LeishMANIAdb
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Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Arrestin_N domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X7U3_LEIDO
TriTrypDb:
LdBPK_341540.1 * , LdCL_340021700 , LDHU3_34.2360
Length:
995

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7U3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7U3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.744
CLV_C14_Caspase3-7 380 384 PF00656 0.577
CLV_C14_Caspase3-7 390 394 PF00656 0.553
CLV_C14_Caspase3-7 45 49 PF00656 0.633
CLV_C14_Caspase3-7 622 626 PF00656 0.757
CLV_NRD_NRD_1 106 108 PF00675 0.480
CLV_NRD_NRD_1 181 183 PF00675 0.528
CLV_NRD_NRD_1 247 249 PF00675 0.703
CLV_NRD_NRD_1 295 297 PF00675 0.681
CLV_NRD_NRD_1 412 414 PF00675 0.683
CLV_NRD_NRD_1 729 731 PF00675 0.565
CLV_PCSK_FUR_1 410 414 PF00082 0.678
CLV_PCSK_FUR_1 726 730 PF00082 0.513
CLV_PCSK_KEX2_1 106 108 PF00082 0.480
CLV_PCSK_KEX2_1 181 183 PF00082 0.528
CLV_PCSK_KEX2_1 229 231 PF00082 0.650
CLV_PCSK_KEX2_1 247 249 PF00082 0.525
CLV_PCSK_KEX2_1 294 296 PF00082 0.686
CLV_PCSK_KEX2_1 412 414 PF00082 0.707
CLV_PCSK_KEX2_1 728 730 PF00082 0.575
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.740
CLV_PCSK_PC7_1 243 249 PF00082 0.698
CLV_PCSK_PC7_1 290 296 PF00082 0.649
CLV_PCSK_SKI1_1 398 402 PF00082 0.634
CLV_PCSK_SKI1_1 671 675 PF00082 0.662
CLV_PCSK_SKI1_1 952 956 PF00082 0.580
CLV_Separin_Metazoa 740 744 PF03568 0.653
DEG_APCC_DBOX_1 159 167 PF00400 0.445
DEG_APCC_DBOX_1 727 735 PF00400 0.551
DEG_APCC_DBOX_1 944 952 PF00400 0.511
DEG_APCC_KENBOX_2 673 677 PF00400 0.672
DEG_Nend_UBRbox_1 1 4 PF02207 0.535
DEG_SPOP_SBC_1 423 427 PF00917 0.650
DEG_SPOP_SBC_1 819 823 PF00917 0.644
DOC_AGCK_PIF_1 474 479 PF00069 0.408
DOC_CKS1_1 100 105 PF01111 0.468
DOC_CKS1_1 5 10 PF01111 0.425
DOC_CKS1_1 650 655 PF01111 0.570
DOC_CYCLIN_RxL_1 334 345 PF00134 0.613
DOC_MAPK_gen_1 202 209 PF00069 0.394
DOC_MAPK_gen_1 22 30 PF00069 0.388
DOC_MAPK_gen_1 490 497 PF00069 0.535
DOC_MAPK_gen_1 671 680 PF00069 0.648
DOC_MAPK_gen_1 726 735 PF00069 0.563
DOC_MAPK_MEF2A_6 18 25 PF00069 0.396
DOC_MAPK_MEF2A_6 202 209 PF00069 0.357
DOC_MAPK_MEF2A_6 467 474 PF00069 0.481
DOC_MAPK_MEF2A_6 490 497 PF00069 0.502
DOC_MAPK_MEF2A_6 571 579 PF00069 0.459
DOC_MAPK_MEF2A_6 726 735 PF00069 0.563
DOC_MAPK_NFAT4_5 18 26 PF00069 0.397
DOC_PP1_RVXF_1 585 592 PF00149 0.434
DOC_PP2B_LxvP_1 13 16 PF13499 0.483
DOC_PP2B_LxvP_1 624 627 PF13499 0.673
DOC_PP2B_LxvP_1 860 863 PF13499 0.572
DOC_PP4_FxxP_1 44 47 PF00568 0.628
