Alba_putative/Pfam:PF01918

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ALBA-domain protein 3

Species:

Leishmania donovani

UniProt:

A0A3S7X842_LEIDO

TriTrypDb:

LdBPK_342410.1 , LdCL_340031700 , LDHU3_34.3980

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7X842

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X842

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034605	cellular response to heat	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.620
CLV_NRD_NRD_1	117	119	PF00675	0.561
CLV_NRD_NRD_1	153	155	PF00675	0.801
CLV_NRD_NRD_1	160	162	PF00675	0.755
CLV_NRD_NRD_1	199	201	PF00675	0.846
CLV_NRD_NRD_1	82	84	PF00675	0.387
CLV_PCSK_KEX2_1	11	13	PF00082	0.620
CLV_PCSK_KEX2_1	153	155	PF00082	0.791
CLV_PCSK_KEX2_1	160	162	PF00082	0.756
CLV_PCSK_KEX2_1	199	201	PF00082	0.846
CLV_PCSK_KEX2_1	81	83	PF00082	0.387
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.387
CLV_PCSK_PC7_1	7	13	PF00082	0.628
CLV_Separin_Metazoa	96	100	PF03568	0.717
DOC_ANK_TNKS_1	19	26	PF00023	0.751
DOC_MAPK_gen_1	107	116	PF00069	0.576
DOC_MAPK_gen_1	118	125	PF00069	0.526
DOC_MAPK_gen_1	55	63	PF00069	0.617
DOC_MAPK_HePTP_8	115	127	PF00069	0.641
DOC_MAPK_MEF2A_6	118	127	PF00069	0.511
DOC_USP7_MATH_1	156	160	PF00917	0.820
DOC_USP7_MATH_1	3	7	PF00917	0.730
LIG_14-3-3_CanoR_1	118	127	PF00244	0.508
LIG_14-3-3_CanoR_1	31	41	PF00244	0.610
LIG_FHA_1	120	126	PF00498	0.504
LIG_FHA_1	58	64	PF00498	0.624
LIG_FHA_2	147	153	PF00498	0.787
LIG_FHA_2	54	60	PF00498	0.590
LIG_LIR_Nem_3	100	105	PF02991	0.571
LIG_LIR_Nem_3	40	44	PF02991	0.578
LIG_LIR_Nem_3	8	13	PF02991	0.622
LIG_PTB_Apo_2	133	140	PF02174	0.693
LIG_PTB_Phospho_1	133	139	PF10480	0.692
LIG_SH2_CRK	10	14	PF00017	0.628
LIG_SH2_CRK	71	75	PF00017	0.637
LIG_SH2_NCK_1	102	106	PF00017	0.595
LIG_SH2_NCK_1	71	75	PF00017	0.662
LIG_SH2_SRC	102	105	PF00017	0.642
LIG_SH2_SRC	139	142	PF00017	0.611
LIG_SH2_SRC	44	47	PF00017	0.601
LIG_SH2_STAT5	41	44	PF00017	0.576
LIG_SH3_2	2	7	PF14604	0.642
LIG_SUMO_SIM_par_1	121	128	PF11976	0.499
LIG_TRAF2_1	149	152	PF00917	0.798
LIG_WW_3	1	5	PF00397	0.666
MOD_CK1_1	146	152	PF00069	0.757
MOD_CK1_1	40	46	PF00069	0.617
MOD_CK2_1	146	152	PF00069	0.769
MOD_CK2_1	3	9	PF00069	0.688
MOD_GlcNHglycan	63	66	PF01048	0.376
MOD_GlcNHglycan	84	87	PF01048	0.437
MOD_GSK3_1	119	126	PF00069	0.507
MOD_GSK3_1	53	60	PF00069	0.595
MOD_GSK3_1	88	95	PF00069	0.578
MOD_N-GLC_1	156	161	PF02516	0.876
MOD_N-GLC_1	57	62	PF02516	0.462
MOD_NEK2_1	132	137	PF00069	0.657
MOD_PKA_1	118	124	PF00069	0.523
MOD_PKA_1	82	88	PF00069	0.528
MOD_PKA_2	3	9	PF00069	0.742
MOD_PKA_2	30	36	PF00069	0.576
MOD_PKA_2	82	88	PF00069	0.528
MOD_Plk_1	57	63	PF00069	0.654
MOD_Plk_4	119	125	PF00069	0.510
MOD_Plk_4	37	43	PF00069	0.662
MOD_SUMO_rev_2	112	121	PF00179	0.565
MOD_SUMO_rev_2	52	56	PF00179	0.594
TRG_ENDOCYTIC_2	10	13	PF00928	0.614
TRG_ENDOCYTIC_2	102	105	PF00928	0.572
TRG_ENDOCYTIC_2	71	74	PF00928	0.637
TRG_ER_diArg_1	10	12	PF00400	0.611
TRG_ER_diArg_1	82	84	PF00400	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L2	Leptomonas seymouri	87%	100%
A0A1X0P9P6	Trypanosomatidae	61%	97%
A0A3R7M9A3	Trypanosoma rangeli	62%	100%
A0A422N8E8	Trypanosoma rangeli	62%	100%
A4HAX5	Leishmania braziliensis	88%	100%
A4IA34	Leishmania infantum	96%	97%
C9ZM65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	94%
C9ZMI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B549	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q2T7	Leishmania major	98%	100%