Dynamin_family/50S_ribosome-binding_GTPase_putati ve/Pfam:PF00350/Pfam:PF01926

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynamin family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X801_LEIDO

TriTrypDb:

LdBPK_342040.1 , LdCL_340028100 , LDHU3_34.3450

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7X801

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X801

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0005525	GTP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0019001	guanyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032561	guanyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.362
CLV_C14_Caspase3-7	364	368	PF00656	0.377
CLV_C14_Caspase3-7	411	415	PF00656	0.425
CLV_NRD_NRD_1	165	167	PF00675	0.356
CLV_NRD_NRD_1	292	294	PF00675	0.285
CLV_NRD_NRD_1	299	301	PF00675	0.283
CLV_NRD_NRD_1	419	421	PF00675	0.525
CLV_PCSK_KEX2_1	165	167	PF00082	0.334
CLV_PCSK_KEX2_1	292	294	PF00082	0.304
CLV_PCSK_KEX2_1	299	301	PF00082	0.286
CLV_PCSK_KEX2_1	379	381	PF00082	0.306
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.303
CLV_PCSK_SKI1_1	199	203	PF00082	0.335
CLV_PCSK_SKI1_1	204	208	PF00082	0.328
CLV_PCSK_SKI1_1	292	296	PF00082	0.307
CLV_PCSK_SKI1_1	360	364	PF00082	0.290
CLV_PCSK_SKI1_1	384	388	PF00082	0.307
CLV_PCSK_SKI1_1	434	438	PF00082	0.741
CLV_Separin_Metazoa	227	231	PF03568	0.341
CLV_Separin_Metazoa	247	251	PF03568	0.342
DEG_APCC_DBOX_1	314	322	PF00400	0.321
DEG_APCC_DBOX_1	359	367	PF00400	0.347
DEG_SPOP_SBC_1	468	472	PF00917	0.533
DOC_CKS1_1	150	155	PF01111	0.285
DOC_CYCLIN_RxL_1	199	211	PF00134	0.282
DOC_MAPK_gen_1	165	172	PF00069	0.361
DOC_MAPK_gen_1	299	307	PF00069	0.302
DOC_MAPK_gen_1	376	385	PF00069	0.271
DOC_MAPK_gen_1	410	418	PF00069	0.520
DOC_MAPK_gen_1	55	63	PF00069	0.398
DOC_MAPK_MEF2A_6	387	394	PF00069	0.389
DOC_MAPK_MEF2A_6	55	63	PF00069	0.447
DOC_PP1_RVXF_1	143	150	PF00149	0.432
DOC_PP4_FxxP_1	63	66	PF00568	0.207
DOC_USP7_MATH_1	286	290	PF00917	0.356
DOC_USP7_MATH_1	464	468	PF00917	0.544
DOC_USP7_MATH_1	66	70	PF00917	0.219
DOC_USP7_UBL2_3	324	328	PF12436	0.286
DOC_USP7_UBL2_3	417	421	PF12436	0.574
DOC_WW_Pin1_4	149	154	PF00397	0.291
DOC_WW_Pin1_4	447	452	PF00397	0.710
DOC_WW_Pin1_4	453	458	PF00397	0.727
DOC_WW_Pin1_4	494	499	PF00397	0.617
DOC_WW_Pin1_4	501	506	PF00397	0.661
LIG_14-3-3_CanoR_1	121	130	PF00244	0.380
LIG_14-3-3_CanoR_1	145	150	PF00244	0.397
LIG_14-3-3_CanoR_1	250	260	PF00244	0.331
LIG_14-3-3_CanoR_1	292	298	PF00244	0.294
LIG_14-3-3_CanoR_1	299	307	PF00244	0.292
LIG_14-3-3_CanoR_1	345	354	PF00244	0.338
LIG_14-3-3_CanoR_1	426	432	PF00244	0.619
LIG_14-3-3_CanoR_1	434	439	PF00244	0.655
LIG_Actin_WH2_2	130	147	PF00022	0.356
LIG_AP2alpha_1	126	130	PF02296	0.385
LIG_APCC_ABBA_1	97	102	PF00400	0.230
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.260
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BIR_III_2	193	197	PF00653	0.461
LIG_BRCT_BRCA1_1	367	371	PF00533	0.344
LIG_CaM_NSCaTE_8	14	21	PF13499	0.337
LIG_CaM_NSCaTE_8	382	389	PF13499	0.210
LIG_FHA_1	150	156	PF00498	0.292
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_1	282	288	PF00498	0.332
LIG_FHA_1	387	393	PF00498	0.341
LIG_FHA_1	478	484	PF00498	0.607
LIG_FHA_2	188	194	PF00498	0.328
LIG_FHA_2	353	359	PF00498	0.215
LIG_FHA_2	362	368	PF00498	0.224
LIG_LIR_Apic_2	254	260	PF02991	0.345
LIG_LIR_Apic_2	62	66	PF02991	0.207
LIG_LIR_Gen_1	102	112	PF02991	0.339
LIG_LIR_Gen_1	128	138	PF02991	0.332
LIG_LIR_Gen_1	164	172	PF02991	0.340
LIG_LIR_Gen_1	276	287	PF02991	0.404
LIG_LIR_Gen_1	333	343	PF02991	0.248
LIG_LIR_Gen_1	39	50	PF02991	0.422
LIG_LIR_Gen_1	92	100	PF02991	0.260
LIG_LIR_Nem_3	102	107	PF02991	0.258
LIG_LIR_Nem_3	128	133	PF02991	0.332
LIG_LIR_Nem_3	164	170	PF02991	0.348
LIG_LIR_Nem_3	181	187	PF02991	0.238
LIG_LIR_Nem_3	234	239	PF02991	0.379
LIG_LIR_Nem_3	276	282	PF02991	0.390
LIG_LIR_Nem_3	329	335	PF02991	0.279
LIG_LIR_Nem_3	368	374	PF02991	0.370
LIG_LIR_Nem_3	39	45	PF02991	0.434
LIG_LIR_Nem_3	72	77	PF02991	0.250
LIG_LIR_Nem_3	92	98	PF02991	0.114
LIG_NRBOX	74	80	PF00104	0.158
LIG_Pex14_1	257	261	PF04695	0.364
LIG_Pex14_2	126	130	PF04695	0.333
LIG_Pex14_2	45	49	PF04695	0.295
LIG_Pex14_2	63	67	PF04695	0.260
LIG_Rb_pABgroove_1	181	189	PF01858	0.224
LIG_SH2_CRK	120	124	PF00017	0.493
LIG_SH2_CRK	232	236	PF00017	0.326
LIG_SH2_GRB2like	236	239	PF00017	0.448
LIG_SH2_PTP2	169	172	PF00017	0.332
LIG_SH2_SRC	167	170	PF00017	0.361
LIG_SH2_STAP1	279	283	PF00017	0.452
LIG_SH2_STAP1	29	33	PF00017	0.410
LIG_SH2_STAP1	335	339	PF00017	0.332
LIG_SH2_STAT3	100	103	PF00017	0.210
LIG_SH2_STAT3	422	425	PF00017	0.547
LIG_SH2_STAT3	77	80	PF00017	0.288
LIG_SH2_STAT5	169	172	PF00017	0.310
LIG_SH2_STAT5	252	255	PF00017	0.310
LIG_SH2_STAT5	27	30	PF00017	0.340
LIG_SH2_STAT5	77	80	PF00017	0.268
LIG_SH2_STAT5	83	86	PF00017	0.251
LIG_SH3_3	134	140	PF00018	0.352
LIG_SH3_3	280	286	PF00018	0.447
LIG_SH3_3	389	395	PF00018	0.278
LIG_SH3_3	41	47	PF00018	0.331
LIG_SH3_3	451	457	PF00018	0.747
LIG_SUMO_SIM_par_1	388	393	PF11976	0.196
LIG_TRAF2_2	286	291	PF00917	0.331
LIG_TYR_ITIM	118	123	PF00017	0.266
LIG_TYR_ITIM	277	282	PF00017	0.467
LIG_UBA3_1	397	402	PF00899	0.442
LIG_WRC_WIRS_1	253	258	PF05994	0.326
LIG_WRC_WIRS_1	60	65	PF05994	0.207
LIG_WW_3	247	251	PF00397	0.342
MOD_CDK_SPK_2	447	452	PF00069	0.536
MOD_CK1_1	313	319	PF00069	0.377
MOD_CK1_1	349	355	PF00069	0.425
MOD_CK1_1	467	473	PF00069	0.569
MOD_CK1_1	496	502	PF00069	0.583
MOD_CK1_1	69	75	PF00069	0.338
MOD_CK2_1	28	34	PF00069	0.401
MOD_GlcNHglycan	157	161	PF01048	0.555
MOD_GlcNHglycan	427	430	PF01048	0.633
MOD_GlcNHglycan	447	450	PF01048	0.624
MOD_GlcNHglycan	68	71	PF01048	0.261
MOD_GSK3_1	145	152	PF00069	0.329
MOD_GSK3_1	23	30	PF00069	0.485
MOD_GSK3_1	341	348	PF00069	0.212
MOD_GSK3_1	361	368	PF00069	0.321
MOD_GSK3_1	464	471	PF00069	0.700
MOD_GSK3_1	493	500	PF00069	0.744
MOD_GSK3_1	65	72	PF00069	0.260
MOD_GSK3_1	89	96	PF00069	0.260
MOD_N-GLC_1	237	242	PF02516	0.335
MOD_NEK2_1	113	118	PF00069	0.405
MOD_NEK2_1	18	23	PF00069	0.318
MOD_NEK2_1	251	256	PF00069	0.398
MOD_NEK2_1	28	33	PF00069	0.237
MOD_NEK2_1	281	286	PF00069	0.408
MOD_NEK2_1	385	390	PF00069	0.337
MOD_NEK2_1	50	55	PF00069	0.244
MOD_NEK2_1	516	521	PF00069	0.495
MOD_PIKK_1	121	127	PF00454	0.368
MOD_PIKK_1	471	477	PF00454	0.592
MOD_PIKK_1	533	539	PF00454	0.617
MOD_PK_1	219	225	PF00069	0.299
MOD_PKA_1	292	298	PF00069	0.393
MOD_PKA_1	299	305	PF00069	0.393
MOD_PKA_2	292	298	PF00069	0.315
MOD_PKA_2	299	305	PF00069	0.300
MOD_PKA_2	425	431	PF00069	0.627
MOD_PKA_2	45	51	PF00069	0.278
MOD_Plk_1	18	24	PF00069	0.427
MOD_Plk_1	349	355	PF00069	0.406
MOD_Plk_1	36	42	PF00069	0.296
MOD_Plk_1	402	408	PF00069	0.579
MOD_Plk_1	516	522	PF00069	0.617
MOD_Plk_4	145	151	PF00069	0.308
MOD_Plk_4	18	24	PF00069	0.420
MOD_Plk_4	231	237	PF00069	0.373
MOD_Plk_4	252	258	PF00069	0.322
MOD_Plk_4	293	299	PF00069	0.279
MOD_Plk_4	334	340	PF00069	0.240
MOD_Plk_4	45	51	PF00069	0.279
MOD_Plk_4	477	483	PF00069	0.586
MOD_Plk_4	519	525	PF00069	0.583
MOD_Plk_4	59	65	PF00069	0.254
MOD_Plk_4	70	76	PF00069	0.269
MOD_ProDKin_1	149	155	PF00069	0.293
MOD_ProDKin_1	447	453	PF00069	0.712
MOD_ProDKin_1	494	500	PF00069	0.621
MOD_ProDKin_1	501	507	PF00069	0.660
MOD_SUMO_rev_2	209	213	PF00179	0.378
TRG_DiLeu_BaEn_1	178	183	PF01217	0.290
TRG_DiLeu_BaEn_1	273	278	PF01217	0.311
TRG_DiLeu_BaEn_3	333	339	PF01217	0.240
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.432
TRG_ENDOCYTIC_2	120	123	PF00928	0.288
TRG_ENDOCYTIC_2	167	170	PF00928	0.325
TRG_ENDOCYTIC_2	232	235	PF00928	0.330
TRG_ENDOCYTIC_2	236	239	PF00928	0.331
TRG_ENDOCYTIC_2	279	282	PF00928	0.470
TRG_ENDOCYTIC_2	335	338	PF00928	0.310
TRG_ENDOCYTIC_2	42	45	PF00928	0.230
TRG_ER_diArg_1	165	167	PF00400	0.309
TRG_ER_diArg_1	292	294	PF00400	0.314
TRG_ER_diArg_1	298	300	PF00400	0.302
TRG_ER_diArg_1	314	317	PF00400	0.284
TRG_NES_CRM1_1	514	530	PF08389	0.640
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.256

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	47%	91%
A0A0N0P9A4	Leptomonas seymouri	75%	98%
A0A0S4KGM0	Bodo saltans	48%	89%
A0A1X0P6D7	Trypanosomatidae	50%	99%
A0A1X0P9Q8	Trypanosomatidae	62%	97%
A0A3R7LDF3	Trypanosoma rangeli	48%	100%
A0A3S7WV81	Leishmania donovani	46%	86%
A0A422P0G8	Trypanosoma rangeli	60%	99%
A4H9Y5	Leishmania braziliensis	46%	86%
A4HAT9	Leishmania braziliensis	78%	100%
A4HY50	Leishmania infantum	46%	86%
A4IA07	Leishmania infantum	100%	100%
B3LF48	Arabidopsis thaliana	35%	99%
C9ZMM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	86%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2X3	Leishmania major	94%	100%
Q4QDJ3	Leishmania major	45%	85%
Q4V8H8	Rattus norvegicus	34%	100%
Q5E9R3	Bos taurus	34%	100%
Q5RBP4	Pongo abelii	34%	100%
Q641Z6	Rattus norvegicus	34%	100%
Q94CF0	Arabidopsis thaliana	36%	99%
Q9H223	Homo sapiens	34%	100%
Q9H4M9	Homo sapiens	34%	100%
Q9NZN4	Homo sapiens	33%	100%
Q9WVK4	Mus musculus	34%	100%
V5BSA9	Trypanosoma cruzi	46%	100%
V5DGT0	Trypanosoma cruzi	61%	99%
V5DMH3	Trypanosoma cruzi	26%	100%