Elongation factor Tu GTP binding domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongation factor Tu GTP binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X814_LEIDO

TriTrypDb:

LdBPK_342230.1 , LdCL_340030000 , LDHU3_34.3710

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X814

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X814

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	3
GO:0003746	translation elongation factor activity	4	3
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0008135	translation factor activity, RNA binding	3	3
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.626
CLV_C14_Caspase3-7	587	591	PF00656	0.648
CLV_C14_Caspase3-7	78	82	PF00656	0.651
CLV_C14_Caspase3-7	819	823	PF00656	0.799
CLV_C14_Caspase3-7	847	851	PF00656	0.638
CLV_NRD_NRD_1	10	12	PF00675	0.787
CLV_NRD_NRD_1	118	120	PF00675	0.782
CLV_NRD_NRD_1	286	288	PF00675	0.681
CLV_NRD_NRD_1	315	317	PF00675	0.707
CLV_NRD_NRD_1	370	372	PF00675	0.674
CLV_NRD_NRD_1	519	521	PF00675	0.383
CLV_PCSK_KEX2_1	118	120	PF00082	0.782
CLV_PCSK_KEX2_1	286	288	PF00082	0.675
CLV_PCSK_KEX2_1	370	372	PF00082	0.674
CLV_PCSK_KEX2_1	449	451	PF00082	0.395
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.309
CLV_PCSK_PC7_1	282	288	PF00082	0.655
CLV_PCSK_SKI1_1	282	286	PF00082	0.561
CLV_PCSK_SKI1_1	412	416	PF00082	0.350
CLV_PCSK_SKI1_1	498	502	PF00082	0.373
CLV_PCSK_SKI1_1	511	515	PF00082	0.316
CLV_PCSK_SKI1_1	838	842	PF00082	0.593
DEG_APCC_DBOX_1	655	663	PF00400	0.610
DEG_APCC_KENBOX_2	354	358	PF00400	0.753
DEG_Nend_Nbox_1	1	3	PF02207	0.808
DEG_SCF_FBW7_1	437	444	PF00400	0.509
DEG_SCF_FBW7_1	620	627	PF00400	0.661
DEG_SCF_FBW7_1	812	817	PF00400	0.525
DEG_SPOP_SBC_1	132	136	PF00917	0.669
DEG_SPOP_SBC_1	207	211	PF00917	0.654
DEG_SPOP_SBC_1	29	33	PF00917	0.805
DEG_SPOP_SBC_1	35	39	PF00917	0.820
DEG_SPOP_SBC_1	442	446	PF00917	0.509
DEG_SPOP_SBC_1	615	619	PF00917	0.665
DEG_SPOP_SBC_1	74	78	PF00917	0.761
DOC_CKS1_1	549	554	PF01111	0.638
DOC_CKS1_1	621	626	PF01111	0.661
DOC_CYCLIN_RxL_1	835	844	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	202	205	PF00134	0.755
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.564
DOC_MAPK_gen_1	520	527	PF00069	0.638
DOC_MAPK_gen_1	632	640	PF00069	0.606
DOC_MAPK_gen_1	702	710	PF00069	0.599
DOC_MAPK_gen_1	801	809	PF00069	0.578
DOC_MAPK_HePTP_8	517	529	PF00069	0.638
DOC_MAPK_MEF2A_6	392	400	PF00069	0.558
