LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X845_LEIDO
TriTrypDb:
LdBPK_342720.1 , LdCL_340035200 , LDHU3_34.4670
Length:
118

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 12
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043228 non-membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043232 intracellular non-membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12

Expansion

Sequence features

A0A3S7X845
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X845

PDB structure(s): 7aih_U , 7ane_U

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 59 63 PF00656 0.519
CLV_NRD_NRD_1 31 33 PF00675 0.544
CLV_NRD_NRD_1 65 67 PF00675 0.486
CLV_NRD_NRD_1 99 101 PF00675 0.544
CLV_PCSK_KEX2_1 20 22 PF00082 0.553
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.553
DEG_Nend_Nbox_1 1 3 PF02207 0.547
DOC_MAPK_gen_1 17 25 PF00069 0.568
DOC_MAPK_gen_1 32 41 PF00069 0.437
DOC_PP1_RVXF_1 1 7 PF00149 0.613
DOC_PP1_RVXF_1 19 26 PF00149 0.571
DOC_PP1_RVXF_1 98 105 PF00149 0.496
DOC_USP7_MATH_1 40 44 PF00917 0.411
DOC_USP7_UBL2_3 113 117 PF12436 0.697
DOC_USP7_UBL2_3 15 19 PF12436 0.547
LIG_14-3-3_CanoR_1 3 9 PF00244 0.562
LIG_14-3-3_CanoR_1 79 83 PF00244 0.497
LIG_BIR_III_4 62 66 PF00653 0.530
LIG_FHA_2 54 60 PF00498 0.474
LIG_FHA_2 69 75 PF00498 0.495
LIG_LIR_Gen_1 5 14 PF02991 0.657
LIG_LIR_Nem_3 5 9 PF02991 0.565
LIG_LIR_Nem_3 71 76 PF02991 0.489
LIG_Pex14_2 2 6 PF04695 0.590
LIG_SH2_STAT5 53 56 PF00017 0.466
LIG_SH2_STAT5 80 83 PF00017 0.491
LIG_SH3_3 85 91 PF00018 0.519
LIG_SUMO_SIM_par_1 37 44 PF11976 0.429
MOD_CK2_1 53 59 PF00069 0.466
MOD_Cter_Amidation 64 67 PF01082 0.497
MOD_GlcNHglycan 113 116 PF01048 0.671
MOD_GSK3_1 40 47 PF00069 0.407
MOD_NEK2_1 2 7 PF00069 0.530
MOD_NEK2_1 61 66 PF00069 0.515
MOD_NEK2_1 68 73 PF00069 0.432
MOD_NEK2_1 83 88 PF00069 0.324
MOD_NEK2_1 93 98 PF00069 0.435
MOD_PKA_2 2 8 PF00069 0.556
MOD_PKA_2 78 84 PF00069 0.507
MOD_Plk_4 68 74 PF00069 0.525
MOD_Plk_4 78 84 PF00069 0.487
MOD_SUMO_for_1 54 57 PF00179 0.472
TRG_ENDOCYTIC_2 80 83 PF00928 0.478
TRG_NLS_Bipartite_1 19 36 PF00514 0.552
TRG_NLS_MonoExtN_4 17 23 PF00514 0.554
TRG_NLS_MonoExtN_4 31 36 PF00514 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2X7 Leptomonas seymouri 86% 100%
A0A0S4IY48 Bodo saltans 72% 100%
A0A1X0PA43 Trypanosomatidae 83% 100%
A0A3R7NLI3 Trypanosoma rangeli 75% 100%
A4HB08 Leishmania braziliensis 92% 100%
A4IA65 Leishmania infantum 100% 100%
C9ZM42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 82% 100%
E9B577 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q2Q8 Leishmania major 94% 100%
V5BKZ6 Trypanosoma cruzi 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS