Signal recognition particle subunit SRP68

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X839_LEIDO

TriTrypDb:

LdBPK_342630.1 , LdCL_340033900 , LDHU3_34.4280

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0048500	signal recognition particle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A0A3S7X839

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X839

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	11
GO:0006612	protein targeting to membrane	5	11
GO:0006613	cotranslational protein targeting to membrane	6	11
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045047	protein targeting to ER	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051668	localization within membrane	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0070972	protein localization to endoplasmic reticulum	6	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	11
GO:0072657	protein localization to membrane	4	11
GO:0090150	establishment of protein localization to membrane	4	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005047	signal recognition particle binding	4	11
GO:0005048	signal sequence binding	4	11
GO:0005488	binding	1	11
GO:0008312	7S RNA binding	5	11
GO:0030942	endoplasmic reticulum signal peptide binding	5	11
GO:0033218	amide binding	2	11
GO:0042277	peptide binding	3	11
GO:0043021	ribonucleoprotein complex binding	3	11
GO:0044877	protein-containing complex binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	562	566	PF00656	0.737
CLV_NRD_NRD_1	113	115	PF00675	0.245
CLV_NRD_NRD_1	297	299	PF00675	0.271
CLV_NRD_NRD_1	342	344	PF00675	0.293
CLV_NRD_NRD_1	353	355	PF00675	0.217
CLV_NRD_NRD_1	384	386	PF00675	0.303
CLV_NRD_NRD_1	40	42	PF00675	0.305
CLV_NRD_NRD_1	468	470	PF00675	0.326
CLV_NRD_NRD_1	507	509	PF00675	0.671
CLV_NRD_NRD_1	53	55	PF00675	0.322
CLV_PCSK_KEX2_1	115	117	PF00082	0.243
CLV_PCSK_KEX2_1	297	299	PF00082	0.271
CLV_PCSK_KEX2_1	342	344	PF00082	0.293
CLV_PCSK_KEX2_1	352	354	PF00082	0.225
CLV_PCSK_KEX2_1	40	42	PF00082	0.305
CLV_PCSK_KEX2_1	468	470	PF00082	0.315
CLV_PCSK_KEX2_1	507	509	PF00082	0.669
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.259
CLV_PCSK_SKI1_1	119	123	PF00082	0.273
CLV_PCSK_SKI1_1	162	166	PF00082	0.285
CLV_PCSK_SKI1_1	258	262	PF00082	0.273
CLV_PCSK_SKI1_1	343	347	PF00082	0.254
CLV_PCSK_SKI1_1	35	39	PF00082	0.324
CLV_PCSK_SKI1_1	360	364	PF00082	0.282
CLV_PCSK_SKI1_1	468	472	PF00082	0.308
CLV_PCSK_SKI1_1	50	54	PF00082	0.195
CLV_PCSK_SKI1_1	543	547	PF00082	0.481
CLV_PCSK_SKI1_1	55	59	PF00082	0.126
CLV_PCSK_SKI1_1	573	577	PF00082	0.657
CLV_Separin_Metazoa	401	405	PF03568	0.473
DEG_APCC_DBOX_1	309	317	PF00400	0.426
DEG_SCF_FBW7_1	57	62	PF00400	0.354
DEG_SPOP_SBC_1	366	370	PF00917	0.543
DOC_ANK_TNKS_1	313	320	PF00023	0.562
DOC_CYCLIN_RxL_1	340	349	PF00134	0.464
DOC_CYCLIN_RxL_1	35	48	PF00134	0.522
DOC_MAPK_MEF2A_6	66	73	PF00069	0.463
DOC_MAPK_NFAT4_5	66	74	PF00069	0.539
DOC_PP1_RVXF_1	117	124	PF00149	0.459
DOC_USP7_MATH_1	366	370	PF00917	0.495
DOC_USP7_MATH_1	409	413	PF00917	0.504
DOC_USP7_MATH_1	433	437	PF00917	0.514
DOC_USP7_MATH_1	557	561	PF00917	0.634
DOC_USP7_UBL2_3	115	119	PF12436	0.459
DOC_USP7_UBL2_3	122	126	PF12436	0.459
DOC_USP7_UBL2_3	379	383	PF12436	0.511
DOC_USP7_UBL2_3	51	55	PF12436	0.511
DOC_WW_Pin1_4	368	373	PF00397	0.538
DOC_WW_Pin1_4	395	400	PF00397	0.467
DOC_WW_Pin1_4	507	512	PF00397	0.676
DOC_WW_Pin1_4	55	60	PF00397	0.505
LIG_14-3-3_CanoR_1	116	122	PF00244	0.451
LIG_14-3-3_CanoR_1	153	161	PF00244	0.489
LIG_14-3-3_CanoR_1	179	189	PF00244	0.488
LIG_14-3-3_CanoR_1	200	204	PF00244	0.511
LIG_14-3-3_CanoR_1	248	253	PF00244	0.543
LIG_14-3-3_CanoR_1	342	346	PF00244	0.472
LIG_14-3-3_CanoR_1	35	40	PF00244	0.487
LIG_14-3-3_CanoR_1	41	46	PF00244	0.494
LIG_14-3-3_CanoR_1	507	511	PF00244	0.649
LIG_Actin_WH2_2	326	344	PF00022	0.539
LIG_APCC_ABBA_1	71	76	PF00400	0.489
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	370	374	PF00533	0.534
LIG_deltaCOP1_diTrp_1	445	453	PF00928	0.539
LIG_FHA_1	247	253	PF00498	0.522
LIG_FHA_1	277	283	PF00498	0.560
LIG_FHA_1	31	37	PF00498	0.473
LIG_FHA_1	342	348	PF00498	0.512
LIG_FHA_1	512	518	PF00498	0.646
LIG_FHA_1	521	527	PF00498	0.598
LIG_FHA_1	572	578	PF00498	0.760
LIG_FHA_1	6	12	PF00498	0.466
LIG_FHA_1	60	66	PF00498	0.440
LIG_Integrin_isoDGR_2	246	248	PF01839	0.274
LIG_LIR_Apic_2	394	399	PF02991	0.445
LIG_LIR_Gen_1	173	181	PF02991	0.496
LIG_LIR_Gen_1	184	194	PF02991	0.429
LIG_LIR_Nem_3	173	178	PF02991	0.458
LIG_LIR_Nem_3	184	190	PF02991	0.460
LIG_LIR_Nem_3	23	28	PF02991	0.456
LIG_LIR_Nem_3	551	556	PF02991	0.540
LIG_SH2_CRK	175	179	PF00017	0.539
LIG_SH2_CRK	396	400	PF00017	0.440
LIG_SH2_GRB2like	301	304	PF00017	0.539
LIG_SH2_STAP1	253	257	PF00017	0.562
LIG_SH2_STAT3	203	206	PF00017	0.539
LIG_SH2_STAT5	146	149	PF00017	0.511
LIG_SH2_STAT5	203	206	PF00017	0.473
LIG_SH2_STAT5	31	34	PF00017	0.454
LIG_SH2_STAT5	460	463	PF00017	0.560
LIG_SH2_STAT5	515	518	PF00017	0.570
LIG_SH3_3	369	375	PF00018	0.563
LIG_SH3_3	467	473	PF00018	0.439
LIG_SH3_3	528	534	PF00018	0.593
LIG_SH3_3	538	544	PF00018	0.432
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.473
LIG_SUMO_SIM_anti_2	462	468	PF11976	0.531
LIG_SUMO_SIM_par_1	248	254	PF11976	0.409
LIG_SUMO_SIM_par_1	290	296	PF11976	0.473
LIG_TRAF2_1	412	415	PF00917	0.479
LIG_TRAF2_1	519	522	PF00917	0.599
LIG_WW_1	534	537	PF00397	0.483
MOD_CK1_1	180	186	PF00069	0.481
MOD_CK1_1	241	247	PF00069	0.537
MOD_CK1_1	251	257	PF00069	0.535
MOD_CK1_1	368	374	PF00069	0.516
MOD_CK1_1	95	101	PF00069	0.507
MOD_CK2_1	395	401	PF00069	0.470
MOD_CK2_1	409	415	PF00069	0.484
MOD_CK2_1	474	480	PF00069	0.524
MOD_CK2_1	557	563	PF00069	0.674
MOD_GlcNHglycan	142	146	PF01048	0.309
MOD_GlcNHglycan	224	227	PF01048	0.335
MOD_GlcNHglycan	232	235	PF01048	0.325
MOD_GlcNHglycan	435	438	PF01048	0.305
MOD_GlcNHglycan	559	562	PF01048	0.662
MOD_GlcNHglycan	567	572	PF01048	0.685
MOD_GlcNHglycan	584	587	PF01048	0.516
MOD_GSK3_1	337	344	PF00069	0.450
MOD_GSK3_1	358	365	PF00069	0.512
MOD_GSK3_1	366	373	PF00069	0.402
MOD_GSK3_1	391	398	PF00069	0.449
MOD_GSK3_1	443	450	PF00069	0.482
MOD_GSK3_1	503	510	PF00069	0.598
MOD_GSK3_1	55	62	PF00069	0.429
MOD_GSK3_1	563	570	PF00069	0.742
MOD_GSK3_1	573	580	PF00069	0.775
MOD_N-GLC_1	117	122	PF02516	0.273
MOD_N-GLC_1	582	587	PF02516	0.750
MOD_N-GLC_1	60	65	PF02516	0.287
MOD_NEK2_1	117	122	PF00069	0.473
MOD_NEK2_1	147	152	PF00069	0.562
MOD_NEK2_1	276	281	PF00069	0.525
MOD_NEK2_1	341	346	PF00069	0.459
MOD_NEK2_1	362	367	PF00069	0.505
MOD_NEK2_1	495	500	PF00069	0.532
MOD_NEK2_1	5	10	PF00069	0.360
MOD_NEK2_1	581	586	PF00069	0.551
MOD_NEK2_2	337	342	PF00069	0.539
MOD_PIKK_1	11	17	PF00454	0.480
MOD_PIKK_1	182	188	PF00454	0.508
MOD_PIKK_1	238	244	PF00454	0.539
MOD_PIKK_1	391	397	PF00454	0.456
MOD_PIKK_1	521	527	PF00454	0.684
MOD_PK_1	248	254	PF00069	0.409
MOD_PKA_1	92	98	PF00069	0.562
MOD_PKA_2	171	177	PF00069	0.488
MOD_PKA_2	199	205	PF00069	0.518
MOD_PKA_2	341	347	PF00069	0.539
MOD_PKA_2	447	453	PF00069	0.473
MOD_PKA_2	506	512	PF00069	0.649
MOD_PKA_2	95	101	PF00069	0.507
MOD_Plk_1	117	123	PF00069	0.473
MOD_Plk_1	141	147	PF00069	0.511
MOD_Plk_1	358	364	PF00069	0.510
MOD_Plk_1	5	11	PF00069	0.382
MOD_Plk_1	521	527	PF00069	0.609
MOD_Plk_2-3	563	569	PF00069	0.684
MOD_Plk_4	248	254	PF00069	0.506
MOD_Plk_4	495	501	PF00069	0.511
MOD_Plk_4	5	11	PF00069	0.415
MOD_Plk_4	511	517	PF00069	0.670
MOD_Plk_4	549	555	PF00069	0.466
MOD_ProDKin_1	368	374	PF00069	0.538
MOD_ProDKin_1	395	401	PF00069	0.467
MOD_ProDKin_1	507	513	PF00069	0.676
MOD_ProDKin_1	55	61	PF00069	0.505
MOD_SUMO_for_1	139	142	PF00179	0.493
MOD_SUMO_for_1	91	94	PF00179	0.534
MOD_SUMO_rev_2	157	167	PF00179	0.511
MOD_SUMO_rev_2	268	276	PF00179	0.529
MOD_SUMO_rev_2	44	52	PF00179	0.513
TRG_DiLeu_BaEn_1	414	419	PF01217	0.479
TRG_DiLeu_BaEn_4	414	420	PF01217	0.534
TRG_ENDOCYTIC_2	175	178	PF00928	0.459
TRG_ER_diArg_1	113	116	PF00400	0.459
TRG_ER_diArg_1	297	299	PF00400	0.470
TRG_ER_diArg_1	341	343	PF00400	0.539
TRG_ER_diArg_1	351	354	PF00400	0.461
TRG_ER_diArg_1	39	41	PF00400	0.505
TRG_ER_diArg_1	467	469	PF00400	0.534
TRG_NLS_MonoCore_2	384	389	PF00514	0.437
TRG_NLS_MonoExtC_3	384	390	PF00514	0.508
TRG_NLS_MonoExtN_4	383	389	PF00514	0.420
TRG_NLS_MonoExtN_4	591	596	PF00514	0.685
TRG_PTS2	1	43	PF00400	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH42	Leptomonas seymouri	69%	100%
A0A0S4J2Z5	Bodo saltans	43%	100%
A0A1X0PAR6	Trypanosomatidae	48%	100%
A4HAZ6	Leishmania braziliensis	81%	100%
A4IA56	Leishmania infantum	99%	100%
C9ZM46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B570	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q00004	Canis lupus familiaris	25%	97%
Q4Q2R5	Leishmania major	92%	100%
Q8BMA6	Mus musculus	25%	96%
Q9UHB9	Homo sapiens	25%	96%
Q9VSS2	Drosophila melanogaster	23%	100%
V5BV06	Trypanosoma cruzi	49%	100%