Nucleoside diphosphate kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside diphosphate kinase 3

Species:

Leishmania donovani

UniProt:

A0A3S7X855_LEIDO

TriTrypDb:

LdBPK_342810.1 , LdCL_340036200 , LDHU3_34.4810

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X855

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X855

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0044237	cellular metabolic process	2	17

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0004550	nucleoside diphosphate kinase activity	5	9
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	9
GO:0019205	nucleobase-containing compound kinase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.437
CLV_NRD_NRD_1	156	158	PF00675	0.507
CLV_NRD_NRD_1	291	293	PF00675	0.137
CLV_PCSK_KEX2_1	51	53	PF00082	0.344
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.363
CLV_PCSK_PC7_1	47	53	PF00082	0.370
CLV_PCSK_SKI1_1	256	260	PF00082	0.231
CLV_PCSK_SKI1_1	338	342	PF00082	0.281
CLV_PCSK_SKI1_1	9	13	PF00082	0.301
DEG_APCC_DBOX_1	255	263	PF00400	0.489
DOC_MAPK_gen_1	51	57	PF00069	0.285
DOC_MAPK_RevD_3	38	52	PF00069	0.463
DOC_PP1_RVXF_1	336	342	PF00149	0.327
DOC_PP4_FxxP_1	139	142	PF00568	0.274
DOC_PP4_FxxP_1	251	254	PF00568	0.419
DOC_USP7_MATH_1	204	208	PF00917	0.290
DOC_USP7_MATH_1	90	94	PF00917	0.369
DOC_USP7_UBL2_3	159	163	PF12436	0.251
DOC_USP7_UBL2_3	305	309	PF12436	0.539
LIG_Actin_WH2_2	36	53	PF00022	0.394
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_FHA_1	1	7	PF00498	0.651
LIG_FHA_1	146	152	PF00498	0.337
LIG_FHA_1	270	276	PF00498	0.418
LIG_FHA_1	282	288	PF00498	0.430
LIG_FHA_1	35	41	PF00498	0.369
LIG_FHA_1	65	71	PF00498	0.390
LIG_FHA_1	83	89	PF00498	0.371
LIG_FHA_1	94	100	PF00498	0.289
LIG_FHA_2	120	126	PF00498	0.391
LIG_FHA_2	174	180	PF00498	0.430
LIG_LIR_Apic_2	137	142	PF02991	0.408
LIG_LIR_Apic_2	250	254	PF02991	0.421
LIG_LIR_Gen_1	162	171	PF02991	0.427
LIG_LIR_Gen_1	223	233	PF02991	0.353
LIG_LIR_Nem_3	102	108	PF02991	0.333
LIG_LIR_Nem_3	162	168	PF02991	0.418
LIG_LIR_Nem_3	223	228	PF02991	0.353
LIG_LIR_Nem_3	253	258	PF02991	0.484
LIG_MYND_3	259	263	PF01753	0.387
LIG_SH2_CRK	255	259	PF00017	0.449
LIG_SH2_CRK	298	302	PF00017	0.508
LIG_SH2_CRK	336	340	PF00017	0.327
LIG_SH2_NCK_1	336	340	PF00017	0.327
LIG_SH2_STAP1	298	302	PF00017	0.508
LIG_SH2_STAP1	336	340	PF00017	0.413
LIG_SH2_STAT5	111	114	PF00017	0.309
LIG_SH2_STAT5	31	34	PF00017	0.355
LIG_SH2_STAT5	336	339	PF00017	0.431
LIG_SH2_STAT5	49	52	PF00017	0.292
LIG_SH3_3	16	22	PF00018	0.537
LIG_SH3_3	207	213	PF00018	0.408
LIG_SH3_3	52	58	PF00018	0.306
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.414
LIG_SUMO_SIM_anti_2	282	290	PF11976	0.407
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.422
LIG_SUMO_SIM_par_1	150	156	PF11976	0.425
LIG_SUMO_SIM_par_1	282	290	PF11976	0.435
LIG_SUMO_SIM_par_1	34	42	PF11976	0.436
MOD_CK1_1	60	66	PF00069	0.346
MOD_CK1_1	93	99	PF00069	0.326
MOD_CK2_1	121	127	PF00069	0.435
MOD_CK2_1	277	283	PF00069	0.473
MOD_CK2_1	315	321	PF00069	0.486
MOD_GlcNHglycan	136	139	PF01048	0.450
MOD_GlcNHglycan	216	219	PF01048	0.255
MOD_GlcNHglycan	222	225	PF01048	0.256
MOD_GlcNHglycan	244	247	PF01048	0.259
MOD_GlcNHglycan	34	37	PF01048	0.394
MOD_GlcNHglycan	44	47	PF01048	0.447
MOD_GlcNHglycan	59	62	PF01048	0.328
MOD_GSK3_1	169	176	PF00069	0.323
MOD_GSK3_1	233	240	PF00069	0.466
MOD_GSK3_1	265	272	PF00069	0.477
MOD_GSK3_1	277	284	PF00069	0.413
MOD_GSK3_1	60	67	PF00069	0.389
MOD_N-GLC_1	204	209	PF02516	0.243
MOD_NEK2_1	1	6	PF00069	0.492
MOD_NEK2_1	145	150	PF00069	0.372
MOD_NEK2_1	262	267	PF00069	0.485
MOD_NEK2_1	269	274	PF00069	0.484
MOD_NEK2_1	32	37	PF00069	0.496
MOD_NEK2_1	50	55	PF00069	0.332
MOD_PKA_2	169	175	PF00069	0.353
MOD_Plk_1	204	210	PF00069	0.249
MOD_Plk_1	281	287	PF00069	0.429
MOD_Plk_1	93	99	PF00069	0.330
MOD_Plk_2-3	34	40	PF00069	0.314
MOD_Plk_4	204	210	PF00069	0.256
MOD_Plk_4	265	271	PF00069	0.477
MOD_Plk_4	297	303	PF00069	0.488
MOD_Plk_4	64	70	PF00069	0.418
TRG_DiLeu_BaEn_3	102	108	PF01217	0.228
TRG_ENDOCYTIC_2	111	114	PF00928	0.322
TRG_ENDOCYTIC_2	255	258	PF00928	0.443
TRG_ENDOCYTIC_2	298	301	PF00928	0.508
TRG_ENDOCYTIC_2	336	339	PF00928	0.426
TRG_NES_CRM1_1	277	289	PF08389	0.449
TRG_NLS_MonoExtC_3	156	162	PF00514	0.260
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	72%	100%
A0A0N1PC23	Leptomonas seymouri	27%	100%
A0A0S4IXH2	Bodo saltans	28%	100%
A0A1X0P5C0	Trypanosomatidae	30%	100%
A0A1X0PAT4	Trypanosomatidae	46%	98%
A0A3Q8IJQ8	Leishmania donovani	28%	100%
A0A3R7M6K1	Trypanosoma rangeli	46%	99%
A0A3R7N390	Trypanosoma rangeli	30%	100%
A4HB17	Leishmania braziliensis	84%	100%
A4HN58	Leishmania braziliensis	28%	100%
A4IA74	Leishmania infantum	99%	100%
A4IBS5	Leishmania infantum	28%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFL1	Leishmania major	28%	100%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q2P6	Leishmania major	94%	100%
Q5E9Y9	Bos taurus	25%	91%
Q9QXL7	Rattus norvegicus	25%	87%
Q9QXL8	Mus musculus	24%	87%
Q9Y5B8	Homo sapiens	24%	91%
V5BXY9	Trypanosoma cruzi	28%	99%
V5DLW4	Trypanosoma cruzi	45%	98%