Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7Y8_LEIDO

TriTrypDb:

LdBPK_342210.1 , LdCL_340029800 , LDHU3_34.3670

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Y8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.556
CLV_NRD_NRD_1	179	181	PF00675	0.593
CLV_NRD_NRD_1	31	33	PF00675	0.597
CLV_PCSK_KEX2_1	181	183	PF00082	0.666
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.596
CLV_PCSK_SKI1_1	181	185	PF00082	0.497
CLV_PCSK_SKI1_1	33	37	PF00082	0.563
DOC_ANK_TNKS_1	144	151	PF00023	0.581
DOC_CKS1_1	15	20	PF01111	0.582
DOC_MAPK_MEF2A_6	80	89	PF00069	0.519
DOC_PP4_FxxP_1	100	103	PF00568	0.625
DOC_PP4_FxxP_1	146	149	PF00568	0.545
DOC_PP4_FxxP_1	15	18	PF00568	0.578
DOC_PP4_FxxP_1	91	94	PF00568	0.608
DOC_SPAK_OSR1_1	145	149	PF12202	0.585
DOC_USP7_MATH_1	115	119	PF00917	0.602
DOC_USP7_MATH_1	18	22	PF00917	0.536
DOC_WW_Pin1_4	14	19	PF00397	0.583
DOC_WW_Pin1_4	72	77	PF00397	0.527
LIG_14-3-3_CanoR_1	128	136	PF00244	0.572
LIG_14-3-3_CanoR_1	32	40	PF00244	0.613
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_eIF4E_1	59	65	PF01652	0.530
LIG_FHA_1	97	103	PF00498	0.560
LIG_FHA_2	15	21	PF00498	0.509
LIG_FHA_2	164	170	PF00498	0.586
LIG_LIR_Apic_2	90	94	PF02991	0.523
LIG_LIR_Apic_2	97	103	PF02991	0.528
LIG_LIR_Gen_1	20	29	PF02991	0.640
LIG_LIR_Nem_3	20	25	PF02991	0.499
LIG_SH2_CRK	79	83	PF00017	0.520
LIG_SH2_STAT5	22	25	PF00017	0.617
LIG_SH2_STAT5	59	62	PF00017	0.539
LIG_UBA3_1	151	159	PF00899	0.508
MOD_CK1_1	111	117	PF00069	0.614
MOD_CK1_1	118	124	PF00069	0.592
MOD_CK1_1	27	33	PF00069	0.666
MOD_CK2_1	120	126	PF00069	0.670
MOD_CK2_1	14	20	PF00069	0.533
MOD_GlcNHglycan	27	30	PF01048	0.591
MOD_GSK3_1	111	118	PF00069	0.556
MOD_GSK3_1	122	129	PF00069	0.614
MOD_GSK3_1	14	21	PF00069	0.521
MOD_LATS_1	120	126	PF00433	0.582
MOD_N-GLC_1	72	77	PF02516	0.638
MOD_NEK2_1	108	113	PF00069	0.583
MOD_NEK2_1	25	30	PF00069	0.615
MOD_NEK2_1	35	40	PF00069	0.499
MOD_NEK2_1	83	88	PF00069	0.576
MOD_NEK2_1	95	100	PF00069	0.552
MOD_NEK2_2	115	120	PF00069	0.440
MOD_PKA_2	121	127	PF00069	0.583
MOD_PKA_2	57	63	PF00069	0.509
MOD_Plk_1	96	102	PF00069	0.623
MOD_Plk_4	18	24	PF00069	0.558
MOD_Plk_4	35	41	PF00069	0.506
MOD_ProDKin_1	14	20	PF00069	0.584
MOD_ProDKin_1	72	78	PF00069	0.523
TRG_ENDOCYTIC_2	22	25	PF00928	0.528
TRG_ENDOCYTIC_2	81	84	PF00928	0.645
TRG_ER_diArg_1	179	182	PF00400	0.656
TRG_NLS_MonoExtC_3	179	184	PF00514	0.597
TRG_NLS_MonoExtN_4	178	185	PF00514	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I235	Leptomonas seymouri	71%	99%
A0A0S4INZ5	Bodo saltans	40%	93%
A0A1X0P9P7	Trypanosomatidae	57%	100%
A0A3R7KWP6	Trypanosoma rangeli	53%	100%
A4HAV5	Leishmania braziliensis	85%	100%
A4IA02	Leishmania infantum	98%	100%
C9ZMK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B530	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2V6	Leishmania major	94%	100%