LeishMANIAdb
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Cytosolic carboxypeptidase-like protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytosolic carboxypeptidase-like protein 5
Gene product:
Carboxypeptidase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X873_LEIDO
TriTrypDb:
LdBPK_342670.1 , LdCL_340034700 , LDHU3_34.4590
Length:
843

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 10
GO:0005819 spindle 5 10
GO:0030496 midbody 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0043228 non-membrane-bounded organelle 3 10
GO:0043229 intracellular organelle 3 10
GO:0043231 intracellular membrane-bounded organelle 4 10
GO:0043232 intracellular non-membrane-bounded organelle 4 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3S7X873
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X873

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0018193 peptidyl-amino acid modification 5 10
GO:0018200 peptidyl-glutamic acid modification 6 10
GO:0019538 protein metabolic process 3 10
GO:0035608 protein deglutamylation 7 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044238 primary metabolic process 2 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004180 carboxypeptidase activity 5 10
GO:0004181 metallocarboxypeptidase activity 6 10
GO:0005488 binding 1 10
GO:0008233 peptidase activity 3 10
GO:0008235 metalloexopeptidase activity 5 10
GO:0008237 metallopeptidase activity 4 10
GO:0008238 exopeptidase activity 4 10
GO:0008270 zinc ion binding 6 10
GO:0016787 hydrolase activity 2 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0046914 transition metal ion binding 5 10
GO:0140096 catalytic activity, acting on a protein 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.619
CLV_C14_Caspase3-7 188 192 PF00656 0.594
CLV_C14_Caspase3-7 315 319 PF00656 0.595
CLV_C14_Caspase3-7 478 482 PF00656 0.395
CLV_NRD_NRD_1 289 291 PF00675 0.440
CLV_NRD_NRD_1 307 309 PF00675 0.493
CLV_NRD_NRD_1 495 497 PF00675 0.383
CLV_NRD_NRD_1 580 582 PF00675 0.441
CLV_NRD_NRD_1 803 805 PF00675 0.645
CLV_NRD_NRD_1 828 830 PF00675 0.607
CLV_PCSK_KEX2_1 289 291 PF00082 0.525
CLV_PCSK_KEX2_1 307 309 PF00082 0.493
CLV_PCSK_KEX2_1 497 499 PF00082 0.268
CLV_PCSK_KEX2_1 528 530 PF00082 0.372
CLV_PCSK_KEX2_1 580 582 PF00082 0.452
CLV_PCSK_KEX2_1 803 805 PF00082 0.672
CLV_PCSK_KEX2_1 827 829 PF00082 0.647
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.268
CLV_PCSK_PC1ET2_1 528 530 PF00082 0.407
CLV_PCSK_PC1ET2_1 580 582 PF00082 0.492
CLV_PCSK_SKI1_1 363 367 PF00082 0.368
