Amastin surface glycoprotein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7U4_LEIDO

TriTrypDb:

LdBPK_341670.1 , LdCL_340023000 , LDHU3_34.2530

Length:

259

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 186
NetGPI	no	yes: 0, no: 196

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	173
GO:0110165	cellular anatomical entity	1	173

Expansion

Sequence features

A0A3S7X7U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7U4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.506
CLV_PCSK_KEX2_1	135	137	PF00082	0.536
CLV_PCSK_SKI1_1	136	140	PF00082	0.598
DEG_APCC_DBOX_1	134	142	PF00400	0.218
DEG_SPOP_SBC_1	39	43	PF00917	0.569
DOC_CKS1_1	85	90	PF01111	0.408
DOC_CYCLIN_yCln2_LP_2	234	240	PF00134	0.407
DOC_MAPK_MEF2A_6	171	179	PF00069	0.564
DOC_MAPK_MEF2A_6	62	71	PF00069	0.523
DOC_PP2B_LxvP_1	234	237	PF13499	0.556
DOC_USP7_MATH_1	131	135	PF00917	0.201
DOC_USP7_MATH_1	45	49	PF00917	0.615
DOC_WW_Pin1_4	12	17	PF00397	0.575
DOC_WW_Pin1_4	127	132	PF00397	0.289
DOC_WW_Pin1_4	249	254	PF00397	0.597
DOC_WW_Pin1_4	84	89	PF00397	0.395
LIG_Actin_WH2_2	155	173	PF00022	0.317
LIG_BIR_II_1	1	5	PF00653	0.581
LIG_CSL_BTD_1	128	131	PF09270	0.198
LIG_FHA_1	118	124	PF00498	0.302
LIG_FHA_1	182	188	PF00498	0.439
LIG_FHA_1	2	8	PF00498	0.572
LIG_FHA_1	66	72	PF00498	0.349
LIG_FHA_2	85	91	PF00498	0.493
LIG_LIR_Nem_3	195	200	PF02991	0.280
LIG_PCNA_PIPBox_1	91	100	PF02747	0.197
LIG_Pex14_1	110	114	PF04695	0.294
LIG_PTB_Apo_2	101	108	PF02174	0.205
LIG_PTB_Phospho_1	101	107	PF10480	0.199
LIG_SH2_CRK	98	102	PF00017	0.201
LIG_SH2_PTP2	72	75	PF00017	0.359
LIG_SH2_SRC	98	101	PF00017	0.197
LIG_SH2_STAP1	121	125	PF00017	0.343
LIG_SH2_STAT5	107	110	PF00017	0.268
LIG_SH2_STAT5	72	75	PF00017	0.448
LIG_SH3_3	247	253	PF00018	0.713
LIG_SH3_3	33	39	PF00018	0.774
LIG_SH3_3	82	88	PF00018	0.352
LIG_Sin3_3	79	86	PF02671	0.353
LIG_SUMO_SIM_anti_2	65	71	PF11976	0.464
LIG_SUMO_SIM_par_1	81	87	PF11976	0.342
LIG_TYR_ITIM	70	75	PF00017	0.445
LIG_TYR_ITSM	193	200	PF00017	0.198
LIG_UBA3_1	91	96	PF00899	0.237
MOD_CDK_SPK_2	249	254	PF00069	0.453
MOD_CK1_1	117	123	PF00069	0.516
MOD_CK1_1	249	255	PF00069	0.762
MOD_CK1_1	55	61	PF00069	0.454
MOD_CK1_1	65	71	PF00069	0.259
MOD_CK2_1	55	61	PF00069	0.573
MOD_CMANNOS	169	172	PF00535	0.199
MOD_GlcNHglycan	32	35	PF01048	0.466
MOD_GlcNHglycan	36	39	PF01048	0.464
MOD_GSK3_1	115	122	PF00069	0.392
MOD_GSK3_1	123	130	PF00069	0.305
MOD_GSK3_1	30	37	PF00069	0.487
MOD_NEK2_1	1	6	PF00069	0.468
MOD_NEK2_1	114	119	PF00069	0.403
MOD_NEK2_1	192	197	PF00069	0.445
MOD_NEK2_1	52	57	PF00069	0.382
MOD_NEK2_2	146	151	PF00069	0.514
MOD_OFUCOSY	57	64	PF10250	0.358
MOD_Plk_4	105	111	PF00069	0.355
MOD_Plk_4	123	129	PF00069	0.323
MOD_Plk_4	192	198	PF00069	0.301
MOD_Plk_4	65	71	PF00069	0.287
MOD_ProDKin_1	12	18	PF00069	0.444
MOD_ProDKin_1	127	133	PF00069	0.327
MOD_ProDKin_1	249	255	PF00069	0.477
MOD_ProDKin_1	84	90	PF00069	0.395
TRG_ENDOCYTIC_2	197	200	PF00928	0.322
TRG_ENDOCYTIC_2	72	75	PF00928	0.431