DOC_PP4_FxxP_1 514 517 PF00568 0.471
DOC_PP4_FxxP_1 591 594 PF00568 0.460
DOC_PP4_FxxP_1 75 78 PF00568 0.441
DOC_USP7_MATH_1 280 284 PF00917 0.744
DOC_USP7_MATH_1 480 484 PF00917 0.516
DOC_USP7_MATH_1 510 514 PF00917 0.459
DOC_USP7_MATH_1 596 600 PF00917 0.550
DOC_USP7_MATH_1 64 68 PF00917 0.616
DOC_USP7_MATH_1 665 669 PF00917 0.593
DOC_USP7_MATH_1 710 714 PF00917 0.574
DOC_USP7_MATH_1 820 824 PF00917 0.641
DOC_USP7_MATH_1 846 850 PF00917 0.595
DOC_USP7_MATH_2 264 270 PF00917 0.689
DOC_WW_Pin1_4 130 135 PF00397 0.496
DOC_WW_Pin1_4 276 281 PF00397 0.685
DOC_WW_Pin1_4 283 288 PF00397 0.820
DOC_WW_Pin1_4 35 40 PF00397 0.434
DOC_WW_Pin1_4 4 9 PF00397 0.421
DOC_WW_Pin1_4 424 429 PF00397 0.620
DOC_WW_Pin1_4 649 654 PF00397 0.601
DOC_WW_Pin1_4 68 73 PF00397 0.610
DOC_WW_Pin1_4 712 717 PF00397 0.636
DOC_WW_Pin1_4 965 970 PF00397 0.557
DOC_WW_Pin1_4 99 104 PF00397 0.464
LIG_14-3-3_CanoR_1 107 113 PF00244 0.409
LIG_14-3-3_CanoR_1 151 157 PF00244 0.504
LIG_14-3-3_CanoR_1 158 164 PF00244 0.459
LIG_14-3-3_CanoR_1 182 192 PF00244 0.580
LIG_14-3-3_CanoR_1 247 253 PF00244 0.748
LIG_14-3-3_CanoR_1 337 342 PF00244 0.683
LIG_14-3-3_CanoR_1 496 504 PF00244 0.501
LIG_14-3-3_CanoR_1 651 660 PF00244 0.588
LIG_14-3-3_CanoR_1 815 820 PF00244 0.679
LIG_14-3-3_CanoR_1 900 904 PF00244 0.658
LIG_14-3-3_CanoR_1 952 958 PF00244 0.566
LIG_14-3-3_CanoR_1 989 995 PF00244 0.530
LIG_APCC_ABBAyCdc20_2 587 593 PF00400 0.441
LIG_BIR_III_2 656 660 PF00653 0.648
LIG_BRCT_BRCA1_1 598 602 PF00533 0.432
LIG_FHA_1 100 106 PF00498 0.475
LIG_FHA_1 204 210 PF00498 0.496
LIG_FHA_1 306 312 PF00498 0.702
LIG_FHA_1 316 322 PF00498 0.506
LIG_FHA_1 368 374 PF00498 0.556
LIG_FHA_1 483 489 PF00498 0.430
LIG_FHA_1 596 602 PF00498 0.541
LIG_FHA_1 618 624 PF00498 0.727
LIG_FHA_1 857 863 PF00498 0.602
LIG_FHA_1 877 883 PF00498 0.672
LIG_FHA_1 941 947 PF00498 0.501
LIG_FHA_2 15 21 PF00498 0.423
LIG_FHA_2 254 260 PF00498 0.752
LIG_FHA_2 268 274 PF00498 0.590
LIG_FHA_2 388 394 PF00498 0.759
LIG_FHA_2 448 454 PF00498 0.688
LIG_FHA_2 500 506 PF00498 0.458
LIG_FHA_2 620 626 PF00498 0.731
LIG_FHA_2 722 728 PF00498 0.556
LIG_FHA_2 790 796 PF00498 0.542
LIG_FHA_2 974 980 PF00498 0.663
LIG_LIR_Apic_2 512 517 PF02991 0.441
LIG_LIR_Apic_2 782 787 PF02991 0.605
LIG_LIR_Gen_1 193 203 PF02991 0.530
LIG_LIR_Gen_1 364 373 PF02991 0.627
LIG_LIR_Gen_1 471 480 PF02991 0.399
LIG_LIR_Gen_1 599 609 PF02991 0.425
LIG_LIR_Gen_1 638 646 PF02991 0.571
LIG_LIR_Gen_1 789 797 PF02991 0.547
LIG_LIR_Gen_1 80 88 PF02991 0.373
LIG_LIR_Gen_1 984 994 PF02991 0.523
LIG_LIR_LC3C_4 539 543 PF02991 0.371
LIG_LIR_Nem_3 121 126 PF02991 0.420
LIG_LIR_Nem_3 193 198 PF02991 0.577
LIG_LIR_Nem_3 364 368 PF02991 0.682
LIG_LIR_Nem_3 471 477 PF02991 0.392
LIG_LIR_Nem_3 599 605 PF02991 0.422
LIG_LIR_Nem_3 638 642 PF02991 0.576
LIG_LIR_Nem_3 789 793 PF02991 0.537
LIG_LIR_Nem_3 80 84 PF02991 0.377
LIG_LIR_Nem_3 958 964 PF02991 0.588
LIG_LIR_Nem_3 984 990 PF02991 0.521
LIG_MAD2 2 10 PF02301 0.505
LIG_PTB_Apo_2 473 480 PF02174 0.495
LIG_PTB_Apo_2 848 855 PF02174 0.586
LIG_PTB_Phospho_1 848 854 PF10480 0.588
LIG_Rb_pABgroove_1 523 531 PF01858 0.438
LIG_SH2_CRK 5 9 PF00017 0.424
LIG_SH2_CRK 81 85 PF00017 0.370
LIG_SH2_CRK 961 965 PF00017 0.490
LIG_SH2_NCK_1 389 393 PF00017 0.542
LIG_SH2_NCK_1 736 740 PF00017 0.651
LIG_SH2_NCK_1 784 788 PF00017 0.685
LIG_SH2_PTP2 195 198 PF00017 0.501
LIG_SH2_PTP2 987 990 PF00017 0.615
LIG_SH2_SRC 784 787 PF00017 0.690
LIG_SH2_STAP1 840 844 PF00017 0.595
LIG_SH2_STAP1 856 860 PF00017 0.563
LIG_SH2_STAT5 126 129 PF00017 0.462
LIG_SH2_STAT5 195 198 PF00017 0.549
LIG_SH2_STAT5 389 392 PF00017 0.588
LIG_SH2_STAT5 81 84 PF00017 0.375
LIG_SH2_STAT5 831 834 PF00017 0.576
LIG_SH2_STAT5 953 956 PF00017 0.542
LIG_SH2_STAT5 987 990 PF00017 0.525
LIG_SH3_1 5 11 PF00018 0.430
LIG_SH3_2 168 173 PF14604 0.555
LIG_SH3_3 139 145 PF00018 0.435
LIG_SH3_3 165 171 PF00018 0.465
LIG_SH3_3 236 242 PF00018 0.672
LIG_SH3_3 425 431 PF00018 0.650
LIG_SH3_3 5 11 PF00018 0.430
LIG_SH3_3 517 523 PF00018 0.499
LIG_SH3_3 560 566 PF00018 0.663
LIG_SH3_3 97 103 PF00018 0.455
LIG_SUMO_SIM_anti_2 448 456 PF11976 0.686
LIG_SUMO_SIM_par_1 205 210 PF11976 0.398
LIG_TRAF2_1 394 397 PF00917 0.551
LIG_TRAF2_1 570 573 PF00917 0.460
LIG_TRAF2_1 697 700 PF00917 0.602
LIG_TRAF2_1 792 795 PF00917 0.538
LIG_TYR_ITIM 79 84 PF00017 0.379
LIG_TYR_ITIM 985 990 PF00017 0.524
LIG_WRC_WIRS_1 511 516 PF05994 0.536
LIG_WRC_WIRS_1 531 536 PF05994 0.266
MOD_CDK_SPxxK_3 283 290 PF00069 0.677
MOD_CDK_SPxxK_3 99 106 PF00069 0.473
MOD_CK1_1 146 152 PF00069 0.551
MOD_CK1_1 268 274 PF00069 0.678
MOD_CK1_1 279 285 PF00069 0.686
MOD_CK1_1 315 321 PF00069 0.626
MOD_CK1_1 382 388 PF00069 0.620
MOD_CK1_1 391 397 PF00069 0.557
MOD_CK1_1 475 481 PF00069 0.419
MOD_CK1_1 499 505 PF00069 0.495
MOD_CK1_1 617 623 PF00069 0.712
MOD_CK1_1 649 655 PF00069 0.629
MOD_CK1_1 720 726 PF00069 0.761
MOD_CK1_1 789 795 PF00069 0.595
MOD_CK1_1 818 824 PF00069 0.716
MOD_CK1_1 850 856 PF00069 0.619
MOD_CK1_1 896 902 PF00069 0.670
MOD_CK1_1 917 923 PF00069 0.622
MOD_CK2_1 14 20 PF00069 0.444
MOD_CK2_1 183 189 PF00069 0.574
MOD_CK2_1 267 273 PF00069 0.741
MOD_CK2_1 391 397 PF00069 0.567
MOD_CK2_1 447 453 PF00069 0.605
MOD_CK2_1 499 505 PF00069 0.453
MOD_CK2_1 530 536 PF00069 0.401
MOD_CK2_1 547 553 PF00069 0.458
MOD_CK2_1 682 688 PF00069 0.598
MOD_CK2_1 693 699 PF00069 0.564
MOD_CK2_1 721 727 PF00069 0.677
MOD_CK2_1 734 740 PF00069 0.526
MOD_CK2_1 769 775 PF00069 0.684
MOD_CK2_1 780 786 PF00069 0.547
MOD_CK2_1 789 795 PF00069 0.405
MOD_CK2_1 975 981 PF00069 0.664
MOD_GlcNHglycan 148 151 PF01048 0.680
MOD_GlcNHglycan 185 188 PF01048 0.585
MOD_GlcNHglycan 218 221 PF01048 0.678
MOD_GlcNHglycan 299 302 PF01048 0.650
MOD_GlcNHglycan 313 317 PF01048 0.580
MOD_GlcNHglycan 383 387 PF01048 0.599
MOD_GlcNHglycan 390 393 PF01048 0.552
MOD_GlcNHglycan 441 444 PF01048 0.698
MOD_GlcNHglycan 48 51 PF01048 0.581
MOD_GlcNHglycan 507 510 PF01048 0.600
MOD_GlcNHglycan 694 698 PF01048 0.609
MOD_GlcNHglycan 736 739 PF01048 0.531
MOD_GlcNHglycan 757 760 PF01048 0.675
MOD_GlcNHglycan 766 769 PF01048 0.614
MOD_GlcNHglycan 817 820 PF01048 0.824
MOD_GlcNHglycan 841 845 PF01048 0.623
MOD_GlcNHglycan 905 908 PF01048 0.676
MOD_GlcNHglycan 916 919 PF01048 0.586
MOD_GlcNHglycan 94 97 PF01048 0.530
MOD_GlcNHglycan 970 973 PF01048 0.658
MOD_GSK3_1 212 219 PF00069 0.595
MOD_GSK3_1 262 269 PF00069 0.776
MOD_GSK3_1 276 283 PF00069 0.649
MOD_GSK3_1 344 351 PF00069 0.629
MOD_GSK3_1 387 394 PF00069 0.611
MOD_GSK3_1 418 425 PF00069 0.727
MOD_GSK3_1 459 466 PF00069 0.588
MOD_GSK3_1 475 482 PF00069 0.376
MOD_GSK3_1 495 502 PF00069 0.490
MOD_GSK3_1 505 512 PF00069 0.569
MOD_GSK3_1 60 67 PF00069 0.662
MOD_GSK3_1 614 621 PF00069 0.701
MOD_GSK3_1 642 649 PF00069 0.584
MOD_GSK3_1 678 685 PF00069 0.655
MOD_GSK3_1 717 724 PF00069 0.626
MOD_GSK3_1 802 809 PF00069 0.693
MOD_GSK3_1 811 818 PF00069 0.632
MOD_GSK3_1 819 826 PF00069 0.520
MOD_GSK3_1 846 853 PF00069 0.629
MOD_GSK3_1 866 873 PF00069 0.471
MOD_GSK3_1 899 906 PF00069 0.663
MOD_GSK3_1 975 982 PF00069 0.653
MOD_N-GLC_1 35 40 PF02516 0.453
MOD_N-GLC_1 475 480 PF02516 0.555
MOD_N-GLC_1 614 619 PF02516 0.559
MOD_N-GLC_1 646 651 PF02516 0.638
MOD_N-GLC_1 718 723 PF02516 0.618
MOD_N-GLC_1 870 875 PF02516 0.646
MOD_NEK2_1 118 123 PF00069 0.411
MOD_NEK2_1 438 443 PF00069 0.761
MOD_NEK2_1 472 477 PF00069 0.392
MOD_NEK2_1 479 484 PF00069 0.431
MOD_NEK2_1 575 580 PF00069 0.425
MOD_NEK2_1 903 908 PF00069 0.598
MOD_NEK2_1 990 995 PF00069 0.542
MOD_NEK2_2 940 945 PF00069 0.509
MOD_OFUCOSY 937 944 PF10250 0.612
MOD_PIKK_1 118 124 PF00454 0.412
MOD_PK_1 769 775 PF00069 0.706
MOD_PKA_2 128 134 PF00069 0.474
MOD_PKA_2 159 165 PF00069 0.410