CLV_PCSK_SKI1_1 373 377 PF00082 0.380
CLV_PCSK_SKI1_1 515 519 PF00082 0.318
CLV_PCSK_SKI1_1 648 652 PF00082 0.315
CLV_PCSK_SKI1_1 772 776 PF00082 0.513
CLV_PCSK_SKI1_1 831 835 PF00082 0.699
DEG_APCC_DBOX_1 647 655 PF00400 0.428
DEG_Nend_UBRbox_3 1 3 PF02207 0.627
DOC_CDC14_PxL_1 388 396 PF14671 0.245
DOC_CDC14_PxL_1 462 470 PF14671 0.338
DOC_CKS1_1 163 168 PF01111 0.531
DOC_CKS1_1 555 560 PF01111 0.305
DOC_CYCLIN_RxL_1 769 778 PF00134 0.441
DOC_MAPK_gen_1 226 238 PF00069 0.571
DOC_MAPK_gen_1 827 835 PF00069 0.612
DOC_MAPK_MEF2A_6 113 121 PF00069 0.492
DOC_MAPK_MEF2A_6 231 240 PF00069 0.483
DOC_MAPK_MEF2A_6 258 266 PF00069 0.513
DOC_MAPK_MEF2A_6 515 522 PF00069 0.262
DOC_PP1_RVXF_1 585 592 PF00149 0.406
DOC_PP2B_LxvP_1 299 302 PF13499 0.527
DOC_PP2B_LxvP_1 30 33 PF13499 0.497
DOC_PP2B_PxIxI_1 261 267 PF00149 0.478
DOC_PP4_FxxP_1 44 47 PF00568 0.447
DOC_USP7_MATH_1 20 24 PF00917 0.737
DOC_USP7_MATH_1 288 292 PF00917 0.525
DOC_USP7_MATH_1 306 310 PF00917 0.538
DOC_USP7_MATH_1 330 334 PF00917 0.548
DOC_USP7_MATH_1 340 344 PF00917 0.509
DOC_USP7_MATH_1 401 405 PF00917 0.279
DOC_USP7_MATH_1 705 709 PF00917 0.471
DOC_USP7_UBL2_3 174 178 PF12436 0.593
DOC_USP7_UBL2_3 226 230 PF12436 0.594
DOC_USP7_UBL2_3 699 703 PF12436 0.526
DOC_WW_Pin1_4 162 167 PF00397 0.525
DOC_WW_Pin1_4 212 217 PF00397 0.655
DOC_WW_Pin1_4 250 255 PF00397 0.527
DOC_WW_Pin1_4 258 263 PF00397 0.495
DOC_WW_Pin1_4 554 559 PF00397 0.303
DOC_WW_Pin1_4 629 634 PF00397 0.499
DOC_WW_Pin1_4 636 641 PF00397 0.413
DOC_WW_Pin1_4 804 809 PF00397 0.708
LIG_14-3-3_CanoR_1 26 31 PF00244 0.776
LIG_14-3-3_CanoR_1 289 295 PF00244 0.439
LIG_14-3-3_CanoR_1 307 317 PF00244 0.702
LIG_14-3-3_CanoR_1 411 416 PF00244 0.291
LIG_14-3-3_CanoR_1 743 747 PF00244 0.403
LIG_APCC_ABBA_1 516 521 PF00400 0.316
LIG_APCC_ABBAyCdc20_2 515 521 PF00400 0.258
LIG_BRCT_BRCA1_1 126 130 PF00533 0.527
LIG_BRCT_BRCA1_1 352 356 PF00533 0.563
LIG_BRCT_BRCA1_1 563 567 PF00533 0.309
LIG_BRCT_BRCA1_1 63 67 PF00533 0.452
LIG_BRCT_BRCA1_1 806 810 PF00533 0.597
LIG_Clathr_ClatBox_1 72 76 PF01394 0.444
LIG_deltaCOP1_diTrp_1 38 44 PF00928 0.557
LIG_EH1_1 502 510 PF00400 0.303
LIG_eIF4E_1 503 509 PF01652 0.338
LIG_EVH1_1 630 634 PF00568 0.425
LIG_FHA_1 343 349 PF00498 0.578
LIG_FHA_1 422 428 PF00498 0.303
LIG_FHA_1 555 561 PF00498 0.365
LIG_FHA_1 602 608 PF00498 0.400
LIG_FHA_1 621 627 PF00498 0.560
LIG_FHA_1 672 678 PF00498 0.401
LIG_FHA_1 755 761 PF00498 0.488
LIG_FHA_1 814 820 PF00498 0.728
LIG_FHA_2 291 297 PF00498 0.416
LIG_FHA_2 377 383 PF00498 0.303
