Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7Y3_LEIDO

TriTrypDb:

LdBPK_341810.1 , LdCL_340025700 , LDHU3_34.3110

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.659
CLV_C14_Caspase3-7	141	145	PF00656	0.567
CLV_C14_Caspase3-7	274	278	PF00656	0.636
CLV_NRD_NRD_1	174	176	PF00675	0.466
CLV_NRD_NRD_1	197	199	PF00675	0.715
CLV_NRD_NRD_1	21	23	PF00675	0.470
CLV_NRD_NRD_1	210	212	PF00675	0.522
CLV_PCSK_KEX2_1	197	199	PF00082	0.643
CLV_PCSK_KEX2_1	21	23	PF00082	0.470
CLV_PCSK_KEX2_1	210	212	PF00082	0.612
CLV_PCSK_PC7_1	17	23	PF00082	0.515
CLV_PCSK_SKI1_1	297	301	PF00082	0.519
DEG_COP1_1	101	109	PF00400	0.587
DEG_SPOP_SBC_1	92	96	PF00917	0.552
DOC_CDC14_PxL_1	76	84	PF14671	0.382
DOC_CKS1_1	133	138	PF01111	0.530
DOC_CKS1_1	52	57	PF01111	0.534
DOC_MAPK_gen_1	19	28	PF00069	0.493
DOC_MAPK_gen_1	63	72	PF00069	0.507
DOC_MAPK_HePTP_8	62	74	PF00069	0.365
DOC_MAPK_MEF2A_6	65	74	PF00069	0.376
DOC_PP2B_LxvP_1	104	107	PF13499	0.653
DOC_PP2B_LxvP_1	300	303	PF13499	0.562
DOC_PP4_FxxP_1	52	55	PF00568	0.526
DOC_USP7_MATH_1	13	17	PF00917	0.636
DOC_USP7_MATH_1	55	59	PF00917	0.559
DOC_WW_Pin1_4	132	137	PF00397	0.510
DOC_WW_Pin1_4	217	222	PF00397	0.542
DOC_WW_Pin1_4	236	241	PF00397	0.570
DOC_WW_Pin1_4	248	253	PF00397	0.588
DOC_WW_Pin1_4	51	56	PF00397	0.531
LIG_14-3-3_CanoR_1	21	28	PF00244	0.362
LIG_14-3-3_CanoR_1	69	75	PF00244	0.444
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_4	204	208	PF00653	0.483
LIG_FHA_1	124	130	PF00498	0.565
LIG_FHA_1	21	27	PF00498	0.570
LIG_FHA_1	271	277	PF00498	0.530
LIG_FHA_1	29	35	PF00498	0.492
LIG_FHA_1	40	46	PF00498	0.371
LIG_FHA_1	65	71	PF00498	0.489
LIG_FHA_1	99	105	PF00498	0.803
LIG_FHA_2	106	112	PF00498	0.637
LIG_FHA_2	30	36	PF00498	0.498
LIG_FHA_2	42	48	PF00498	0.353
LIG_FHA_2	52	58	PF00498	0.448
LIG_FHA_2	79	85	PF00498	0.456
LIG_LIR_Apic_2	199	203	PF02991	0.576
LIG_LIR_Apic_2	235	240	PF02991	0.465
LIG_LIR_Apic_2	50	55	PF02991	0.532
LIG_LIR_Gen_1	124	134	PF02991	0.533
LIG_LIR_Gen_1	31	40	PF02991	0.431
LIG_LIR_Nem_3	124	130	PF02991	0.549
LIG_LIR_Nem_3	217	222	PF02991	0.496
LIG_LIR_Nem_3	31	36	PF02991	0.414
LIG_LIR_Nem_3	73	79	PF02991	0.440
LIG_MYND_3	79	83	PF01753	0.444
LIG_Pex14_2	289	293	PF04695	0.469
LIG_Pex14_2	52	56	PF04695	0.531
LIG_SH2_CRK	127	131	PF00017	0.514
LIG_SH2_CRK	237	241	PF00017	0.551
LIG_SH2_GRB2like	110	113	PF00017	0.666
LIG_SH2_NCK_1	110	114	PF00017	0.616
LIG_SH2_NCK_1	127	131	PF00017	0.514
LIG_SH2_NCK_1	200	204	PF00017	0.596
LIG_SH2_SRC	110	113	PF00017	0.616
LIG_SH2_SRC	275	278	PF00017	0.578
