LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Amastin surface glycoprotein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin surface glycoprotein, putative
Gene product:
Amastin surface glycoprotein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X7U1_LEIDO
TriTrypDb:
LdCL_340023500 , LDHU3_34.2560
Length:
210

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 9
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 12, no: 200
NetGPI no yes: 0, no: 212
Cellular components
Term Name Level Count
GO:0016020 membrane 2 189
GO:0110165 cellular anatomical entity 1 189

Expansion

Sequence features

A0A3S7X7U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7U1

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016485 protein processing 5 1
GO:0016540 protein autoprocessing 6 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 91 93 PF00675 0.480
CLV_PCSK_SKI1_1 57 61 PF00082 0.405
DEG_APCC_KENBOX_2 64 68 PF00400 0.196
DOC_CKS1_1 38 43 PF01111 0.344
DOC_MAPK_gen_1 16 24 PF00069 0.441
DOC_MAPK_gen_1 92 102 PF00069 0.262
DOC_MAPK_MEF2A_6 123 131 PF00069 0.561
DOC_MAPK_MEF2A_6 16 24 PF00069 0.536
DOC_MAPK_MEF2A_6 96 104 PF00069 0.234
DOC_MAPK_RevD_3 4 17 PF00069 0.541
DOC_WW_Pin1_4 37 42 PF00397 0.354
DOC_WW_Pin1_4 4 9 PF00397 0.569
LIG_14-3-3_CanoR_1 57 62 PF00244 0.356
LIG_14-3-3_CanoR_1 90 100 PF00244 0.303
LIG_Actin_WH2_2 107 125 PF00022 0.359
LIG_BIR_II_1 1 5 PF00653 0.552
LIG_BRCT_MDC1_1 206 210 PF00533 0.565
LIG_FHA_1 134 140 PF00498 0.375
LIG_FHA_1 74 80 PF00498 0.343
LIG_FHA_1 84 90 PF00498 0.304
LIG_FHA_2 38 44 PF00498 0.380
LIG_LIR_Gen_1 121 132 PF02991 0.481
LIG_LIR_Gen_1 7 18 PF02991 0.663
LIG_LIR_Gen_1 76 85 PF02991 0.325
LIG_LIR_LC3C_4 21 24 PF02991 0.219
LIG_LIR_Nem_3 121 127 PF02991 0.563
LIG_LIR_Nem_3 50 56 PF02991 0.275
LIG_LIR_Nem_3 7 13 PF02991 0.692
LIG_LIR_Nem_3 76 81 PF02991 0.321
LIG_Pex14_2 166 170 PF04695 0.377
LIG_SH2_CRK 119 123 PF00017 0.404
LIG_SH2_CRK 53 57 PF00017 0.200
LIG_SH2_PTP2 10 13 PF00017 0.719
LIG_SH2_PTP2 25 28 PF00017 0.517
LIG_SH2_SRC 10 13 PF00017 0.547
LIG_SH2_STAP1 73 77 PF00017 0.320
LIG_SH2_STAT5 10 13 PF00017 0.660
LIG_SH2_STAT5 119 122 PF00017 0.498
LIG_SH2_STAT5 193 196 PF00017 0.563
LIG_SH2_STAT5 25 28 PF00017 0.441
LIG_SH2_STAT5 78 81 PF00017 0.246
LIG_SH3_3 2 8 PF00018 0.549
LIG_SH3_3 35 41 PF00018 0.358
LIG_SUMO_SIM_par_1 34 40 PF11976 0.309
LIG_TYR_ITIM 23 28 PF00017 0.456
LIG_TYR_ITSM 49 56 PF00017 0.193
MOD_CK1_1 154 160 PF00069 0.261
MOD_CK1_1 83 89 PF00069 0.261
MOD_CK2_1 44 50 PF00069 0.283
MOD_CK2_1 79 85 PF00069 0.337
MOD_GlcNHglycan 1 4 PF01048 0.490
MOD_GSK3_1 187 194 PF00069 0.574
MOD_GSK3_1 199 206 PF00069 0.583
MOD_GSK3_1 44 51 PF00069 0.312
MOD_GSK3_1 79 86 PF00069 0.266
MOD_N-GLC_1 18 23 PF02516 0.201
MOD_NEK2_1 144 149 PF00069 0.441
MOD_NEK2_1 189 194 PF00069 0.580
MOD_NEK2_1 44 49 PF00069 0.331
MOD_NEK2_1 79 84 PF00069 0.258
MOD_NEK2_1 91 96 PF00069 0.241
MOD_NEK2_2 118 123 PF00069 0.475
MOD_NEK2_2 52 57 PF00069 0.249
MOD_NEK2_2 73 78 PF00069 0.293
MOD_PIKK_1 91 97 PF00454 0.196
MOD_PKA_2 154 160 PF00069 0.275
MOD_PKA_2 91 97 PF00069 0.277
MOD_Plk_1 18 24 PF00069 0.408
MOD_Plk_1 73 79 PF00069 0.396
MOD_Plk_4 18 24 PF00069 0.467
MOD_Plk_4 73 79 PF00069 0.287
MOD_ProDKin_1 37 43 PF00069 0.354
MOD_ProDKin_1 4 10 PF00069 0.569
TRG_ENDOCYTIC_2 10 13 PF00928 0.659
TRG_ENDOCYTIC_2 119 122 PF00928 0.452
TRG_ENDOCYTIC_2 25 28 PF00928 0.420
TRG_ENDOCYTIC_2 53 56 PF00928 0.249
TRG_ENDOCYTIC_2 78 81 PF00928 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C4 Leptomonas seymouri 30% 100%
A0A0N0P547 Leptomonas seymouri 42% 100%
A0A0N0P6P9 Leptomonas seymouri 24% 91%
A0A0N1HWY5 Leptomonas seymouri 26% 100%
A0A0N1PAD5 Leptomonas seymouri 26% 84%
A0A0N1PDH0 Leptomonas seymouri 35% 100%
A0A1X0NQ58 Trypanosomatidae 30% 100%
A0A1X0NUH1 Trypanosomatidae 29% 93%
A0A1X0NVN5 Trypanosomatidae 28% 100%
A0A1X0NVT7 Trypanosomatidae 29% 100%
A0A1X0NX02 Trypanosomatidae 27% 100%
A0A1X0NX81 Trypanosomatidae 25% 100%
A0A1X0P2R3 Trypanosomatidae 27% 100%
A0A1X0P988 Trypanosomatidae 36% 100%
A0A381MTA7 Leishmania infantum 55% 99%
A0A381MTB8 Leishmania infantum 48% 100%
A0A381MTC7 Leishmania infantum 53% 100%
A0A381MTN2 Leishmania infantum 44% 100%
A0A381MVY0 Leishmania infantum 52% 99%
A0A3Q8ID16 Leishmania donovani 26% 100%
A0A3Q8IEC2 Leishmania donovani 53% 100%
A0A3Q8IEI1 Leishmania donovani 47% 100%
A0A3Q8IF65 Leishmania donovani 43% 100%
A0A3Q8IFB9 Leishmania donovani 28% 100%
A0A3Q8IFH7 Leishmania donovani 53% 100%
A0A3Q8IH65 Leishmania donovani 50% 100%
A0A3Q8IHN2 Leishmania donovani 47% 100%
A0A3Q8IHW7 Leishmania donovani 43% 100%
A0A3Q8IHZ6 Leishmania donovani 47% 100%
A0A3Q8IIH1 Leishmania donovani 49% 100%
A0A3Q8IL03 Leishmania donovani 44% 99%
A0A3Q8IMR4 Leishmania donovani 24% 100%
A0A3Q8IUK8 Leishmania donovani 52% 100%
A0A3Q8IUR5 Leishmania donovani 44% 100%
A0A3S5H662 Leishmania donovani 45% 100%
A0A3S5H663 Leishmania donovani 45% 100%
A0A3S5H665 Leishmania donovani 45% 100%
A0A3S5H666 Leishmania donovani 42% 100%
A0A3S5H667 Leishmania donovani 45% 100%
A0A3S5H7D2 Leishmania donovani 27% 100%
A0A3S5H7L2 Leishmania donovani 38% 100%
A0A3S5H7V9 Leishmania donovani 45% 100%
A0A3S5H7W2 Leishmania donovani 27% 100%
A0A3S5H7W6 Leishmania donovani 54% 100%
A0A3S7WQA0 Leishmania donovani 45% 100%
A0A3S7WQA8 Leishmania donovani 47% 100%
A0A3S7WQC1 Leishmania donovani 47% 100%
A0A3S7X2E6 Leishmania donovani 38% 100%
A0A3S7X357 Leishmania donovani 27% 95%
A0A3S7X453 Leishmania donovani 43% 100%
A0A3S7X472 Leishmania donovani 45% 100%
A0A3S7X7E5 Leishmania donovani 45% 84%
A0A3S7X7M4 Leishmania donovani 47% 100%
A0A3S7X7U4 Leishmania donovani 48% 81%
A0A3S7X7W2 Leishmania donovani 48% 100%
A0A3S7X7Y0 Leishmania donovani 56% 100%
A4H595 Leishmania braziliensis 41% 100%
A4H596 Leishmania braziliensis 42% 100%
A4H597 Leishmania braziliensis 43% 91%
A4H5D1 Leishmania braziliensis 50% 100%
A4H5D2 Leishmania braziliensis 35% 100%
A4H5G0 Leishmania braziliensis 47% 100%
A4H5G4 Leishmania braziliensis 43% 100%
A4H5G6 Leishmania braziliensis 38% 100%
A4H5G7 Leishmania braziliensis 43% 100%
A4H5G9 Leishmania braziliensis 48% 100%
A4H5H0 Leishmania braziliensis 48% 100%
A4H5H1 Leishmania braziliensis 46% 100%
A4H5H2 Leishmania braziliensis 46% 100%
A4H5H3 Leishmania braziliensis 41% 100%
A4H6C8 Leishmania braziliensis 45% 100%
A4H7D7 Leishmania braziliensis 49% 100%
A4H9E8 Leishmania braziliensis 46% 100%
A4H9E9 Leishmania braziliensis 44% 100%
A4HAJ4 Leishmania braziliensis 43% 100%
A4HAJ5 Leishmania braziliensis 41% 100%
A4HAJ6 Leishmania braziliensis 42% 100%
A4HAL2 Leishmania braziliensis 29% 100%
A4HAM2 Leishmania braziliensis 45% 100%
A4HAM4 Leishmania braziliensis 44% 100%
A4HAR1 Leishmania braziliensis 45% 100%
A4HAZ8 Leishmania braziliensis 47% 100%
A4HB00 Leishmania braziliensis 45% 100%
A4HB02 Leishmania braziliensis 40% 100%
A4HB47 Leishmania braziliensis 29% 100%
A4HBJ0 Leishmania braziliensis 43% 100%
A4HBJ1 Leishmania braziliensis 44% 100%
A4HBJ2 Leishmania braziliensis 49% 100%
A4HDI2 Leishmania braziliensis 25% 100%
A4HDI3 Leishmania braziliensis 29% 87%
A4HDI4 Leishmania braziliensis 27% 100%
A4HDL3 Leishmania braziliensis 29% 100%
A4HDL4 Leishmania braziliensis 28% 100%
A4HDL5 Leishmania braziliensis 25% 68%
A4HTM3 Leishmania infantum 47% 100%
A4HTM4 Leishmania infantum 46% 100%
A4HTM5 Leishmania infantum 48% 100%
A4I0W3 Leishmania infantum 24% 100%
A4I0W4 Leishmania infantum 26% 100%
A4I0W5 Leishmania infantum 26% 100%
A4I0W6 Leishmania infantum 25% 71%
A4I4J2 Leishmania infantum 37% 100%
A4I4J3 Leishmania infantum 42% 81%
A4I5B9 Leishmania infantum 27% 95%
A4I6E5 Leishmania infantum 43% 100%
A4I9Q4 Leishmania infantum 44% 100%
A4I9R4 Leishmania infantum 27% 100%
A4I9R5 Leishmania infantum 28% 100%
A4I9R7 Leishmania infantum 45% 100%
A4I9W8 Leishmania infantum 48% 81%
A4I9X0 Leishmania infantum 48% 100%
A4IA59 Leishmania infantum 40% 100%
A4IAL7 Leishmania infantum 42% 100%
A4IAM1 Leishmania infantum 45% 100%
A4IAM2 Leishmania infantum 47% 100%
C6K3X9 Leptomonas seymouri 27% 100%
E8NHC3 Leishmania infantum 47% 100%
E8NHD3 Leishmania infantum 38% 100%
E8NHD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E8NHE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
E8NHI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E8NHK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHK9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E8NHL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E8NHM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E8NHM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E8NHM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E8NHP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E8NHQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E8NHR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E8NHS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHS5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 68%
