Regulatory subunit of protein kinase a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulatory subunit of protein kinase a-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X836_LEIDO

TriTrypDb:

LdBPK_342680.1 , LdCL_340034800 , LDHU3_34.4600

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X836

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X836

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016310	phosphorylation	5	4
GO:0044237	cellular metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016301	kinase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.730
CLV_NRD_NRD_1	103	105	PF00675	0.619
CLV_NRD_NRD_1	13	15	PF00675	0.586
CLV_NRD_NRD_1	170	172	PF00675	0.638
CLV_NRD_NRD_1	315	317	PF00675	0.592
CLV_NRD_NRD_1	460	462	PF00675	0.339
CLV_NRD_NRD_1	476	478	PF00675	0.420
CLV_NRD_NRD_1	585	587	PF00675	0.345
CLV_NRD_NRD_1	59	61	PF00675	0.559
CLV_NRD_NRD_1	63	65	PF00675	0.474
CLV_NRD_NRD_1	73	75	PF00675	0.678
CLV_PCSK_FUR_1	71	75	PF00082	0.619
CLV_PCSK_KEX2_1	13	15	PF00082	0.593
CLV_PCSK_KEX2_1	170	172	PF00082	0.746
CLV_PCSK_KEX2_1	226	228	PF00082	0.683
CLV_PCSK_KEX2_1	314	316	PF00082	0.587
CLV_PCSK_KEX2_1	460	462	PF00082	0.339
CLV_PCSK_KEX2_1	474	476	PF00082	0.418
CLV_PCSK_KEX2_1	58	60	PF00082	0.539
CLV_PCSK_KEX2_1	585	587	PF00082	0.345
CLV_PCSK_KEX2_1	614	616	PF00082	0.596
CLV_PCSK_KEX2_1	71	73	PF00082	0.458
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.683
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.407
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.614
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.596
CLV_PCSK_SKI1_1	362	366	PF00082	0.427
CLV_PCSK_SKI1_1	464	468	PF00082	0.422
CLV_PCSK_SKI1_1	579	583	PF00082	0.339
CLV_PCSK_SKI1_1	64	68	PF00082	0.619
DOC_CKS1_1	344	349	PF01111	0.507
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.545
DOC_MAPK_gen_1	143	151	PF00069	0.644
DOC_MAPK_gen_1	21	31	PF00069	0.589
DOC_MAPK_gen_1	352	361	PF00069	0.430
DOC_MAPK_gen_1	474	481	PF00069	0.401
DOC_MAPK_MEF2A_6	24	31	PF00069	0.577
DOC_MAPK_NFAT4_5	24	32	PF00069	0.581
DOC_PP1_RVXF_1	475	482	PF00149	0.397
DOC_PP2B_LxvP_1	255	258	PF13499	0.694
DOC_PP2B_LxvP_1	84	87	PF13499	0.583
DOC_PP4_MxPP_1	228	231	PF00568	0.722
DOC_USP7_MATH_1	112	116	PF00917	0.810
DOC_USP7_MATH_1	141	145	PF00917	0.575
DOC_USP7_MATH_1	175	179	PF00917	0.588
DOC_USP7_MATH_1	449	453	PF00917	0.466
DOC_USP7_MATH_1	489	493	PF00917	0.510
DOC_USP7_MATH_1	632	636	PF00917	0.406
DOC_USP7_UBL2_3	101	105	PF12436	0.699
DOC_USP7_UBL2_3	348	352	PF12436	0.485
DOC_WW_Pin1_4	193	198	PF00397	0.821
DOC_WW_Pin1_4	226	231	PF00397	0.670
DOC_WW_Pin1_4	343	348	PF00397	0.505
DOC_WW_Pin1_4	624	629	PF00397	0.641
LIG_14-3-3_CanoR_1	325	335	PF00244	0.585
LIG_14-3-3_CanoR_1	339	344	PF00244	0.546
LIG_14-3-3_CanoR_1	428	433	PF00244	0.466
LIG_14-3-3_CanoR_1	450	454	PF00244	0.399
LIG_14-3-3_CanoR_1	460	464	PF00244	0.284
LIG_14-3-3_CanoR_1	585	589	PF00244	0.339
LIG_14-3-3_CanoR_1	638	642	PF00244	0.505
