Rhodanese-like domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

rhodanese-like domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X866_LEIDO

TriTrypDb:

LdBPK_342840.1 , LdCL_340036500 , LDHU3_34.4850

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7X866

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X866

Function

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Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0018095	protein polyglutamylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018200	peptidyl-glutamic acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.461
CLV_NRD_NRD_1	213	215	PF00675	0.587
CLV_NRD_NRD_1	244	246	PF00675	0.586
CLV_PCSK_FUR_1	210	214	PF00082	0.543
CLV_PCSK_KEX2_1	15	17	PF00082	0.480
CLV_PCSK_KEX2_1	212	214	PF00082	0.467
CLV_PCSK_KEX2_1	50	52	PF00082	0.491
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.467
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.491
CLV_PCSK_SKI1_1	10	14	PF00082	0.475

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F3	Leptomonas seymouri	69%	100%
A0A1X0PB71	Trypanosomatidae	48%	100%
A0A422N4N2	Trypanosoma rangeli	51%	99%
A4HB20	Leishmania braziliensis	86%	100%
A4IA77	Leishmania infantum	99%	100%
C9ZM32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B590	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q28FA8	Xenopus tropicalis	27%	68%
Q4Q2P3	Leishmania major	94%	100%
Q9BYV8	Homo sapiens	25%	67%

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