Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X888_LEIDO

TriTrypDb:

LdBPK_342900.1 , LdCL_340037100 , LDHU3_31.1250

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A0A3S7X888

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X888

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.774
CLV_NRD_NRD_1	175	177	PF00675	0.414
CLV_NRD_NRD_1	342	344	PF00675	0.322
CLV_NRD_NRD_1	406	408	PF00675	0.398
CLV_PCSK_KEX2_1	175	177	PF00082	0.360
CLV_PCSK_KEX2_1	342	344	PF00082	0.328
CLV_PCSK_KEX2_1	396	398	PF00082	0.405
CLV_PCSK_KEX2_1	406	408	PF00082	0.393
CLV_PCSK_KEX2_1	574	576	PF00082	0.476
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.417
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.475
CLV_PCSK_PC7_1	338	344	PF00082	0.312
CLV_PCSK_SKI1_1	124	128	PF00082	0.349
CLV_PCSK_SKI1_1	139	143	PF00082	0.367
CLV_PCSK_SKI1_1	176	180	PF00082	0.464
CLV_PCSK_SKI1_1	393	397	PF00082	0.398
CLV_PCSK_SKI1_1	407	411	PF00082	0.336
CLV_PCSK_SKI1_1	511	515	PF00082	0.283
DEG_APCC_DBOX_1	381	389	PF00400	0.560
DOC_CYCLIN_RxL_1	532	545	PF00134	0.269
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.528
DOC_MAPK_DCC_7	599	607	PF00069	0.298
DOC_MAPK_MEF2A_6	152	160	PF00069	0.509
DOC_MAPK_MEF2A_6	599	607	PF00069	0.287
DOC_MAPK_RevD_3	386	402	PF00069	0.502
DOC_PP1_RVXF_1	122	129	PF00149	0.531
DOC_PP1_RVXF_1	307	313	PF00149	0.613
DOC_PP1_RVXF_1	535	542	PF00149	0.266
DOC_PP4_FxxP_1	324	327	PF00568	0.587
DOC_USP7_MATH_1	316	320	PF00917	0.563
DOC_USP7_MATH_1	4	8	PF00917	0.636
DOC_USP7_MATH_1	488	492	PF00917	0.242
DOC_USP7_MATH_1	566	570	PF00917	0.432
DOC_USP7_MATH_1	588	592	PF00917	0.284
DOC_USP7_MATH_1	60	64	PF00917	0.738
DOC_USP7_MATH_1	75	79	PF00917	0.769
DOC_USP7_UBL2_3	396	400	PF12436	0.553
DOC_WW_Pin1_4	112	117	PF00397	0.598
LIG_14-3-3_CanoR_1	124	129	PF00244	0.546
LIG_14-3-3_CanoR_1	162	170	PF00244	0.583
LIG_14-3-3_CanoR_1	360	370	PF00244	0.544
LIG_14-3-3_CanoR_1	43	48	PF00244	0.736
LIG_14-3-3_CanoR_1	496	500	PF00244	0.525
LIG_14-3-3_CanoR_1	511	517	PF00244	0.476
LIG_14-3-3_CanoR_1	537	542	PF00244	0.287
LIG_Actin_WH2_2	104	122	PF00022	0.645
LIG_Clathr_ClatBox_1	388	392	PF01394	0.537
LIG_deltaCOP1_diTrp_1	27	30	PF00928	0.614
LIG_EH1_1	625	633	PF00400	0.581
LIG_eIF4E_1	596	602	PF01652	0.268
LIG_eIF4E_1	620	626	PF01652	0.524
LIG_FHA_1	152	158	PF00498	0.546
LIG_FHA_1	3	9	PF00498	0.629
LIG_FHA_1	421	427	PF00498	0.554
LIG_FHA_1	433	439	PF00498	0.486
LIG_FHA_1	444	450	PF00498	0.234
LIG_FHA_1	453	459	PF00498	0.165
LIG_FHA_1	477	483	PF00498	0.408
LIG_FHA_1	50	56	PF00498	0.698
LIG_FHA_2	162	168	PF00498	0.552
LIG_FHA_2	210	216	PF00498	0.652
LIG_FHA_2	273	279	PF00498	0.685
LIG_FHA_2	378	384	PF00498	0.567
LIG_GBD_Chelix_1	628	636	PF00786	0.421
LIG_LIR_Apic_2	322	327	PF02991	0.576
LIG_LIR_Gen_1	318	327	PF02991	0.517
LIG_LIR_Gen_1	534	542	PF02991	0.313
LIG_LIR_Gen_1	618	628	PF02991	0.389
LIG_LIR_Nem_3	140	146	PF02991	0.608
LIG_LIR_Nem_3	318	324	PF02991	0.518
LIG_LIR_Nem_3	534	538	PF02991	0.305
LIG_LIR_Nem_3	614	620	PF02991	0.350
LIG_LYPXL_S_1	472	476	PF13949	0.377
LIG_LYPXL_yS_3	473	476	PF13949	0.377
LIG_PCNA_yPIPBox_3	590	599	PF02747	0.260
LIG_Pex14_2	248	252	PF04695	0.615
LIG_Pex14_2	320	324	PF04695	0.560
LIG_Pex14_2	612	616	PF04695	0.454
LIG_PTAP_UEV_1	76	81	PF05743	0.642
LIG_SH2_CRK	413	417	PF00017	0.624
LIG_SH2_GRB2like	221	224	PF00017	0.704
LIG_SH2_SRC	344	347	PF00017	0.570
LIG_SH2_STAP1	535	539	PF00017	0.349
LIG_SH2_STAT3	555	558	PF00017	0.361
LIG_SH2_STAT3	587	590	PF00017	0.260
LIG_SH2_STAT5	163	166	PF00017	0.575
LIG_SH2_STAT5	299	302	PF00017	0.630
LIG_SH2_STAT5	331	334	PF00017	0.517
LIG_SH2_STAT5	344	347	PF00017	0.528
LIG_SH2_STAT5	468	471	PF00017	0.282
LIG_SH2_STAT5	475	478	PF00017	0.278
LIG_SH2_STAT5	596	599	PF00017	0.460
LIG_SH2_STAT5	620	623	PF00017	0.521
LIG_SH3_3	226	232	PF00018	0.639
LIG_SH3_3	543	549	PF00018	0.364
LIG_SH3_3	71	77	PF00018	0.706
LIG_SH3_3	79	85	PF00018	0.688
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.509
LIG_SUMO_SIM_anti_2	437	442	PF11976	0.276
LIG_SUMO_SIM_anti_2	446	452	PF11976	0.253
LIG_SUMO_SIM_par_1	478	483	PF11976	0.270
LIG_TRAF2_1	213	216	PF00917	0.665
LIG_TRAF2_1	381	384	PF00917	0.498
LIG_TRAF2_1	92	95	PF00917	0.567
LIG_UBA3_1	146	152	PF00899	0.458
LIG_UBA3_1	388	396	PF00899	0.526
LIG_WRC_WIRS_1	299	304	PF05994	0.573
LIG_WRC_WIRS_1	44	49	PF05994	0.628
LIG_WRC_WIRS_1	538	543	PF05994	0.378
LIG_WRC_WIRS_1	612	617	PF05994	0.274
MOD_CK1_1	319	325	PF00069	0.522
MOD_CK1_1	53	59	PF00069	0.789
MOD_CK1_1	561	567	PF00069	0.352
MOD_CK2_1	112	118	PF00069	0.567
MOD_CK2_1	209	215	PF00069	0.693
MOD_CK2_1	255	261	PF00069	0.716
MOD_CK2_1	272	278	PF00069	0.688
MOD_CK2_1	377	383	PF00069	0.562
MOD_CK2_1	537	543	PF00069	0.369
MOD_GlcNHglycan	205	208	PF01048	0.538
MOD_GlcNHglycan	30	33	PF01048	0.559
MOD_GlcNHglycan	516	519	PF01048	0.428
MOD_GlcNHglycan	52	55	PF01048	0.528
MOD_GlcNHglycan	555	558	PF01048	0.524
MOD_GlcNHglycan	560	563	PF01048	0.490
MOD_GlcNHglycan	59	63	PF01048	0.507
MOD_GlcNHglycan	77	80	PF01048	0.590
MOD_GSK3_1	253	260	PF00069	0.662
MOD_GSK3_1	298	305	PF00069	0.568
MOD_GSK3_1	315	322	PF00069	0.541
MOD_GSK3_1	452	459	PF00069	0.399
MOD_GSK3_1	476	483	PF00069	0.367
MOD_GSK3_1	484	491	PF00069	0.366
MOD_GSK3_1	49	56	PF00069	0.685
MOD_GSK3_1	512	519	PF00069	0.367
MOD_GSK3_1	537	544	PF00069	0.323
MOD_GSK3_1	561	568	PF00069	0.368
MOD_N-GLC_1	219	224	PF02516	0.528
MOD_N-GLC_1	97	102	PF02516	0.407
MOD_NEK2_1	146	151	PF00069	0.543
MOD_NEK2_1	185	190	PF00069	0.742
MOD_NEK2_1	272	277	PF00069	0.761
