Tuzin, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin, putative

Gene product:

tuzin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X835_LEIDO

TriTrypDb:

LdBPK_342640.1 , LdCL_340034200 , LDHU3_34.4300

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A0A3S7X835

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X835

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	510	514	PF00656	0.434
CLV_NRD_NRD_1	120	122	PF00675	0.365
CLV_NRD_NRD_1	126	128	PF00675	0.353
CLV_NRD_NRD_1	266	268	PF00675	0.634
CLV_NRD_NRD_1	279	281	PF00675	0.601
CLV_NRD_NRD_1	389	391	PF00675	0.527
CLV_NRD_NRD_1	463	465	PF00675	0.602
CLV_PCSK_KEX2_1	120	122	PF00082	0.344
CLV_PCSK_KEX2_1	126	128	PF00082	0.343
CLV_PCSK_KEX2_1	231	233	PF00082	0.669
CLV_PCSK_KEX2_1	266	268	PF00082	0.634
CLV_PCSK_KEX2_1	279	281	PF00082	0.601
CLV_PCSK_KEX2_1	389	391	PF00082	0.527
CLV_PCSK_KEX2_1	463	465	PF00082	0.604
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.668
CLV_PCSK_PC7_1	275	281	PF00082	0.612
CLV_PCSK_SKI1_1	184	188	PF00082	0.412
CLV_PCSK_SKI1_1	275	279	PF00082	0.615
CLV_PCSK_SKI1_1	353	357	PF00082	0.633
CLV_PCSK_SKI1_1	474	478	PF00082	0.491
CLV_PCSK_SKI1_1	493	497	PF00082	0.461
DEG_APCC_DBOX_1	274	282	PF00400	0.435
DEG_APCC_DBOX_1	492	500	PF00400	0.388
DOC_CYCLIN_RxL_1	179	189	PF00134	0.639
DOC_MAPK_gen_1	140	149	PF00069	0.560
DOC_MAPK_gen_1	228	238	PF00069	0.284
DOC_MAPK_gen_1	389	396	PF00069	0.285
DOC_MAPK_MEF2A_6	231	240	PF00069	0.407
DOC_MAPK_MEF2A_6	311	319	PF00069	0.300
DOC_MAPK_MEF2A_6	389	398	PF00069	0.298
DOC_PP1_RVXF_1	285	292	PF00149	0.251
DOC_PP1_RVXF_1	410	416	PF00149	0.335
DOC_PP2B_PxIxI_1	285	291	PF00149	0.308
DOC_PP2B_PxIxI_1	42	48	PF00149	0.508
DOC_PP4_FxxP_1	40	43	PF00568	0.663
DOC_PP4_FxxP_1	527	530	PF00568	0.314
DOC_USP7_MATH_1	19	23	PF00917	0.483
DOC_USP7_MATH_1	399	403	PF00917	0.300
DOC_USP7_MATH_1	516	520	PF00917	0.397
DOC_USP7_MATH_2	399	405	PF00917	0.258
DOC_USP7_UBL2_3	20	24	PF12436	0.618
DOC_USP7_UBL2_3	237	241	PF12436	0.363
DOC_WW_Pin1_4	255	260	PF00397	0.540
DOC_WW_Pin1_4	359	364	PF00397	0.302
DOC_WW_Pin1_4	39	44	PF00397	0.579
LIG_14-3-3_CanoR_1	463	470	PF00244	0.373
LIG_14-3-3_CanoR_1	480	490	PF00244	0.426
LIG_14-3-3_CanoR_1	491	499	PF00244	0.328
LIG_Actin_WH2_2	312	329	PF00022	0.364
LIG_APCC_ABBA_1	96	101	PF00400	0.497
LIG_BIR_II_1	1	5	PF00653	0.506
LIG_BIR_III_4	435	439	PF00653	0.268
LIG_deltaCOP1_diTrp_1	533	542	PF00928	0.331
LIG_eIF4E_1	470	476	PF01652	0.309
LIG_FHA_1	255	261	PF00498	0.393
LIG_FHA_1	360	366	PF00498	0.300
LIG_FHA_1	405	411	PF00498	0.427
LIG_FHA_1	76	82	PF00498	0.573
LIG_FHA_2	356	362	PF00498	0.420
LIG_FHA_2	508	514	PF00498	0.292
LIG_LIR_Apic_2	524	530	PF02991	0.230
LIG_LIR_Gen_1	373	383	PF02991	0.343
LIG_LIR_Gen_1	414	421	PF02991	0.302
LIG_LIR_Gen_1	454	465	PF02991	0.340
LIG_LIR_Nem_3	201	206	PF02991	0.466
LIG_LIR_Nem_3	373	378	PF02991	0.346
LIG_LIR_Nem_3	414	418	PF02991	0.335
LIG_LIR_Nem_3	454	460	PF02991	0.329
LIG_LIR_Nem_3	78	82	PF02991	0.535
LIG_NRP_CendR_1	558	559	PF00754	0.599
LIG_Pex14_2	138	142	PF04695	0.563
LIG_Pex14_2	218	222	PF04695	0.309
LIG_PTB_Apo_2	536	543	PF02174	0.292
LIG_PTB_Apo_2	82	89	PF02174	0.557
LIG_REV1ctd_RIR_1	4	13	PF16727	0.540
LIG_SH2_CRK	203	207	PF00017	0.292
LIG_SH2_CRK	528	532	PF00017	0.362
LIG_SH2_CRK	79	83	PF00017	0.530
LIG_SH2_GRB2like	470	473	PF00017	0.279
LIG_SH2_NCK_1	528	532	PF00017	0.357
LIG_SH2_PTP2	316	319	PF00017	0.351
LIG_SH2_SRC	316	319	PF00017	0.328
LIG_SH2_SRC	528	531	PF00017	0.376
LIG_SH2_STAP1	32	36	PF00017	0.520
LIG_SH2_STAT3	148	151	PF00017	0.458
LIG_SH2_STAT5	148	151	PF00017	0.560
LIG_SH2_STAT5	316	319	PF00017	0.351
LIG_SH2_STAT5	429	432	PF00017	0.344
LIG_SH2_STAT5	470	473	PF00017	0.357
LIG_SH2_STAT5	52	55	PF00017	0.557
LIG_SH3_3	280	286	PF00018	0.397
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.303
LIG_SUMO_SIM_par_1	42	49	PF11976	0.545
LIG_TRAF2_1	128	131	PF00917	0.490
LIG_TYR_ITIM	526	531	PF00017	0.333
LIG_TYR_ITSM	199	206	PF00017	0.531
LIG_UBA3_1	364	368	PF00899	0.262
MOD_CK1_1	22	28	PF00069	0.666
MOD_CK1_1	351	357	PF00069	0.380
MOD_CK1_1	404	410	PF00069	0.416
MOD_CK1_1	466	472	PF00069	0.283
MOD_CK2_1	105	111	PF00069	0.653
MOD_CK2_1	355	361	PF00069	0.402
MOD_GlcNHglycan	203	206	PF01048	0.302
MOD_GlcNHglycan	207	210	PF01048	0.295
MOD_GlcNHglycan	270	274	PF01048	0.627
MOD_GlcNHglycan	465	468	PF01048	0.508
MOD_GlcNHglycan	493	496	PF01048	0.545
MOD_GlcNHglycan	499	502	PF01048	0.544
MOD_GlcNHglycan	518	521	PF01048	0.643
MOD_GlcNHglycan	543	546	PF01048	0.484
MOD_GlcNHglycan	9	12	PF01048	0.405
MOD_GSK3_1	201	208	PF00069	0.457
MOD_GSK3_1	250	257	PF00069	0.519
MOD_GSK3_1	351	358	PF00069	0.449
MOD_LATS_1	461	467	PF00433	0.374
MOD_N-GLC_1	75	80	PF02516	0.381
MOD_N-GLC_1	84	89	PF02516	0.385
MOD_NEK2_1	243	248	PF00069	0.382
MOD_NEK2_1	254	259	PF00069	0.521
