Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7X6_LEIDO

TriTrypDb:

LdBPK_342050.1 , LdCL_340028200 , LDHU3_34.3460

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7X6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.545
CLV_C14_Caspase3-7	206	210	PF00656	0.505
CLV_C14_Caspase3-7	283	287	PF00656	0.634
CLV_C14_Caspase3-7	60	64	PF00656	0.727
CLV_C14_Caspase3-7	690	694	PF00656	0.692
CLV_C14_Caspase3-7	73	77	PF00656	0.730
CLV_NRD_NRD_1	182	184	PF00675	0.496
CLV_NRD_NRD_1	215	217	PF00675	0.620
CLV_NRD_NRD_1	249	251	PF00675	0.667
CLV_NRD_NRD_1	258	260	PF00675	0.682
CLV_NRD_NRD_1	511	513	PF00675	0.680
CLV_NRD_NRD_1	514	516	PF00675	0.650
CLV_NRD_NRD_1	673	675	PF00675	0.687
CLV_PCSK_FUR_1	512	516	PF00082	0.686
CLV_PCSK_KEX2_1	182	184	PF00082	0.496
CLV_PCSK_KEX2_1	258	260	PF00082	0.633
CLV_PCSK_KEX2_1	301	303	PF00082	0.664
CLV_PCSK_KEX2_1	511	513	PF00082	0.680
CLV_PCSK_KEX2_1	514	516	PF00082	0.650
CLV_PCSK_KEX2_1	673	675	PF00082	0.708
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.646
CLV_PCSK_PC7_1	297	303	PF00082	0.658
CLV_PCSK_PC7_1	669	675	PF00082	0.672
CLV_PCSK_SKI1_1	168	172	PF00082	0.535
CLV_PCSK_SKI1_1	201	205	PF00082	0.547
CLV_PCSK_SKI1_1	276	280	PF00082	0.585
CLV_PCSK_SKI1_1	402	406	PF00082	0.359
CLV_PCSK_SKI1_1	502	506	PF00082	0.520
CLV_PCSK_SKI1_1	620	624	PF00082	0.422
CLV_PCSK_SKI1_1	669	673	PF00082	0.674
CLV_Separin_Metazoa	106	110	PF03568	0.501
CLV_Separin_Metazoa	491	495	PF03568	0.488
DEG_COP1_1	7	16	PF00400	0.580
DEG_SPOP_SBC_1	475	479	PF00917	0.569
DEG_SPOP_SBC_1	590	594	PF00917	0.707
DEG_SPOP_SBC_1	655	659	PF00917	0.651
DOC_CKS1_1	613	618	PF01111	0.467
DOC_CYCLIN_RxL_1	398	407	PF00134	0.401
DOC_CYCLIN_RxL_1	497	507	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	672	678	PF00134	0.593
DOC_MAPK_MEF2A_6	109	118	PF00069	0.477
DOC_MAPK_MEF2A_6	355	362	PF00069	0.409
DOC_PP1_RVXF_1	400	406	PF00149	0.444
DOC_PP4_FxxP_1	606	609	PF00568	0.638
DOC_PP4_FxxP_1	613	616	PF00568	0.488
DOC_USP7_MATH_1	291	295	PF00917	0.643
DOC_USP7_MATH_1	335	339	PF00917	0.574
DOC_USP7_MATH_1	38	42	PF00917	0.756
DOC_USP7_MATH_1	384	388	PF00917	0.576
DOC_USP7_MATH_1	549	553	PF00917	0.593
DOC_USP7_MATH_1	569	573	PF00917	0.677
DOC_USP7_MATH_1	70	74	PF00917	0.752
DOC_USP7_MATH_1	718	722	PF00917	0.724
DOC_WW_Pin1_4	232	237	PF00397	0.638
DOC_WW_Pin1_4	265	270	PF00397	0.601
DOC_WW_Pin1_4	295	300	PF00397	0.702
DOC_WW_Pin1_4	313	318	PF00397	0.390
DOC_WW_Pin1_4	41	46	PF00397	0.692
DOC_WW_Pin1_4	576	581	PF00397	0.756
DOC_WW_Pin1_4	595	600	PF00397	0.453
DOC_WW_Pin1_4	612	617	PF00397	0.466
DOC_WW_Pin1_4	66	71	PF00397	0.753
DOC_WW_Pin1_4	694	699	PF00397	0.626
DOC_WW_Pin1_4	707	712	PF00397	0.527
DOC_WW_Pin1_4	78	83	PF00397	0.573
LIG_14-3-3_CanoR_1	201	211	PF00244	0.545
LIG_14-3-3_CanoR_1	216	222	PF00244	0.468
LIG_14-3-3_CanoR_1	258	267	PF00244	0.647
LIG_14-3-3_CanoR_1	355	359	PF00244	0.409
LIG_14-3-3_CanoR_1	402	410	PF00244	0.450
LIG_14-3-3_CanoR_1	47	57	PF00244	0.667
LIG_Actin_WH2_2	93	111	PF00022	0.532
LIG_BIR_III_2	52	56	PF00653	0.668
LIG_BRCT_BRCA1_1	478	482	PF00533	0.611
LIG_BRCT_BRCA1_1	591	595	PF00533	0.697
LIG_deltaCOP1_diTrp_1	197	202	PF00928	0.363
LIG_FHA_1	155	161	PF00498	0.639
LIG_FHA_1	164	170	PF00498	0.456
LIG_FHA_1	275	281	PF00498	0.475
LIG_FHA_1	404	410	PF00498	0.472
LIG_FHA_1	499	505	PF00498	0.513
LIG_FHA_1	8	14	PF00498	0.561
LIG_FHA_2	56	62	PF00498	0.750
LIG_FHA_2	677	683	PF00498	0.717
LIG_FHA_2	79	85	PF00498	0.678
LIG_Integrin_RGD_1	582	584	PF01839	0.659
LIG_IRF3_LxIS_1	310	316	PF10401	0.536
LIG_LIR_Apic_2	612	616	PF02991	0.525
LIG_LIR_Apic_2	627	632	PF02991	0.411
LIG_LIR_Apic_2	9	14	PF02991	0.604
LIG_LIR_Gen_1	244	253	PF02991	0.661
LIG_LIR_Nem_3	197	203	PF02991	0.506
LIG_LIR_Nem_3	244	249	PF02991	0.668
LIG_LIR_Nem_3	390	395	PF02991	0.535
LIG_LIR_Nem_3	7	11	PF02991	0.557
LIG_NRBOX	143	149	PF00104	0.505
LIG_NRBOX	93	99	PF00104	0.575
LIG_PCNA_yPIPBox_3	137	148	PF02747	0.538
LIG_PCNA_yPIPBox_3	391	404	PF02747	0.526
LIG_PDZ_Class_3	745	750	PF00595	0.628
LIG_Pex14_2	118	122	PF04695	0.409
LIG_SH2_SRC	662	665	PF00017	0.533
LIG_SH2_STAP1	442	446	PF00017	0.478
LIG_SH2_STAT3	548	551	PF00017	0.697
LIG_SH2_STAT5	11	14	PF00017	0.679
LIG_SH2_STAT5	462	465	PF00017	0.492
LIG_SH2_STAT5	629	632	PF00017	0.558
LIG_SH3_1	629	635	PF00018	0.464
LIG_SH3_2	266	271	PF14604	0.630
LIG_SH3_3	263	269	PF00018	0.622
LIG_SH3_3	596	602	PF00018	0.657
LIG_SH3_3	629	635	PF00018	0.609
LIG_Sin3_3	430	437	PF02671	0.432
LIG_SUMO_SIM_anti_2	450	455	PF11976	0.403
LIG_SUMO_SIM_par_1	145	152	PF11976	0.569
LIG_SUMO_SIM_par_1	309	314	PF11976	0.464
LIG_SUMO_SIM_par_1	586	594	PF11976	0.698
LIG_SUMO_SIM_par_1	96	102	PF11976	0.548
LIG_TRAF2_1	343	346	PF00917	0.505
LIG_TRAF2_1	553	556	PF00917	0.727
MOD_CDC14_SPxK_1	235	238	PF00782	0.633
MOD_CDC14_SPxK_1	268	271	PF00782	0.627
MOD_CDC14_SPxK_1	298	301	PF00782	0.694
MOD_CDC14_SPxK_1	44	47	PF00782	0.689
MOD_CDC14_SPxK_1	579	582	PF00782	0.707
MOD_CDK_SPxK_1	232	238	PF00069	0.636
MOD_CDK_SPxK_1	265	271	PF00069	0.628
MOD_CDK_SPxK_1	295	301	PF00069	0.701
MOD_CDK_SPxK_1	41	47	PF00069	0.692
MOD_CDK_SPxK_1	576	582	PF00069	0.708
MOD_CDK_SPxxK_3	295	302	PF00069	0.698
MOD_CK1_1	163	169	PF00069	0.455
MOD_CK1_1	285	291	PF00069	0.563
MOD_CK1_1	300	306	PF00069	0.555
MOD_CK1_1	316	322	PF00069	0.386
MOD_CK1_1	338	344	PF00069	0.510
MOD_CK1_1	41	47	PF00069	0.756
MOD_CK1_1	476	482	PF00069	0.607
MOD_CK1_1	586	592	PF00069	0.721
MOD_CK1_1	598	604	PF00069	0.599
MOD_CK1_1	657	663	PF00069	0.706
MOD_CK1_1	687	693	PF00069	0.788
MOD_CK1_1	69	75	PF00069	0.797
MOD_CK1_1	697	703	PF00069	0.636
MOD_CK1_1	7	13	PF00069	0.561
MOD_CK1_1	90	96	PF00069	0.530
MOD_CK2_1	143	149	PF00069	0.570
MOD_CK2_1	339	345	PF00069	0.502
MOD_CK2_1	55	61	PF00069	0.729
MOD_CK2_1	676	682	PF00069	0.722
MOD_CK2_1	718	724	PF00069	0.731
MOD_GlcNHglycan	14	17	PF01048	0.587
MOD_GlcNHglycan	162	165	PF01048	0.520
MOD_GlcNHglycan	205	208	PF01048	0.459
MOD_GlcNHglycan	24	27	PF01048	0.538
MOD_GlcNHglycan	286	290	PF01048	0.624
MOD_GlcNHglycan	305	308	PF01048	0.672
MOD_GlcNHglycan	318	321	PF01048	0.284
MOD_GlcNHglycan	328	331	PF01048	0.532
MOD_GlcNHglycan	341	344	PF01048	0.537
MOD_GlcNHglycan	365	368	PF01048	0.441
MOD_GlcNHglycan	468	471	PF01048	0.683
MOD_GlcNHglycan	478	481	PF01048	0.482
MOD_GlcNHglycan	551	554	PF01048	0.772
MOD_GlcNHglycan	676	679	PF01048	0.671
MOD_GlcNHglycan	701	704	PF01048	0.765
MOD_GlcNHglycan	718	721	PF01048	0.699
MOD_GlcNHglycan	72	75	PF01048	0.762
MOD_GlcNHglycan	76	79	PF01048	0.708
MOD_GSK3_1	18	25	PF00069	0.670
MOD_GSK3_1	274	281	PF00069	0.536
MOD_GSK3_1	291	298	PF00069	0.655
MOD_GSK3_1	33	40	PF00069	0.526
MOD_GSK3_1	335	342	PF00069	0.563
MOD_GSK3_1	466	473	PF00069	0.625
MOD_GSK3_1	482	489	PF00069	0.401
MOD_GSK3_1	527	534	PF00069	0.535
MOD_GSK3_1	564	571	PF00069	0.739
MOD_GSK3_1	57	64	PF00069	0.741
MOD_GSK3_1	586	593	PF00069	0.686
MOD_GSK3_1	650	657	PF00069	0.772
MOD_GSK3_1	66	73	PF00069	0.807
MOD_GSK3_1	674	681	PF00069	0.675
MOD_GSK3_1	697	704	PF00069	0.750
MOD_GSK3_1	74	81	PF00069	0.679
MOD_GSK3_1	85	92	PF00069	0.532
MOD_NEK2_1	125	130	PF00069	0.582
MOD_NEK2_1	18	23	PF00069	0.681
MOD_NEK2_1	195	200	PF00069	0.422
MOD_NEK2_1	202	207	PF00069	0.431
MOD_NEK2_1	351	356	PF00069	0.451
MOD_NEK2_1	404	409	PF00069	0.379
MOD_NEK2_1	482	487	PF00069	0.562
MOD_NEK2_1	504	509	PF00069	0.555
MOD_NEK2_1	547	552	PF00069	0.682
MOD_NEK2_1	701	706	PF00069	0.727
MOD_NEK2_1	89	94	PF00069	0.507
MOD_NEK2_2	274	279	PF00069	0.561
MOD_NEK2_2	384	389	PF00069	0.572
MOD_NEK2_2	569	574	PF00069	0.557
MOD_PIKK_1	300	306	PF00454	0.583
MOD_PIKK_1	328	334	PF00454	0.589
MOD_PIKK_1	482	488	PF00454	0.527
MOD_PIKK_1	547	553	PF00454	0.694
MOD_PKA_2	354	360	PF00069	0.412
MOD_PKA_2	638	644	PF00069	0.677
MOD_PKA_2	716	722	PF00069	0.700
MOD_Plk_1	241	247	PF00069	0.640
MOD_Plk_1	422	428	PF00069	0.456
MOD_Plk_1	583	589	PF00069	0.701
MOD_Plk_1	684	690	PF00069	0.692
MOD_Plk_1	731	737	PF00069	0.581
MOD_Plk_4	143	149	PF00069	0.561
MOD_Plk_4	195	201	PF00069	0.469
MOD_Plk_4	354	360	PF00069	0.430
MOD_Plk_4	458	464	PF00069	0.514
MOD_Plk_4	518	524	PF00069	0.718
MOD_Plk_4	583	589	PF00069	0.765
MOD_Plk_4	591	597	PF00069	0.620
MOD_Plk_4	633	639	PF00069	0.690
MOD_Plk_4	657	663	PF00069	0.707
MOD_Plk_4	7	13	PF00069	0.612
MOD_Plk_4	734	740	PF00069	0.555
MOD_Plk_4	90	96	PF00069	0.506
MOD_ProDKin_1	232	238	PF00069	0.636
MOD_ProDKin_1	265	271	PF00069	0.602
MOD_ProDKin_1	295	301	PF00069	0.701
MOD_ProDKin_1	313	319	PF00069	0.395
MOD_ProDKin_1	41	47	PF00069	0.692
MOD_ProDKin_1	576	582	PF00069	0.757
MOD_ProDKin_1	595	601	PF00069	0.451
MOD_ProDKin_1	612	618	PF00069	0.456
MOD_ProDKin_1	66	72	PF00069	0.756
MOD_ProDKin_1	694	700	PF00069	0.626
MOD_ProDKin_1	707	713	PF00069	0.529
MOD_ProDKin_1	78	84	PF00069	0.570
TRG_DiLeu_BaEn_1	633	638	PF01217	0.645
TRG_ER_diArg_1	136	139	PF00400	0.475
TRG_ER_diArg_1	257	259	PF00400	0.572
TRG_ER_diArg_1	511	514	PF00400	0.677
TRG_ER_diArg_1	672	674	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8V5	Leptomonas seymouri	59%	99%
A0A1X0PAK4	Trypanosomatidae	31%	100%
A0A3R7N1B1	Trypanosoma rangeli	33%	100%
A4HAU0	Leishmania braziliensis	73%	100%
A4IA08	Leishmania infantum	100%	100%
E9B514	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q2X2	Leishmania major	92%	100%