Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 28

Species:

Leishmania donovani

UniProt:

A0A3S7X876_LEIDO

TriTrypDb:

LdBPK_342910.1 , LdCL_340037900 , LDHU3_34.5030

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X876

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X876

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.473
CLV_C14_Caspase3-7	191	195	PF00656	0.552
CLV_C14_Caspase3-7	60	64	PF00656	0.704
CLV_NRD_NRD_1	81	83	PF00675	0.455
CLV_PCSK_KEX2_1	179	181	PF00082	0.528
CLV_PCSK_KEX2_1	431	433	PF00082	0.616
CLV_PCSK_KEX2_1	80	82	PF00082	0.449
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.556
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.596
CLV_PCSK_SKI1_1	124	128	PF00082	0.606
CLV_PCSK_SKI1_1	224	228	PF00082	0.385
CLV_PCSK_SKI1_1	336	340	PF00082	0.420
CLV_PCSK_SKI1_1	364	368	PF00082	0.470
DEG_APCC_DBOX_1	71	79	PF00400	0.502
DEG_Nend_UBRbox_2	1	3	PF02207	0.694
DOC_CDC14_PxL_1	231	239	PF14671	0.582
DOC_CKS1_1	1	6	PF01111	0.518
DOC_MAPK_DCC_7	302	312	PF00069	0.394
DOC_MAPK_gen_1	364	374	PF00069	0.511
DOC_MAPK_gen_1	80	91	PF00069	0.538
DOC_MAPK_MEF2A_6	283	290	PF00069	0.386
DOC_MAPK_MEF2A_6	85	93	PF00069	0.545
DOC_PP2B_LxvP_1	145	148	PF13499	0.407
DOC_PP4_FxxP_1	113	116	PF00568	0.382
DOC_SPAK_OSR1_1	417	421	PF12202	0.554
DOC_USP7_MATH_1	12	16	PF00917	0.619
DOC_USP7_MATH_1	165	169	PF00917	0.723
DOC_USP7_MATH_1	300	304	PF00917	0.469
DOC_USP7_MATH_1	326	330	PF00917	0.500
DOC_USP7_MATH_1	406	410	PF00917	0.537
DOC_USP7_UBL2_3	229	233	PF12436	0.350
DOC_USP7_UBL2_3	332	336	PF12436	0.549
DOC_WW_Pin1_4	139	144	PF00397	0.403
DOC_WW_Pin1_4	215	220	PF00397	0.423
DOC_WW_Pin1_4	291	296	PF00397	0.375
LIG_14-3-3_CanoR_1	122	131	PF00244	0.557
LIG_14-3-3_CanoR_1	283	289	PF00244	0.395
LIG_14-3-3_CanoR_1	392	399	PF00244	0.435
LIG_Actin_WH2_2	270	285	PF00022	0.420
LIG_Actin_WH2_2	354	369	PF00022	0.453
LIG_FHA_1	1	7	PF00498	0.690
LIG_FHA_1	140	146	PF00498	0.411
LIG_FHA_1	414	420	PF00498	0.430
LIG_FHA_1	68	74	PF00498	0.514
LIG_FHA_2	15	21	PF00498	0.686
LIG_FHA_2	326	332	PF00498	0.557
LIG_FHA_2	395	401	PF00498	0.504
LIG_FHA_2	48	54	PF00498	0.664
LIG_LIR_Gen_1	181	191	PF02991	0.541
LIG_LIR_Gen_1	99	105	PF02991	0.496
LIG_LIR_Nem_3	139	144	PF02991	0.501
LIG_LIR_Nem_3	181	187	PF02991	0.501
LIG_LIR_Nem_3	97	103	PF02991	0.434
LIG_Pex14_2	341	345	PF04695	0.480
LIG_PTB_Apo_2	236	243	PF02174	0.449
LIG_PTB_Phospho_1	236	242	PF10480	0.452
LIG_REV1ctd_RIR_1	338	348	PF16727	0.441
LIG_SH2_PTP2	359	362	PF00017	0.447
LIG_SH2_STAP1	87	91	PF00017	0.467