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BIR_III_2	631	635	PF00653	0.675
LIG_BRCT_BRCA1_1	586	590	PF00533	0.399
LIG_EVH1_1	81	85	PF00568	0.683
LIG_FHA_1	24	30	PF00498	0.500
LIG_FHA_1	252	258	PF00498	0.658
LIG_FHA_1	388	394	PF00498	0.402
LIG_FHA_1	399	405	PF00498	0.286
LIG_FHA_1	410	416	PF00498	0.339
LIG_FHA_1	578	584	PF00498	0.339
LIG_FHA_2	104	110	PF00498	0.643
LIG_FHA_2	203	209	PF00498	0.646
LIG_FHA_2	366	372	PF00498	0.434
LIG_FHA_2	429	435	PF00498	0.339
LIG_LIR_Gen_1	36	45	PF02991	0.566
LIG_LIR_Gen_1	400	410	PF02991	0.339
LIG_LIR_Gen_1	560	571	PF02991	0.328
LIG_LIR_Gen_1	587	595	PF02991	0.432
LIG_LIR_Gen_1	627	637	PF02991	0.456
LIG_LIR_Nem_3	2	7	PF02991	0.520
LIG_LIR_Nem_3	267	272	PF02991	0.667
LIG_LIR_Nem_3	36	41	PF02991	0.560
LIG_LIR_Nem_3	400	406	PF02991	0.339
LIG_LIR_Nem_3	430	435	PF02991	0.466
LIG_LIR_Nem_3	462	466	PF02991	0.409
LIG_LIR_Nem_3	560	566	PF02991	0.333
LIG_LIR_Nem_3	587	591	PF02991	0.339
LIG_LIR_Nem_3	606	612	PF02991	0.500
LIG_LIR_Nem_3	627	633	PF02991	0.457
LIG_MYND_1	82	86	PF01753	0.552
LIG_PDZ_Class_3	642	647	PF00595	0.639
LIG_PTAP_UEV_1	200	205	PF05743	0.604
LIG_SH2_CRK	38	42	PF00017	0.641
LIG_SH2_CRK	463	467	PF00017	0.412
LIG_SH2_SRC	439	442	PF00017	0.366
LIG_SH2_STAT3	7	10	PF00017	0.503
LIG_SH2_STAT5	478	481	PF00017	0.390
LIG_SH2_STAT5	508	511	PF00017	0.466
LIG_SH2_STAT5	7	10	PF00017	0.503
LIG_SH3_2	83	88	PF14604	0.568
LIG_SH3_3	198	204	PF00018	0.634
LIG_SH3_3	341	347	PF00018	0.515
LIG_SH3_3	419	425	PF00018	0.466
LIG_SH3_3	531	537	PF00018	0.349
LIG_SH3_3	79	85	PF00018	0.599
LIG_SH3_CIN85_PxpxPR_1	83	88	PF14604	0.590
LIG_SUMO_SIM_anti_2	546	551	PF11976	0.450
LIG_SUMO_SIM_par_1	570	575	PF11976	0.399
LIG_SxIP_EBH_1	215	229	PF03271	0.609
LIG_TRAF2_1	182	185	PF00917	0.663
LIG_TRAF2_1	264	267	PF00917	0.594
LIG_TRAF2_1	602	605	PF00917	0.599
LIG_TRAF2_1	66	69	PF00917	0.539
LIG_UBA3_1	27	32	PF00899	0.579
LIG_WRC_WIRS_1	1	6	PF05994	0.669
LIG_WRC_WIRS_1	269	274	PF05994	0.603
LIG_WW_2	82	85	PF00397	0.605
LIG_WW_3	85	89	PF00397	0.595
MOD_CDK_SPK_2	343	348	PF00069	0.505
MOD_CK1_1	100	106	PF00069	0.634
MOD_CK1_1	121	127	PF00069	0.747
MOD_CK1_1	202	208	PF00069	0.676
MOD_CK1_1	329	335	PF00069	0.502
MOD_CK1_1	342	348	PF00069	0.511
MOD_CK1_1	584	590	PF00069	0.339
MOD_CK2_1	103	109	PF00069	0.762
MOD_CK2_1	120	126	PF00069	0.633
MOD_CK2_1	179	185	PF00069	0.665
MOD_CK2_1	202	208	PF00069	0.646
MOD_CK2_1	238	244	PF00069	0.702
MOD_CK2_1	261	267	PF00069	0.591
MOD_CK2_1	282	288	PF00069	0.786
MOD_GlcNHglycan	109	113	PF01048	0.702
MOD_GlcNHglycan	120	123	PF01048	0.593
MOD_GlcNHglycan	134	137	PF01048	0.696
MOD_GlcNHglycan	201	204	PF01048	0.801
MOD_GlcNHglycan	220	223	PF01048	0.541
MOD_GlcNHglycan	540	543	PF01048	0.433
MOD_GlcNHglycan	574	577	PF01048	0.399
MOD_GlcNHglycan	617	620	PF01048	0.580
MOD_GSK3_1	108	115	PF00069	0.581
MOD_GSK3_1	141	148	PF00069	0.571
MOD_GSK3_1	175	182	PF00069	0.628
MOD_GSK3_1	199	206	PF00069	0.644
MOD_GSK3_1	257	264	PF00069	0.713
