LeishMANIAdb
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RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259
Gene product:
eukaryotic translation initiation factor 3 subunit g
Species:
Leishmania donovani
UniProt:
A0A3S7X829_LEIDO
TriTrypDb:
LdBPK_342530.1 , LdCL_340032900 , LDHU3_34.4130
Length:
255

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005852 eukaryotic translation initiation factor 3 complex 2 11
GO:0032991 protein-containing complex 1 11
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3S7X829
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X829

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003743 translation initiation factor activity 4 11
GO:0005488 binding 1 12
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 21 25 PF00656 0.825
CLV_NRD_NRD_1 57 59 PF00675 0.698
CLV_PCSK_KEX2_1 117 119 PF00082 0.690
CLV_PCSK_PC1ET2_1 117 119 PF00082 0.717
CLV_PCSK_PC7_1 113 119 PF00082 0.714
CLV_PCSK_SKI1_1 67 71 PF00082 0.614
CLV_Separin_Metazoa 55 59 PF03568 0.742
DOC_SPAK_OSR1_1 53 57 PF12202 0.716
DOC_USP7_MATH_1 162 166 PF00917 0.812
DOC_USP7_MATH_1 17 21 PF00917 0.881
DOC_USP7_MATH_1 32 36 PF00917 0.652
DOC_USP7_UBL2_3 238 242 PF12436 0.661
LIG_14-3-3_CanoR_1 58 64 PF00244 0.666
LIG_14-3-3_CanoR_1 67 72 PF00244 0.554
LIG_Actin_WH2_2 123 138 PF00022 0.729
LIG_APCC_ABBA_1 221 226 PF00400 0.662
LIG_BIR_II_1 1 5 PF00653 0.732
LIG_BIR_III_4 48 52 PF00653 0.730
LIG_BRCT_BRCA1_1 192 196 PF00533 0.662
LIG_FHA_1 173 179 PF00498 0.682
LIG_FHA_1 201 207 PF00498 0.691
LIG_FHA_1 42 48 PF00498 0.659
LIG_FHA_2 68 74 PF00498 0.581
LIG_Integrin_RGD_1 210 212 PF01839 0.462
LIG_LIR_Apic_2 27 32 PF02991 0.794
LIG_LIR_Gen_1 216 227 PF02991 0.662
LIG_LIR_Nem_3 158 163 PF02991 0.817
LIG_LIR_Nem_3 216 222 PF02991 0.595
LIG_LIR_Nem_3 24 29 PF02991 0.851
LIG_Pex14_2 224 228 PF04695 0.662
LIG_RPA_C_Fungi 48 60 PF08784 0.746
LIG_SH2_SRC 29 32 PF00017 0.784
LIG_SH3_3 203 209 PF00018 0.549
LIG_SH3_3 62 68 PF00018 0.633
LIG_SUMO_SIM_par_1 244 249 PF11976 0.635
LIG_SUMO_SIM_par_1 95 101 PF11976 0.625
MOD_CK1_1 165 171 PF00069 0.795
MOD_CK1_1 35 41 PF00069 0.776
MOD_CK2_1 109 115 PF00069 0.712
MOD_CK2_1 22 28 PF00069 0.784
MOD_CK2_1 246 252 PF00069 0.640
MOD_GlcNHglycan 122 126 PF01048 0.749
MOD_GlcNHglycan 153 156 PF01048 0.847
MOD_GlcNHglycan 92 95 PF01048 0.793
MOD_GSK3_1 151 158 PF00069 0.798
MOD_GSK3_1 181 188 PF00069 0.426
MOD_GSK3_1 246 253 PF00069 0.651
MOD_GSK3_1 86 93 PF00069 0.764
MOD_N-GLC_1 181 186 PF02516 0.428
MOD_N-GLC_1 190 195 PF02516 0.245
MOD_N-GLC_1 213 218 PF02516 0.518
MOD_N-GLC_1 22 27 PF02516 0.840
MOD_NEK2_1 246 251 PF00069 0.566
MOD_PIKK_1 185 191 PF00454 0.549
MOD_PKA_2 109 115 PF00069 0.693
MOD_PKB_1 179 187 PF00069 0.549
MOD_Plk_1 190 196 PF00069 0.520
MOD_Plk_1 22 28 PF00069 0.791
MOD_Plk_1 41 47 PF00069 0.750
MOD_Plk_1 86 92 PF00069 0.765
MOD_Plk_2-3 101 107 PF00069 0.721
MOD_Plk_2-3 22 28 PF00069 0.870
MOD_Plk_4 87 93 PF00069 0.768
MOD_SUMO_for_1 130 133 PF00179 0.649
MOD_SUMO_for_1 39 42 PF00179 0.726
MOD_SUMO_rev_2 109 119 PF00179 0.703
MOD_SUMO_rev_2 140 145 PF00179 0.734
MOD_SUMO_rev_2 231 239 PF00179 0.575
MOD_SUMO_rev_2 25 35 PF00179 0.777
TRG_ER_diArg_1 178 181 PF00400 0.451
TRG_Pf-PMV_PEXEL_1 118 122 PF00026 0.721
TRG_Pf-PMV_PEXEL_1 181 185 PF00026 0.549

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCI2 Leptomonas seymouri 71% 100%
A0A0S4JUP4 Bodo saltans 30% 85%
A0A1X0PAQ4 Trypanosomatidae 34% 95%
A0A3S5IRQ9 Trypanosoma rangeli 37% 93%
A4HAY7 Leishmania braziliensis 95% 100%
A4IA46 Leishmania infantum 100% 100%
C9ZM55 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 94%
E9B560 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4Q2S5 Leishmania major 98% 100%
V5BV73 Trypanosoma cruzi 39% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS