DNA-(apurinic or apyrimidinic site) lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

8-oxoguanine DNA glycosylase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7Y5_LEIDO

TriTrypDb:

LdBPK_341930.1 , LdCL_340027000 , LDHU3_34.3280

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Y5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006281	DNA repair	5	11
GO:0006284	base-excision repair	6	10
GO:0006289	nucleotide-excision repair	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0033554	cellular response to stress	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006285	base-excision repair, AP site formation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000702	oxidized base lesion DNA N-glycosylase activity	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003684	damaged DNA binding	5	11
GO:0003824	catalytic activity	1	11
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0005488	binding	1	11
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	11
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0019104	DNA N-glycosylase activity	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	4	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.530
CLV_C14_Caspase3-7	297	301	PF00656	0.559
CLV_NRD_NRD_1	114	116	PF00675	0.364
CLV_NRD_NRD_1	180	182	PF00675	0.339
CLV_NRD_NRD_1	274	276	PF00675	0.393
CLV_NRD_NRD_1	298	300	PF00675	0.394
CLV_NRD_NRD_1	421	423	PF00675	0.317
CLV_NRD_NRD_1	463	465	PF00675	0.609
CLV_NRD_NRD_1	488	490	PF00675	0.509
CLV_NRD_NRD_1	523	525	PF00675	0.692
CLV_NRD_NRD_1	563	565	PF00675	0.450
CLV_NRD_NRD_1	85	87	PF00675	0.362
CLV_PCSK_FUR_1	82	86	PF00082	0.302
CLV_PCSK_KEX2_1	114	116	PF00082	0.386
CLV_PCSK_KEX2_1	298	300	PF00082	0.360
CLV_PCSK_KEX2_1	465	467	PF00082	0.614
CLV_PCSK_KEX2_1	84	86	PF00082	0.335
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.614
CLV_PCSK_SKI1_1	13	17	PF00082	0.563
CLV_PCSK_SKI1_1	196	200	PF00082	0.330
CLV_PCSK_SKI1_1	371	375	PF00082	0.352
CLV_PCSK_SKI1_1	411	415	PF00082	0.386
DEG_APCC_DBOX_1	410	418	PF00400	0.482
DEG_SPOP_SBC_1	133	137	PF00917	0.447
DEG_SPOP_SBC_1	14	18	PF00917	0.549
DOC_CKS1_1	38	43	PF01111	0.558
DOC_CYCLIN_RxL_1	156	166	PF00134	0.553
DOC_CYCLIN_RxL_1	337	348	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.530
DOC_MAPK_gen_1	20	29	PF00069	0.583
DOC_MAPK_gen_1	422	430	PF00069	0.509
DOC_MAPK_gen_1	489	497	PF00069	0.470
DOC_MAPK_MEF2A_6	159	167	PF00069	0.499
DOC_MAPK_MEF2A_6	20	27	PF00069	0.586
DOC_PP1_RVXF_1	338	345	PF00149	0.482
DOC_PP2B_LxvP_1	217	220	PF13499	0.530
DOC_PP2B_LxvP_1	415	418	PF13499	0.496
DOC_PP2B_LxvP_1	453	456	PF13499	0.529
DOC_USP7_MATH_1	133	137	PF00917	0.573
DOC_USP7_MATH_1	21	25	PF00917	0.525
DOC_USP7_MATH_1	274	278	PF00917	0.550
DOC_USP7_MATH_1	303	307	PF00917	0.562
DOC_USP7_MATH_1	454	458	PF00917	0.653
DOC_USP7_MATH_1	8	12	PF00917	0.587
DOC_USP7_UBL2_3	370	374	PF12436	0.525
DOC_WW_Pin1_4	129	134	PF00397	0.570
DOC_WW_Pin1_4	174	179	PF00397	0.585
DOC_WW_Pin1_4	301	306	PF00397	0.558
