14-3-3_CanoR_1	205	211	PF00244	0.496
LIG_14-3-3_CanoR_1	21	25	PF00244	0.842
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	172	176	PF00533	0.555
LIG_BRCT_BRCA1_1	206	210	PF00533	0.573
LIG_deltaCOP1_diTrp_1	126	131	PF00928	0.497
LIG_FHA_1	134	140	PF00498	0.565
LIG_FHA_1	153	159	PF00498	0.343
LIG_FHA_1	216	222	PF00498	0.695
LIG_LIR_Apic_2	130	134	PF02991	0.509
LIG_LIR_Gen_1	118	129	PF02991	0.544
LIG_LIR_Nem_3	118	124	PF02991	0.572
LIG_LIR_Nem_3	126	132	PF02991	0.504
LIG_LYPXL_yS_3	78	81	PF13949	0.621
LIG_PCNA_PIPBox_1	99	108	PF02747	0.584
LIG_PCNA_yPIPBox_3	99	108	PF02747	0.611
LIG_Pex14_1	128	132	PF04695	0.497
LIG_SH2_GRB2like	141	144	PF00017	0.516
LIG_SH2_SRC	141	144	PF00017	0.516
LIG_SH2_STAT5	105	108	PF00017	0.572
LIG_SH2_STAT5	164	167	PF00017	0.464
LIG_SH2_STAT5	67	70	PF00017	0.561
MOD_CDK_SPxxK_3	45	52	PF00069	0.549
MOD_CK1_1	144	150	PF00069	0.537
MOD_CK1_1	20	26	PF00069	0.694
MOD_CK1_1	201	207	PF00069	0.708
MOD_CK1_1	208	214	PF00069	0.713
MOD_CK1_1	215	221	PF00069	0.761
MOD_CK1_1	222	228	PF00069	0.704
MOD_CK1_1	230	236	PF00069	0.796
MOD_CK1_1	33	39	PF00069	0.492
MOD_CK1_1	4	10	PF00069	0.831
MOD_CK2_1	9	15	PF00069	0.797
MOD_GlcNHglycan	172	175	PF01048	0.515
MOD_GlcNHglycan	198	201	PF01048	0.761
MOD_GlcNHglycan	227	230	PF01048	0.783
MOD_GlcNHglycan	240	246	PF01048	0.633
MOD_GlcNHglycan	32	35	PF01048	0.747
MOD_GlcNHglycan	95	98	PF01048	0.593
MOD_GSK3_1	194	201	PF00069	0.665
MOD_GSK3_1	204	211	PF00069	0.660
MOD_GSK3_1	212	219	PF00069	0.515
MOD_GSK3_1	221	228	PF00069	0.649
MOD_GSK3_1	229	236	PF00069	0.650
MOD_GSK3_1	29	36	PF00069	0.824
MOD_N-GLC_1	211	216	PF02516	0.598
MOD_NEK2_1	1	6	PF00069	0.837
MOD_NEK2_1	181	186	PF00069	0.527
MOD_NEK2_1	210	215	PF00069	0.574
MOD_NEK2_2	62	67	PF00069	0.324
MOD_PIKK_1	144	150	PF00454	0.586
MOD_PIKK_1	95	101	PF00454	0.516
MOD_PKA_1	17	23	PF00069	0.716
MOD_PKA_1	9	15	PF00069	0.737
MOD_PKA_2	20	26	PF00069	0.634
MOD_PKA_2	204	210	PF00069	0.509
MOD_PKA_2	30	36	PF00069	0.632
MOD_PKA_2	4	10	PF00069	0.725
MOD_Plk_1	144	150	PF00069	0.586
MOD_Plk_1	216	222	PF00069	0.695
MOD_Plk_2-3	235	241	PF00069	0.709
MOD_Plk_4	157	163	PF00069	0.496
MOD_ProDKin_1	219	225	PF00069	0.598
MOD_ProDKin_1	45	51	PF00069	0.547
MOD_SUMO_rev_2	127	136	PF00179	0.590
TRG_ENDOCYTIC_2	78	81	PF00928	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M7	Leptomonas seymouri	73%	99%
A4HB33	Leishmania braziliensis	87%	100%
A4IAN6	Leishmania infantum	99%	100%
E9B5A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q2N0	Leishmania major	89%	100%