MOD_PKA_2 183 189 PF00069 0.594
MOD_PKA_2 246 252 PF00069 0.661
MOD_PKA_2 289 295 PF00069 0.620
MOD_PKA_2 297 303 PF00069 0.632
MOD_PKA_2 439 445 PF00069 0.662
MOD_PKA_2 495 501 PF00069 0.492
MOD_PKA_2 583 589 PF00069 0.432
MOD_PKA_2 642 648 PF00069 0.567
MOD_PKA_2 823 829 PF00069 0.700
MOD_PKA_2 899 905 PF00069 0.601
MOD_PKA_2 92 98 PF00069 0.474
MOD_PKA_2 922 928 PF00069 0.687
MOD_PKA_2 988 994 PF00069 0.525
MOD_Plk_1 312 318 PF00069 0.616
MOD_Plk_1 475 481 PF00069 0.543
MOD_Plk_1 499 505 PF00069 0.563
MOD_Plk_1 646 652 PF00069 0.657
MOD_Plk_1 699 705 PF00069 0.672
MOD_Plk_1 840 846 PF00069 0.594
MOD_Plk_1 856 862 PF00069 0.566
MOD_Plk_1 863 869 PF00069 0.633
MOD_Plk_2-3 500 506 PF00069 0.577
MOD_Plk_2-3 530 536 PF00069 0.401
MOD_Plk_4 108 114 PF00069 0.350
MOD_Plk_4 280 286 PF00069 0.673
MOD_Plk_4 510 516 PF00069 0.455
MOD_Plk_4 530 536 PF00069 0.370
MOD_Plk_4 575 581 PF00069 0.410
MOD_Plk_4 619 625 PF00069 0.731
MOD_Plk_4 786 792 PF00069 0.557
MOD_Plk_4 905 911 PF00069 0.637
MOD_ProDKin_1 130 136 PF00069 0.500
MOD_ProDKin_1 276 282 PF00069 0.686
MOD_ProDKin_1 283 289 PF00069 0.819
MOD_ProDKin_1 35 41 PF00069 0.436
MOD_ProDKin_1 4 10 PF00069 0.422
MOD_ProDKin_1 424 430 PF00069 0.620
MOD_ProDKin_1 649 655 PF00069 0.601
MOD_ProDKin_1 68 74 PF00069 0.600
MOD_ProDKin_1 712 718 PF00069 0.637
MOD_ProDKin_1 965 971 PF00069 0.564
MOD_ProDKin_1 99 105 PF00069 0.466
MOD_SUMO_for_1 570 573 PF00179 0.497
MOD_SUMO_rev_2 391 400 PF00179 0.651
TRG_DiLeu_BaEn_2 785 791 PF01217 0.562
TRG_DiLeu_BaEn_4 396 402 PF01217 0.546
TRG_DiLeu_BaEn_4 572 578 PF01217 0.417
TRG_ENDOCYTIC_2 195 198 PF00928 0.528
TRG_ENDOCYTIC_2 546 549 PF00928 0.407
TRG_ENDOCYTIC_2 81 84 PF00928 0.375
TRG_ENDOCYTIC_2 960 963 PF00928 0.534
TRG_ENDOCYTIC_2 987 990 PF00928 0.525
TRG_ER_diArg_1 105 107 PF00400 0.482
TRG_ER_diArg_1 158 161 PF00400 0.433
TRG_ER_diArg_1 181 184 PF00400 0.540
TRG_ER_diArg_1 21 24 PF00400 0.384
TRG_ER_diArg_1 294 296 PF00400 0.627
TRG_ER_diArg_1 326 329 PF00400 0.561
TRG_ER_diArg_1 607 610 PF00400 0.480
TRG_ER_diArg_1 728 730 PF00400 0.576
TRG_NES_CRM1_1 20 33 PF08389 0.397
TRG_NES_CRM1_1 487 500 PF08389 0.429
TRG_Pf-PMV_PEXEL_1 337 342 PF00026 0.589
TRG_Pf-PMV_PEXEL_1 413 417 PF00026 0.590
TRG_Pf-PMV_PEXEL_1 771 775 PF00026 0.597

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I020 Leptomonas seymouri 47% 100%
A4H7T0 Leishmania braziliensis 73% 100%
A4I9V6 Leishmania infantum 99% 100%
E9B4W9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q358 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS