Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7T6_LEIDO

TriTrypDb:

LdBPK_341460.1 , LdCL_340020600 , LDHU3_34.2230

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	472	476	PF00656	0.627
CLV_C14_Caspase3-7	562	566	PF00656	0.615
CLV_NRD_NRD_1	483	485	PF00675	0.493
CLV_PCSK_KEX2_1	34	36	PF00082	0.485
CLV_PCSK_KEX2_1	519	521	PF00082	0.553
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.485
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.553
CLV_PCSK_SKI1_1	193	197	PF00082	0.536
CLV_PCSK_SKI1_1	379	383	PF00082	0.448
CLV_PCSK_SKI1_1	491	495	PF00082	0.535
CLV_PCSK_SKI1_1	51	55	PF00082	0.531
DEG_SCF_FBW7_1	290	297	PF00400	0.656
DEG_SPOP_SBC_1	116	120	PF00917	0.689
DOC_CKS1_1	140	145	PF01111	0.662
DOC_CKS1_1	246	251	PF01111	0.638
DOC_CKS1_1	279	284	PF01111	0.671
DOC_CKS1_1	291	296	PF01111	0.577
DOC_CKS1_1	322	327	PF01111	0.713
DOC_CKS1_1	498	503	PF01111	0.525
DOC_CKS1_1	83	88	PF01111	0.584
DOC_MAPK_MEF2A_6	261	268	PF00069	0.649
DOC_PP2B_LxvP_1	541	544	PF13499	0.644
DOC_USP7_MATH_1	116	120	PF00917	0.646
DOC_USP7_MATH_1	232	236	PF00917	0.654
DOC_USP7_MATH_1	239	243	PF00917	0.758
DOC_USP7_MATH_1	24	28	PF00917	0.445
DOC_USP7_MATH_1	272	276	PF00917	0.723
DOC_USP7_MATH_1	280	284	PF00917	0.665
DOC_USP7_MATH_1	294	298	PF00917	0.602
DOC_USP7_MATH_1	315	319	PF00917	0.682
DOC_USP7_MATH_1	45	49	PF00917	0.444
DOC_USP7_MATH_1	546	550	PF00917	0.686
DOC_USP7_UBL2_3	60	64	PF12436	0.459
DOC_WW_Pin1_4	139	144	PF00397	0.660
DOC_WW_Pin1_4	241	246	PF00397	0.780
DOC_WW_Pin1_4	259	264	PF00397	0.648
DOC_WW_Pin1_4	268	273	PF00397	0.618
DOC_WW_Pin1_4	278	283	PF00397	0.640
DOC_WW_Pin1_4	284	289	PF00397	0.611
DOC_WW_Pin1_4	290	295	PF00397	0.653
DOC_WW_Pin1_4	299	304	PF00397	0.565
DOC_WW_Pin1_4	311	316	PF00397	0.609
DOC_WW_Pin1_4	318	323	PF00397	0.531
DOC_WW_Pin1_4	36	41	PF00397	0.494
DOC_WW_Pin1_4	406	411	PF00397	0.656
DOC_WW_Pin1_4	413	418	PF00397	0.525
DOC_WW_Pin1_4	497	502	PF00397	0.534
DOC_WW_Pin1_4	82	87	PF00397	0.601
LIG_14-3-3_CanoR_1	152	160	PF00244	0.525
LIG_14-3-3_CanoR_1	364	372	PF00244	0.505
LIG_14-3-3_CanoR_1	405	410	PF00244	0.689
LIG_14-3-3_CanoR_1	491	501	PF00244	0.500
LIG_14-3-3_CanoR_1	545	553	PF00244	0.518
LIG_APCC_ABBA_1	195	200	PF00400	0.432
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_3	1	5	PF00653	0.611
LIG_CtBP_PxDLS_1	148	152	PF00389	0.569
LIG_FHA_1	140	146	PF00498	0.648
LIG_FHA_1	169	175	PF00498	0.480
LIG_FHA_1	279	285	PF00498	0.686
LIG_FHA_1	493	499	PF00498	0.544
LIG_FHA_1	565	571	PF00498	0.561
LIG_FHA_1	83	89	PF00498	0.559
LIG_FHA_2	124	130	PF00498	0.637
LIG_FHA_2	355	361	PF00498	0.697
LIG_FHA_2	414	420	PF00498	0.536
LIG_FHA_2	470	476	PF00498	0.622
LIG_FHA_2	498	504	PF00498	0.473
LIG_FHA_2	52	58	PF00498	0.526
LIG_FHA_2	530	536	PF00498	0.692
LIG_FHA_2	546	552	PF00498	0.493
LIG_LIR_Apic_2	183	187	PF02991	0.467
LIG_LIR_Nem_3	522	527	PF02991	0.549
LIG_NRBOX	69	75	PF00104	0.531
LIG_PALB2_WD40_1	186	194	PF16756	0.441
LIG_SH2_CRK	184	188	PF00017	0.462
LIG_SH2_STAT3	460	463	PF00017	0.428
LIG_SH2_STAT3	81	84	PF00017	0.607
LIG_SH2_STAT5	167	170	PF00017	0.471
LIG_SH2_STAT5	371	374	PF00017	0.521
LIG_SH2_STAT5	376	379	PF00017	0.475
LIG_SH2_STAT5	525	528	PF00017	0.566
LIG_SH2_STAT5	66	69	PF00017	0.521
LIG_SH2_STAT5	81	84	PF00017	0.453
LIG_SH3_3	134	140	PF00018	0.573
LIG_SH3_3	243	249	PF00018	0.794
LIG_SH3_3	257	263	PF00018	0.569
LIG_SH3_3	279	285	PF00018	0.685
LIG_SH3_3	319	325	PF00018	0.650
LIG_SUMO_SIM_anti_2	512	519	PF11976	0.546
LIG_TRAF2_1	4	7	PF00917	0.501
LIG_TRAF2_1	500	503	PF00917	0.446
LIG_UBA3_1	515	519	PF00899	0.538
LIG_WRPW_2	63	66	PF00400	0.504
MOD_CDK_SPK_2	268	273	PF00069	0.621
MOD_CDK_SPxxK_3	245	252	PF00069	0.639
MOD_CDK_SPxxK_3	413	420	PF00069	0.607
MOD_CK1_1	118	124	PF00069	0.612
MOD_CK1_1	212	218	PF00069	0.749
MOD_CK1_1	241	247	PF00069	0.750
MOD_CK1_1	27	33	PF00069	0.478
MOD_CK1_1	271	277	PF00069	0.640
MOD_CK1_1	311	317	PF00069	0.633
MOD_CK1_1	318	324	PF00069	0.681
MOD_CK1_1	395	401	PF00069	0.815
MOD_CK1_1	413	419	PF00069	0.467
MOD_CK1_1	480	486	PF00069	0.560
MOD_CK1_1	529	535	PF00069	0.639
MOD_CK2_1	413	419	PF00069	0.528
MOD_CK2_1	497	503	PF00069	0.454
MOD_CK2_1	51	57	PF00069	0.530
MOD_CK2_1	545	551	PF00069	0.677
MOD_GlcNHglycan	241	244	PF01048	0.771
MOD_GlcNHglycan	26	29	PF01048	0.461
MOD_GlcNHglycan	310	313	PF01048	0.677
MOD_GlcNHglycan	317	320	PF01048	0.760
MOD_GlcNHglycan	331	334	PF01048	0.671
MOD_GlcNHglycan	397	400	PF01048	0.773
MOD_GlcNHglycan	413	416	PF01048	0.524
MOD_GlcNHglycan	440	443	PF01048	0.548
MOD_GlcNHglycan	447	450	PF01048	0.460
MOD_GlcNHglycan	477	482	PF01048	0.562
MOD_GlcNHglycan	528	531	PF01048	0.643
MOD_GlcNHglycan	538	541	PF01048	0.550
MOD_GlcNHglycan	548	551	PF01048	0.421
MOD_GSK3_1	112	119	PF00069	0.655
MOD_GSK3_1	120	127	PF00069	0.670
MOD_GSK3_1	212	219	PF00069	0.608
MOD_GSK3_1	234	241	PF00069	0.631