LIG_SH2_STAP1	127	131	PF00017	0.494
LIG_SH2_STAP1	272	276	PF00017	0.554
LIG_SH2_STAT5	27	30	PF00017	0.479
LIG_SH2_STAT5	272	275	PF00017	0.521
LIG_SH3_1	200	206	PF00018	0.563
LIG_SH3_3	133	139	PF00018	0.545
LIG_SH3_3	200	206	PF00018	0.619
LIG_SH3_3	69	75	PF00018	0.551
LIG_SUMO_SIM_par_1	189	194	PF11976	0.605
LIG_SUMO_SIM_par_1	41	47	PF11976	0.463
LIG_TRAF2_1	305	308	PF00917	0.411
LIG_TRAF2_1	44	47	PF00917	0.436
LIG_TRAF2_1	81	84	PF00917	0.399
LIG_TYR_ITIM	129	134	PF00017	0.503
LIG_TYR_ITSM	123	130	PF00017	0.530
LIG_WRC_WIRS_1	290	295	PF05994	0.469
MOD_CDC14_SPxK_1	220	223	PF00782	0.541
MOD_CDK_SPxK_1	217	223	PF00069	0.542
MOD_CK1_1	161	167	PF00069	0.566
MOD_CK1_1	20	26	PF00069	0.381
MOD_CK1_1	217	223	PF00069	0.511
MOD_CK1_1	245	251	PF00069	0.619
MOD_CK1_1	41	47	PF00069	0.516
MOD_CK2_1	29	35	PF00069	0.496
MOD_CK2_1	302	308	PF00069	0.454
MOD_CK2_1	41	47	PF00069	0.529
MOD_CK2_1	51	57	PF00069	0.514
MOD_CK2_1	78	84	PF00069	0.380
MOD_GlcNHglycan	160	163	PF01048	0.549
MOD_GlcNHglycan	247	250	PF01048	0.679
MOD_GlcNHglycan	57	60	PF01048	0.518
MOD_GSK3_1	13	20	PF00069	0.565
MOD_GSK3_1	154	161	PF00069	0.538
MOD_GSK3_1	232	239	PF00069	0.614
MOD_GSK3_1	251	258	PF00069	0.542
MOD_GSK3_1	271	278	PF00069	0.612
MOD_GSK3_1	51	58	PF00069	0.470
MOD_GSK3_1	91	98	PF00069	0.739
MOD_N-GLC_1	158	163	PF02516	0.563
MOD_NEK2_1	191	196	PF00069	0.632
MOD_NEK2_1	271	276	PF00069	0.606
MOD_NEK2_1	28	33	PF00069	0.497
MOD_NEK2_1	289	294	PF00069	0.514
MOD_NEK2_1	8	13	PF00069	0.612
MOD_NEK2_2	232	237	PF00069	0.471
MOD_PIKK_1	191	197	PF00454	0.596
MOD_PIKK_1	260	266	PF00454	0.594
MOD_PIKK_1	8	14	PF00454	0.580
MOD_PKA_2	20	26	PF00069	0.381
MOD_PKA_2	64	70	PF00069	0.431
MOD_Plk_1	102	108	PF00069	0.784
MOD_Plk_1	123	129	PF00069	0.583
MOD_Plk_4	232	238	PF00069	0.546
MOD_Plk_4	271	277	PF00069	0.617
MOD_Plk_4	29	35	PF00069	0.496
MOD_ProDKin_1	132	138	PF00069	0.524
MOD_ProDKin_1	217	223	PF00069	0.542
MOD_ProDKin_1	236	242	PF00069	0.572
MOD_ProDKin_1	248	254	PF00069	0.588
MOD_ProDKin_1	51	57	PF00069	0.534
MOD_SUMO_for_1	90	93	PF00179	0.575
MOD_SUMO_rev_2	225	235	PF00179	0.584
TRG_ENDOCYTIC_2	127	130	PF00928	0.563
TRG_ENDOCYTIC_2	131	134	PF00928	0.546
TRG_ER_diArg_1	209	211	PF00400	0.613
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I215	Leptomonas seymouri	50%	100%
A0A1X0P9H8	Trypanosomatidae	32%	100%
A0A3S5IS94	Trypanosoma rangeli	32%	100%
A4HAR8	Leishmania braziliensis	76%	100%
A4I9Y3	Leishmania infantum	100%	100%
E9B4Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q2Z5	Leishmania major	88%	100%