MOD_GSK3_1	339	346	PF00069	0.532
MOD_GSK3_1	365	372	PF00069	0.423
MOD_GSK3_1	577	584	PF00069	0.353
MOD_GSK3_1	86	93	PF00069	0.661
MOD_GSK3_1	95	102	PF00069	0.724
MOD_N-GLC_1	118	123	PF02516	0.743
MOD_N-GLC_1	244	249	PF02516	0.735
MOD_N-GLC_1	280	285	PF02516	0.728
MOD_N-GLC_1	288	293	PF02516	0.650
MOD_N-GLC_1	398	403	PF02516	0.339
MOD_N-GLC_1	90	95	PF02516	0.648
MOD_NEK2_1	120	125	PF00069	0.676
MOD_NEK2_1	15	20	PF00069	0.614
MOD_NEK2_1	179	184	PF00069	0.698
MOD_NEK2_1	23	28	PF00069	0.499
MOD_NEK2_1	233	238	PF00069	0.807
MOD_NEK2_1	364	369	PF00069	0.421
MOD_NEK2_1	465	470	PF00069	0.426
MOD_NEK2_1	481	486	PF00069	0.411
MOD_NEK2_1	528	533	PF00069	0.279
MOD_NEK2_1	637	642	PF00069	0.664
MOD_NEK2_2	265	270	PF00069	0.731
MOD_PIKK_1	180	186	PF00454	0.694
MOD_PIKK_1	288	294	PF00454	0.817
MOD_PIKK_1	346	352	PF00454	0.493
MOD_PIKK_1	387	393	PF00454	0.366
MOD_PIKK_1	90	96	PF00454	0.648
MOD_PK_1	145	151	PF00069	0.620
MOD_PK_1	376	382	PF00069	0.416
MOD_PKA_1	314	320	PF00069	0.589
MOD_PKA_2	103	109	PF00069	0.628
MOD_PKA_2	23	29	PF00069	0.503
MOD_PKA_2	314	320	PF00069	0.589
MOD_PKA_2	321	327	PF00069	0.573
MOD_PKA_2	427	433	PF00069	0.466
MOD_PKA_2	449	455	PF00069	0.399
MOD_PKA_2	459	465	PF00069	0.284
MOD_PKA_2	584	590	PF00069	0.339
MOD_PKA_2	637	643	PF00069	0.517
MOD_Plk_1	233	239	PF00069	0.808
MOD_Plk_1	243	249	PF00069	0.619
MOD_Plk_1	251	257	PF00069	0.727
MOD_Plk_1	329	335	PF00069	0.502
MOD_Plk_1	398	404	PF00069	0.339
MOD_Plk_1	410	416	PF00069	0.339
MOD_Plk_1	504	510	PF00069	0.466
MOD_Plk_1	605	611	PF00069	0.508
MOD_Plk_2-3	261	267	PF00069	0.707
MOD_Plk_4	23	29	PF00069	0.503
MOD_Plk_4	376	382	PF00069	0.416
MOD_Plk_4	398	404	PF00069	0.339
MOD_Plk_4	410	416	PF00069	0.339
MOD_Plk_4	504	510	PF00069	0.516
MOD_ProDKin_1	193	199	PF00069	0.823
MOD_ProDKin_1	226	232	PF00069	0.668
MOD_ProDKin_1	343	349	PF00069	0.504
MOD_ProDKin_1	624	630	PF00069	0.635
MOD_SUMO_for_1	66	69	PF00179	0.600
MOD_SUMO_rev_2	278	287	PF00179	0.609
MOD_SUMO_rev_2	538	547	PF00179	0.466
TRG_AP2beta_CARGO_1	267	276	PF09066	0.753
TRG_DiLeu_BaEn_2	301	307	PF01217	0.664
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.476
TRG_ENDOCYTIC_2	38	41	PF00928	0.576
TRG_ENDOCYTIC_2	463	466	PF00928	0.410
TRG_ENDOCYTIC_2	478	481	PF00928	0.401
TRG_ENDOCYTIC_2	563	566	PF00928	0.328
TRG_ER_diArg_1	12	14	PF00400	0.555
TRG_ER_diArg_1	169	171	PF00400	0.686
TRG_ER_diArg_1	314	316	PF00400	0.587
TRG_ER_diArg_1	475	477	PF00400	0.433
TRG_ER_diArg_1	71	74	PF00400	0.535
TRG_NES_CRM1_1	373	387	PF08389	0.422
TRG_NES_CRM1_1	558	570	PF08389	0.366
TRG_NLS_MonoCore_2	56	61	PF00514	0.602
TRG_NLS_MonoExtN_4	215	221	PF00514	0.602
TRG_NLS_MonoExtN_4	224	229	PF00514	0.572
TRG_NLS_MonoExtN_4	57	62	PF00514	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC94	Leptomonas seymouri	47%	93%
A4HB05	Leishmania braziliensis	63%	99%
A4IA61	Leishmania infantum	99%	100%
E9B573	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2R2	Leishmania major	90%	100%