Zeta toxin, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zeta toxin, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7W4_LEIDO

TriTrypDb:

LdBPK_341740.1 , LdCL_340025000 , LDHU3_34.3010

Length:

1014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7W4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.575
CLV_C14_Caspase3-7	554	558	PF00656	0.596
CLV_C14_Caspase3-7	570	574	PF00656	0.608
CLV_C14_Caspase3-7	89	93	PF00656	0.702
CLV_C14_Caspase3-7	998	1002	PF00656	0.548
CLV_NRD_NRD_1	224	226	PF00675	0.561
CLV_NRD_NRD_1	358	360	PF00675	0.424
CLV_NRD_NRD_1	434	436	PF00675	0.570
CLV_NRD_NRD_1	504	506	PF00675	0.683
CLV_NRD_NRD_1	538	540	PF00675	0.648

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4HAR2	Leishmania braziliensis	65%	100%
A4I9X6	Leishmania infantum	99%	100%
E9B4Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q302	Leishmania major	84%	100%

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