LeishMANIAdb
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p25-alpha, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
p25-alpha, putative
Gene product:
p25-alpha, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X7W0_LEIDO
TriTrypDb:
LdBPK_341630.1 , LdCL_340022600 , LDHU3_34.2470
Length:
142

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 14
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A0A3S7X7W0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7W0

Function

Biological processes
Term Name Level Count
GO:0031334 positive regulation of protein-containing complex assembly 6 2
GO:0032271 regulation of protein polymerization 6 2
GO:0032273 positive regulation of protein polymerization 7 2
GO:0043254 regulation of protein-containing complex assembly 5 2
GO:0044087 regulation of cellular component biogenesis 4 2
GO:0044089 positive regulation of cellular component biogenesis 5 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051128 regulation of cellular component organization 4 2
GO:0051130 positive regulation of cellular component organization 5 2
GO:0065007 biological regulation 1 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 120 124 PF00656 0.427
CLV_C14_Caspase3-7 21 25 PF00656 0.417
CLV_NRD_NRD_1 117 119 PF00675 0.232
CLV_NRD_NRD_1 37 39 PF00675 0.225
CLV_PCSK_KEX2_1 117 119 PF00082 0.232
CLV_PCSK_SKI1_1 131 135 PF00082 0.532
CLV_PCSK_SKI1_1 18 22 PF00082 0.223
CLV_PCSK_SKI1_1 8 12 PF00082 0.217
DEG_Nend_UBRbox_2 1 3 PF02207 0.394
DOC_MAPK_gen_1 33 42 PF00069 0.442
DOC_PP1_RVXF_1 36 43 PF00149 0.474
DOC_USP7_MATH_1 73 77 PF00917 0.488
DOC_USP7_UBL2_3 14 18 PF12436 0.428
DOC_USP7_UBL2_3 31 35 PF12436 0.417
DOC_WW_Pin1_4 57 62 PF00397 0.477
LIG_14-3-3_CanoR_1 125 133 PF00244 0.665
LIG_14-3-3_CanoR_1 38 43 PF00244 0.443
LIG_FHA_2 100 106 PF00498 0.428
LIG_FHA_2 19 25 PF00498 0.417
LIG_FHA_2 58 64 PF00498 0.460
LIG_FHA_2 76 82 PF00498 0.417
LIG_LIR_Gen_1 26 37 PF02991 0.440
LIG_LIR_Gen_1 4 10 PF02991 0.442
LIG_LIR_Gen_1 41 50 PF02991 0.440
LIG_LIR_Nem_3 127 133 PF02991 0.409
LIG_LIR_Nem_3 26 32 PF02991 0.440
LIG_LIR_Nem_3 41 45 PF02991 0.440
LIG_SH2_CRK 130 134 PF00017 0.423
LIG_SH2_STAT5 92 95 PF00017 0.429
LIG_TYR_ITSM 126 133 PF00017 0.525
MOD_CK1_1 19 25 PF00069 0.464
MOD_CK1_1 4 10 PF00069 0.442
MOD_CK1_1 75 81 PF00069 0.485
MOD_CK1_1 90 96 PF00069 0.408
MOD_CK2_1 38 44 PF00069 0.459
MOD_GlcNHglycan 75 78 PF01048 0.317
MOD_GSK3_1 16 23 PF00069 0.428
MOD_GSK3_1 75 82 PF00069 0.540
MOD_NEK2_1 1 6 PF00069 0.458
MOD_NEK2_1 27 32 PF00069 0.502
MOD_PKA_1 38 44 PF00069 0.428
MOD_PKA_2 124 130 PF00069 0.431
MOD_Plk_1 1 7 PF00069 0.442
MOD_Plk_1 87 93 PF00069 0.444
MOD_ProDKin_1 57 63 PF00069 0.477
MOD_SUMO_rev_2 7 16 PF00179 0.417
MOD_SUMO_rev_2 81 91 PF00179 0.417
TRG_ENDOCYTIC_2 130 133 PF00928 0.420
TRG_Pf-PMV_PEXEL_1 8 12 PF00026 0.217

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMI7 Leptomonas seymouri 81% 92%
A0A0N1PDJ8 Leptomonas seymouri 76% 92%
A0A0S4IQF6 Bodo saltans 69% 72%
A0A1X0PAD0 Trypanosomatidae 71% 93%
A0A3R7N9A0 Trypanosoma rangeli 67% 93%
A4H7S1 Leishmania braziliensis 90% 76%
A4H7S2 Leishmania braziliensis 91% 100%
A4I9W4 Leishmania infantum 99% 100%
A4I9W5 Leishmania infantum 99% 100%
A4IIY2 Xenopus tropicalis 39% 81%
C9ZMR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 67% 95%
E9B4X7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
Q0P5Y3 Mus musculus 40% 84%
Q2VPM9 Xenopus laevis 42% 81%
Q3T077 Bos taurus 39% 83%
Q3ZCC8 Bos taurus 40% 81%
Q4Q349 Leishmania major 98% 100%
Q4Q350 Leishmania major 100% 100%
Q5PPN5 Rattus norvegicus 40% 81%
Q9BW30 Homo sapiens 40% 81%
Q9CRB6 Mus musculus 40% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS