Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X887_LEIDO

TriTrypDb:

LdBPK_343090.1 , LdCL_340039800 , LDHU3_34.5250

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A0A3S7X887

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X887

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.505
CLV_C14_Caspase3-7	81	85	PF00656	0.551
CLV_NRD_NRD_1	172	174	PF00675	0.678
CLV_NRD_NRD_1	250	252	PF00675	0.537
CLV_NRD_NRD_1	339	341	PF00675	0.431
CLV_NRD_NRD_1	464	466	PF00675	0.557
CLV_PCSK_KEX2_1	172	174	PF00082	0.809
CLV_PCSK_KEX2_1	250	252	PF00082	0.537
CLV_PCSK_KEX2_1	339	341	PF00082	0.431
CLV_PCSK_KEX2_1	57	59	PF00082	0.691
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.576
CLV_PCSK_SKI1_1	156	160	PF00082	0.753
CLV_PCSK_SKI1_1	181	185	PF00082	0.515
CLV_PCSK_SKI1_1	392	396	PF00082	0.464
CLV_PCSK_SKI1_1	397	401	PF00082	0.408
CLV_PCSK_SKI1_1	466	470	PF00082	0.594
CLV_Separin_Metazoa	462	466	PF03568	0.462
DEG_APCC_DBOX_1	180	188	PF00400	0.601
DEG_COP1_1	402	409	PF00400	0.433
DEG_Nend_UBRbox_2	1	3	PF02207	0.711
DOC_CDC14_PxL_1	387	395	PF14671	0.442
DOC_CKS1_1	195	200	PF01111	0.637
DOC_CYCLIN_RxL_1	392	403	PF00134	0.446
DOC_CYCLIN_yClb1_LxF_4	66	72	PF00134	0.377
DOC_MAPK_gen_1	392	401	PF00069	0.479
DOC_MAPK_MEF2A_6	392	400	PF00069	0.437
DOC_MAPK_MEF2A_6	420	428	PF00069	0.484
DOC_MAPK_MEF2A_6	57	66	PF00069	0.633
DOC_PP1_RVXF_1	179	186	PF00149	0.735
DOC_PP4_FxxP_1	134	137	PF00568	0.572
DOC_PP4_FxxP_1	235	238	PF00568	0.524
DOC_PP4_FxxP_1	31	34	PF00568	0.663
DOC_USP7_MATH_1	151	155	PF00917	0.698
DOC_USP7_MATH_1	206	210	PF00917	0.447
DOC_USP7_MATH_1	265	269	PF00917	0.608
DOC_USP7_MATH_1	3	7	PF00917	0.670
DOC_USP7_MATH_1	381	385	PF00917	0.510
DOC_USP7_MATH_1	405	409	PF00917	0.440
DOC_WW_Pin1_4	194	199	PF00397	0.646
LIG_14-3-3_CanoR_1	172	180	PF00244	0.749
LIG_14-3-3_CanoR_1	339	344	PF00244	0.403
LIG_14-3-3_CanoR_1	465	474	PF00244	0.574
LIG_14-3-3_CanoR_1	74	83	PF00244	0.566
LIG_14-3-3_CanoR_1	8	15	PF00244	0.773
LIG_BRCT_BRCA1_1	231	235	PF00533	0.537
LIG_deltaCOP1_diTrp_1	127	134	PF00928	0.451
LIG_eIF4E_1	135	141	PF01652	0.559
LIG_FHA_1	153	159	PF00498	0.755
LIG_FHA_1	195	201	PF00498	0.589
LIG_FHA_1	221	227	PF00498	0.558
LIG_FHA_1	278	284	PF00498	0.445
LIG_FHA_1	328	334	PF00498	0.379
LIG_FHA_1	381	387	PF00498	0.474
LIG_FHA_1	419	425	PF00498	0.541
LIG_FHA_1	497	503	PF00498	0.610
LIG_FHA_2	184	190	PF00498	0.565
LIG_FHA_2	347	353	PF00498	0.547
LIG_FHA_2	441	447	PF00498	0.555
LIG_FHA_2	508	514	PF00498	0.487
LIG_FHA_2	79	85	PF00498	0.468
LIG_FHA_2	95	101	PF00498	0.464
LIG_LIR_Apic_2	118	122	PF02991	0.461
LIG_LIR_Apic_2	131	137	PF02991	0.566
LIG_LIR_Apic_2	232	238	PF02991	0.528
LIG_LIR_Gen_1	315	326	PF02991	0.411
LIG_LIR_Gen_1	332	343	PF02991	0.429
LIG_LIR_Gen_1	372	381	PF02991	0.439
LIG_LIR_Gen_1	478	488	PF02991	0.404
LIG_LIR_Gen_1	97	107	PF02991	0.478
LIG_LIR_Nem_3	193	199	PF02991	0.574
LIG_LIR_Nem_3	2	7	PF02991	0.572
LIG_LIR_Nem_3	247	252	PF02991	0.486
LIG_LIR_Nem_3	315	321	PF02991	0.384
LIG_LIR_Nem_3	332	338	PF02991	0.392
LIG_LIR_Nem_3	372	378	PF02991	0.462
LIG_LIR_Nem_3	408	414	PF02991	0.507
LIG_LIR_Nem_3	469	474	PF02991	0.536
LIG_LIR_Nem_3	478	483	PF02991	0.326
LIG_LIR_Nem_3	97	102	PF02991	0.508
LIG_NRBOX	292	298	PF00104	0.362
LIG_NRBOX	355	361	PF00104	0.527
LIG_NRBOX	395	401	PF00104	0.412
LIG_Pex14_2	134	138	PF04695	0.490
LIG_Pex14_2	479	483	PF04695	0.383
LIG_PTB_Apo_2	473	480	PF02174	0.595
LIG_SH2_CRK	196	200	PF00017	0.593
LIG_SH2_CRK	375	379	PF00017	0.409
LIG_SH2_STAP1	440	444	PF00017	0.554
LIG_SH2_STAT5	196	199	PF00017	0.556
LIG_SH2_STAT5	302	305	PF00017	0.471
LIG_SH2_STAT5	375	378	PF00017	0.393
LIG_SH2_STAT5	389	392	PF00017	0.383
LIG_SH2_STAT5	471	474	PF00017	0.608
LIG_SH3_3	401	407	PF00018	0.401
LIG_SH3_4	191	198	PF00018	0.541
LIG_Sin3_3	291	298	PF02671	0.389
LIG_SUMO_SIM_par_1	197	202	PF11976	0.635
LIG_SUMO_SIM_par_1	279	285	PF11976	0.481
LIG_SUMO_SIM_par_1	397	403	PF11976	0.394
LIG_TRAF2_1	124	127	PF00917	0.579
LIG_TRAF2_1	20	23	PF00917	0.753
LIG_TRAF2_1	443	446	PF00917	0.482
LIG_TYR_ITIM	316	321	PF00017	0.349
LIG_TYR_ITIM	373	378	PF00017	0.384
LIG_TYR_ITSM	467	474	PF00017	0.449
LIG_UBA3_1	102	109	PF00899	0.524
LIG_UBA3_1	183	191	PF00899	0.587
LIG_UBA3_1	296	305	PF00899	0.422
LIG_UBA3_1	386	395	PF00899	0.483
LIG_WRC_WIRS_1	102	107	PF05994	0.323
LIG_WW_3	178	182	PF00397	0.527
MOD_CK1_1	154	160	PF00069	0.779
MOD_CK1_1	164	170	PF00069	0.578
MOD_CK1_1	276	282	PF00069	0.517
MOD_CK1_1	91	97	PF00069	0.491
MOD_CK2_1	183	189	PF00069	0.577
MOD_CK2_1	440	446	PF00069	0.559
MOD_GlcNHglycan	163	166	PF01048	0.730
MOD_GlcNHglycan	175	178	PF01048	0.729
MOD_GlcNHglycan	231	234	PF01048	0.495
MOD_GlcNHglycan	263	266	PF01048	0.685
MOD_GlcNHglycan	289	292	PF01048	0.458
MOD_GlcNHglycan	352	356	PF01048	0.328
MOD_GlcNHglycan	378	381	PF01048	0.503
MOD_GlcNHglycan	383	386	PF01048	0.468
MOD_GlcNHglycan	407	410	PF01048	0.554
MOD_GSK3_1	11	18	PF00069	0.694
MOD_GSK3_1	157	164	PF00069	0.771
MOD_GSK3_1	253	260	PF00069	0.592
MOD_GSK3_1	261	268	PF00069	0.639
MOD_GSK3_1	273	280	PF00069	0.606
MOD_GSK3_1	3	10	PF00069	0.746
MOD_GSK3_1	310	317	PF00069	0.463
MOD_GSK3_1	329	336	PF00069	0.485
MOD_GSK3_1	347	354	PF00069	0.362
MOD_GSK3_1	376	383	PF00069	0.361
MOD_GSK3_1	74	81	PF00069	0.521
MOD_GSK3_1	91	98	PF00069	0.431
MOD_N-GLC_1	161	166	PF02516	0.605
MOD_N-GLC_1	475	480	PF02516	0.542
MOD_NEK2_1	110	115	PF00069	0.522
MOD_NEK2_1	183	188	PF00069	0.666
MOD_NEK2_1	229	234	PF00069	0.482
MOD_NEK2_1	277	282	PF00069	0.456
MOD_NEK2_1	314	319	PF00069	0.369
MOD_NEK2_1	321	326	PF00069	0.380
MOD_NEK2_1	329	334	PF00069	0.311
MOD_NEK2_1	371	376	PF00069	0.357
MOD_NEK2_1	484	489	PF00069	0.516
MOD_NEK2_1	495	500	PF00069	0.652
MOD_NEK2_1	88	93	PF00069	0.537
MOD_NEK2_2	3	8	PF00069	0.651
MOD_PIKK_1	206	212	PF00454	0.514
MOD_PIKK_1	327	333	PF00454	0.457
MOD_PKA_1	339	345	PF00069	0.431
MOD_PKA_2	171	177	PF00069	0.662
MOD_PKA_2	339	345	PF00069	0.416
MOD_PKA_2	7	13	PF00069	0.770
MOD_PKA_2	73	79	PF00069	0.572
MOD_Plk_1	201	207	PF00069	0.619
MOD_Plk_1	273	279	PF00069	0.557
MOD_Plk_1	314	320	PF00069	0.348
MOD_Plk_1	371	377	PF00069	0.490
MOD_Plk_1	475	481	PF00069	0.555
MOD_Plk_2-3	78	84	PF00069	0.452
MOD_Plk_4	101	107	PF00069	0.407
MOD_Plk_4	273	279	PF00069	0.565
MOD_Plk_4	322	328	PF00069	0.401
MOD_Plk_4	432	438	PF00069	0.483
MOD_Plk_4	475	481	PF00069	0.400
MOD_Plk_4	484	490	PF00069	0.378
MOD_ProDKin_1	194	200	PF00069	0.638
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.504
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.488
TRG_ENDOCYTIC_2	196	199	PF00928	0.532
TRG_ENDOCYTIC_2	318	321	PF00928	0.349
TRG_ENDOCYTIC_2	375	378	PF00928	0.400
TRG_ENDOCYTIC_2	471	474	PF00928	0.655
TRG_ENDOCYTIC_2	506	509	PF00928	0.522
TRG_ER_diArg_1	249	251	PF00400	0.533
TRG_ER_diArg_1	338	340	PF00400	0.430
TRG_ER_diArg_1	449	452	PF00400	0.566
TRG_NES_CRM1_1	388	403	PF08389	0.456
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4I9	Leptomonas seymouri	41%	96%
A0A1X0P9X1	Trypanosomatidae	28%	100%
A0A3R7RMD9	Trypanosoma rangeli	30%	100%
A4HB50	Leishmania braziliensis	63%	99%
A4IA98	Leishmania infantum	100%	100%
C9ZLZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2L3	Leishmania major	89%	100%
V5BV51	Trypanosoma cruzi	30%	100%