GPI transamidase subunit 16, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase subunit 16, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X824_LEIDO

TriTrypDb:

LdBPK_342560.1 , LdCL_340033200 , LDHU3_34.4170

Length:

738

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X824

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X824

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.595
CLV_NRD_NRD_1	118	120	PF00675	0.589
CLV_NRD_NRD_1	145	147	PF00675	0.757
CLV_NRD_NRD_1	168	170	PF00675	0.717
CLV_NRD_NRD_1	42	44	PF00675	0.608
CLV_NRD_NRD_1	594	596	PF00675	0.584
CLV_NRD_NRD_1	6	8	PF00675	0.541
CLV_NRD_NRD_1	618	620	PF00675	0.702
CLV_NRD_NRD_1	715	717	PF00675	0.430
CLV_PCSK_FUR_1	166	170	PF00082	0.664
CLV_PCSK_KEX2_1	117	119	PF00082	0.587
CLV_PCSK_KEX2_1	145	147	PF00082	0.761
CLV_PCSK_KEX2_1	168	170	PF00082	0.665
CLV_PCSK_KEX2_1	42	44	PF00082	0.608
CLV_PCSK_KEX2_1	449	451	PF00082	0.750
CLV_PCSK_KEX2_1	594	596	PF00082	0.584
CLV_PCSK_KEX2_1	6	8	PF00082	0.522
CLV_PCSK_KEX2_1	618	620	PF00082	0.652
CLV_PCSK_KEX2_1	715	717	PF00082	0.416
CLV_PCSK_KEX2_1	720	722	PF00082	0.427
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.766
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.511
CLV_PCSK_PC7_1	716	722	PF00082	0.467
CLV_PCSK_SKI1_1	168	172	PF00082	0.735
CLV_PCSK_SKI1_1	279	283	PF00082	0.554
CLV_PCSK_SKI1_1	373	377	PF00082	0.633
CLV_PCSK_SKI1_1	475	479	PF00082	0.616
CLV_PCSK_SKI1_1	715	719	PF00082	0.383
DEG_APCC_DBOX_1	485	493	PF00400	0.374
DEG_APCC_DBOX_1	720	728	PF00400	0.729
DEG_SPOP_SBC_1	605	609	PF00917	0.413
DOC_CYCLIN_yCln2_LP_2	478	484	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	73	79	PF00134	0.463
DOC_MAPK_DCC_7	475	484	PF00069	0.433
DOC_MAPK_DCC_7	584	592	PF00069	0.477
DOC_MAPK_gen_1	220	229	PF00069	0.532
DOC_MAPK_gen_1	355	363	PF00069	0.479
DOC_MAPK_gen_1	42	48	PF00069	0.358
DOC_MAPK_gen_1	551	561	PF00069	0.474
DOC_MAPK_gen_1	720	727	PF00069	0.677
DOC_MAPK_MEF2A_6	322	329	PF00069	0.431
DOC_MAPK_MEF2A_6	355	363	PF00069	0.460
DOC_MAPK_MEF2A_6	423	432	PF00069	0.448
DOC_MAPK_MEF2A_6	584	593	PF00069	0.393
DOC_PP1_RVXF_1	121	127	PF00149	0.469
DOC_PP2B_LxvP_1	73	76	PF13499	0.355
DOC_PP4_FxxP_1	293	296	PF00568	0.445
DOC_USP7_MATH_1	219	223	PF00917	0.551
DOC_USP7_MATH_1	285	289	PF00917	0.428
DOC_USP7_MATH_1	310	314	PF00917	0.503
DOC_USP7_MATH_1	38	42	PF00917	0.434
DOC_USP7_MATH_1	380	384	PF00917	0.446
DOC_USP7_MATH_1	398	402	PF00917	0.579
DOC_USP7_MATH_1	596	600	PF00917	0.540
DOC_USP7_MATH_1	605	609	PF00917	0.559
DOC_USP7_MATH_1	8	12	PF00917	0.593
DOC_WW_Pin1_4	207	212	PF00397	0.403
DOC_WW_Pin1_4	215	220	PF00397	0.458
DOC_WW_Pin1_4	258	263	PF00397	0.456
DOC_WW_Pin1_4	381	386	PF00397	0.511
DOC_WW_Pin1_4	390	395	PF00397	0.507
DOC_WW_Pin1_4	400	405	PF00397	0.495
DOC_WW_Pin1_4	408	413	PF00397	0.409
DOC_WW_Pin1_4	519	524	PF00397	0.397
DOC_WW_Pin1_4	58	63	PF00397	0.513
LIG_14-3-3_CanoR_1	191	199	PF00244	0.439
LIG_14-3-3_CanoR_1	328	332	PF00244	0.425
LIG_14-3-3_CanoR_1	396	405	PF00244	0.572
LIG_14-3-3_CanoR_1	42	47	PF00244	0.404
LIG_14-3-3_CanoR_1	619	625	PF00244	0.525
LIG_14-3-3_CanoR_1	675	685	PF00244	0.527
LIG_14-3-3_CanoR_1	715	724	PF00244	0.721
LIG_AP_GAE_1	105	111	PF02883	0.448
LIG_AP2alpha_1	104	108	PF02296	0.356
LIG_BRCT_BRCA1_1	160	164	PF00533	0.544
LIG_BRCT_BRCA1_1	180	184	PF00533	0.236
LIG_CaM_IQ_9	637	652	PF13499	0.367
LIG_Clathr_ClatBox_1	436	440	PF01394	0.496
LIG_deltaCOP1_diTrp_1	125	133	PF00928	0.401
LIG_EH1_1	489	497	PF00400	0.457
LIG_eIF4E_1	490	496	PF01652	0.478
LIG_FHA_1	255	261	PF00498	0.385
LIG_FHA_1	318	324	PF00498	0.480
LIG_FHA_1	376	382	PF00498	0.394
LIG_FHA_1	427	433	PF00498	0.349
LIG_FHA_1	474	480	PF00498	0.415
LIG_FHA_1	496	502	PF00498	0.455
LIG_FHA_1	50	56	PF00498	0.441
LIG_FHA_1	510	516	PF00498	0.368
LIG_FHA_1	59	65	PF00498	0.412
LIG_FHA_1	712	718	PF00498	0.611
LIG_FHA_1	732	738	PF00498	0.664
LIG_FHA_2	101	107	PF00498	0.406
LIG_FHA_2	596	602	PF00498	0.492
LIG_HCF-1_HBM_1	424	427	PF13415	0.466
LIG_LIR_Apic_2	136	140	PF02991	0.550
LIG_LIR_Gen_1	178	187	PF02991	0.480
LIG_LIR_Gen_1	246	255	PF02991	0.470
LIG_LIR_Gen_1	41	51	PF02991	0.444
LIG_LIR_Gen_1	424	435	PF02991	0.416
LIG_LIR_Nem_3	105	111	PF02991	0.379
LIG_LIR_Nem_3	161	167	PF02991	0.521
LIG_LIR_Nem_3	178	182	PF02991	0.371
LIG_LIR_Nem_3	241	247	PF02991	0.423
LIG_LIR_Nem_3	288	292	PF02991	0.360
LIG_LIR_Nem_3	424	430	PF02991	0.386
LIG_NRBOX	166	172	PF00104	0.463
LIG_NRBOX	512	518	PF00104	0.408
LIG_Pex14_1	199	203	PF04695	0.364
LIG_Pex14_2	104	108	PF04695	0.457
LIG_Pex14_2	282	286	PF04695	0.351
LIG_Pex14_2	289	293	PF04695	0.342
LIG_Pex14_2	564	568	PF04695	0.350
LIG_SH2_CRK	179	183	PF00017	0.461
LIG_SH2_CRK	247	251	PF00017	0.462
LIG_SH2_NCK_1	179	183	PF00017	0.461
LIG_SH2_NCK_1	529	533	PF00017	0.439
LIG_SH2_SRC	533	536	PF00017	0.474
LIG_SH2_STAP1	44	48	PF00017	0.373
LIG_SH2_STAP1	529	533	PF00017	0.439
LIG_SH2_STAT5	114	117	PF00017	0.444
LIG_SH2_STAT5	292	295	PF00017	0.453
LIG_SH2_STAT5	427	430	PF00017	0.408
LIG_SH3_3	26	32	PF00018	0.378
LIG_SH3_3	379	385	PF00018	0.495
LIG_SH3_3	583	589	PF00018	0.521
LIG_SH3_3	73	79	PF00018	0.463
LIG_SUMO_SIM_anti_2	512	520	PF11976	0.406
LIG_SUMO_SIM_par_1	18	23	PF11976	0.389
LIG_SUMO_SIM_par_1	435	440	PF11976	0.476
LIG_TRAF2_1	304	307	PF00917	0.460
LIG_TRAF2_1	456	459	PF00917	0.486
LIG_TYR_ITIM	111	116	PF00017	0.540
LIG_Vh1_VBS_1	502	520	PF01044	0.543
LIG_WRC_WIRS_1	286	291	PF05994	0.523
MOD_CDK_SPK_2	215	220	PF00069	0.600
MOD_CDK_SPxK_1	390	396	PF00069	0.719
MOD_CDK_SPxxK_3	400	407	PF00069	0.736
MOD_CK1_1	180	186	PF00069	0.466
MOD_CK1_1	205	211	PF00069	0.496
MOD_CK1_1	234	240	PF00069	0.696
MOD_CK1_1	403	409	PF00069	0.682
MOD_CK1_1	608	614	PF00069	0.685
MOD_CK1_1	623	629	PF00069	0.612
MOD_CK1_1	676	682	PF00069	0.638
MOD_CK2_1	210	216	PF00069	0.442
MOD_CK2_1	234	240	PF00069	0.656
MOD_CK2_1	334	340	PF00069	0.589
MOD_CK2_1	381	387	PF00069	0.607
MOD_CK2_1	51	57	PF00069	0.625
MOD_GlcNHglycan	153	156	PF01048	0.746
MOD_GlcNHglycan	236	239	PF01048	0.620
MOD_GlcNHglycan	268	271	PF01048	0.609
MOD_GlcNHglycan	312	315	PF01048	0.598
MOD_GlcNHglycan	373	376	PF01048	0.502
MOD_GlcNHglycan	398	401	PF01048	0.737
MOD_GlcNHglycan	457	462	PF01048	0.633
MOD_GlcNHglycan	570	573	PF01048	0.503
MOD_GlcNHglycan	598	601	PF01048	0.636
MOD_GlcNHglycan	657	660	PF01048	0.689
MOD_GlcNHglycan	679	682	PF01048	0.645
MOD_GlcNHglycan	8	11	PF01048	0.626
MOD_GSK3_1	202	209	PF00069	0.484
MOD_GSK3_1	215	222	PF00069	0.589
MOD_GSK3_1	230	237	PF00069	0.594
MOD_GSK3_1	254	261	PF00069	0.481
MOD_GSK3_1	298	305	PF00069	0.504
MOD_GSK3_1	340	347	PF00069	0.571
MOD_GSK3_1	371	378	PF00069	0.491
MOD_GSK3_1	38	45	PF00069	0.509
MOD_GSK3_1	396	403	PF00069	0.719
MOD_GSK3_1	491	498	PF00069	0.574
MOD_GSK3_1	604	611	PF00069	0.612
MOD_GSK3_1	673	680	PF00069	0.578
MOD_GSK3_1	711	718	PF00069	0.650
MOD_N-GLC_1	38	43	PF02516	0.538
MOD_NEK2_1	203	208	PF00069	0.452
MOD_NEK2_1	462	467	PF00069	0.645
MOD_NEK2_1	495	500	PF00069	0.547
MOD_NEK2_1	516	521	PF00069	0.434
MOD_NEK2_1	568	573	PF00069	0.514
MOD_NEK2_1	643	648	PF00069	0.544
MOD_NEK2_1	69	74	PF00069	0.510
