Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X837_LEIDO

TriTrypDb:

LdBPK_342590.1 , LdCL_340033500 , LDHU3_34.4200

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X837

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X837

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.514
CLV_C14_Caspase3-7	98	102	PF00656	0.750
CLV_NRD_NRD_1	131	133	PF00675	0.488
CLV_NRD_NRD_1	275	277	PF00675	0.510
CLV_NRD_NRD_1	279	281	PF00675	0.515
CLV_NRD_NRD_1	282	284	PF00675	0.529
CLV_NRD_NRD_1	57	59	PF00675	0.482
CLV_PCSK_FUR_1	280	284	PF00082	0.460
CLV_PCSK_KEX2_1	131	133	PF00082	0.488
CLV_PCSK_KEX2_1	275	277	PF00082	0.510
CLV_PCSK_KEX2_1	279	281	PF00082	0.515
CLV_PCSK_KEX2_1	282	284	PF00082	0.529
CLV_PCSK_KEX2_1	57	59	PF00082	0.482
CLV_PCSK_PC7_1	271	277	PF00082	0.492
CLV_PCSK_SKI1_1	183	187	PF00082	0.415
CLV_PCSK_SKI1_1	222	226	PF00082	0.609
CLV_Separin_Metazoa	254	258	PF03568	0.580
DEG_Nend_UBRbox_3	1	3	PF02207	0.658
DOC_CYCLIN_RxL_1	177	190	PF00134	0.414
DOC_MAPK_HePTP_8	189	201	PF00069	0.356
DOC_MAPK_MEF2A_6	192	201	PF00069	0.357
DOC_USP7_MATH_1	104	108	PF00917	0.674
DOC_WW_Pin1_4	191	196	PF00397	0.424
LIG_Actin_WH2_2	194	209	PF00022	0.427
LIG_FHA_1	20	26	PF00498	0.416
LIG_FHA_1	226	232	PF00498	0.499
LIG_FHA_1	45	51	PF00498	0.411
LIG_FHA_2	145	151	PF00498	0.419
LIG_FHA_2	165	171	PF00498	0.466
LIG_FHA_2	84	90	PF00498	0.601
LIG_LIR_Gen_1	156	166	PF02991	0.476
LIG_LIR_Nem_3	134	139	PF02991	0.417
LIG_LIR_Nem_3	156	162	PF02991	0.468
LIG_LYPXL_yS_3	61	64	PF13949	0.502
LIG_NRBOX	181	187	PF00104	0.402
LIG_PALB2_WD40_1	237	245	PF16756	0.542
LIG_Pex14_1	238	242	PF04695	0.543
LIG_RPA_C_Fungi	120	132	PF08784	0.511
LIG_RPA_C_Insects	120	135	PF08784	0.499
LIG_SH2_CRK	159	163	PF00017	0.461
LIG_SH2_STAP1	208	212	PF00017	0.504
LIG_SH2_STAT5	200	203	PF00017	0.456
LIG_SH3_3	61	67	PF00018	0.516
LIG_SUMO_SIM_par_1	187	194	PF11976	0.423
LIG_TRAF2_1	288	291	PF00917	0.689
LIG_TYR_ITIM	59	64	PF00017	0.485
MOD_CDK_SPxxK_3	191	198	PF00069	0.492
MOD_CK1_1	193	199	PF00069	0.541
MOD_CK1_1	258	264	PF00069	0.629
MOD_CK1_1	69	75	PF00069	0.588
MOD_CK2_1	164	170	PF00069	0.450
MOD_CK2_1	69	75	PF00069	0.799
MOD_CK2_1	76	82	PF00069	0.722
MOD_CK2_1	8	14	PF00069	0.647
MOD_CMANNOS	238	241	PF00535	0.541
MOD_GlcNHglycan	106	109	PF01048	0.537
MOD_GlcNHglycan	208	211	PF01048	0.548
MOD_GlcNHglycan	233	236	PF01048	0.661
MOD_GSK3_1	206	213	PF00069	0.476
MOD_GSK3_1	4	11	PF00069	0.673
MOD_GSK3_1	66	73	PF00069	0.660
MOD_LATS_1	68	74	PF00433	0.636
MOD_N-GLC_2	40	42	PF02516	0.402
MOD_NEK2_1	206	211	PF00069	0.474
MOD_NEK2_1	231	236	PF00069	0.543
MOD_OFUCOSY	142	148	PF10250	0.389
MOD_PIKK_1	126	132	PF00454	0.563
MOD_PIKK_1	95	101	PF00454	0.820
MOD_PKA_1	131	137	PF00069	0.468
MOD_PKA_2	124	130	PF00069	0.579
MOD_PKA_2	131	137	PF00069	0.371
MOD_PKA_2	206	212	PF00069	0.465
MOD_Plk_1	144	150	PF00069	0.390
MOD_Plk_2-3	76	82	PF00069	0.734
MOD_Plk_2-3	8	14	PF00069	0.640
MOD_Plk_2-3	83	89	PF00069	0.656
MOD_Plk_4	157	163	PF00069	0.588
MOD_ProDKin_1	191	197	PF00069	0.419
TRG_DiLeu_BaEn_1	184	189	PF01217	0.389
TRG_ENDOCYTIC_2	114	117	PF00928	0.497
TRG_ENDOCYTIC_2	159	162	PF00928	0.453
TRG_ENDOCYTIC_2	208	211	PF00928	0.476
TRG_ENDOCYTIC_2	61	64	PF00928	0.502
TRG_ER_diArg_1	56	58	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P606	Leptomonas seymouri	59%	100%
A4HAZ2	Leishmania braziliensis	84%	100%
A4IA52	Leishmania infantum	100%	100%
E9B566	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2R9	Leishmania major	95%	100%