LIG_SH2_STAT3	347	350	PF00017	0.502
LIG_SH2_STAT5	242	245	PF00017	0.446
LIG_SH2_STAT5	267	270	PF00017	0.389
LIG_SH2_STAT5	323	326	PF00017	0.540
LIG_SH2_STAT5	359	362	PF00017	0.391
LIG_SH2_STAT5	7	10	PF00017	0.630
LIG_SH3_1	359	365	PF00018	0.468
LIG_SH3_2	362	367	PF14604	0.480
LIG_SH3_3	359	365	PF00018	0.412
LIG_SUMO_SIM_par_1	142	150	PF11976	0.400
LIG_TRAF2_1	410	413	PF00917	0.543
LIG_UBA3_1	226	233	PF00899	0.496
LIG_WRC_WIRS_1	337	342	PF05994	0.422
MOD_CK1_1	163	169	PF00069	0.732
MOD_CK1_1	218	224	PF00069	0.423
MOD_CK1_1	251	257	PF00069	0.478
MOD_CK1_1	291	297	PF00069	0.385
MOD_CK1_1	394	400	PF00069	0.480
MOD_CK2_1	325	331	PF00069	0.403
MOD_CK2_1	382	388	PF00069	0.529
MOD_CK2_1	394	400	PF00069	0.420
MOD_GlcNHglycan	124	127	PF01048	0.633
MOD_GlcNHglycan	164	168	PF01048	0.669
MOD_GlcNHglycan	268	271	PF01048	0.341
MOD_GlcNHglycan	331	335	PF01048	0.507
MOD_GlcNHglycan	404	407	PF01048	0.506
MOD_GlcNHglycan	408	411	PF01048	0.477
MOD_GSK3_1	114	121	PF00069	0.466
MOD_GSK3_1	159	166	PF00069	0.653
MOD_GSK3_1	186	193	PF00069	0.571
MOD_GSK3_1	207	214	PF00069	0.372
MOD_GSK3_1	229	236	PF00069	0.575
MOD_GSK3_1	284	291	PF00069	0.374
MOD_GSK3_1	326	333	PF00069	0.483
MOD_GSK3_1	394	401	PF00069	0.519
MOD_GSK3_1	402	409	PF00069	0.480
MOD_GSK3_1	43	50	PF00069	0.727
MOD_GSK3_1	57	64	PF00069	0.751
MOD_N-GLC_1	251	256	PF02516	0.594
MOD_NEK2_1	201	206	PF00069	0.388
MOD_NEK2_1	290	295	PF00069	0.380
MOD_NEK2_1	89	94	PF00069	0.539
MOD_PKA_2	326	332	PF00069	0.472
MOD_PKA_2	391	397	PF00069	0.425
MOD_PKA_2	61	67	PF00069	0.721
MOD_Plk_1	251	257	PF00069	0.523
MOD_Plk_1	89	95	PF00069	0.518
MOD_Plk_2-3	382	388	PF00069	0.626
MOD_Plk_4	336	342	PF00069	0.494
MOD_Plk_4	398	404	PF00069	0.562
MOD_Plk_4	96	102	PF00069	0.504
MOD_ProDKin_1	139	145	PF00069	0.399
MOD_ProDKin_1	215	221	PF00069	0.429
MOD_ProDKin_1	291	297	PF00069	0.382
MOD_SUMO_for_1	178	181	PF00179	0.621
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.392
TRG_ENDOCYTIC_2	101	104	PF00928	0.442
TRG_ER_diArg_1	80	82	PF00400	0.469
TRG_NES_CRM1_1	196	211	PF08389	0.486
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	81	86	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E1	Leptomonas seymouri	64%	92%
A0A0S4INK9	Bodo saltans	48%	99%
A0A1X0PAR0	Trypanosomatidae	59%	100%
A0A422NNH0	Trypanosoma rangeli	59%	86%
A4HB32	Leishmania braziliensis	83%	100%
A4IAN7	Leishmania infantum	100%	100%
C9ZM15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9B5A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2N1	Leishmania major	94%	100%
V5DLX6	Trypanosoma cruzi	61%	100%