Histone-like transcription factor (CBF/NF-Y) and archaeal histone/Core histone H2A/H2B/H3/H4, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X811_LEIDO

TriTrypDb:

LdBPK_342140.1 , LdCL_340029100 , LDHU3_34.3570

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X811

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X811

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0046982	protein heterodimerization activity	4	8
GO:0046983	protein dimerization activity	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.720
CLV_C14_Caspase3-7	158	162	PF00656	0.676
CLV_MEL_PAP_1	252	258	PF00089	0.436
CLV_NRD_NRD_1	175	177	PF00675	0.517
CLV_NRD_NRD_1	237	239	PF00675	0.257
CLV_NRD_NRD_1	299	301	PF00675	0.570
CLV_PCSK_KEX2_1	174	176	PF00082	0.530
CLV_PCSK_KEX2_1	235	237	PF00082	0.260
CLV_PCSK_KEX2_1	299	301	PF00082	0.662
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.251
CLV_PCSK_PC7_1	170	176	PF00082	0.531
CLV_PCSK_SKI1_1	194	198	PF00082	0.257
CLV_PCSK_SKI1_1	239	243	PF00082	0.257
CLV_PCSK_SKI1_1	317	321	PF00082	0.672
CLV_PCSK_SKI1_1	359	363	PF00082	0.574
CLV_PCSK_SKI1_1	36	40	PF00082	0.617
DEG_APCC_DBOX_1	316	324	PF00400	0.580
DEG_SCF_TRCP1_1	83	88	PF00400	0.621
DEG_SPOP_SBC_1	267	271	PF00917	0.552
DEG_SPOP_SBC_1	292	296	PF00917	0.566
DEG_SPOP_SBC_1	41	45	PF00917	0.609
DEG_SPOP_SBC_1	46	50	PF00917	0.645
DOC_CYCLIN_RxL_1	190	200	PF00134	0.294
DOC_MAPK_gen_1	332	340	PF00069	0.582
DOC_USP7_MATH_1	110	114	PF00917	0.696
DOC_USP7_MATH_1	267	271	PF00917	0.541
DOC_USP7_MATH_1	276	280	PF00917	0.568
DOC_USP7_MATH_1	292	296	PF00917	0.553
DOC_USP7_MATH_1	345	349	PF00917	0.615
DOC_USP7_MATH_1	46	50	PF00917	0.699
DOC_USP7_MATH_1	81	85	PF00917	0.623
DOC_USP7_UBL2_3	194	198	PF12436	0.500
DOC_USP7_UBL2_3	235	239	PF12436	0.418
DOC_WW_Pin1_4	113	118	PF00397	0.657
DOC_WW_Pin1_4	323	328	PF00397	0.698
DOC_WW_Pin1_4	42	47	PF00397	0.627
LIG_14-3-3_CanoR_1	104	111	PF00244	0.652
LIG_14-3-3_CanoR_1	175	185	PF00244	0.473
LIG_14-3-3_CanoR_1	236	242	PF00244	0.460
LIG_14-3-3_CanoR_1	255	259	PF00244	0.318
LIG_14-3-3_CanoR_1	307	315	PF00244	0.708
LIG_14-3-3_CanoR_1	332	341	PF00244	0.727
LIG_14-3-3_CanoR_1	359	364	PF00244	0.582
LIG_14-3-3_CanoR_1	36	41	PF00244	0.616
LIG_AP2alpha_2	130	132	PF02296	0.573
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_2	164	168	PF00653	0.614
LIG_FHA_1	220	226	PF00498	0.504
LIG_FHA_1	333	339	PF00498	0.607
LIG_FHA_1	42	48	PF00498	0.533
LIG_FHA_2	132	138	PF00498	0.611
LIG_FHA_2	240	246	PF00498	0.457
LIG_LIR_Apic_2	31	35	PF02991	0.616
LIG_LIR_Gen_1	240	250	PF02991	0.460
LIG_LIR_Gen_1	254	264	PF02991	0.373
LIG_LIR_Nem_3	240	246	PF02991	0.460
LIG_LIR_Nem_3	254	259	PF02991	0.361
LIG_PDZ_Class_2	360	365	PF00595	0.538
LIG_SH2_GRB2like	184	187	PF00017	0.512
LIG_SH2_NCK_1	243	247	PF00017	0.457
LIG_SH2_SRC	184	187	PF00017	0.512
LIG_SH2_SRC	243	246	PF00017	0.457
LIG_SH2_SRC	40	43	PF00017	0.613
LIG_SH2_STAP1	243	247	PF00017	0.457
LIG_SH2_STAT5	184	187	PF00017	0.512
LIG_SH2_STAT5	32	35	PF00017	0.609
LIG_SH3_3	259	265	PF00018	0.483
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.460
LIG_TRAF2_1	117	120	PF00917	0.602
LIG_TRAF2_1	61	64	PF00917	0.654
LIG_TYR_ITIM	241	246	PF00017	0.457
MOD_CK1_1	113	119	PF00069	0.703
MOD_CK1_1	204	210	PF00069	0.462
MOD_CK1_1	212	218	PF00069	0.465
MOD_CK1_1	285	291	PF00069	0.761
MOD_CK1_1	295	301	PF00069	0.634
MOD_CK1_1	305	311	PF00069	0.645
MOD_CK1_1	330	336	PF00069	0.696
MOD_CK1_1	45	51	PF00069	0.643
MOD_CK2_1	113	119	PF00069	0.682
MOD_GlcNHglycan	1	4	PF01048	0.629
MOD_GlcNHglycan	113	116	PF01048	0.704
MOD_GlcNHglycan	126	129	PF01048	0.613
MOD_GlcNHglycan	170	173	PF01048	0.765
MOD_GlcNHglycan	178	181	PF01048	0.576
MOD_GlcNHglycan	211	214	PF01048	0.304
MOD_GlcNHglycan	284	287	PF01048	0.712
MOD_GlcNHglycan	295	298	PF01048	0.723
MOD_GlcNHglycan	309	312	PF01048	0.643
MOD_GlcNHglycan	329	332	PF01048	0.490
MOD_GlcNHglycan	347	350	PF01048	0.549
MOD_GlcNHglycan	76	79	PF01048	0.672
MOD_GlcNHglycan	83	86	PF01048	0.581
MOD_GlcNHglycan	87	90	PF01048	0.728
MOD_GSK3_1	12	19	PF00069	0.648
MOD_GSK3_1	166	173	PF00069	0.707
MOD_GSK3_1	200	207	PF00069	0.500
MOD_GSK3_1	281	288	PF00069	0.672
MOD_GSK3_1	291	298	PF00069	0.610
MOD_GSK3_1	323	330	PF00069	0.649
MOD_GSK3_1	36	43	PF00069	0.626
MOD_GSK3_1	46	53	PF00069	0.617
MOD_GSK3_1	81	88	PF00069	0.625
MOD_LATS_1	237	243	PF00433	0.504
MOD_NEK2_1	103	108	PF00069	0.742
MOD_NEK2_1	111	116	PF00069	0.673
MOD_NEK2_1	188	193	PF00069	0.473
MOD_NEK2_1	47	52	PF00069	0.700
MOD_NEK2_1	74	79	PF00069	0.548
MOD_PIKK_1	50	56	PF00454	0.728
MOD_PIKK_1	76	82	PF00454	0.698
MOD_PKA_2	103	109	PF00069	0.655
MOD_PKA_2	237	243	PF00069	0.479
MOD_PKA_2	254	260	PF00069	0.343
MOD_PKB_1	174	182	PF00069	0.487
MOD_Plk_1	94	100	PF00069	0.627
MOD_Plk_2-3	94	100	PF00069	0.545
MOD_Plk_4	201	207	PF00069	0.524
MOD_Plk_4	276	282	PF00069	0.522
MOD_Plk_4	28	34	PF00069	0.653
MOD_ProDKin_1	113	119	PF00069	0.656
MOD_ProDKin_1	323	329	PF00069	0.698
MOD_ProDKin_1	42	48	PF00069	0.631
MOD_SUMO_for_1	197	200	PF00179	0.500
TRG_DiLeu_BaEn_1	216	221	PF01217	0.457
TRG_DiLeu_BaEn_4	63	69	PF01217	0.555
TRG_ENDOCYTIC_2	243	246	PF00928	0.471
TRG_ER_diArg_1	174	176	PF00400	0.774
TRG_ER_diArg_1	306	309	PF00400	0.600
TRG_NES_CRM1_1	209	224	PF08389	0.553
TRG_NLS_MonoExtC_3	234	239	PF00514	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A7	Leptomonas seymouri	44%	100%
A0A422P0E4	Trypanosoma rangeli	30%	100%
A4HAU8	Leishmania braziliensis	70%	100%
A4IA16	Leishmania infantum	100%	100%
E9B523	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2W3	Leishmania major	91%	100%