Adaptor complexes medium subunit family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AP-3 complex subunit mu, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X806_LEIDO

TriTrypDb:

LdBPK_342420.1 , LdCL_340031800 , LDHU3_34.3990

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	12
GO:0030131	clathrin adaptor complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X806

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X806

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006897	endocytosis	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.376
CLV_PCSK_SKI1_1	146	150	PF00082	0.529
CLV_PCSK_SKI1_1	335	339	PF00082	0.415
CLV_PCSK_SKI1_1	452	456	PF00082	0.323
CLV_PCSK_SKI1_1	90	94	PF00082	0.439
DEG_Kelch_Keap1_1	390	395	PF01344	0.240
DEG_Nend_Nbox_1	1	3	PF02207	0.362
DEG_SCF_FBW7_1	293	298	PF00400	0.323
DEG_SPOP_SBC_1	340	344	PF00917	0.367
DOC_CKS1_1	149	154	PF01111	0.654
DOC_CKS1_1	292	297	PF01111	0.323
DOC_CKS1_1	374	379	PF01111	0.240
DOC_CYCLIN_yCln2_LP_2	337	340	PF00134	0.427
DOC_MAPK_gen_1	325	334	PF00069	0.427
DOC_MAPK_HePTP_8	223	235	PF00069	0.283
DOC_MAPK_MEF2A_6	226	235	PF00069	0.283
DOC_MAPK_MEF2A_6	327	336	PF00069	0.337
DOC_PP1_RVXF_1	260	267	PF00149	0.307
DOC_PP2B_LxvP_1	336	339	PF13499	0.308
DOC_PP4_FxxP_1	266	269	PF00568	0.323
DOC_PP4_FxxP_1	426	429	PF00568	0.307
DOC_USP7_MATH_1	159	163	PF00917	0.667
DOC_USP7_MATH_1	340	344	PF00917	0.427
DOC_USP7_MATH_1	375	379	PF00917	0.380
DOC_USP7_MATH_1	387	391	PF00917	0.332
DOC_USP7_MATH_1	401	405	PF00917	0.333
DOC_USP7_MATH_1	422	426	PF00917	0.376
DOC_USP7_UBL2_3	277	281	PF12436	0.454
DOC_WW_Pin1_4	148	153	PF00397	0.651
DOC_WW_Pin1_4	291	296	PF00397	0.331
DOC_WW_Pin1_4	373	378	PF00397	0.394
LIG_14-3-3_CanoR_1	144	149	PF00244	0.590
LIG_14-3-3_CanoR_1	171	177	PF00244	0.649
LIG_14-3-3_CanoR_1	188	196	PF00244	0.297
LIG_14-3-3_CanoR_1	23	33	PF00244	0.410
LIG_14-3-3_CanoR_1	331	335	PF00244	0.454
LIG_14-3-3_CanoR_1	359	365	PF00244	0.364
LIG_14-3-3_CanoR_1	408	416	PF00244	0.429
LIG_14-3-3_CanoR_1	431	437	PF00244	0.427
LIG_14-3-3_CanoR_1	90	96	PF00244	0.477
LIG_Actin_WH2_2	223	240	PF00022	0.423
LIG_BRCT_BRCA1_1	173	177	PF00533	0.645
LIG_BRCT_BRCA1_1	2	6	PF00533	0.338
LIG_Clathr_ClatBox_1	79	83	PF01394	0.398
LIG_FHA_1	149	155	PF00498	0.657
LIG_FHA_1	189	195	PF00498	0.427
LIG_FHA_1	292	298	PF00498	0.311
LIG_FHA_1	340	346	PF00498	0.323
LIG_FHA_1	363	369	PF00498	0.323
LIG_FHA_1	374	380	PF00498	0.304
LIG_FHA_1	75	81	PF00498	0.459
LIG_FHA_1	91	97	PF00498	0.494
LIG_FHA_2	101	107	PF00498	0.406
LIG_FHA_2	145	151	PF00498	0.599
LIG_FHA_2	353	359	PF00498	0.422
LIG_GBD_Chelix_1	198	206	PF00786	0.427
LIG_GBD_Chelix_1	88	96	PF00786	0.416
LIG_LIR_Apic_2	120	124	PF02991	0.514
LIG_LIR_Apic_2	263	269	PF02991	0.342
LIG_LIR_Apic_2	34	39	PF02991	0.435
LIG_LIR_Apic_2	372	377	PF02991	0.240
LIG_LIR_Apic_2	425	429	PF02991	0.306
LIG_LIR_Gen_1	106	115	PF02991	0.372
LIG_LIR_Gen_1	126	137	PF02991	0.207
LIG_LIR_Gen_1	193	204	PF02991	0.283
LIG_LIR_Gen_1	270	278	PF02991	0.307
LIG_LIR_Gen_1	56	66	PF02991	0.371
LIG_LIR_LC3C_4	76	81	PF02991	0.531
LIG_LIR_Nem_3	106	111	PF02991	0.382
LIG_LIR_Nem_3	126	132	PF02991	0.196
LIG_LIR_Nem_3	174	180	PF02991	0.632
LIG_LIR_Nem_3	193	199	PF02991	0.142
LIG_LIR_Nem_3	30	36	PF02991	0.404
LIG_LIR_Nem_3	56	61	PF02991	0.357
LIG_LRP6_Inhibitor_1	99	105	PF00058	0.488
LIG_MLH1_MIPbox_1	173	177	PF16413	0.520
LIG_PCNA_yPIPBox_3	188	199	PF02747	0.427
LIG_Rb_pABgroove_1	113	121	PF01858	0.490
LIG_SH2_CRK	112	116	PF00017	0.452
LIG_SH2_CRK	121	125	PF00017	0.479
LIG_SH2_CRK	36	40	PF00017	0.440
LIG_SH2_CRK	374	378	PF00017	0.240
LIG_SH2_CRK	451	455	PF00017	0.319
LIG_SH2_NCK_1	374	378	PF00017	0.240
LIG_SH2_PTP2	292	295	PF00017	0.307
LIG_SH2_STAT3	456	459	PF00017	0.376
LIG_SH2_STAT5	204	207	PF00017	0.404
LIG_SH2_STAT5	278	281	PF00017	0.343
LIG_SH2_STAT5	292	295	PF00017	0.241
LIG_SH2_STAT5	456	459	PF00017	0.308
LIG_SH2_STAT5	463	466	PF00017	0.304
LIG_SH2_STAT5	95	98	PF00017	0.392
LIG_SH3_3	133	139	PF00018	0.415
LIG_SH3_3	284	290	PF00018	0.367
LIG_SUMO_SIM_anti_2	74	83	PF11976	0.434
LIG_SUMO_SIM_par_1	74	83	PF11976	0.420
LIG_TRAF2_1	131	134	PF00917	0.510
LIG_TRFH_1	383	387	PF08558	0.376
LIG_WW_1	289	292	PF00397	0.427
MOD_CK1_1	162	168	PF00069	0.486
MOD_CK1_1	343	349	PF00069	0.395
MOD_CK1_1	351	357	PF00069	0.325
MOD_CK1_1	360	366	PF00069	0.211
MOD_CK1_1	390	396	PF00069	0.326
MOD_CK1_1	74	80	PF00069	0.548
MOD_CK1_1	97	103	PF00069	0.424
MOD_CK2_1	100	106	PF00069	0.407
MOD_CK2_1	187	193	PF00069	0.276
MOD_CK2_1	24	30	PF00069	0.389
MOD_CK2_1	318	324	PF00069	0.427
MOD_CK2_1	389	395	PF00069	0.405
MOD_GlcNHglycan	227	230	PF01048	0.335
MOD_GlcNHglycan	351	354	PF01048	0.427
MOD_GlcNHglycan	391	395	PF01048	0.304
MOD_GlcNHglycan	405	408	PF01048	0.219
MOD_GlcNHglycan	459	462	PF01048	0.354
MOD_GSK3_1	144	151	PF00069	0.601
MOD_GSK3_1	167	174	PF00069	0.626
MOD_GSK3_1	184	191	PF00069	0.173
MOD_GSK3_1	276	283	PF00069	0.392
MOD_GSK3_1	291	298	PF00069	0.221
MOD_GSK3_1	339	346	PF00069	0.349
MOD_GSK3_1	348	355	PF00069	0.268
MOD_GSK3_1	360	367	PF00069	0.317
MOD_GSK3_1	369	376	PF00069	0.283
MOD_GSK3_1	403	410	PF00069	0.376
MOD_GSK3_1	455	462	PF00069	0.465
MOD_GSK3_1	90	97	PF00069	0.525
MOD_N-GLC_1	106	111	PF02516	0.386
MOD_N-GLC_1	299	304	PF02516	0.392
MOD_N-GLC_1	340	345	PF02516	0.409
MOD_N-GLC_1	348	353	PF02516	0.320
MOD_N-GLC_1	369	374	PF02516	0.420
MOD_N-GLC_1	417	422	PF02516	0.409
MOD_NEK2_1	276	281	PF00069	0.427
MOD_NEK2_1	299	304	PF00069	0.342
MOD_NEK2_1	32	37	PF00069	0.396
MOD_NEK2_1	345	350	PF00069	0.374
MOD_NEK2_1	357	362	PF00069	0.255
MOD_NEK2_1	364	369	PF00069	0.162
MOD_NEK2_1	457	462	PF00069	0.415
MOD_NEK2_1	68	73	PF00069	0.441
MOD_NEK2_2	53	58	PF00069	0.531
MOD_PIKK_1	280	286	PF00454	0.240
MOD_PIKK_1	455	461	PF00454	0.376
MOD_PK_1	437	443	PF00069	0.299
MOD_PKA_2	137	143	PF00069	0.581
MOD_PKA_2	162	168	PF00069	0.542
MOD_PKA_2	187	193	PF00069	0.412
MOD_PKA_2	225	231	PF00069	0.313
MOD_PKA_2	25	31	PF00069	0.432
MOD_PKA_2	330	336	PF00069	0.454
MOD_PKA_2	407	413	PF00069	0.454
MOD_Plk_1	100	106	PF00069	0.396
MOD_Plk_1	260	266	PF00069	0.358
MOD_Plk_1	340	346	PF00069	0.454
MOD_Plk_1	369	375	PF00069	0.354
MOD_Plk_1	417	423	PF00069	0.351
MOD_Plk_1	74	80	PF00069	0.521
MOD_Plk_4	107	113	PF00069	0.440
MOD_Plk_4	172	178	PF00069	0.569
MOD_Plk_4	32	38	PF00069	0.403
MOD_Plk_4	352	358	PF00069	0.434
MOD_Plk_4	459	465	PF00069	0.337
MOD_Plk_4	53	59	PF00069	0.461
MOD_Plk_4	91	97	PF00069	0.413
MOD_ProDKin_1	148	154	PF00069	0.652
MOD_ProDKin_1	291	297	PF00069	0.331
MOD_ProDKin_1	373	379	PF00069	0.394
TRG_DiLeu_BaEn_1	83	88	PF01217	0.379
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.376
TRG_ENDOCYTIC_2	112	115	PF00928	0.428
TRG_ENDOCYTIC_2	451	454	PF00928	0.319
TRG_ER_diArg_1	235	238	PF00400	0.453
TRG_NES_CRM1_1	427	439	PF08389	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F2	Leptomonas seymouri	74%	99%
A0A0N1I7F0	Leptomonas seymouri	27%	100%
A0A0N1ILY9	Leptomonas seymouri	23%	100%
A0A0N1PAY6	Leptomonas seymouri	23%	100%
A0A0S4INT9	Bodo saltans	24%	100%
A0A0S4JHW9	Bodo saltans	22%	100%
A0A0S4JX54	Bodo saltans	47%	97%
A0A1X0NL86	Trypanosomatidae	24%	100%
A0A1X0P9U6	Trypanosomatidae	50%	100%
A0A3Q8IB94	Leishmania donovani	25%	100%
A0A3Q8IKF7	Leishmania donovani	25%	100%
A0A3R7KIH0	Trypanosoma rangeli	50%	100%
A0A422NHS3	Trypanosoma rangeli	30%	100%
A0A422NLU9	Trypanosoma rangeli	24%	96%
A4HAX6	Leishmania braziliensis	87%	100%
A4HCF3	Leishmania braziliensis	24%	89%
A4HPG9	Leishmania braziliensis	24%	100%
A4HZY5	Leishmania infantum	24%	86%
A4IA35	Leishmania infantum	100%	100%
A4ID91	Leishmania infantum	25%	100%
C9ZM64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZSM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D3ZRP6	Rattus norvegicus	25%	100%
E2RED8	Canis lupus familiaris	26%	100%
E9AT81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVU6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	89%
E9B550	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
F4I562	Arabidopsis thaliana	30%	100%
O00189	Homo sapiens	26%	100%
O22715	Arabidopsis thaliana	27%	100%
O23140	Arabidopsis thaliana	25%	100%
O94669	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
P35585	Mus musculus	26%	100%
P35602	Caenorhabditis elegans	24%	100%
P35603	Caenorhabditis elegans	25%	100%
P47795	Diplobatis ommata	31%	100%
P53676	Rattus norvegicus	30%	100%
P53677	Homo sapiens	28%	100%
P53678	Rattus norvegicus	29%	100%
P54672	Dictyostelium discoideum	27%	100%
P84091	Mus musculus	25%	100%
P84092	Rattus norvegicus	25%	100%
Q00776	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q09718	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q24K11	Bos taurus	29%	100%
Q29RY8	Bos taurus	26%	100%
Q2KJ81	Bos taurus	26%	100%
Q2PWT8	Rattus norvegicus	26%	100%
Q32Q06	Rattus norvegicus	26%	100%
Q3SYW1	Bos taurus	26%	100%
Q3ZC13	Bos taurus	25%	100%
Q4Q1B6	Leishmania major	25%	100%
Q4Q2T6	Leishmania major	96%	100%
Q4QBN3	Leishmania major	25%	100%
Q4R706	Macaca fascicularis	25%	100%
Q54HS9	Dictyostelium discoideum	25%	100%
Q5NVF7	Pongo abelii	25%	100%
Q5R478	Pongo abelii	29%	100%
Q5ZMP6	Gallus gallus	25%	100%
Q5ZMP7	Gallus gallus	29%	100%
Q6NWK2	Danio rerio	25%	100%
Q6P856	Xenopus tropicalis	26%	100%
Q750L8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7ZW98	Danio rerio	25%	100%
Q801Q8	Xenopus laevis	25%	100%
Q8R2R9	Mus musculus	29%	100%
Q96CW1	Homo sapiens	25%	100%
Q99186	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	95%
Q9BXS5	Homo sapiens	26%	100%
Q9GPF0	Dictyostelium discoideum	21%	88%
Q9GPF1	Dictyostelium discoideum	30%	100%
Q9HFE5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9JKC7	Mus musculus	26%	100%
Q9JKC8	Mus musculus	29%	100%
Q9SAC9	Arabidopsis thaliana	26%	100%
Q9SB50	Arabidopsis thaliana	26%	100%
Q9WVP1	Mus musculus	26%	100%
Q9Y2T2	Homo sapiens	29%	100%
Q9Y6Q5	Homo sapiens	26%	100%
V5BKQ8	Trypanosoma cruzi	50%	100%
V5BLL2	Trypanosoma cruzi	29%	100%
V5D569	Trypanosoma cruzi	26%	94%
V5DGM7	Trypanosoma cruzi	25%	100%