Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X865_LEIDO

TriTrypDb:

LdBPK_342880.1 , LdCL_340036900 , LDHU3_34.4890

Length:

178

Annotations

Annotations by Jardim et al.

Mitochondrial protein, cytochrome b5-like Heme/Steroid binding domain containing , putative (POMP29 Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0012505	endomembrane system	2	2
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7X865

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X865

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.634
CLV_PCSK_KEX2_1	50	52	PF00082	0.621
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.631
DOC_MAPK_gen_1	87	95	PF00069	0.274
DOC_MAPK_MEF2A_6	90	97	PF00069	0.218
DOC_PP4_FxxP_1	106	109	PF00568	0.307
DOC_USP7_MATH_1	20	24	PF00917	0.374
DOC_USP7_UBL2_3	156	160	PF12436	0.335
DOC_USP7_UBL2_3	31	35	PF12436	0.423
LIG_14-3-3_CanoR_1	51	60	PF00244	0.400
LIG_14-3-3_CanoR_1	90	96	PF00244	0.269
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_LIR_Gen_1	89	100	PF02991	0.280
LIG_LIR_Nem_3	159	164	PF02991	0.310
LIG_LIR_Nem_3	170	176	PF02991	0.333
LIG_LIR_Nem_3	81	86	PF02991	0.243
LIG_LIR_Nem_3	89	95	PF02991	0.280
LIG_LYPXL_yS_3	161	164	PF13949	0.314
LIG_SH2_CRK	83	87	PF00017	0.264
LIG_SH2_GRB2like	134	137	PF00017	0.234
LIG_SH2_NCK_1	100	104	PF00017	0.240
LIG_SH2_STAT3	134	137	PF00017	0.234
LIG_SH2_STAT5	134	137	PF00017	0.234
LIG_SH2_STAT5	153	156	PF00017	0.151
LIG_SH2_STAT5	167	170	PF00017	0.230
LIG_SH2_STAT5	26	29	PF00017	0.544
LIG_SH2_STAT5	75	78	PF00017	0.299
LIG_SUMO_SIM_anti_2	143	152	PF11976	0.307
LIG_TRAF2_1	143	146	PF00917	0.324
LIG_UBA3_1	24	31	PF00899	0.663
MOD_CK2_1	140	146	PF00069	0.285
MOD_CK2_1	52	58	PF00069	0.524
MOD_GlcNHglycan	54	57	PF01048	0.689
MOD_GlcNHglycan	61	64	PF01048	0.609
MOD_GlcNHglycan	67	70	PF01048	0.575
MOD_N-GLC_1	140	145	PF02516	0.524
MOD_NEK2_2	20	25	PF00069	0.240
MOD_PIKK_1	78	84	PF00454	0.253
MOD_PKA_1	49	55	PF00069	0.473
MOD_PKA_2	50	56	PF00069	0.518
MOD_PKB_1	49	57	PF00069	0.374
MOD_Plk_4	20	26	PF00069	0.373
MOD_SUMO_for_1	86	89	PF00179	0.307
TRG_DiLeu_BaEn_4	145	151	PF01217	0.264
TRG_ENDOCYTIC_2	113	116	PF00928	0.313
TRG_ENDOCYTIC_2	161	164	PF00928	0.282
TRG_ENDOCYTIC_2	83	86	PF00928	0.258
TRG_ER_diArg_1	48	51	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I427	Leptomonas seymouri	71%	95%
A0A0S4IWT4	Bodo saltans	38%	100%
A0A0S4KHZ8	Bodo saltans	40%	100%
A0A3Q8IGX1	Leishmania donovani	41%	100%
A0A3R7RC54	Trypanosoma rangeli	41%	99%
A2CES0	Danio rerio	31%	67%
A4H7Y9	Leishmania braziliensis	40%	100%
A4HB24	Leishmania braziliensis	83%	100%
A4HQJ0	Leishmania braziliensis	37%	100%
A4IA81	Leishmania infantum	100%	100%
E9AHZ9	Leishmania infantum	41%	100%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O00264	Homo sapiens	32%	91%
O55022	Mus musculus	32%	91%
Q12091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q1JQA5	Bos taurus	34%	100%
Q4Q088	Leishmania major	40%	100%
Q4Q2N9	Leishmania major	96%	100%
Q5RED0	Pongo abelii	32%	91%
Q5XIU9	Rattus norvegicus	34%	82%
Q5ZKN2	Gallus gallus	36%	93%
Q80UU9	Mus musculus	34%	82%
Q9UMX5	Homo sapiens	33%	100%
V5DM24	Trypanosoma cruzi	54%	99%