Protein_kinase_putative/GeneDB:LmjF.34.2090

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7Y2_LEIDO

TriTrypDb:

LdBPK_341840.1 , LdCL_340026100 , LDHU3_34.3160

Length:

385

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

A0A3S7X7Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7Y2

Function

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Biological processes
Term	Name	Level	Count
GO:0000165	MAPK cascade	4	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0001934	positive regulation of protein phosphorylation	8	1
GO:0006468	protein phosphorylation	5	25
GO:0006793	phosphorus metabolic process	3	25
GO:0006796	phosphate-containing compound metabolic process	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	25
GO:0009893	positive regulation of metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	25
GO:0003824	catalytic activity	1	25
GO:0004672	protein kinase activity	3	25
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0004708	MAP kinase kinase activity	5	1
GO:0004712	protein serine/threonine/tyrosine kinase activity	4	1
GO:0005488	binding	1	25
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	25
GO:0016301	kinase activity	4	25

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.396
CLV_NRD_NRD_1	242	244	PF00675	0.396
CLV_NRD_NRD_1	49	51	PF00675	0.599
CLV_PCSK_KEX2_1	242	244	PF00082	0.396
CLV_PCSK_KEX2_1	49	51	PF00082	0.574
CLV_PCSK_KEX2_1	59	61	PF00082	0.347
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.324
CLV_PCSK_PC7_1	238	244	PF00082	0.396
CLV_PCSK_SKI1_1	107	111	PF00082	0.283
CLV_PCSK_SKI1_1	193	197	PF00082	0.292

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	29%	69%
A0A0N0P3N5	Leptomonas seymouri	28%	90%
A0A0N0P3Q8	Leptomonas seymouri	35%	100%
A0A0N0P8X6	Leptomonas seymouri	84%	99%
A0A0N0P953	Leptomonas seymouri	28%	80%
A0A0N1HVN6	Leptomonas seymouri	30%	100%
A0A0N1HWQ2	Leptomonas seymouri	28%	100%
A0A0N1HY86	Leptomonas seymouri	28%	74%
A0A0N1I0B6	Leptomonas seymouri	33%	72%
A0A0N1IM47	Leptomonas seymouri	24%	100%

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