MOD_PIKK_1	192	198	PF00454	0.550
MOD_PIKK_1	254	260	PF00454	0.484
MOD_PIKK_1	302	308	PF00454	0.507
MOD_PIKK_1	366	372	PF00454	0.577
MOD_PIKK_1	606	612	PF00454	0.694
MOD_PKA_1	42	48	PF00069	0.474
MOD_PKA_1	6	12	PF00069	0.590
MOD_PKA_1	653	659	PF00069	0.630
MOD_PKA_1	715	721	PF00069	0.667
MOD_PKA_2	219	225	PF00069	0.694
MOD_PKA_2	230	236	PF00069	0.689
MOD_PKA_2	327	333	PF00069	0.518
MOD_PKA_2	42	48	PF00069	0.504
MOD_PKA_2	485	491	PF00069	0.464
MOD_PKA_2	57	63	PF00069	0.569
MOD_PKA_2	6	12	PF00069	0.630
MOD_PKA_2	674	680	PF00069	0.500
MOD_PKA_2	711	717	PF00069	0.496
MOD_Plk_1	135	141	PF00069	0.647
MOD_Plk_1	457	463	PF00069	0.665
MOD_Plk_1	517	523	PF00069	0.560
MOD_Plk_1	632	638	PF00069	0.635
MOD_Plk_1	69	75	PF00069	0.431
MOD_Plk_4	158	164	PF00069	0.660
MOD_Plk_4	20	26	PF00069	0.448
MOD_Plk_4	285	291	PF00069	0.500
MOD_Plk_4	327	333	PF00069	0.495
MOD_Plk_4	42	48	PF00069	0.525
MOD_Plk_4	462	468	PF00069	0.551
MOD_Plk_4	485	491	PF00069	0.514
MOD_Plk_4	60	66	PF00069	0.309
MOD_Plk_4	732	738	PF00069	0.677
MOD_ProDKin_1	207	213	PF00069	0.512
MOD_ProDKin_1	215	221	PF00069	0.584
MOD_ProDKin_1	258	264	PF00069	0.578
MOD_ProDKin_1	381	387	PF00069	0.670
MOD_ProDKin_1	390	396	PF00069	0.648
MOD_ProDKin_1	400	406	PF00069	0.630
MOD_ProDKin_1	408	414	PF00069	0.505
MOD_ProDKin_1	519	525	PF00069	0.490
MOD_ProDKin_1	58	64	PF00069	0.647
MOD_SUMO_for_1	323	326	PF00179	0.508
MOD_SUMO_rev_2	646	656	PF00179	0.506
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.589
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.566
TRG_ENDOCYTIC_2	113	116	PF00928	0.546
TRG_ENDOCYTIC_2	179	182	PF00928	0.592
TRG_ENDOCYTIC_2	247	250	PF00928	0.580
TRG_ENDOCYTIC_2	427	430	PF00928	0.443
TRG_ENDOCYTIC_2	44	47	PF00928	0.551
TRG_ER_diArg_1	116	119	PF00400	0.469
TRG_ER_diArg_1	166	169	PF00400	0.592
TRG_ER_diArg_1	42	44	PF00400	0.511
TRG_ER_diArg_1	593	595	PF00400	0.454
TRG_ER_diArg_1	6	8	PF00400	0.663
TRG_ER_diArg_1	715	717	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I790	Leptomonas seymouri	59%	100%
A0A1X0P9R2	Trypanosomatidae	34%	100%
A0A3R7MUC6	Trypanosoma rangeli	35%	100%
A4HAY9	Leishmania braziliensis	78%	100%
A4IA49	Leishmania infantum	99%	100%
C9ZM54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B563	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
Q4Q2S2	Leishmania major	94%	100%
V5BV01	Trypanosoma cruzi	34%	100%