DOC_MAPK_MEF2A_6	520	529	PF00069	0.638
DOC_MAPK_MEF2A_6	632	640	PF00069	0.606
DOC_PP2B_LxvP_1	202	205	PF13499	0.828
DOC_PP2B_LxvP_1	48	51	PF13499	0.709
DOC_PP2B_LxvP_1	636	639	PF13499	0.610
DOC_PP2B_LxvP_1	72	75	PF13499	0.726
DOC_USP7_MATH_1	110	114	PF00917	0.782
DOC_USP7_MATH_1	132	136	PF00917	0.843
DOC_USP7_MATH_1	16	20	PF00917	0.784
DOC_USP7_MATH_1	165	169	PF00917	0.813
DOC_USP7_MATH_1	323	327	PF00917	0.765
DOC_USP7_MATH_1	35	39	PF00917	0.686
DOC_USP7_MATH_1	351	355	PF00917	0.682
DOC_USP7_MATH_1	373	377	PF00917	0.632
DOC_USP7_MATH_1	387	391	PF00917	0.603
DOC_USP7_MATH_1	442	446	PF00917	0.557
DOC_USP7_MATH_1	534	538	PF00917	0.643
DOC_USP7_MATH_1	66	70	PF00917	0.817
DOC_USP7_MATH_1	75	79	PF00917	0.713
DOC_USP7_MATH_1	781	785	PF00917	0.614
DOC_WW_Pin1_4	134	139	PF00397	0.859
DOC_WW_Pin1_4	144	149	PF00397	0.699
DOC_WW_Pin1_4	163	168	PF00397	0.608
DOC_WW_Pin1_4	195	200	PF00397	0.843
DOC_WW_Pin1_4	244	249	PF00397	0.626
DOC_WW_Pin1_4	277	282	PF00397	0.568
DOC_WW_Pin1_4	318	323	PF00397	0.723
DOC_WW_Pin1_4	326	331	PF00397	0.761
DOC_WW_Pin1_4	437	442	PF00397	0.632
DOC_WW_Pin1_4	456	461	PF00397	0.556
DOC_WW_Pin1_4	477	482	PF00397	0.644
DOC_WW_Pin1_4	493	498	PF00397	0.472
DOC_WW_Pin1_4	548	553	PF00397	0.611
DOC_WW_Pin1_4	616	621	PF00397	0.635
DOC_WW_Pin1_4	665	670	PF00397	0.639
DOC_WW_Pin1_4	810	815	PF00397	0.589
LIG_14-3-3_CanoR_1	109	115	PF00244	0.820
LIG_14-3-3_CanoR_1	11	20	PF00244	0.801
LIG_14-3-3_CanoR_1	177	187	PF00244	0.771
LIG_14-3-3_CanoR_1	316	322	PF00244	0.765
LIG_14-3-3_CanoR_1	426	431	PF00244	0.658
LIG_14-3-3_CanoR_1	433	438	PF00244	0.638
LIG_14-3-3_CanoR_1	450	458	PF00244	0.628
LIG_14-3-3_CanoR_1	498	503	PF00244	0.590
LIG_14-3-3_CanoR_1	656	666	PF00244	0.618
LIG_14-3-3_CanoR_1	865	870	PF00244	0.667
LIG_APCC_ABBA_1	539	544	PF00400	0.634
LIG_BIR_III_4	504	508	PF00653	0.638
LIG_BRCT_BRCA1_1	380	384	PF00533	0.523
LIG_CSL_BTD_1	601	604	PF09270	0.606
LIG_FHA_1	128	134	PF00498	0.807
LIG_FHA_1	15	21	PF00498	0.853
LIG_FHA_1	29	35	PF00498	0.667
LIG_FHA_1	399	405	PF00498	0.589
LIG_FHA_1	425	431	PF00498	0.558
LIG_FHA_1	531	537	PF00498	0.616
LIG_FHA_1	549	555	PF00498	0.638
LIG_FHA_1	55	61	PF00498	0.808
LIG_FHA_1	616	622	PF00498	0.669
LIG_FHA_1	624	630	PF00498	0.485
LIG_FHA_1	747	753	PF00498	0.496
LIG_FHA_2	227	233	PF00498	0.651
LIG_FHA_2	283	289	PF00498	0.566
LIG_FHA_2	438	444	PF00498	0.600
LIG_FHA_2	499	505	PF00498	0.583
LIG_FHA_2	556	562	PF00498	0.549
LIG_GSK3_LRP6_1	665	670	PF00069	0.762
LIG_IRF3_LxIS_1	330	337	PF10401	0.557
LIG_LIR_Apic_2	137	143	PF02991	0.637
LIG_LIR_Apic_2	713	718	PF02991	0.584
LIG_LIR_Gen_1	147	158	PF02991	0.795
LIG_LIR_Gen_1	249	258	PF02991	0.563
LIG_LIR_Gen_1	328	339	PF02991	0.863
LIG_LIR_Gen_1	512	522	PF02991	0.654
LIG_LIR_Gen_1	523	531	PF02991	0.604
LIG_LIR_Gen_1	540	549	PF02991	0.496
LIG_LIR_Gen_1	551	557	PF02991	0.592
LIG_LIR_Nem_3	147	153	PF02991	0.747
LIG_LIR_Nem_3	249	254	PF02991	0.552
LIG_LIR_Nem_3	328	334	PF02991	0.858
LIG_LIR_Nem_3	523	527	PF02991	0.570
LIG_LIR_Nem_3	540	545	PF02991	0.512
LIG_LIR_Nem_3	551	556	PF02991	0.634
LIG_LIR_Nem_3	721	727	PF02991	0.489
LIG_MYND_1	200	204	PF01753	0.790
LIG_MYND_1	669	673	PF01753	0.779
LIG_Rb_LxCxE_1	356	376	PF01857	0.578
LIG_SH2_CRK	225	229	PF00017	0.741
LIG_SH2_CRK	331	335	PF00017	0.851
LIG_SH2_CRK	725	729	PF00017	0.585
LIG_SH2_PTP2	524	527	PF00017	0.638
LIG_SH2_PTP2	715	718	PF00017	0.573
LIG_SH2_SRC	542	545	PF00017	0.634
LIG_SH2_STAP1	688	692	PF00017	0.578
LIG_SH2_STAP1	725	729	PF00017	0.547
LIG_SH2_STAP1	799	803	PF00017	0.544
LIG_SH2_STAT5	524	527	PF00017	0.635
LIG_SH2_STAT5	598	601	PF00017	0.638
LIG_SH2_STAT5	657	660	PF00017	0.653
LIG_SH2_STAT5	715	718	PF00017	0.573
LIG_SH2_STAT5	799	802	PF00017	0.513
LIG_SH3_3	135	141	PF00018	0.867
LIG_SH3_3	148	154	PF00018	0.620
LIG_SH3_3	324	330	PF00018	0.725
LIG_SH3_3	478	484	PF00018	0.671
LIG_SH3_3	663	669	PF00018	0.579
LIG_SH3_3	766	772	PF00018	0.595
LIG_SH3_3	809	815	PF00018	0.661
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.610
LIG_SUMO_SIM_par_1	553	558	PF11976	0.637
LIG_SUMO_SIM_par_1	83	90	PF11976	0.656
LIG_TRAF2_1	817	820	PF00917	0.800
LIG_TYR_ITIM	223	228	PF00017	0.766
LIG_UBA3_1	513	521	PF00899	0.623
LIG_WRC_WIRS_1	776	781	PF05994	0.532
LIG_WW_3	629	633	PF00397	0.606
MOD_CDC14_SPxK_1	247	250	PF00782	0.608
MOD_CDK_SPK_2	277	282	PF00069	0.545
MOD_CDK_SPK_2	456	461	PF00069	0.661
MOD_CDK_SPK_2	493	498	PF00069	0.638
MOD_CDK_SPxK_1	244	250	PF00069	0.636
MOD_CDK_SPxxK_3	326	333	PF00069	0.846
MOD_CK1_1	134	140	PF00069	0.812
MOD_CK1_1	14	20	PF00069	0.863
MOD_CK1_1	161	167	PF00069	0.835
MOD_CK1_1	190	196	PF00069	0.841
MOD_CK1_1	206	212	PF00069	0.877
MOD_CK1_1	292	298	PF00069	0.514
MOD_CK1_1	326	332	PF00069	0.768
MOD_CK1_1	390	396	PF00069	0.592
MOD_CK1_1	429	435	PF00069	0.584
MOD_CK1_1	471	477	PF00069	0.673
MOD_CK1_1	496	502	PF00069	0.641
MOD_CK1_1	537	543	PF00069	0.669