DOC_WW_Pin1_4	37	42	PF00397	0.496
DOC_WW_Pin1_4	376	381	PF00397	0.579
DOC_WW_Pin1_4	477	482	PF00397	0.578
DOC_WW_Pin1_4	499	504	PF00397	0.612
DOC_WW_Pin1_4	523	528	PF00397	0.619
LIG_14-3-3_CanoR_1	159	164	PF00244	0.555
LIG_14-3-3_CanoR_1	513	520	PF00244	0.657
LIG_14-3-3_CanoR_1	86	92	PF00244	0.517
LIG_14-3-3_CanoR_1	9	13	PF00244	0.573
LIG_Actin_WH2_1	42	59	PF00022	0.586
LIG_Actin_WH2_2	187	202	PF00022	0.433
LIG_BRCT_BRCA1_1	229	233	PF00533	0.562
LIG_BRCT_BRCA1_1	555	559	PF00533	0.361
LIG_deltaCOP1_diTrp_1	168	174	PF00928	0.562
LIG_deltaCOP1_diTrp_1	318	325	PF00928	0.557
LIG_deltaCOP1_diTrp_1	541	547	PF00928	0.509
LIG_FHA_1	129	135	PF00498	0.530
LIG_FHA_1	14	20	PF00498	0.526
LIG_FHA_1	245	251	PF00498	0.513
LIG_FHA_1	266	272	PF00498	0.482
LIG_FHA_1	434	440	PF00498	0.539
LIG_FHA_2	254	260	PF00498	0.542
LIG_FHA_2	295	301	PF00498	0.587
LIG_LIR_Apic_2	321	326	PF02991	0.562
LIG_LIR_Gen_1	158	167	PF02991	0.562
LIG_LIR_Gen_1	316	326	PF02991	0.496
LIG_LIR_Nem_3	11	15	PF02991	0.520
LIG_LIR_Nem_3	112	116	PF02991	0.537
LIG_LIR_Nem_3	158	163	PF02991	0.562
LIG_LIR_Nem_3	230	236	PF02991	0.547
LIG_LIR_Nem_3	316	322	PF02991	0.483
LIG_LIR_Nem_3	324	328	PF02991	0.506
LIG_LIR_Nem_3	541	547	PF02991	0.487
LIG_MYND_2	380	384	PF01753	0.530
LIG_Pex14_1	319	323	PF04695	0.562
LIG_Pex14_2	543	547	PF04695	0.389
LIG_PTB_Apo_2	338	345	PF02174	0.405
LIG_PTB_Apo_2	390	397	PF02174	0.586
LIG_PTB_Phospho_1	390	396	PF10480	0.586
LIG_SH2_CRK	323	327	PF00017	0.586
LIG_SH2_CRK	38	42	PF00017	0.502
LIG_SH2_CRK	396	400	PF00017	0.586
LIG_SH2_PTP2	218	221	PF00017	0.562
LIG_SH2_SRC	218	221	PF00017	0.553
LIG_SH2_STAP1	396	400	PF00017	0.485
LIG_SH2_STAT3	405	408	PF00017	0.502
LIG_SH2_STAT5	160	163	PF00017	0.482
LIG_SH2_STAT5	188	191	PF00017	0.513
LIG_SH2_STAT5	218	221	PF00017	0.562
LIG_SH2_STAT5	350	353	PF00017	0.475
LIG_SH2_STAT5	452	455	PF00017	0.429
LIG_SH3_1	524	530	PF00018	0.591
LIG_SH3_1	72	78	PF00018	0.433
LIG_SH3_2	77	82	PF14604	0.433
LIG_SH3_3	268	274	PF00018	0.553
LIG_SH3_3	524	530	PF00018	0.551
LIG_SH3_3	72	78	PF00018	0.582
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.586
LIG_TRAF2_1	152	155	PF00917	0.560
LIG_TRAF2_1	474	477	PF00917	0.708
LIG_TRAF2_1	508	511	PF00917	0.577
LIG_TYR_ITIM	111	116	PF00017	0.562
LIG_TYR_ITIM	558	563	PF00017	0.482
LIG_WRC_WIRS_1	232	237	PF05994	0.447
LIG_WW_1	529	532	PF00397	0.566
MOD_CDK_SPK_2	37	42	PF00069	0.496
MOD_CDK_SPxxK_3	174	181	PF00069	0.586
MOD_CDK_SPxxK_3	301	308	PF00069	0.558
MOD_CK1_1	132	138	PF00069	0.553
MOD_CK1_1	177	183	PF00069	0.586
MOD_CK1_1	306	312	PF00069	0.538
MOD_CK1_1	313	319	PF00069	0.540
MOD_CK1_1	321	327	PF00069	0.542
MOD_CK1_1	502	508	PF00069	0.696
MOD_CK1_1	515	521	PF00069	0.652
MOD_CK1_1	523	529	PF00069	0.566
MOD_CK2_1	149	155	PF00069	0.541
MOD_CK2_1	471	477	PF00069	0.591
MOD_CK2_1	91	97	PF00069	0.588
MOD_CMANNOS	171	174	PF00535	0.282
MOD_Cter_Amidation	420	423	PF01082	0.282
MOD_Cter_Amidation	462	465	PF01082	0.733
MOD_GlcNHglycan	125	128	PF01048	0.347
MOD_GlcNHglycan	144	147	PF01048	0.291
MOD_GlcNHglycan	200	203	PF01048	0.330
MOD_GlcNHglycan	276	279	PF01048	0.386
MOD_GlcNHglycan	315	318	PF01048	0.240
MOD_GlcNHglycan	396	399	PF01048	0.330
MOD_GlcNHglycan	456	459	PF01048	0.619
MOD_GlcNHglycan	514	517	PF01048	0.706
MOD_GlcNHglycan	61	64	PF01048	0.233
MOD_GlcNHglycan	89	92	PF01048	0.385
MOD_GSK3_1	128	135	PF00069	0.571
MOD_GSK3_1	138	145	PF00069	0.547
MOD_GSK3_1	155	162	PF00069	0.508
MOD_GSK3_1	21	28	PF00069	0.540
MOD_GSK3_1	227	234	PF00069	0.556
MOD_GSK3_1	274	281	PF00069	0.528
MOD_GSK3_1	285	292	PF00069	0.516
MOD_GSK3_1	306	313	PF00069	0.539
MOD_GSK3_1	353	360	PF00069	0.502
MOD_GSK3_1	37	44	PF00069	0.426
MOD_GSK3_1	394	401	PF00069	0.476
MOD_GSK3_1	511	518	PF00069	0.541
MOD_GSK3_1	87	94	PF00069	0.519
MOD_N-GLC_1	241	246	PF02516	0.362
MOD_N-GLC_1	433	438	PF02516	0.386
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	134	139	PF00069	0.522
MOD_NEK2_1	15	20	PF00069	0.523
MOD_NEK2_1	198	203	PF00069	0.499
MOD_NEK2_1	235	240	PF00069	0.465
MOD_NEK2_1	25	30	PF00069	0.534
MOD_NEK2_1	253	258	PF00069	0.482
MOD_NEK2_1	357	362	PF00069	0.586
MOD_NEK2_1	433	438	PF00069	0.542
MOD_NEK2_1	520	525	PF00069	0.600
MOD_NEK2_1	70	75	PF00069	0.565
MOD_PIKK_1	235	241	PF00454	0.482
MOD_PIKK_1	285	291	PF00454	0.458
MOD_PIKK_1	357	363	PF00454	0.586
MOD_PKA_1	464	470	PF00069	0.638
MOD_PKA_2	123	129	PF00069	0.497
MOD_PKA_2	138	144	PF00069	0.526
MOD_PKA_2	244	250	PF00069	0.490
MOD_PKA_2	274	280	PF00069	0.537
MOD_PKA_2	41	47	PF00069	0.496
MOD_PKA_2	512	518	PF00069	0.651
MOD_PKA_2	520	526	PF00069	0.703
MOD_PKA_2	8	14	PF00069	0.523
MOD_Plk_1	241	247	PF00069	0.562
MOD_Plk_1	335	341	PF00069	0.532
MOD_Plk_1	433	439	PF00069	0.586
MOD_Plk_4	318	324	PF00069	0.562
MOD_Plk_4	353	359	PF00069	0.486
MOD_Plk_4	41	47	PF00069	0.482
MOD_Plk_4	515	521	PF00069	0.508
MOD_Plk_4	553	559	PF00069	0.353
MOD_ProDKin_1	129	135	PF00069	0.570
MOD_ProDKin_1	174	180	PF00069	0.585
MOD_ProDKin_1	301	307	PF00069	0.558
MOD_ProDKin_1	37	43	PF00069	0.496
MOD_ProDKin_1	376	382	PF00069	0.579
MOD_ProDKin_1	477	483	PF00069	0.573
MOD_ProDKin_1	499	505	PF00069	0.612
MOD_ProDKin_1	523	529	PF00069	0.608
TRG_DiLeu_BaEn_2	352	358	PF01217	0.530
TRG_ENDOCYTIC_2	113	116	PF00928	0.570
TRG_ENDOCYTIC_2	160	163	PF00928	0.482
TRG_ENDOCYTIC_2	218	221	PF00928	0.557
TRG_ENDOCYTIC_2	396	399	PF00928	0.482
TRG_ENDOCYTIC_2	560	563	PF00928	0.407
TRG_ER_diArg_1	113	115	PF00400	0.586
TRG_ER_diArg_1	466	469	PF00400	0.665
TRG_ER_diArg_1	561	564	PF00400	0.475
TRG_ER_diArg_1	82	85	PF00400	0.503
TRG_NES_CRM1_1	155	168	PF08389	0.586
TRG_NLS_MonoExtC_3	463	468	PF00514	0.653
TRG_NLS_MonoExtN_4	464	469	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I223	Leptomonas seymouri	46%	96%
A0A1X0P9L2	Trypanosomatidae	31%	100%
A0A3R7MS38	Trypanosoma rangeli	35%	100%
A4HAS9	Leishmania braziliensis	69%	100%
A4I9Y9	Leishmania infantum	99%	100%
C9ZMN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B503	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2Y3	Leishmania major	87%	100%
V5BKI1	Trypanosoma cruzi	34%	100%