MOD_NEK2_1	302	307	PF00069	0.569
MOD_NEK2_1	362	367	PF00069	0.509
MOD_NEK2_1	377	382	PF00069	0.491
MOD_NEK2_1	420	425	PF00069	0.558
MOD_NEK2_1	426	431	PF00069	0.540
MOD_NEK2_1	443	448	PF00069	0.325
MOD_NEK2_1	453	458	PF00069	0.316
MOD_NEK2_1	506	511	PF00069	0.548
MOD_NEK2_1	514	519	PF00069	0.369
MOD_NEK2_1	611	616	PF00069	0.397
MOD_NEK2_2	316	321	PF00069	0.545
MOD_NEK2_2	4	9	PF00069	0.607
MOD_NEK2_2	488	493	PF00069	0.287
MOD_NEK2_2	566	571	PF00069	0.452
MOD_PIKK_1	185	191	PF00454	0.681
MOD_PIKK_1	346	352	PF00454	0.520
MOD_PKA_2	161	167	PF00069	0.545
MOD_PKA_2	378	384	PF00069	0.622
MOD_PKA_2	420	426	PF00069	0.525
MOD_PKA_2	495	501	PF00069	0.601
MOD_PKA_2	558	564	PF00069	0.355
MOD_Plk_1	130	136	PF00069	0.552
MOD_Plk_1	26	32	PF00069	0.777
MOD_Plk_1	278	284	PF00069	0.681
MOD_Plk_1	97	103	PF00069	0.567
MOD_Plk_4	151	157	PF00069	0.515
MOD_Plk_4	316	322	PF00069	0.518
MOD_Plk_4	443	449	PF00069	0.358
MOD_Plk_4	453	459	PF00069	0.333
MOD_Plk_4	476	482	PF00069	0.291
MOD_Plk_4	537	543	PF00069	0.337
MOD_Plk_4	566	572	PF00069	0.367
MOD_Plk_4	588	594	PF00069	0.357
MOD_Plk_4	611	617	PF00069	0.350
MOD_Plk_4	97	103	PF00069	0.588
MOD_ProDKin_1	112	118	PF00069	0.596
MOD_SUMO_rev_2	115	122	PF00179	0.605
MOD_SUMO_rev_2	392	398	PF00179	0.601
TRG_DiLeu_BaEn_1	153	158	PF01217	0.587
TRG_DiLeu_BaEn_1	264	269	PF01217	0.710
TRG_DiLeu_BaEn_1	384	389	PF01217	0.530
TRG_DiLeu_BaEn_4	165	171	PF01217	0.623
TRG_DiLeu_BaEn_4	86	92	PF01217	0.568
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.269
TRG_DiLeu_LyEn_5	109	114	PF01217	0.567
TRG_ENDOCYTIC_2	143	146	PF00928	0.522
TRG_ENDOCYTIC_2	299	302	PF00928	0.616
TRG_ENDOCYTIC_2	321	324	PF00928	0.549
TRG_ENDOCYTIC_2	331	334	PF00928	0.542
TRG_ENDOCYTIC_2	473	476	PF00928	0.335
TRG_ENDOCYTIC_2	535	538	PF00928	0.352
TRG_ENDOCYTIC_2	620	623	PF00928	0.447
TRG_ER_diArg_1	283	286	PF00400	0.773
TRG_ER_diArg_1	341	343	PF00400	0.511
TRG_NLS_MonoExtC_3	395	400	PF00514	0.616
TRG_NLS_MonoExtN_4	393	400	PF00514	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	31%	100%
A0A0N1HRT9	Leptomonas seymouri	31%	100%
A0A0N1P9A0	Leptomonas seymouri	30%	100%
A0A0N1PBU6	Leptomonas seymouri	54%	100%
A0A1X0P9W4	Trypanosomatidae	37%	100%
A0A3Q8IFF3	Leishmania donovani	32%	98%
A0A3Q8ISH4	Leishmania donovani	33%	100%
A0A3R7KFP4	Trypanosoma rangeli	36%	100%
A0A3S7X483	Leishmania donovani	32%	98%
A4HB26	Leishmania braziliensis	67%	99%
A4HJ59	Leishmania braziliensis	30%	100%
A4HJ60	Leishmania braziliensis	31%	100%
A4I6H4	Leishmania infantum	32%	98%
A4I6H5	Leishmania infantum	33%	100%
A4IA83	Leishmania infantum	99%	100%
C9ZM24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q6I2	Leishmania major	34%	100%
Q4Q6I3	Leishmania major	31%	99%
V5B5A9	Trypanosoma cruzi	37%	100%