MOD_CK1_1	672	678	PF00069	0.740
MOD_CK1_1	784	790	PF00069	0.650
MOD_CK1_1	87	93	PF00069	0.810
MOD_CK2_1	334	340	PF00069	0.855
MOD_CK2_1	441	447	PF00069	0.613
MOD_CK2_1	814	820	PF00069	0.759
MOD_GlcNHglycan	180	183	PF01048	0.801
MOD_GlcNHglycan	205	208	PF01048	0.833
MOD_GlcNHglycan	212	215	PF01048	0.770
MOD_GlcNHglycan	336	339	PF01048	0.851
MOD_GlcNHglycan	375	378	PF01048	0.680
MOD_GlcNHglycan	389	392	PF01048	0.343
MOD_GlcNHglycan	45	48	PF01048	0.788
MOD_GlcNHglycan	452	455	PF01048	0.424
MOD_GlcNHglycan	470	473	PF01048	0.380
MOD_GlcNHglycan	78	81	PF01048	0.864
MOD_GlcNHglycan	790	793	PF01048	0.575
MOD_GlcNHglycan	846	849	PF01048	0.632
MOD_GSK3_1	10	17	PF00069	0.835
MOD_GSK3_1	127	134	PF00069	0.899
MOD_GSK3_1	161	168	PF00069	0.784
MOD_GSK3_1	178	185	PF00069	0.612
MOD_GSK3_1	190	197	PF00069	0.854
MOD_GSK3_1	203	210	PF00069	0.848
MOD_GSK3_1	273	280	PF00069	0.616
MOD_GSK3_1	30	37	PF00069	0.789
MOD_GSK3_1	387	394	PF00069	0.572
MOD_GSK3_1	421	428	PF00069	0.559
MOD_GSK3_1	429	436	PF00069	0.560
MOD_GSK3_1	437	444	PF00069	0.565
MOD_GSK3_1	456	463	PF00069	0.614
MOD_GSK3_1	471	478	PF00069	0.562
MOD_GSK3_1	486	493	PF00069	0.552
MOD_GSK3_1	530	537	PF00069	0.661
MOD_GSK3_1	615	622	PF00069	0.592
MOD_GSK3_1	665	672	PF00069	0.720
MOD_GSK3_1	771	778	PF00069	0.603
MOD_GSK3_1	784	791	PF00069	0.439
MOD_GSK3_1	810	817	PF00069	0.653
MOD_GSK3_1	92	99	PF00069	0.813
MOD_N-GLC_1	195	200	PF02516	0.732
MOD_N-GLC_1	289	294	PF02516	0.667
MOD_N-GLC_1	624	629	PF02516	0.406
MOD_N-GLC_2	52	54	PF02516	0.745
MOD_NEK2_1	133	138	PF00069	0.848
MOD_NEK2_1	289	294	PF00069	0.625
MOD_NEK2_1	305	310	PF00069	0.527
MOD_NEK2_1	334	339	PF00069	0.859
MOD_NEK2_1	399	404	PF00069	0.623
MOD_NEK2_1	468	473	PF00069	0.667
MOD_NEK2_1	641	646	PF00069	0.552
MOD_NEK2_1	786	791	PF00069	0.578
MOD_NEK2_1	829	834	PF00069	0.607
MOD_NEK2_2	110	115	PF00069	0.787
MOD_PIKK_1	253	259	PF00454	0.531
MOD_PIKK_1	435	441	PF00454	0.517
MOD_PIKK_1	784	790	PF00454	0.578
MOD_PIKK_1	98	104	PF00454	0.778
MOD_PKA_1	11	17	PF00069	0.780
MOD_PKA_2	10	16	PF00069	0.780
MOD_PKA_2	110	116	PF00069	0.821
MOD_PKA_2	127	133	PF00069	0.808
MOD_PKA_2	182	188	PF00069	0.750
MOD_PKA_2	241	247	PF00069	0.520
MOD_PKA_2	260	266	PF00069	0.639
MOD_PKA_2	315	321	PF00069	0.780
MOD_PKA_2	425	431	PF00069	0.643
MOD_PKA_2	468	474	PF00069	0.600
MOD_PKA_2	829	835	PF00069	0.563
MOD_PKA_2	864	870	PF00069	0.628
MOD_Plk_1	289	295	PF00069	0.592
MOD_Plk_1	305	311	PF00069	0.546
MOD_Plk_1	378	384	PF00069	0.523
MOD_Plk_1	537	543	PF00069	0.595
MOD_Plk_1	589	595	PF00069	0.623
MOD_Plk_1	624	630	PF00069	0.509
MOD_Plk_1	746	752	PF00069	0.511
MOD_Plk_4	153	159	PF00069	0.811
MOD_Plk_4	165	171	PF00069	0.813
MOD_Plk_4	190	196	PF00069	0.778
MOD_Plk_4	305	311	PF00069	0.553
MOD_Plk_4	391	397	PF00069	0.558
MOD_Plk_4	509	515	PF00069	0.618
MOD_Plk_4	537	543	PF00069	0.633
MOD_Plk_4	589	595	PF00069	0.631
MOD_Plk_4	67	73	PF00069	0.849
MOD_Plk_4	781	787	PF00069	0.627
MOD_Plk_4	829	835	PF00069	0.677
MOD_Plk_4	87	93	PF00069	0.575
MOD_ProDKin_1	134	140	PF00069	0.857
MOD_ProDKin_1	144	150	PF00069	0.700
MOD_ProDKin_1	163	169	PF00069	0.610
MOD_ProDKin_1	195	201	PF00069	0.844
MOD_ProDKin_1	244	250	PF00069	0.628
MOD_ProDKin_1	277	283	PF00069	0.562
MOD_ProDKin_1	318	324	PF00069	0.726
MOD_ProDKin_1	326	332	PF00069	0.761
MOD_ProDKin_1	437	443	PF00069	0.632
MOD_ProDKin_1	456	462	PF00069	0.556
MOD_ProDKin_1	477	483	PF00069	0.644
MOD_ProDKin_1	493	499	PF00069	0.472
MOD_ProDKin_1	548	554	PF00069	0.611
MOD_ProDKin_1	616	622	PF00069	0.635
MOD_ProDKin_1	665	671	PF00069	0.642
MOD_ProDKin_1	810	816	PF00069	0.597
MOD_SUMO_rev_2	443	451	PF00179	0.570
TRG_DiLeu_BaEn_1	567	572	PF01217	0.638
TRG_DiLeu_BaLyEn_6	666	671	PF01217	0.778
TRG_ENDOCYTIC_2	225	228	PF00928	0.772
TRG_ENDOCYTIC_2	331	334	PF00928	0.851
TRG_ENDOCYTIC_2	524	527	PF00928	0.601
TRG_ENDOCYTIC_2	542	545	PF00928	0.455
TRG_ENDOCYTIC_2	725	728	PF00928	0.551
TRG_ER_diArg_1	118	120	PF00400	0.765
TRG_ER_diArg_1	604	607	PF00400	0.638
TRG_ER_diArg_1	635	638	PF00400	0.638
TRG_NES_CRM1_1	294	306	PF08389	0.537
TRG_NES_CRM1_1	567	580	PF08389	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y7	Leptomonas seymouri	66%	100%
A0A0S4JNB2	Bodo saltans	34%	100%
A0A1X0PAM4	Trypanosomatidae	39%	100%
A0A3R7MTY6	Trypanosoma rangeli	39%	100%
A4HAV7	Leishmania braziliensis	79%	100%
A4IA17	Leishmania infantum	100%	100%
C9ZJA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZMK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D2XV59	Rattus norvegicus	26%	100%
E9B532	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O00178	Homo sapiens	26%	100%
O08582	Mus musculus	26%	100%
Q18905	Caenorhabditis elegans	24%	100%
Q3UJK4	Mus musculus	26%	100%
Q4Q2V4	Leishmania major	92%	100%
Q58DC5	Bos taurus	26%	100%
Q5R8Q7	Pongo abelii	26%	100%
Q5XGS8	Xenopus laevis	26%	100%
Q9BX10	Homo sapiens	26%	100%