Tyrosine phosphatase isoform, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase isoform, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7V0_LEIDO

TriTrypDb:

LdBPK_341530.1 , LdCL_340021600 , LDHU3_34.2340

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005829	cytosol	2	1

Expansion

Sequence features

A0A3S7X7V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7V0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0006470	protein dephosphorylation	5	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0019538	protein metabolic process	3	4
GO:0036211	protein modification process	4	4
GO:0043170	macromolecule metabolic process	3	4
GO:0043412	macromolecule modification	4	4
GO:0044238	primary metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	8	3
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	7	3
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	3
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	197	199	PF00675	0.293
CLV_NRD_NRD_1	242	244	PF00675	0.374
CLV_NRD_NRD_1	300	302	PF00675	0.364
CLV_NRD_NRD_1	382	384	PF00675	0.300
CLV_NRD_NRD_1	385	387	PF00675	0.309
CLV_NRD_NRD_1	398	400	PF00675	0.361
CLV_NRD_NRD_1	416	418	PF00675	0.323
CLV_NRD_NRD_1	540	542	PF00675	0.256
CLV_PCSK_FUR_1	383	387	PF00082	0.336
CLV_PCSK_KEX2_1	197	199	PF00082	0.292
CLV_PCSK_KEX2_1	242	244	PF00082	0.367
CLV_PCSK_KEX2_1	300	302	PF00082	0.256
CLV_PCSK_KEX2_1	382	384	PF00082	0.275
CLV_PCSK_KEX2_1	385	387	PF00082	0.284
CLV_PCSK_KEX2_1	398	400	PF00082	0.350
CLV_PCSK_KEX2_1	416	418	PF00082	0.323
CLV_PCSK_KEX2_1	540	542	PF00082	0.334
CLV_PCSK_SKI1_1	386	390	PF00082	0.236
CLV_PCSK_SKI1_1	424	428	PF00082	0.439
CLV_PCSK_SKI1_1	445	449	PF00082	0.461
DEG_APCC_DBOX_1	385	393	PF00400	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.687
DEG_SCF_FBW7_2	353	359	PF00400	0.506
DOC_CDC14_PxL_1	389	397	PF14671	0.520
DOC_CKS1_1	353	358	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.455
DOC_MAPK_gen_1	25	33	PF00069	0.610
DOC_MAPK_gen_1	382	389	PF00069	0.476
DOC_MAPK_HePTP_8	395	410	PF00069	0.529
DOC_PP1_RVXF_1	422	429	PF00149	0.626
DOC_PP2B_LxvP_1	518	521	PF13499	0.455
DOC_PP2B_LxvP_1	91	94	PF13499	0.363
DOC_PP4_FxxP_1	63	66	PF00568	0.655
DOC_USP7_MATH_1	265	269	PF00917	0.573
DOC_USP7_MATH_1	464	468	PF00917	0.709
DOC_WW_Pin1_4	106	111	PF00397	0.398
DOC_WW_Pin1_4	157	162	PF00397	0.468
DOC_WW_Pin1_4	352	357	PF00397	0.486
DOC_WW_Pin1_4	6	11	PF00397	0.682
LIG_14-3-3_CanoR_1	179	183	PF00244	0.294
LIG_14-3-3_CanoR_1	247	255	PF00244	0.533
LIG_14-3-3_CanoR_1	259	263	PF00244	0.563
