Amastin-like surface protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7W2_LEIDO

TriTrypDb:

LdBPK_341690.1 , LdCL_340024100 , LDHU3_34.2540

Length:

210

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 195
NetGPI	no	yes: 0, no: 207

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	185
GO:0110165	cellular anatomical entity	1	185

Expansion

Sequence features

A0A3S7X7W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7W2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	90	92	PF00675	0.484
CLV_PCSK_FUR_1	88	92	PF00082	0.410
CLV_PCSK_KEX2_1	20	22	PF00082	0.333
CLV_PCSK_KEX2_1	90	92	PF00082	0.500
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.332
DEG_MDM2_SWIB_1	174	182	PF02201	0.316
DOC_CKS1_1	39	44	PF01111	0.357
DOC_MAPK_gen_1	20	27	PF00069	0.469
DOC_MAPK_gen_1	88	97	PF00069	0.272
DOC_MAPK_HePTP_8	17	29	PF00069	0.401
DOC_MAPK_MEF2A_6	10	17	PF00069	0.565
DOC_MAPK_MEF2A_6	124	132	PF00069	0.561
DOC_MAPK_MEF2A_6	20	29	PF00069	0.566
DOC_MAPK_MEF2A_6	55	62	PF00069	0.360
DOC_MAPK_MEF2A_6	90	99	PF00069	0.220
DOC_MAPK_NFAT4_5	20	28	PF00069	0.405
DOC_MAPK_RevD_3	7	21	PF00069	0.540
DOC_PP2B_LxvP_1	188	191	PF13499	0.675
DOC_USP7_MATH_1	5	9	PF00917	0.544
DOC_USP7_MATH_1	51	55	PF00917	0.228
DOC_WW_Pin1_4	202	207	PF00397	0.604
DOC_WW_Pin1_4	38	43	PF00397	0.352
LIG_14-3-3_CanoR_1	124	132	PF00244	0.459
LIG_14-3-3_CanoR_1	159	167	PF00244	0.424
LIG_Actin_WH2_2	110	126	PF00022	0.385
LIG_APCC_ABBA_1	189	194	PF00400	0.390
LIG_BIR_II_1	1	5	PF00653	0.771
LIG_EH1_1	97	105	PF00400	0.355
LIG_FHA_1	20	26	PF00498	0.556
LIG_FHA_2	191	197	PF00498	0.657
LIG_FHA_2	39	45	PF00498	0.387
LIG_FHA_2	75	81	PF00498	0.313
LIG_LIR_Gen_1	170	180	PF02991	0.355
LIG_LIR_Nem_3	170	175	PF02991	0.388
LIG_Pex14_2	110	114	PF04695	0.370
LIG_Pex14_2	174	178	PF04695	0.446
LIG_SH2_PTP2	26	29	PF00017	0.352
LIG_SH2_STAT5	192	195	PF00017	0.550
LIG_SH2_STAT5	26	29	PF00017	0.459
LIG_SH2_STAT5	84	87	PF00017	0.383
LIG_SH3_1	10	16	PF00018	0.542
LIG_SH3_3	10	16	PF00018	0.544
LIG_SH3_3	36	42	PF00018	0.344
LIG_SUMO_SIM_par_1	35	41	PF11976	0.388
LIG_TRAF2_1	207	210	PF00917	0.762
LIG_TYR_ITIM	24	29	PF00017	0.450
MOD_CK1_1	71	77	PF00069	0.369
MOD_CK2_1	190	196	PF00069	0.707
MOD_CK2_1	204	210	PF00069	0.645
MOD_GlcNHglycan	1	4	PF01048	0.466
MOD_GlcNHglycan	196	199	PF01048	0.397
MOD_GSK3_1	155	162	PF00069	0.222
MOD_GSK3_1	190	197	PF00069	0.587
MOD_GSK3_1	67	74	PF00069	0.322
MOD_N-GLC_1	155	160	PF02516	0.533
MOD_N-GLC_2	67	69	PF02516	0.465
MOD_NEK2_1	123	128	PF00069	0.473
MOD_NEK2_1	167	172	PF00069	0.287
MOD_NEK2_1	53	58	PF00069	0.340
MOD_PK_1	159	165	PF00069	0.199
MOD_PKA_2	123	129	PF00069	0.403
MOD_PKA_2	158	164	PF00069	0.432
MOD_Plk_1	155	161	PF00069	0.375
MOD_Plk_1	67	73	PF00069	0.364
MOD_Plk_1	74	80	PF00069	0.381
MOD_Plk_4	132	138	PF00069	0.311
MOD_Plk_4	167	173	PF00069	0.368
MOD_Plk_4	53	59	PF00069	0.313
MOD_Plk_4	99	105	PF00069	0.307
MOD_ProDKin_1	202	208	PF00069	0.603
MOD_ProDKin_1	38	44	PF00069	0.352
MOD_SUMO_rev_2	194	203	PF00179	0.577
TRG_ENDOCYTIC_2	26	29	PF00928	0.437
TRG_ER_diArg_1	88	91	PF00400	0.372
TRG_NES_CRM1_1	181	194	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	29%	100%
A0A0N0P547	Leptomonas seymouri	34%	100%
A0A0N0P993	Leptomonas seymouri	26%	94%
A0A0N1HWY5	Leptomonas seymouri	26%	100%
A0A0N1PDH0	Leptomonas seymouri	33%	100%
A0A1X0NQ58	Trypanosomatidae	26%	100%
A0A1X0NUH1	Trypanosomatidae	30%	93%
A0A1X0P988	Trypanosomatidae	31%	100%
A0A381MTA7	Leishmania infantum	53%	98%
A0A381MTB8	Leishmania infantum	40%	99%
A0A381MTC7	Leishmania infantum	61%	100%
A0A381MTN2	Leishmania infantum	37%	100%
A0A381MVY0	Leishmania infantum	52%	99%
A0A3Q8ID16	Leishmania donovani	26%	100%
A0A3Q8IEC2	Leishmania donovani	57%	99%
A0A3Q8IEI1	Leishmania donovani	38%	100%
A0A3Q8IF65	Leishmania donovani	41%	100%
A0A3Q8IFB9	Leishmania donovani	32%	100%
A0A3Q8IFH7	Leishmania donovani	61%	100%
A0A3Q8IH65	Leishmania donovani	41%	99%
A0A3Q8IHN2	Leishmania donovani	38%	100%
A0A3Q8IHW7	Leishmania donovani	43%	100%
A0A3Q8IHZ6	Leishmania donovani	43%	100%
A0A3Q8IIH1	Leishmania donovani	43%	100%
A0A3Q8IL03	Leishmania donovani	48%	98%
A0A3Q8IMR4	Leishmania donovani	24%	95%
A0A3Q8IUK8	Leishmania donovani	52%	96%
A0A3Q8IUR5	Leishmania donovani	37%	100%
A0A3S5H662	Leishmania donovani	44%	100%
A0A3S5H663	Leishmania donovani	44%	100%
A0A3S5H665	Leishmania donovani	45%	100%
A0A3S5H666	Leishmania donovani	38%	99%
A0A3S5H667	Leishmania donovani	45%	100%
A0A3S5H7L2	Leishmania donovani	39%	100%
A0A3S5H7V9	Leishmania donovani	43%	100%
A0A3S5H7W2	Leishmania donovani	25%	100%
A0A3S5H7W6	Leishmania donovani	48%	100%
A0A3S7WQA0	Leishmania donovani	45%	100%
A0A3S7WQA8	Leishmania donovani	45%	100%
A0A3S7WQC1	Leishmania donovani	41%	100%
A0A3S7X2E6	Leishmania donovani	38%	100%
A0A3S7X357	Leishmania donovani	28%	100%
A0A3S7X453	Leishmania donovani	40%	100%
A0A3S7X472	Leishmania donovani	40%	100%
A0A3S7X7E5	Leishmania donovani	44%	100%
A0A3S7X7M4	Leishmania donovani	43%	100%
A0A3S7X7U1	Leishmania donovani	48%	100%
A0A3S7X7U4	Leishmania donovani	42%	100%
A0A3S7X7Y0	Leishmania donovani	51%	100%
A4H595	Leishmania braziliensis	34%	100%
A4H596	Leishmania braziliensis	35%	100%
A4H597	Leishmania braziliensis	35%	100%
A4H5D1	Leishmania braziliensis	42%	100%
A4H5D2	Leishmania braziliensis	35%	100%
A4H5G0	Leishmania braziliensis	40%	97%
A4H5G4	Leishmania braziliensis	32%	100%
A4H5G6	Leishmania braziliensis	36%	100%
A4H5G7	Leishmania braziliensis	36%	100%
A4H5G9	Leishmania braziliensis	45%	100%
A4H5H0	Leishmania braziliensis	45%	100%
A4H5H1	Leishmania braziliensis	38%	100%
A4H5H2	Leishmania braziliensis	40%	100%
A4H5H3	Leishmania braziliensis	34%	100%
A4H6C8	Leishmania braziliensis	37%	100%
A4H7D7	Leishmania braziliensis	39%	99%
A4H9E8	Leishmania braziliensis	43%	100%
A4H9E9	Leishmania braziliensis	41%	99%
A4HAJ4	Leishmania braziliensis	39%	100%
A4HAJ5	Leishmania braziliensis	32%	100%
A4HAJ6	Leishmania braziliensis	35%	100%
A4HAL2	Leishmania braziliensis	28%	100%
A4HAM2	Leishmania braziliensis	42%	99%
A4HAM4	Leishmania braziliensis	41%	99%
A4HAR1	Leishmania braziliensis	41%	100%
A4HAZ8	Leishmania braziliensis	41%	99%
A4HB00	Leishmania braziliensis	41%	100%
A4HB02	Leishmania braziliensis	39%	100%
A4HB47	Leishmania braziliensis	32%	100%
A4HBJ0	Leishmania braziliensis	42%	99%
A4HBJ1	Leishmania braziliensis	42%	99%
A4HBJ2	Leishmania braziliensis	48%	100%
A4HDI2	Leishmania braziliensis	28%	92%
A4HDI3	Leishmania braziliensis	33%	100%
A4HDI4	Leishmania braziliensis	25%	100%
A4HDL3	Leishmania braziliensis	27%	100%
A4HDL4	Leishmania braziliensis	25%	100%
A4HDL5	Leishmania braziliensis	27%	68%
A4HI41	Leishmania braziliensis	24%	100%
A4HTM3	Leishmania infantum	41%	100%
A4HTM4	Leishmania infantum	45%	100%
A4HTM5	Leishmania infantum	43%	100%
A4I0W3	Leishmania infantum	24%	95%
A4I0W5	Leishmania infantum	26%	100%
A4I0W6	Leishmania infantum	24%	71%
A4I4J2	Leishmania infantum	40%	100%
A4I4J3	Leishmania infantum	41%	100%
A4I5B9	Leishmania infantum	28%	100%
A4I6E5	Leishmania infantum	40%	100%
A4I9Q4	Leishmania infantum	42%	99%
A4I9R4	Leishmania infantum	25%	100%
A4I9R5	Leishmania infantum	32%	100%
A4I9R7	Leishmania infantum	44%	100%
A4I9W8	Leishmania infantum	43%	100%
A4I9X0	Leishmania infantum	98%	100%
A4IA59	Leishmania infantum	36%	100%
A4IAL7	Leishmania infantum	43%	100%
A4IAM1	Leishmania infantum	37%	100%
A4IAM2	Leishmania infantum	39%	100%
C6K3X9	Leptomonas seymouri	26%	100%
E8NHC3	Leishmania infantum	44%	100%
E8NHD3	Leishmania infantum	39%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	96%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AG81	Leishmania infantum	43%	100%
E9AG82	Leishmania infantum	44%	100%
E9AG83	Leishmania infantum	39%	100%
E9AG85	Leishmania infantum	44%	100%
E9AHI9	Leishmania infantum	38%	100%
E9AHT2	Leishmania infantum	44%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	92%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	92%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	99%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q1U9	Leishmania major	51%	99%
Q4Q305	Leishmania major	52%	100%
Q4Q309	Leishmania major	45%	100%
Q4Q313	Leishmania major	52%	100%
Q4Q317	Leishmania major	42%	100%
Q4Q325	Leishmania major	47%	100%
Q4Q327	Leishmania major	47%	98%
Q4Q329	Leishmania major	52%	100%
Q4Q333	Leishmania major	51%	100%
Q4Q335	Leishmania major	52%	100%
Q4Q337	Leishmania major	49%	99%
Q4Q339	Leishmania major	52%	100%
Q4Q341	Leishmania major	54%	100%
Q4Q397	Leishmania major	39%	100%
Q4Q3A7	Leishmania major	25%	100%
Q4Q3A8	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	41%	100%
Q4Q3F7	Leishmania major	46%	100%
Q4Q6L8	Leishmania major	35%	100%
Q4Q7L6	Leishmania major	27%	100%
Q4Q7L7	Leishmania major	25%	100%
Q4Q7L8	Leishmania major	25%	100%
Q4QAK4	Leishmania major	25%	95%
Q4QAK5	Leishmania major	24%	100%
Q4QAK7	Leishmania major	26%	95%
Q4QI84	Leishmania major	46%	100%
Q4QI85	Leishmania major	39%	100%
Q4QI86	Leishmania major	43%	100%
Q4QI87	Leishmania major	43%	100%
Q4QI88	Leishmania major	43%	100%
Q4QI92	Leishmania major	43%	100%
Q4QI93	Leishmania major	42%	100%
Q4QI95	Leishmania major	42%	100%
Q4QI97	Leishmania major	43%	100%
Q4QIA0	Leishmania major	42%	100%
Q4QIA1	Leishmania major	42%	100%