LIG_FHA_2 640 646 PF00498 0.427
LIG_FHA_2 732 738 PF00498 0.455
LIG_FHA_2 837 843 PF00498 0.651
LIG_FHA_2 85 91 PF00498 0.461
LIG_GBD_Chelix_1 677 685 PF00786 0.399
LIG_HOMEOBOX 132 135 PF00046 0.527
LIG_IRF3_LxIS_1 375 381 PF10401 0.395
LIG_LIR_Apic_2 251 255 PF02991 0.558
LIG_LIR_Gen_1 131 140 PF02991 0.551
LIG_LIR_Gen_1 353 361 PF02991 0.408
LIG_LIR_Gen_1 557 567 PF02991 0.405
LIG_LIR_Nem_3 131 137 PF02991 0.469
LIG_LIR_Nem_3 165 171 PF02991 0.538
LIG_LIR_Nem_3 273 277 PF02991 0.371
LIG_LIR_Nem_3 353 359 PF02991 0.503
LIG_LIR_Nem_3 557 562 PF02991 0.352
LIG_LIR_Nem_3 744 749 PF02991 0.344
LIG_LIR_Nem_3 751 755 PF02991 0.326
LIG_LYPXL_yS_3 168 171 PF13949 0.568
LIG_MYND_1 466 470 PF01753 0.338
LIG_NRBOX 650 656 PF00104 0.309
LIG_Pex14_2 130 134 PF04695 0.461
LIG_Pex14_2 63 67 PF04695 0.444
LIG_Pex14_2 694 698 PF04695 0.375
LIG_PTB_Apo_2 543 550 PF02174 0.361
LIG_PTB_Phospho_1 543 549 PF10480 0.362
LIG_REV1ctd_RIR_1 413 422 PF16727 0.223
LIG_SH2_CRK 147 151 PF00017 0.411
LIG_SH2_CRK 252 256 PF00017 0.551
LIG_SH2_CRK 503 507 PF00017 0.352
LIG_SH2_CRK 549 553 PF00017 0.320
LIG_SH2_NCK_1 147 151 PF00017 0.601
LIG_SH2_NCK_1 252 256 PF00017 0.551
LIG_SH2_PTP2 420 423 PF00017 0.338
LIG_SH2_STAP1 147 151 PF00017 0.413
LIG_SH2_STAP1 352 356 PF00017 0.501
LIG_SH2_STAP1 503 507 PF00017 0.395
LIG_SH2_STAP1 549 553 PF00017 0.320
LIG_SH2_STAT3 275 278 PF00017 0.384
LIG_SH2_STAT5 147 150 PF00017 0.376
LIG_SH2_STAT5 252 255 PF00017 0.673
LIG_SH2_STAT5 265 268 PF00017 0.286
LIG_SH2_STAT5 272 275 PF00017 0.365
LIG_SH2_STAT5 360 363 PF00017 0.347
LIG_SH2_STAT5 420 423 PF00017 0.338
LIG_SH2_STAT5 55 58 PF00017 0.438
LIG_SH2_STAT5 559 562 PF00017 0.358
LIG_SH2_STAT5 600 603 PF00017 0.316
LIG_SH2_STAT5 86 89 PF00017 0.464
LIG_SH3_2 767 772 PF14604 0.417
LIG_SH3_3 139 145 PF00018 0.512
LIG_SH3_3 160 166 PF00018 0.512
LIG_SH3_3 169 175 PF00018 0.523
LIG_SH3_3 256 262 PF00018 0.474
LIG_SH3_3 345 351 PF00018 0.495
LIG_SH3_3 628 634 PF00018 0.501
LIG_SH3_3 764 770 PF00018 0.431
LIG_SH3_4 174 181 PF00018 0.598
LIG_SUMO_SIM_anti_2 374 379 PF11976 0.338
LIG_SUMO_SIM_anti_2 756 763 PF11976 0.473
LIG_SUMO_SIM_par_1 376 382 PF11976 0.279
LIG_SUMO_SIM_par_1 551 557 PF11976 0.301
LIG_SUMO_SIM_par_1 613 619 PF11976 0.368
LIG_SUMO_SIM_par_1 756 763 PF11976 0.418
LIG_TRAF2_1 725 728 PF00917 0.614
LIG_TYR_ITIM 547 552 PF00017 0.321
LIG_UBA3_1 650 658 PF00899 0.341
LIG_UBA3_1 716 722 PF00899 0.365
LIG_WRC_WIRS_1 749 754 PF05994 0.462
LIG_WW_3 769 773 PF00397 0.414
MOD_CDK_SPxxK_3 212 219 PF00069 0.655
