Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7T0_LEIDO

TriTrypDb:

LdBPK_341610.1 , LdCL_340022400 , LDHU3_34.2450

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.649
CLV_C14_Caspase3-7	330	334	PF00656	0.553
CLV_C14_Caspase3-7	97	101	PF00656	0.645
CLV_NRD_NRD_1	360	362	PF00675	0.663
CLV_NRD_NRD_1	37	39	PF00675	0.585
CLV_PCSK_KEX2_1	360	362	PF00082	0.663
CLV_PCSK_KEX2_1	37	39	PF00082	0.585
CLV_PCSK_SKI1_1	218	222	PF00082	0.702
CLV_PCSK_SKI1_1	297	301	PF00082	0.526
CLV_PCSK_SKI1_1	462	466	PF00082	0.450
DEG_APCC_DBOX_1	359	367	PF00400	0.590
DEG_APCC_KENBOX_2	260	264	PF00400	0.536
DEG_SCF_FBW7_2	6	11	PF00400	0.522
DEG_SPOP_SBC_1	182	186	PF00917	0.607
DEG_SPOP_SBC_1	205	209	PF00917	0.547
DEG_SPOP_SBC_1	423	427	PF00917	0.574
DOC_CYCLIN_yClb5_NLxxxL_5	144	153	PF00134	0.554
DOC_USP7_MATH_1	143	147	PF00917	0.582
DOC_USP7_MATH_1	355	359	PF00917	0.579
DOC_USP7_MATH_1	376	380	PF00917	0.727
DOC_USP7_MATH_1	455	459	PF00917	0.468
DOC_WW_Pin1_4	132	137	PF00397	0.610
DOC_WW_Pin1_4	273	278	PF00397	0.529
DOC_WW_Pin1_4	387	392	PF00397	0.620
DOC_WW_Pin1_4	4	9	PF00397	0.624
LIG_14-3-3_CanoR_1	138	143	PF00244	0.669
LIG_14-3-3_CanoR_1	180	189	PF00244	0.587
LIG_14-3-3_CanoR_1	360	364	PF00244	0.593
LIG_APCC_ABBA_1	15	20	PF00400	0.569
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BIR_III_4	333	337	PF00653	0.502
LIG_FHA_1	139	145	PF00498	0.617
LIG_FHA_1	182	188	PF00498	0.596
LIG_FHA_1	206	212	PF00498	0.533
LIG_FHA_1	241	247	PF00498	0.560
LIG_FHA_1	34	40	PF00498	0.612
LIG_FHA_2	113	119	PF00498	0.536
LIG_FHA_2	226	232	PF00498	0.496
LIG_FHA_2	249	255	PF00498	0.592
LIG_FHA_2	302	308	PF00498	0.579
LIG_FHA_2	360	366	PF00498	0.583
LIG_FHA_2	425	431	PF00498	0.732
LIG_FHA_2	441	447	PF00498	0.494
LIG_FHA_2	493	499	PF00498	0.450
LIG_FHA_2	66	72	PF00498	0.548
LIG_LIR_Gen_1	238	246	PF02991	0.574
LIG_LIR_Nem_3	463	468	PF02991	0.446
LIG_LIR_Nem_3	53	59	PF02991	0.622
LIG_PCNA_PIPBox_1	485	494	PF02747	0.454
LIG_PCNA_yPIPBox_3	485	497	PF02747	0.387
LIG_PTB_Apo_2	381	388	PF02174	0.590
LIG_SH2_GRB2like	105	108	PF00017	0.643
LIG_SH2_NCK_1	105	109	PF00017	0.564
LIG_SH2_STAT5	175	178	PF00017	0.576
LIG_SH2_STAT5	245	248	PF00017	0.586
LIG_SH2_STAT5	491	494	PF00017	0.420
LIG_SH2_STAT5	56	59	PF00017	0.565
LIG_SH3_3	130	136	PF00018	0.609
LIG_SH3_3	274	280	PF00018	0.535
LIG_TRAF2_1	383	386	PF00917	0.594
LIG_TRAF2_1	414	417	PF00917	0.542
LIG_WRC_WIRS_1	328	333	PF05994	0.610
MOD_CDC14_SPxK_1	135	138	PF00782	0.657
MOD_CDK_SPxK_1	132	138	PF00069	0.656
MOD_CDK_SPxK_1	273	279	PF00069	0.531
MOD_CK1_1	106	112	PF00069	0.597
MOD_CK1_1	183	189	PF00069	0.651
MOD_CK1_1	234	240	PF00069	0.541
MOD_CK1_1	273	279	PF00069	0.535
MOD_CK1_1	298	304	PF00069	0.580
MOD_CK1_1	327	333	PF00069	0.592
MOD_CK1_1	428	434	PF00069	0.634
MOD_CK1_1	80	86	PF00069	0.611
MOD_CK2_1	112	118	PF00069	0.667
MOD_CK2_1	204	210	PF00069	0.584
MOD_CK2_1	248	254	PF00069	0.613
MOD_CK2_1	301	307	PF00069	0.596
MOD_CK2_1	65	71	PF00069	0.562
MOD_GlcNHglycan	145	148	PF01048	0.678
MOD_GlcNHglycan	170	173	PF01048	0.601
MOD_GlcNHglycan	272	275	PF01048	0.539
MOD_GlcNHglycan	297	300	PF01048	0.569
MOD_GlcNHglycan	319	322	PF01048	0.760
MOD_GlcNHglycan	341	344	PF01048	0.620
MOD_GlcNHglycan	350	354	PF01048	0.556
MOD_GlcNHglycan	502	506	PF01048	0.413
MOD_GSK3_1	134	141	PF00069	0.655
MOD_GSK3_1	188	195	PF00069	0.649
MOD_GSK3_1	206	213	PF00069	0.510
MOD_GSK3_1	221	228	PF00069	0.612
MOD_GSK3_1	231	238	PF00069	0.675
MOD_GSK3_1	248	255	PF00069	0.665
MOD_GSK3_1	291	298	PF00069	0.512
MOD_GSK3_1	308	315	PF00069	0.674
MOD_GSK3_1	323	330	PF00069	0.501
MOD_GSK3_1	339	346	PF00069	0.499
MOD_GSK3_1	355	362	PF00069	0.514
MOD_GSK3_1	424	431	PF00069	0.604
MOD_GSK3_1	6	13	PF00069	0.630
MOD_LATS_1	422	428	PF00433	0.650
MOD_N-GLC_1	106	111	PF02516	0.641
MOD_N-GLC_1	180	185	PF02516	0.612
MOD_N-GLC_1	343	348	PF02516	0.599
MOD_N-GLC_1	435	440	PF02516	0.586
MOD_NEK2_1	10	15	PF00069	0.576
MOD_NEK2_1	232	237	PF00069	0.516
MOD_NEK2_1	25	30	PF00069	0.510
MOD_NEK2_1	293	298	PF00069	0.549
MOD_NEK2_1	317	322	PF00069	0.702
MOD_NEK2_1	324	329	PF00069	0.559
MOD_NEK2_1	339	344	PF00069	0.531
MOD_NEK2_1	359	364	PF00069	0.478
MOD_NEK2_1	492	497	PF00069	0.448
MOD_NEK2_2	240	245	PF00069	0.602
MOD_NEK2_2	355	360	PF00069	0.581
MOD_PIKK_1	100	106	PF00454	0.603
MOD_PIKK_1	291	297	PF00454	0.504
MOD_PK_1	221	227	PF00069	0.503
MOD_PK_1	77	83	PF00069	0.623
MOD_PKA_2	359	365	PF00069	0.593
MOD_PKB_1	178	186	PF00069	0.578
MOD_Plk_1	106	112	PF00069	0.720
MOD_Plk_1	113	119	PF00069	0.714
MOD_Plk_1	125	131	PF00069	0.590
MOD_Plk_1	252	258	PF00069	0.601
MOD_Plk_1	435	441	PF00069	0.586
MOD_Plk_1	473	479	PF00069	0.443
MOD_Plk_1	501	507	PF00069	0.415
MOD_Plk_1	77	83	PF00069	0.613
MOD_Plk_2-3	125	131	PF00069	0.601
MOD_Plk_4	183	189	PF00069	0.642
MOD_Plk_4	192	198	PF00069	0.580
MOD_Plk_4	240	246	PF00069	0.572
MOD_Plk_4	285	291	PF00069	0.514
MOD_Plk_4	435	441	PF00069	0.586
MOD_Plk_4	77	83	PF00069	0.623
MOD_ProDKin_1	132	138	PF00069	0.611
MOD_ProDKin_1	273	279	PF00069	0.531
MOD_ProDKin_1	387	393	PF00069	0.620
MOD_ProDKin_1	4	10	PF00069	0.625
TRG_DiLeu_BaEn_1	463	468	PF01217	0.446
TRG_DiLeu_BaEn_4	416	422	PF01217	0.581
TRG_ER_diArg_1	216	219	PF00400	0.594
TRG_ER_diArg_1	359	361	PF00400	0.596
TRG_ER_diArg_1	37	39	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X2	Leptomonas seymouri	54%	92%
A4H7S3	Leishmania braziliensis	76%	100%
A4I9W3	Leishmania infantum	99%	100%
E9B4X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q351	Leishmania major	94%	100%