MOD_GSK3_1	264	271	PF00069	0.659
MOD_GSK3_1	280	287	PF00069	0.579
MOD_GSK3_1	290	297	PF00069	0.720
MOD_GSK3_1	311	318	PF00069	0.650
MOD_GSK3_1	329	336	PF00069	0.649
MOD_GSK3_1	337	344	PF00069	0.764
MOD_GSK3_1	350	357	PF00069	0.791
MOD_GSK3_1	389	396	PF00069	0.660
MOD_GSK3_1	397	404	PF00069	0.690
MOD_GSK3_1	406	413	PF00069	0.649
MOD_GSK3_1	51	58	PF00069	0.559
MOD_GSK3_1	526	533	PF00069	0.565
MOD_N-GLC_1	124	129	PF02516	0.607
MOD_N-GLC_1	406	411	PF02516	0.684
MOD_NEK2_1	151	156	PF00069	0.586
MOD_NEK2_1	168	173	PF00069	0.503
MOD_NEK2_1	266	271	PF00069	0.657
MOD_NEK2_1	308	313	PF00069	0.671
MOD_NEK2_1	489	494	PF00069	0.567
MOD_NEK2_1	564	569	PF00069	0.586
MOD_NEK2_2	333	338	PF00069	0.623
MOD_NEK2_2	45	50	PF00069	0.447
MOD_PIKK_1	210	216	PF00454	0.748
MOD_PIKK_1	337	343	PF00454	0.740
MOD_PIKK_1	436	442	PF00454	0.518
MOD_PK_1	55	61	PF00069	0.524
MOD_PKA_1	519	525	PF00069	0.546
MOD_PKA_2	103	109	PF00069	0.658
MOD_PKA_2	112	118	PF00069	0.613
MOD_PKA_2	151	157	PF00069	0.538
MOD_PKA_2	329	335	PF00069	0.687
MOD_PKA_2	519	525	PF00069	0.546
MOD_PKA_2	546	552	PF00069	0.570
MOD_Plk_1	382	388	PF00069	0.515
MOD_Plk_1	564	570	PF00069	0.605
MOD_Plk_2-3	91	97	PF00069	0.798
MOD_Plk_4	294	300	PF00069	0.589
MOD_Plk_4	333	339	PF00069	0.804
MOD_Plk_4	494	500	PF00069	0.518
MOD_Plk_4	77	83	PF00069	0.549
MOD_ProDKin_1	139	145	PF00069	0.664
MOD_ProDKin_1	241	247	PF00069	0.781
MOD_ProDKin_1	259	265	PF00069	0.649
MOD_ProDKin_1	268	274	PF00069	0.617
MOD_ProDKin_1	278	284	PF00069	0.642
MOD_ProDKin_1	290	296	PF00069	0.655
MOD_ProDKin_1	299	305	PF00069	0.610
MOD_ProDKin_1	311	317	PF00069	0.611
MOD_ProDKin_1	318	324	PF00069	0.534
MOD_ProDKin_1	36	42	PF00069	0.496
MOD_ProDKin_1	406	412	PF00069	0.654
MOD_ProDKin_1	413	419	PF00069	0.521
MOD_ProDKin_1	497	503	PF00069	0.530
MOD_ProDKin_1	82	88	PF00069	0.609
MOD_SUMO_for_1	372	375	PF00179	0.550
TRG_DiLeu_BaEn_1	513	518	PF01217	0.546
TRG_DiLeu_BaEn_1	7	12	PF01217	0.467
TRG_DiLeu_BaEn_4	513	519	PF01217	0.553
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.584
TRG_ER_diArg_1	158	161	PF00400	0.523
TRG_ER_diArg_1	252	255	PF00400	0.676
TRG_ER_diArg_1	544	547	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C9	Leptomonas seymouri	53%	98%
A4HAQ2	Leishmania braziliensis	78%	100%
A4I9U8	Leishmania infantum	97%	100%
E9B4V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q367	Leishmania major	95%	100%