Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7Z9_LEIDO

TriTrypDb:

LdBPK_342260.1 , LdCL_340030300 , LDHU3_34.3770

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X7Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	328	334	PF00089	0.499
CLV_NRD_NRD_1	168	170	PF00675	0.720
CLV_NRD_NRD_1	207	209	PF00675	0.436
CLV_NRD_NRD_1	281	283	PF00675	0.440
CLV_NRD_NRD_1	360	362	PF00675	0.515
CLV_NRD_NRD_1	374	376	PF00675	0.425
CLV_NRD_NRD_1	65	67	PF00675	0.722
CLV_PCSK_KEX2_1	168	170	PF00082	0.725
CLV_PCSK_KEX2_1	206	208	PF00082	0.444
CLV_PCSK_KEX2_1	281	283	PF00082	0.440
CLV_PCSK_KEX2_1	360	362	PF00082	0.515
CLV_PCSK_KEX2_1	373	375	PF00082	0.433
CLV_PCSK_KEX2_1	65	67	PF00082	0.722
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.444
CLV_PCSK_SKI1_1	172	176	PF00082	0.435
CLV_PCSK_SKI1_1	27	31	PF00082	0.790
DEG_Nend_Nbox_1	1	3	PF02207	0.661
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.484
DOC_MAPK_gen_1	168	175	PF00069	0.522
DOC_MAPK_JIP1_4	169	175	PF00069	0.276
DOC_MAPK_MEF2A_6	168	175	PF00069	0.421
DOC_PP1_RVXF_1	259	266	PF00149	0.364
DOC_PP1_SILK_1	257	262	PF00149	0.307
DOC_PP2B_LxvP_1	109	112	PF13499	0.485
DOC_USP7_MATH_1	105	109	PF00917	0.526
DOC_USP7_MATH_1	115	119	PF00917	0.518
DOC_USP7_MATH_1	128	132	PF00917	0.431
DOC_USP7_MATH_1	160	164	PF00917	0.472
DOC_USP7_MATH_1	288	292	PF00917	0.657
DOC_USP7_MATH_1	306	310	PF00917	0.597
DOC_USP7_MATH_1	37	41	PF00917	0.610
DOC_USP7_MATH_1	6	10	PF00917	0.552
DOC_USP7_MATH_1	83	87	PF00917	0.559
DOC_WW_Pin1_4	110	115	PF00397	0.513
DOC_WW_Pin1_4	119	124	PF00397	0.508
DOC_WW_Pin1_4	133	138	PF00397	0.436
DOC_WW_Pin1_4	147	152	PF00397	0.446
DOC_WW_Pin1_4	162	167	PF00397	0.394
DOC_WW_Pin1_4	47	52	PF00397	0.569
DOC_WW_Pin1_4	56	61	PF00397	0.478
DOC_WW_Pin1_4	85	90	PF00397	0.549
DOC_WW_Pin1_4	98	103	PF00397	0.437
LIG_14-3-3_CanoR_1	104	110	PF00244	0.534
LIG_14-3-3_CanoR_1	214	224	PF00244	0.525
LIG_14-3-3_CanoR_1	236	242	PF00244	0.510
LIG_14-3-3_CanoR_1	300	307	PF00244	0.702
LIG_14-3-3_CanoR_1	308	317	PF00244	0.663
LIG_14-3-3_CanoR_1	331	341	PF00244	0.705
LIG_14-3-3_CanoR_1	360	370	PF00244	0.718
LIG_14-3-3_CanoR_1	45	50	PF00244	0.550
LIG_CSL_BTD_1	33	36	PF09270	0.499
LIG_EH1_1	224	232	PF00400	0.375
LIG_eIF4E_1	225	231	PF01652	0.375
LIG_FHA_1	134	140	PF00498	0.460
LIG_FHA_1	193	199	PF00498	0.412
LIG_FHA_1	218	224	PF00498	0.399
LIG_FHA_1	238	244	PF00498	0.437
LIG_FHA_1	48	54	PF00498	0.590
LIG_GBD_Chelix_1	243	251	PF00786	0.555
LIG_LIR_Apic_2	117	123	PF02991	0.452
LIG_LIR_Nem_3	292	298	PF02991	0.608
LIG_Pex14_2	187	191	PF04695	0.375
LIG_PTB_Apo_2	92	99	PF02174	0.545
LIG_SH2_CRK	295	299	PF00017	0.617
LIG_SH2_SRC	225	228	PF00017	0.375
LIG_SH2_STAT3	121	124	PF00017	0.499
LIG_SH2_STAT5	225	228	PF00017	0.382
LIG_SH3_1	120	126	PF00018	0.445
LIG_SH3_3	109	115	PF00018	0.484
LIG_SH3_3	120	126	PF00018	0.502
LIG_SH3_3	272	278	PF00018	0.613
LIG_SH3_3	314	320	PF00018	0.694
LIG_SH3_3	86	92	PF00018	0.507
LIG_SUMO_SIM_anti_2	238	245	PF11976	0.397
LIG_SUMO_SIM_par_1	229	235	PF11976	0.375
LIG_TRFH_1	98	102	PF08558	0.544
LIG_TYR_ITIM	223	228	PF00017	0.375
LIG_WRC_WIRS_1	139	144	PF05994	0.492
MOD_CDC14_SPxK_1	101	104	PF00782	0.544
MOD_CDC14_SPxK_1	165	168	PF00782	0.460
MOD_CDK_SPxK_1	162	168	PF00069	0.469
MOD_CDK_SPxK_1	98	104	PF00069	0.545
MOD_CDK_SPxxK_3	162	169	PF00069	0.465
MOD_CK1_1	131	137	PF00069	0.501
MOD_CK1_1	141	147	PF00069	0.458
MOD_CK1_1	215	221	PF00069	0.375
MOD_CK1_1	5	11	PF00069	0.551
MOD_CK1_1	67	73	PF00069	0.544
MOD_CK2_1	345	351	PF00069	0.728
MOD_CMANNOS	262	265	PF00535	0.375
MOD_GlcNHglycan	130	133	PF01048	0.715
MOD_GlcNHglycan	158	161	PF01048	0.709
MOD_GlcNHglycan	213	217	PF01048	0.318
MOD_GlcNHglycan	27	30	PF01048	0.723
MOD_GlcNHglycan	302	305	PF01048	0.468
MOD_GlcNHglycan	310	313	PF01048	0.445
MOD_GlcNHglycan	323	326	PF01048	0.452
MOD_GlcNHglycan	363	366	PF01048	0.519
MOD_GlcNHglycan	4	7	PF01048	0.820
MOD_GlcNHglycan	45	48	PF01048	0.640
MOD_GlcNHglycan	85	88	PF01048	0.817
MOD_GSK3_1	110	117	PF00069	0.500
MOD_GSK3_1	131	138	PF00069	0.496
MOD_GSK3_1	141	148	PF00069	0.454
MOD_GSK3_1	156	163	PF00069	0.473
MOD_GSK3_1	2	9	PF00069	0.552
MOD_GSK3_1	332	339	PF00069	0.690
MOD_GSK3_1	341	348	PF00069	0.671
MOD_GSK3_1	43	50	PF00069	0.597
MOD_GSK3_1	52	59	PF00069	0.478
MOD_LATS_1	43	49	PF00433	0.532
MOD_N-GLC_1	53	58	PF02516	0.670
MOD_N-GLC_1	67	72	PF02516	0.689
MOD_NEK2_1	142	147	PF00069	0.583
MOD_NEK2_1	187	192	PF00069	0.375
MOD_NEK2_1	2	7	PF00069	0.629
MOD_NEK2_1	200	205	PF00069	0.575
MOD_NEK2_1	237	242	PF00069	0.395
MOD_NEK2_1	25	30	PF00069	0.543
MOD_NEK2_1	298	303	PF00069	0.696
MOD_NEK2_1	307	312	PF00069	0.659
MOD_NEK2_1	332	337	PF00069	0.702
MOD_NEK2_1	341	346	PF00069	0.664
MOD_NEK2_1	53	58	PF00069	0.507
MOD_NEK2_1	64	69	PF00069	0.451
MOD_NEK2_2	115	120	PF00069	0.519
MOD_NEK2_2	368	373	PF00069	0.716
MOD_PIKK_1	160	166	PF00454	0.412
MOD_PIKK_1	192	198	PF00454	0.498
MOD_PIKK_1	332	338	PF00454	0.703
MOD_PIKK_1	341	347	PF00454	0.665
MOD_PIKK_1	6	12	PF00454	0.550
MOD_PKA_2	103	109	PF00069	0.536
MOD_PKA_2	2	8	PF00069	0.629
MOD_PKA_2	235	241	PF00069	0.423
MOD_PKA_2	307	313	PF00069	0.716
MOD_PKA_2	330	336	PF00069	0.699
MOD_PKA_2	64	70	PF00069	0.523
MOD_Plk_1	37	43	PF00069	0.513
MOD_Plk_4	115	121	PF00069	0.453
MOD_Plk_4	138	144	PF00069	0.558
MOD_Plk_4	255	261	PF00069	0.307
MOD_ProDKin_1	110	116	PF00069	0.513
MOD_ProDKin_1	119	125	PF00069	0.505
MOD_ProDKin_1	133	139	PF00069	0.434
MOD_ProDKin_1	147	153	PF00069	0.445
MOD_ProDKin_1	162	168	PF00069	0.391
MOD_ProDKin_1	47	53	PF00069	0.567
MOD_ProDKin_1	56	62	PF00069	0.477
MOD_ProDKin_1	85	91	PF00069	0.547
MOD_ProDKin_1	98	104	PF00069	0.438
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.635
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.533
TRG_ENDOCYTIC_2	224	227	PF00928	0.375
TRG_ENDOCYTIC_2	295	298	PF00928	0.614
TRG_ER_diArg_1	168	170	PF00400	0.443
TRG_ER_diArg_1	207	209	PF00400	0.636
TRG_ER_diArg_1	280	282	PF00400	0.639
TRG_ER_diArg_1	360	362	PF00400	0.715
TRG_ER_diArg_1	372	375	PF00400	0.638
TRG_ER_diArg_1	64	66	PF00400	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4IA20	Leishmania infantum	99%	100%
E9B535	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2V1	Leishmania major	88%	100%