LIG_14-3-3_CanoR_1	266	271	PF00244	0.573
LIG_14-3-3_CanoR_1	336	341	PF00244	0.521
LIG_14-3-3_CanoR_1	424	429	PF00244	0.703
LIG_BIR_III_4	567	571	PF00653	0.687
LIG_BRCT_BRCA1_1	108	112	PF00533	0.310
LIG_eIF4E_1	86	92	PF01652	0.363
LIG_EVH1_2	520	524	PF00568	0.455
LIG_FHA_1	211	217	PF00498	0.525
LIG_FHA_1	224	230	PF00498	0.581
LIG_FHA_1	26	32	PF00498	0.462
LIG_FHA_1	267	273	PF00498	0.569
LIG_FHA_1	40	46	PF00498	0.637
LIG_FHA_1	405	411	PF00498	0.535
LIG_FHA_1	468	474	PF00498	0.594
LIG_FHA_1	486	492	PF00498	0.523
LIG_FHA_1	533	539	PF00498	0.490
LIG_FHA_1	7	13	PF00498	0.673
LIG_FHA_2	116	122	PF00498	0.279
LIG_FHA_2	13	19	PF00498	0.599
LIG_FHA_2	526	532	PF00498	0.444
LIG_FHA_2	548	554	PF00498	0.437
LIG_FHA_2	67	73	PF00498	0.611
LIG_Integrin_RGD_1	551	553	PF01839	0.208
LIG_IRF3_LxIS_1	280	285	PF10401	0.484
LIG_LIR_Apic_2	227	233	PF02991	0.488
LIG_LIR_Apic_2	60	66	PF02991	0.656
LIG_LIR_Gen_1	109	120	PF02991	0.258
LIG_LIR_Gen_1	143	153	PF02991	0.473
LIG_LIR_Gen_1	28	38	PF02991	0.574
LIG_LIR_Gen_1	402	412	PF02991	0.545
LIG_LIR_Gen_1	95	104	PF02991	0.410
LIG_LIR_Nem_3	109	115	PF02991	0.279
LIG_LIR_Nem_3	143	149	PF02991	0.473
LIG_LIR_Nem_3	28	33	PF02991	0.568
LIG_LIR_Nem_3	359	364	PF02991	0.516
LIG_LIR_Nem_3	402	408	PF02991	0.546
LIG_LIR_Nem_3	503	509	PF02991	0.497
LIG_LIR_Nem_3	95	101	PF02991	0.410
LIG_NRBOX	164	170	PF00104	0.360
LIG_NRBOX	95	101	PF00104	0.394
LIG_Pex14_2	136	140	PF04695	0.600
LIG_PTB_Apo_2	46	53	PF02174	0.572
LIG_PTB_Phospho_1	46	52	PF10480	0.572
LIG_REV1ctd_RIR_1	506	514	PF16727	0.497
LIG_RPA_C_Fungi	339	351	PF08784	0.491
LIG_SH2_CRK	116	120	PF00017	0.360
LIG_SH2_CRK	245	249	PF00017	0.432
LIG_SH2_PTP2	52	55	PF00017	0.576
LIG_SH2_SRC	30	33	PF00017	0.523
LIG_SH2_SRC	456	459	PF00017	0.558
LIG_SH2_STAP1	116	120	PF00017	0.363
LIG_SH2_STAT3	324	327	PF00017	0.406
LIG_SH2_STAT5	200	203	PF00017	0.424
LIG_SH2_STAT5	211	214	PF00017	0.356
LIG_SH2_STAT5	23	26	PF00017	0.392
LIG_SH2_STAT5	293	296	PF00017	0.418
LIG_SH2_STAT5	30	33	PF00017	0.452
LIG_SH2_STAT5	321	324	PF00017	0.293
LIG_SH2_STAT5	361	364	PF00017	0.343
LIG_SH2_STAT5	420	423	PF00017	0.360
LIG_SH2_STAT5	472	475	PF00017	0.546
LIG_SH2_STAT5	52	55	PF00017	0.565
LIG_SH2_STAT5	572	575	PF00017	0.583
LIG_SH2_STAT5	73	76	PF00017	0.452
LIG_SH2_STAT5	86	89	PF00017	0.368
LIG_SH3_2	378	383	PF14604	0.458
LIG_SH3_3	350	356	PF00018	0.370
LIG_SH3_3	375	381	PF00018	0.467
LIG_SH3_3	514	520	PF00018	0.363
LIG_SH3_3	52	58	PF00018	0.675
LIG_SH3_3	7	13	PF00018	0.585
LIG_SUMO_SIM_anti_2	121	126	PF11976	0.300
LIG_SUMO_SIM_par_1	117	123	PF11976	0.289
LIG_SUMO_SIM_par_1	249	258	PF11976	0.410
LIG_SUMO_SIM_par_1	279	285	PF11976	0.402
LIG_TRAF2_1	356	359	PF00917	0.360
LIG_TYR_ITIM	114	119	PF00017	0.333
LIG_TYR_ITSM	26	33	PF00017	0.508
LIG_WRC_WIRS_1	283	288	PF05994	0.385
MOD_CK1_1	467	473	PF00069	0.604
MOD_CK2_1	12	18	PF00069	0.511
MOD_CK2_1	525	531	PF00069	0.289
MOD_CK2_1	570	576	PF00069	0.615
MOD_GlcNHglycan	329	332	PF01048	0.390
MOD_GlcNHglycan	466	469	PF01048	0.699
MOD_GSK3_1	247	254	PF00069	0.447
MOD_GSK3_1	336	343	PF00069	0.442
MOD_GSK3_1	525	532	PF00069	0.306
MOD_N-GLC_1	422	427	PF02516	0.528
MOD_NEK2_1	114	119	PF00069	0.363
MOD_NEK2_1	151	156	PF00069	0.336
MOD_NEK2_1	282	287	PF00069	0.416
MOD_NEK2_1	340	345	PF00069	0.455
MOD_NEK2_1	404	409	PF00069	0.415
MOD_NEK2_1	547	552	PF00069	0.375
MOD_NEK2_1	61	66	PF00069	0.699
MOD_NEK2_1	81	86	PF00069	0.307
MOD_PIKK_1	354	360	PF00454	0.330
MOD_PIKK_1	439	445	PF00454	0.685
MOD_PKA_2	178	184	PF00069	0.339
MOD_PKA_2	223	229	PF00069	0.445
MOD_PKA_2	246	252	PF00069	0.440
MOD_PKA_2	258	264	PF00069	0.450
MOD_PKA_2	265	271	PF00069	0.469
MOD_PKA_2	61	67	PF00069	0.623
MOD_Plk_1	25	31	PF00069	0.455
MOD_Plk_1	422	428	PF00069	0.590
MOD_Plk_1	67	73	PF00069	0.585
MOD_Plk_4	115	121	PF00069	0.362
MOD_Plk_4	123	129	PF00069	0.384
MOD_Plk_4	313	319	PF00069	0.319
MOD_Plk_4	404	410	PF00069	0.482
MOD_Plk_4	81	87	PF00069	0.338
MOD_Plk_4	92	98	PF00069	0.405
MOD_ProDKin_1	106	112	PF00069	0.510
MOD_ProDKin_1	157	163	PF00069	0.306
MOD_ProDKin_1	352	358	PF00069	0.342
MOD_ProDKin_1	6	12	PF00069	0.616
TRG_DiLeu_BaEn_1	143	148	PF01217	0.473
TRG_DiLeu_BaEn_2	235	241	PF01217	0.363
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.324
TRG_ENDOCYTIC_2	116	119	PF00928	0.348
TRG_ENDOCYTIC_2	245	248	PF00928	0.432
TRG_ENDOCYTIC_2	30	33	PF00928	0.526
TRG_ENDOCYTIC_2	52	55	PF00928	0.576
TRG_ENDOCYTIC_2	79	82	PF00928	0.541
TRG_ER_diArg_1	241	243	PF00400	0.439
TRG_ER_diArg_1	27	30	PF00400	0.459
TRG_ER_diArg_1	299	301	PF00400	0.328
TRG_ER_diArg_1	341	344	PF00400	0.449
TRG_ER_diArg_1	381	383	PF00400	0.392
TRG_ER_diArg_1	384	386	PF00400	0.381
TRG_ER_diArg_1	397	399	PF00400	0.462
TRG_ER_diArg_1	416	418	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N6	Leptomonas seymouri	70%	95%
A0A0S4JNQ3	Bodo saltans	26%	66%
A0A1X0PAB6	Trypanosomatidae	40%	92%
A4H7T1	Leishmania braziliensis	85%	100%
A4I9V5	Leishmania infantum	100%	100%
E9B4W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q359	Leishmania major	95%	100%
Q6XPS3	Homo sapiens	31%	100%
V5BT25	Trypanosoma cruzi	40%	92%