MOD_NEK2_1	427	432	PF00069	0.312
MOD_NEK2_1	482	487	PF00069	0.370
MOD_NEK2_1	541	546	PF00069	0.300
MOD_NEK2_1	7	12	PF00069	0.552
MOD_NEK2_2	19	24	PF00069	0.486
MOD_PIKK_1	172	178	PF00454	0.488
MOD_PIKK_1	226	232	PF00454	0.366
MOD_PIKK_1	427	433	PF00454	0.333
MOD_PKA_1	463	469	PF00069	0.425
MOD_PKA_2	319	325	PF00069	0.327
MOD_PKA_2	463	469	PF00069	0.378
MOD_PKB_1	489	497	PF00069	0.255
MOD_Plk_1	269	275	PF00069	0.387
MOD_Plk_1	322	328	PF00069	0.415
MOD_Plk_1	84	90	PF00069	0.616
MOD_Plk_2-3	84	90	PF00069	0.570
MOD_Plk_4	27	33	PF00069	0.545
MOD_Plk_4	61	67	PF00069	0.584
MOD_ProDKin_1	255	261	PF00069	0.540
MOD_ProDKin_1	359	365	PF00069	0.298
MOD_ProDKin_1	39	45	PF00069	0.568
TRG_DiLeu_BaEn_1	361	366	PF01217	0.330
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.307
TRG_ENDOCYTIC_2	203	206	PF00928	0.314
TRG_ENDOCYTIC_2	316	319	PF00928	0.328
TRG_ENDOCYTIC_2	528	531	PF00928	0.356
TRG_ENDOCYTIC_2	79	82	PF00928	0.604
TRG_ER_diArg_1	119	121	PF00400	0.667
TRG_ER_diArg_1	165	168	PF00400	0.655
TRG_ER_diArg_1	265	267	PF00400	0.446
TRG_ER_diArg_1	278	280	PF00400	0.409
TRG_ER_diArg_1	389	391	PF00400	0.310
TRG_ER_diArg_1	463	465	PF00400	0.445
TRG_ER_diArg_1	489	492	PF00400	0.474
TRG_ER_diArg_1	557	559	PF00400	0.398
TRG_NES_CRM1_1	324	339	PF08389	0.364
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	85%
A0A0N1PB02	Leptomonas seymouri	71%	85%
A0A0S4J6C6	Bodo saltans	47%	86%
A0A1X0P9A6	Trypanosomatidae	56%	82%
A0A3Q8IHH1	Leishmania donovani	38%	100%
A0A3R7K2Y9	Trypanosoma rangeli	54%	81%
A0A3S5H668	Leishmania donovani	50%	99%
A0A3S5H669	Leishmania donovani	46%	100%
A4H5C9	Leishmania braziliensis	48%	100%
A4H5D0	Leishmania braziliensis	44%	100%
A4HAZ7	Leishmania braziliensis	66%	100%
A4HAZ9	Leishmania braziliensis	69%	100%
A4HB01	Leishmania braziliensis	70%	100%
A4HTM0	Leishmania infantum	50%	99%
A4HTM1	Leishmania infantum	46%	100%
A4IA57	Leishmania infantum	100%	100%
C6K3V8	Leptomonas seymouri	50%	92%
C6K3V9	Leptomonas seymouri	45%	85%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	83%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	99%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q1U8	Leishmania major	39%	100%
Q4Q2R4	Leishmania major	90%	100%
Q4Q310	Leishmania major	41%	100%
Q4Q312	Leishmania major	40%	100%
Q4Q340	Leishmania major	41%	100%
Q4Q342	Leishmania major	41%	100%
Q4QI90	Leishmania major	46%	100%
Q4QI91	Leishmania major	49%	99%