E9AG81 Leishmania infantum 45% 100%
E9AG82 Leishmania infantum 45% 100%
E9AG83 Leishmania infantum 43% 100%
E9AG85 Leishmania infantum 45% 100%
E9AHI9 Leishmania infantum 38% 100%
E9AHT2 Leishmania infantum 47% 100%
E9AME9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9AMF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AMF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AMF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AMF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AMF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9AMF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AMF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9ASP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 100%
E9AWW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AWW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AWW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AWX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B0L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 95%
E9B1J3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9B1J4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B1J5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9B4L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B4R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B4R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B4R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B4S0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B4Y3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
Q4Q1U9 Leishmania major 51% 100%
Q4Q305 Leishmania major 51% 100%
Q4Q309 Leishmania major 54% 100%
Q4Q313 Leishmania major 51% 100%
Q4Q317 Leishmania major 46% 100%
Q4Q325 Leishmania major 54% 100%
Q4Q327 Leishmania major 51% 100%
Q4Q329 Leishmania major 52% 100%
Q4Q333 Leishmania major 51% 100%
Q4Q335 Leishmania major 52% 100%
Q4Q337 Leishmania major 53% 100%
Q4Q339 Leishmania major 51% 100%
Q4Q341 Leishmania major 55% 100%
Q4Q397 Leishmania major 47% 100%
Q4Q3A7 Leishmania major 29% 100%
Q4Q3A8 Leishmania major 29% 100%
Q4Q3A9 Leishmania major 48% 100%
Q4Q3F7 Leishmania major 47% 100%
Q4Q6L8 Leishmania major 44% 100%
Q4Q7L6 Leishmania major 28% 95%
Q4QAK4 Leishmania major 26% 100%
Q4QAK5 Leishmania major 26% 100%
Q4QAK6 Leishmania major 27% 100%
Q4QAK7 Leishmania major 26% 100%
Q4QI84 Leishmania major 45% 100%
Q4QI85 Leishmania major 48% 100%
Q4QI86 Leishmania major 47% 100%
Q4QI87 Leishmania major 47% 100%
Q4QI88 Leishmania major 47% 100%
Q4QI92 Leishmania major 47% 100%
Q4QI93 Leishmania major 47% 100%
Q4QI95 Leishmania major 47% 100%
Q4QI97 Leishmania major 47% 100%
Q4QIA0 Leishmania major 47% 100%
Q4QIA1 Leishmania major 47% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS