Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X803_LEIDO

TriTrypDb:

LdBPK_341890.1 , LdCL_340026600 , LDHU3_34.3220

Length:

156

Annotations

LeishMANIAdb annotations

A protein family with Prokaryotic affinities. Might be a subunit for some uncharacterized complex

Annotations by Jardim et al.

Transporters, Possible sugar permease Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3S7X803

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X803

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.497
CLV_PCSK_FUR_1	136	140	PF00082	0.516
CLV_PCSK_KEX2_1	138	140	PF00082	0.521
CLV_PCSK_SKI1_1	81	85	PF00082	0.275
DEG_Nend_Nbox_1	1	3	PF02207	0.648
DOC_CKS1_1	107	112	PF01111	0.347
DOC_MAPK_MEF2A_6	43	52	PF00069	0.421
DOC_MAPK_MEF2A_6	62	71	PF00069	0.412
DOC_MAPK_MEF2A_6	7	16	PF00069	0.498
DOC_PP2B_LxvP_1	26	29	PF13499	0.405
DOC_PP4_FxxP_1	107	110	PF00568	0.343
DOC_USP7_MATH_1	146	150	PF00917	0.684
DOC_USP7_MATH_1	27	31	PF00917	0.370
DOC_USP7_UBL2_3	47	51	PF12436	0.381
DOC_WW_Pin1_4	106	111	PF00397	0.424
DOC_WW_Pin1_4	50	55	PF00397	0.430
LIG_14-3-3_CanoR_1	81	87	PF00244	0.537
LIG_eIF4E_1	8	14	PF01652	0.413
LIG_FHA_1	61	67	PF00498	0.335
LIG_FHA_1	88	94	PF00498	0.307
LIG_FHA_2	107	113	PF00498	0.414
LIG_LIR_Apic_2	104	110	PF02991	0.394
LIG_LIR_Gen_1	55	64	PF02991	0.286
LIG_LIR_Gen_1	70	79	PF02991	0.291
LIG_LIR_Gen_1	82	92	PF02991	0.385
LIG_LIR_Nem_3	55	60	PF02991	0.341
LIG_LIR_Nem_3	70	74	PF02991	0.266
LIG_LIR_Nem_3	82	87	PF02991	0.363
LIG_NRBOX	72	78	PF00104	0.344
LIG_SH2_PTP2	100	103	PF00017	0.381
LIG_SH2_PTP2	57	60	PF00017	0.337
LIG_SH2_PTP2	8	11	PF00017	0.399
LIG_SH2_SRC	57	60	PF00017	0.325
LIG_SH2_STAT5	100	103	PF00017	0.437
LIG_SH2_STAT5	57	60	PF00017	0.287
LIG_SH2_STAT5	8	11	PF00017	0.330
LIG_TRAF2_1	109	112	PF00917	0.410
LIG_TYR_ITIM	6	11	PF00017	0.487
LIG_UBA3_1	44	51	PF00899	0.299
LIG_WRC_WIRS_1	83	88	PF05994	0.384
MOD_CK1_1	82	88	PF00069	0.400
MOD_CK2_1	106	112	PF00069	0.417
MOD_CK2_1	18	24	PF00069	0.300
MOD_CK2_1	50	56	PF00069	0.397
MOD_GlcNHglycan	132	135	PF01048	0.474
MOD_GlcNHglycan	20	23	PF01048	0.355
MOD_GSK3_1	130	137	PF00069	0.475
MOD_N-GLC_1	119	124	PF02516	0.376
MOD_NEK2_1	128	133	PF00069	0.477
MOD_NEK2_1	18	23	PF00069	0.352
MOD_NEK2_1	36	41	PF00069	0.320
MOD_NEK2_1	67	72	PF00069	0.373
MOD_NEK2_1	87	92	PF00069	0.385
MOD_Plk_1	119	125	PF00069	0.385
MOD_Plk_4	119	125	PF00069	0.421
MOD_ProDKin_1	106	112	PF00069	0.425
MOD_ProDKin_1	50	56	PF00069	0.429
TRG_ENDOCYTIC_2	100	103	PF00928	0.381
TRG_ENDOCYTIC_2	57	60	PF00928	0.269
TRG_ENDOCYTIC_2	8	11	PF00928	0.328
TRG_ER_diArg_1	136	139	PF00400	0.714
TRG_ER_diLys_1	153	156	PF00400	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P4	Leptomonas seymouri	65%	100%
A0A0S4JBG1	Bodo saltans	45%	93%
A0A1X0P9I8	Trypanosomatidae	49%	100%
A0A422NY54	Trypanosoma rangeli	45%	99%
A4HAS5	Leishmania braziliensis	73%	100%
A4IAM6	Leishmania infantum	100%	100%
C9ZMP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9B4Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2Y7	Leishmania major	89%	100%
V5BQ15	Trypanosoma cruzi	51%	99%