TRG_ER_diArg_1	23	26	PF00400	0.419
TRG_ER_diArg_1	238	241	PF00400	0.354
TRG_NES_CRM1_1	227	242	PF08389	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P9	Leptomonas seymouri	26%	100%
A0A0N0P993	Leptomonas seymouri	25%	100%
A0A0N1HWY5	Leptomonas seymouri	27%	100%
A0A0N1PAD5	Leptomonas seymouri	23%	100%
A0A0N1PDH0	Leptomonas seymouri	39%	100%
A0A381MTA7	Leishmania infantum	47%	100%
A0A381MTB8	Leishmania infantum	51%	100%
A0A381MTC7	Leishmania infantum	51%	100%
A0A381MTN2	Leishmania infantum	44%	100%
A0A381MVY0	Leishmania infantum	54%	100%
A0A3Q8ID16	Leishmania donovani	31%	99%
A0A3Q8IEC2	Leishmania donovani	49%	100%
A0A3Q8IEI1	Leishmania donovani	46%	100%
A0A3Q8IF65	Leishmania donovani	47%	100%
A0A3Q8IFB9	Leishmania donovani	33%	100%
A0A3Q8IFH7	Leishmania donovani	51%	100%
A0A3Q8IFI8	Leishmania donovani	23%	100%
A0A3Q8IH65	Leishmania donovani	51%	100%
A0A3Q8IHN2	Leishmania donovani	48%	100%
A0A3Q8IHW7	Leishmania donovani	55%	100%
A0A3Q8IHZ6	Leishmania donovani	53%	100%
A0A3Q8IIH1	Leishmania donovani	52%	100%
A0A3Q8IL03	Leishmania donovani	47%	100%
A0A3Q8IUK8	Leishmania donovani	49%	100%
A0A3Q8IUR5	Leishmania donovani	44%	100%
A0A3S5H662	Leishmania donovani	46%	100%
A0A3S5H663	Leishmania donovani	46%	100%
A0A3S5H665	Leishmania donovani	46%	100%
A0A3S5H666	Leishmania donovani	48%	100%
A0A3S5H667	Leishmania donovani	46%	100%
A0A3S5H7D2	Leishmania donovani	34%	98%
A0A3S5H7L2	Leishmania donovani	48%	100%
A0A3S5H7V9	Leishmania donovani	53%	100%
A0A3S5H7W2	Leishmania donovani	27%	100%
A0A3S5H7W6	Leishmania donovani	46%	97%
A0A3S7WQA0	Leishmania donovani	46%	100%
A0A3S7WQA8	Leishmania donovani	52%	100%
A0A3S7WQC1	Leishmania donovani	51%	100%
A0A3S7X2E6	Leishmania donovani	50%	100%
A0A3S7X357	Leishmania donovani	23%	100%
A0A3S7X453	Leishmania donovani	46%	100%
A0A3S7X472	Leishmania donovani	43%	100%
A0A3S7X7E5	Leishmania donovani	56%	100%
A0A3S7X7M4	Leishmania donovani	54%	100%
A0A3S7X7U1	Leishmania donovani	48%	100%
A0A3S7X7W2	Leishmania donovani	42%	100%
A0A3S7X7Y0	Leishmania donovani	48%	100%
A4H595	Leishmania braziliensis	49%	100%
A4H596	Leishmania braziliensis	51%	100%
A4H597	Leishmania braziliensis	49%	100%
A4H5D1	Leishmania braziliensis	51%	100%
A4H5D2	Leishmania braziliensis	38%	100%
A4H5G0	Leishmania braziliensis	56%	100%
A4H5G4	Leishmania braziliensis	46%	100%
A4H5G6	Leishmania braziliensis	50%	100%
A4H5G7	Leishmania braziliensis	48%	100%
A4H5G9	Leishmania braziliensis	55%	100%
A4H5H0	Leishmania braziliensis	54%	100%
A4H5H1	Leishmania braziliensis	54%	100%
A4H5H2	Leishmania braziliensis	53%	100%
A4H5H3	Leishmania braziliensis	43%	100%
A4H6C8	Leishmania braziliensis	46%	100%
A4H7D7	Leishmania braziliensis	51%	100%
A4H9E8	Leishmania braziliensis	47%	100%
A4H9E9	Leishmania braziliensis	47%	100%
A4HAJ4	Leishmania braziliensis	43%	100%
A4HAJ5	Leishmania braziliensis	51%	100%
A4HAJ6	Leishmania braziliensis	49%	100%
A4HAL2	Leishmania braziliensis	29%	100%
A4HAM2	Leishmania braziliensis	52%	100%
A4HAM4	Leishmania braziliensis	49%	100%
A4HAR1	Leishmania braziliensis	46%	99%
A4HAZ8	Leishmania braziliensis	49%	100%
A4HB00	Leishmania braziliensis	44%	99%
A4HB02	Leishmania braziliensis	49%	100%
A4HB47	Leishmania braziliensis	35%	100%
A4HBJ0	Leishmania braziliensis	51%	100%
A4HBJ1	Leishmania braziliensis	49%	100%
A4HBJ2	Leishmania braziliensis	48%	100%
A4HDI3	Leishmania braziliensis	35%	100%
A4HDI4	Leishmania braziliensis	31%	100%
A4HDL3	Leishmania braziliensis	33%	100%
A4HDL4	Leishmania braziliensis	31%	100%
A4HI41	Leishmania braziliensis	24%	100%
A4HI43	Leishmania braziliensis	22%	100%
A4HTM3	Leishmania infantum	49%	100%
A4HTM4	Leishmania infantum	51%	100%
A4HTM5	Leishmania infantum	53%	100%
A4I0W4	Leishmania infantum	34%	98%
A4I0W5	Leishmania infantum	31%	99%
A4I4J2	Leishmania infantum	49%	100%
A4I4J3	Leishmania infantum	43%	100%
A4I5B8	Leishmania infantum	23%	100%
A4I5B9	Leishmania infantum	23%	100%
A4I6E5	Leishmania infantum	43%	100%
A4I9R4	Leishmania infantum	27%	100%
A4I9R5	Leishmania infantum	33%	100%
A4I9R7	Leishmania infantum	55%	100%
A4I9W8	Leishmania infantum	98%	100%
A4I9X0	Leishmania infantum	42%	100%
A4IA59	Leishmania infantum	40%	100%
A4IAL7	Leishmania infantum	55%	100%
A4IAM1	Leishmania infantum	45%	100%
A4IAM2	Leishmania infantum	47%	100%
C6K3X5	Leptomonas seymouri	29%	100%
C6K3X9	Leptomonas seymouri	24%	100%
E8NHC3	Leishmania infantum	46%	100%
E8NHD3	Leishmania infantum	48%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	76%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AG81	Leishmania infantum	45%	100%
E9AG82	Leishmania infantum	44%	100%
E9AG83	Leishmania infantum	46%	100%
E9AG85	Leishmania infantum	44%	100%
E9AHI9	Leishmania infantum	49%	100%
E9AHT2	Leishmania infantum	55%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	97%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4Q1U9	Leishmania major	54%	100%
Q4Q305	Leishmania major	52%	100%
Q4Q309	Leishmania major	51%	100%
Q4Q313	Leishmania major	52%	100%
Q4Q317	Leishmania major	49%	100%
Q4Q325	Leishmania major	49%	100%
Q4Q327	Leishmania major	52%	100%
Q4Q329	Leishmania major	51%	100%
Q4Q333	Leishmania major	53%	100%
Q4Q335	Leishmania major	53%	100%
Q4Q337	Leishmania major	51%	100%
Q4Q339	Leishmania major	52%	100%
Q4Q341	Leishmania major	55%	100%
Q4Q397	Leishmania major	49%	97%
Q4Q3A7	Leishmania major	29%	100%
Q4Q3A8	Leishmania major	32%	100%
Q4Q3A9	Leishmania major	52%	100%
Q4Q3F7	Leishmania major	51%	100%
Q4Q6L8	Leishmania major	41%	100%
Q4Q7L6	Leishmania major	23%	100%
Q4QAK5	Leishmania major	30%	98%
Q4QAK6	Leishmania major	34%	98%
Q4QI84	Leishmania major	51%	100%
Q4QI85	Leishmania major	51%	98%
Q4QI86	Leishmania major	53%	100%
Q4QI87	Leishmania major	53%	100%
Q4QI88	Leishmania major	50%	100%
Q4QI92	Leishmania major	46%	100%
Q4QI93	Leishmania major	46%	100%
Q4QI95	Leishmania major	46%	100%
Q4QI97	Leishmania major	47%	100%
Q4QIA0	Leishmania major	46%	100%
Q4QIA1	Leishmania major	46%	100%
V5D669	Trypanosoma cruzi	26%	67%