MOD_CK1_1 220 226 PF00069 0.723
MOD_CK1_1 333 339 PF00069 0.676
MOD_CK1_1 342 348 PF00069 0.658
MOD_CK1_1 381 387 PF00069 0.344
MOD_CK1_1 511 517 PF00069 0.425
MOD_CK1_1 554 560 PF00069 0.349
MOD_CK1_1 639 645 PF00069 0.512
MOD_CK1_1 689 695 PF00069 0.351
MOD_CK1_1 712 718 PF00069 0.408
MOD_CK1_1 836 842 PF00069 0.605
MOD_CK2_1 290 296 PF00069 0.519
MOD_CK2_1 306 312 PF00069 0.767
MOD_CK2_1 705 711 PF00069 0.505
MOD_CK2_1 731 737 PF00069 0.478
MOD_CK2_1 836 842 PF00069 0.654
MOD_Cter_Amidation 578 581 PF01082 0.514
MOD_DYRK1A_RPxSP_1 258 262 PF00069 0.445
MOD_GlcNHglycan 220 223 PF01048 0.659
MOD_GlcNHglycan 314 317 PF01048 0.683
MOD_GlcNHglycan 332 335 PF01048 0.490
MOD_GlcNHglycan 352 355 PF01048 0.658
MOD_GlcNHglycan 403 406 PF01048 0.358
MOD_GlcNHglycan 577 580 PF01048 0.609
MOD_GlcNHglycan 68 71 PF01048 0.279
MOD_GlcNHglycan 688 691 PF01048 0.452
MOD_GlcNHglycan 711 714 PF01048 0.619
MOD_GlcNHglycan 746 749 PF01048 0.449
MOD_GlcNHglycan 777 780 PF01048 0.617
MOD_GlcNHglycan 784 787 PF01048 0.590
MOD_GlcNHglycan 799 802 PF01048 0.544
MOD_GlcNHglycan 810 813 PF01048 0.636
MOD_GSK3_1 124 131 PF00069 0.360
MOD_GSK3_1 210 217 PF00069 0.637
MOD_GSK3_1 226 233 PF00069 0.500
MOD_GSK3_1 284 291 PF00069 0.352
MOD_GSK3_1 308 315 PF00069 0.713
MOD_GSK3_1 329 336 PF00069 0.621
MOD_GSK3_1 350 357 PF00069 0.594
MOD_GSK3_1 475 482 PF00069 0.303
MOD_GSK3_1 561 568 PF00069 0.350
MOD_GSK3_1 598 605 PF00069 0.400
MOD_GSK3_1 616 623 PF00069 0.454
MOD_GSK3_1 62 69 PF00069 0.279
MOD_GSK3_1 625 632 PF00069 0.563
MOD_GSK3_1 639 646 PF00069 0.401
MOD_GSK3_1 666 673 PF00069 0.448
MOD_GSK3_1 705 712 PF00069 0.498
MOD_GSK3_1 716 723 PF00069 0.449
MOD_GSK3_1 744 751 PF00069 0.547
MOD_GSK3_1 804 811 PF00069 0.667
MOD_GSK3_1 823 830 PF00069 0.725
MOD_GSK3_1 833 840 PF00069 0.568
MOD_LATS_1 477 483 PF00433 0.303
MOD_LATS_1 82 88 PF00433 0.245
MOD_N-GLC_1 236 241 PF02516 0.357
MOD_N-GLC_1 446 451 PF02516 0.395
MOD_N-GLC_1 565 570 PF02516 0.326
MOD_N-GLC_1 813 818 PF02516 0.688
MOD_N-GLC_2 813 815 PF02516 0.605
MOD_NEK2_1 104 109 PF00069 0.395
MOD_NEK2_1 124 129 PF00069 0.155
MOD_NEK2_1 236 241 PF00069 0.572
MOD_NEK2_1 406 411 PF00069 0.358
MOD_NEK2_1 508 513 PF00069 0.309
MOD_NEK2_1 573 578 PF00069 0.479
MOD_NEK2_1 61 66 PF00069 0.303
MOD_NEK2_1 643 648 PF00069 0.478
MOD_NEK2_1 671 676 PF00069 0.442
MOD_NEK2_1 716 721 PF00069 0.456
MOD_NEK2_1 762 767 PF00069 0.447
MOD_NEK2_1 775 780 PF00069 0.434
MOD_PIKK_1 20 26 PF00454 0.687
MOD_PIKK_1 406 412 PF00454 0.302
MOD_PIKK_1 62 68 PF00454 0.395
MOD_PIKK_1 666 672 PF00454 0.446
MOD_PIKK_1 760 766 PF00454 0.404
MOD_PK_1 230 236 PF00069 0.534
MOD_PKA_1 226 232 PF00069 0.594
MOD_PKA_1 307 313 PF00069 0.565
MOD_PKA_1 528 534 PF00069 0.443
MOD_PKA_1 581 587 PF00069 0.427
MOD_PKA_1 803 809 PF00069 0.668
MOD_PKA_1 827 833 PF00069 0.653
MOD_PKA_2 218 224 PF00069 0.539
MOD_PKA_2 288 294 PF00069 0.485
MOD_PKA_2 306 312 PF00069 0.722
MOD_PKA_2 528 534 PF00069 0.469
MOD_PKA_2 643 649 PF00069 0.474
MOD_PKA_2 742 748 PF00069 0.403
MOD_PKA_2 803 809 PF00069 0.732
MOD_PKA_2 827 833 PF00069 0.702
MOD_Plk_1 236 242 PF00069 0.359
MOD_Plk_1 295 301 PF00069 0.533
MOD_Plk_1 373 379 PF00069 0.395
MOD_Plk_1 381 387 PF00069 0.395
MOD_Plk_1 6 12 PF00069 0.642
MOD_Plk_1 602 608 PF00069 0.349
MOD_Plk_1 837 843 PF00069 0.648
MOD_Plk_2-3 731 737 PF00069 0.494
MOD_Plk_4 270 276 PF00069 0.485
MOD_Plk_4 373 379 PF00069 0.356
MOD_Plk_4 411 417 PF00069 0.223
MOD_Plk_4 528 534 PF00069 0.429
MOD_Plk_4 689 695 PF00069 0.456
MOD_Plk_4 712 718 PF00069 0.413
MOD_ProDKin_1 162 168 PF00069 0.522
MOD_ProDKin_1 212 218 PF00069 0.653
MOD_ProDKin_1 250 256 PF00069 0.517
MOD_ProDKin_1 258 264 PF00069 0.485
MOD_ProDKin_1 554 560 PF00069 0.303
MOD_ProDKin_1 629 635 PF00069 0.496
MOD_ProDKin_1 636 642 PF00069 0.406
MOD_ProDKin_1 804 810 PF00069 0.709
MOD_SUMO_for_1 242 245 PF00179 0.431
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.634
TRG_DiLeu_BaLyEn_6 736 741 PF01217 0.526
TRG_DiLeu_LyEn_5 389 394 PF01217 0.302
TRG_ENDOCYTIC_2 132 135 PF00928 0.324
TRG_ENDOCYTIC_2 147 150 PF00928 0.317
TRG_ENDOCYTIC_2 168 171 PF00928 0.509
TRG_ENDOCYTIC_2 274 277 PF00928 0.378
TRG_ENDOCYTIC_2 413 416 PF00928 0.303
TRG_ENDOCYTIC_2 420 423 PF00928 0.302
TRG_ENDOCYTIC_2 503 506 PF00928 0.363
TRG_ENDOCYTIC_2 549 552 PF00928 0.298
TRG_ENDOCYTIC_2 559 562 PF00928 0.315
TRG_ENDOCYTIC_2 86 89 PF00928 0.395
TRG_ER_diArg_1 827 829 PF00400 0.706
TRG_NLS_MonoCore_2 224 229 PF00514 0.630
TRG_NLS_MonoExtC_3 225 230 PF00514 0.656
TRG_NLS_MonoExtC_3 495 500 PF00514 0.300
TRG_NLS_MonoExtN_4 225 231 PF00514 0.706
TRG_NLS_MonoExtN_4 494 500 PF00514 0.300
TRG_Pf-PMV_PEXEL_1 683 688 PF00026 0.344

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSB1 Leptomonas seymouri 65% 67%
A0A0S4J4P7 Bodo saltans 39% 100%
A0A1X0PB49 Trypanosomatidae 47% 100%
A4HB04 Leishmania braziliensis 77% 100%
A4IA60 Leishmania infantum 99% 100%
C9ZM45 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B572 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2R3 Leishmania major 92% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS