D-isomer specific 2-hydroxyacid dehydrogenase-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-isomer specific 2-hydroxyacid dehydrogenase (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X7S4_LEIDO

TriTrypDb:

LdBPK_044360.1 , LdCL_340021100 , LDHU3_34.2290

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7S4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0005488	binding	1	16
GO:0036094	small molecule binding	2	16
GO:0051287	NAD binding	4	16
GO:0097159	organic cyclic compound binding	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.298
CLV_NRD_NRD_1	182	184	PF00675	0.325
CLV_NRD_NRD_1	223	225	PF00675	0.273
CLV_NRD_NRD_1	321	323	PF00675	0.671
CLV_NRD_NRD_1	75	77	PF00675	0.351
CLV_PCSK_KEX2_1	151	153	PF00082	0.384
CLV_PCSK_KEX2_1	182	184	PF00082	0.263
CLV_PCSK_KEX2_1	223	225	PF00082	0.335
CLV_PCSK_KEX2_1	75	77	PF00082	0.351
CLV_PCSK_SKI1_1	223	227	PF00082	0.266
CLV_PCSK_SKI1_1	228	232	PF00082	0.260
CLV_PCSK_SKI1_1	75	79	PF00082	0.435
DEG_APCC_DBOX_1	151	159	PF00400	0.427
DOC_MAPK_gen_1	151	158	PF00069	0.502
DOC_MAPK_gen_1	187	196	PF00069	0.555
DOC_MAPK_gen_1	233	241	PF00069	0.539
DOC_MAPK_MEF2A_6	235	243	PF00069	0.440
DOC_PP2B_PxIxI_1	2	8	PF00149	0.471
DOC_USP7_MATH_1	144	148	PF00917	0.526
DOC_USP7_MATH_1	277	281	PF00917	0.494
DOC_USP7_MATH_1	315	319	PF00917	0.305
DOC_USP7_UBL2_3	137	141	PF12436	0.556
DOC_USP7_UBL2_3	187	191	PF12436	0.526
LIG_14-3-3_CanoR_1	245	250	PF00244	0.463
LIG_AP2alpha_2	143	145	PF02296	0.427
LIG_BIR_II_1	1	5	PF00653	0.424
LIG_BRCT_BRCA1_1	236	240	PF00533	0.505
LIG_deltaCOP1_diTrp_1	139	145	PF00928	0.474
LIG_FHA_1	2	8	PF00498	0.376
LIG_FHA_1	319	325	PF00498	0.511
LIG_LIR_Gen_1	117	126	PF02991	0.476
LIG_LIR_Gen_1	143	150	PF02991	0.456
LIG_LIR_Gen_1	237	247	PF02991	0.485
LIG_LIR_Gen_1	38	45	PF02991	0.497
LIG_LIR_Gen_1	48	59	PF02991	0.479
LIG_LIR_Nem_3	117	121	PF02991	0.486
LIG_LIR_Nem_3	139	145	PF02991	0.478
LIG_LIR_Nem_3	237	243	PF02991	0.463
LIG_LIR_Nem_3	38	43	PF02991	0.421
LIG_LIR_Nem_3	48	54	PF02991	0.353
LIG_PDZ_Class_2	321	326	PF00595	0.521
LIG_Pex14_2	226	230	PF04695	0.526
LIG_REV1ctd_RIR_1	223	232	PF16727	0.474
LIG_REV1ctd_RIR_1	308	317	PF16727	0.245
LIG_SH2_CRK	160	164	PF00017	0.545
LIG_SH2_GRB2like	125	128	PF00017	0.369
LIG_SH2_STAP1	81	85	PF00017	0.454
LIG_SH2_STAT5	118	121	PF00017	0.370
LIG_SH2_STAT5	125	128	PF00017	0.264
LIG_SUMO_SIM_anti_2	280	288	PF11976	0.315
LIG_SUMO_SIM_par_1	280	288	PF11976	0.342
LIG_TYR_ITIM	158	163	PF00017	0.453
LIG_UBA3_1	254	260	PF00899	0.526
MOD_CK1_1	280	286	PF00069	0.575
MOD_CK1_1	296	302	PF00069	0.564
MOD_CK1_1	318	324	PF00069	0.629
MOD_CK2_1	133	139	PF00069	0.451
MOD_CK2_1	143	149	PF00069	0.451
MOD_CK2_1	202	208	PF00069	0.556
MOD_CK2_1	245	251	PF00069	0.464
MOD_GlcNHglycan	183	186	PF01048	0.284
MOD_GlcNHglycan	236	239	PF01048	0.263
MOD_GlcNHglycan	28	31	PF01048	0.518
MOD_GlcNHglycan	54	57	PF01048	0.457
MOD_GlcNHglycan	83	86	PF01048	0.379
MOD_GlcNHglycan	98	102	PF01048	0.466
MOD_GSK3_1	35	42	PF00069	0.431
MOD_NEK2_1	133	138	PF00069	0.506
MOD_NEK2_1	176	181	PF00069	0.463
MOD_NEK2_1	202	207	PF00069	0.544
MOD_NEK2_1	211	216	PF00069	0.478
MOD_NEK2_1	291	296	PF00069	0.458
MOD_NEK2_1	52	57	PF00069	0.474
MOD_NEK2_1	79	84	PF00069	0.475
MOD_NEK2_2	39	44	PF00069	0.487
MOD_OFUCOSY	33	39	PF10250	0.461
MOD_PIKK_1	304	310	PF00454	0.263
MOD_PK_1	245	251	PF00069	0.582
MOD_PKA_1	259	265	PF00069	0.458
MOD_PKA_2	181	187	PF00069	0.525
MOD_PKA_2	26	32	PF00069	0.479
MOD_PKA_2	296	302	PF00069	0.609
MOD_Plk_1	202	208	PF00069	0.556
MOD_Plk_1	35	41	PF00069	0.524
MOD_Plk_4	211	217	PF00069	0.547
MOD_Plk_4	277	283	PF00069	0.494
MOD_SUMO_for_1	95	98	PF00179	0.441
MOD_SUMO_rev_2	184	189	PF00179	0.556
TRG_ENDOCYTIC_2	118	121	PF00928	0.388
TRG_ENDOCYTIC_2	160	163	PF00928	0.458
TRG_ER_diArg_1	150	152	PF00400	0.518
TRG_ER_diArg_1	181	183	PF00400	0.525
TRG_ER_diArg_1	223	225	PF00400	0.473
TRG_ER_diArg_1	75	77	PF00400	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM0	Leptomonas seymouri	56%	97%
A0A1X0PAE4	Trypanosomatidae	50%	90%
A0A1X0PAT7	Trypanosomatidae	48%	94%
A0A381MVV1	Leishmania infantum	94%	100%
A0A3Q8IN76	Leishmania donovani	94%	100%
A0A3S5H7W5	Leishmania donovani	94%	100%
A0A422MS54	Trypanosoma rangeli	51%	100%
A1AH96	Escherichia coli O1:K1 / APEC	31%	100%
A1RIA7	Shewanella sp. (strain W3-18-1)	23%	87%
A1RYE4	Thermofilum pendens (strain DSM 2475 / Hrk 5)	28%	96%
A1S7K2	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	27%	87%
A4H7T3	Leishmania braziliensis	76%	100%
A4Y882	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	23%	87%
A6TFG7	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	33%	100%
A7MFZ8	Cronobacter sakazakii (strain ATCC BAA-894)	27%	100%
A7ZTA0	Escherichia coli O139:H28 (strain E24377A / ETEC)	31%	100%
B1IZP1	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	31%	100%
B1L765	Korarchaeum cryptofilum (strain OPF8)	27%	98%
B1LJB3	Escherichia coli (strain SMS-3-5 / SECEC)	31%	100%
B1X8G8	Escherichia coli (strain K12 / DH10B)	31%	100%
B2U573	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	31%	100%
B2VCD1	Erwinia tasmaniensis (strain DSM 17950 / CFBP 7177 / CIP 109463 / NCPPB 4357 / Et1/99)	31%	100%
B5XMZ4	Klebsiella pneumoniae (strain 342)	33%	100%
B5YVK6	Escherichia coli O157:H7 (strain EC4115 / EHEC)	31%	100%
B6I3C3	Escherichia coli (strain SE11)	31%	100%
B6YWH0	Thermococcus onnurineus (strain NA1)	28%	98%
B7L6W9	Escherichia coli (strain 55989 / EAEC)	31%	100%
B7M3H6	Escherichia coli O8 (strain IAI1)	31%	100%
B7MER0	Escherichia coli O45:K1 (strain S88 / ExPEC)	31%	100%
B7N1K7	Escherichia coli O81 (strain ED1a)	31%	100%
B7NEK6	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	31%	100%
B7NP49	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	31%	100%
B7ULB4	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	31%	100%
C4ZXE2	Escherichia coli (strain K12 / MC4100 / BW2952)	31%	100%
C5A1V0	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	26%	98%
C6DJ88	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	32%	100%
E9B4W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9B4W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
G9EZR6	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	27%	98%
J7SHB8	Clostridium sporogenes (strain ATCC 15579)	27%	98%
O32264	Bacillus subtilis (strain 168)	28%	100%
P0C1E8	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	30%	100%
P26298	Lactiplantibacillus pentosus	28%	98%
P36234	Hyphomicrobium methylovorum	25%	100%
P37666	Escherichia coli (strain K12)	31%	100%
P58220	Escherichia coli O157:H7	31%	100%
P63940	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	99%
P72357	Staphylococcus aureus	27%	99%
P99116	Staphylococcus aureus (strain N315)	26%	99%
Q03134	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	89%
Q084S1	Shewanella frigidimarina (strain NCIMB 400)	27%	86%
Q0SZE5	Shigella flexneri serotype 5b (strain 8401)	31%	100%
Q0TBP9	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	31%	100%
Q1LTA7	Baumannia cicadellinicola subsp. Homalodisca coagulata	27%	87%
Q1QE21	Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5)	27%	84%
Q1QWN6	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	26%	100%
Q1QXV7	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	24%	85%
Q1R543	Escherichia coli (strain UTI89 / UPEC)	31%	100%
Q31V71	Shigella boydii serotype 4 (strain Sb227)	32%	100%
Q328L4	Shigella dysenteriae serotype 1 (strain Sd197)	32%	100%
Q3K9D1	Pseudomonas fluorescens (strain Pf0-1)	24%	86%
Q49ZM5	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	31%	100%
Q4FV16	Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4)	29%	86%
Q4Q361	Leishmania major	82%	100%
Q4Q362	Leishmania major	88%	100%
Q59516	Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)	29%	100%
Q59642	Pediococcus acidilactici	24%	98%
Q5HD29	Staphylococcus aureus (strain COL)	27%	99%
Q5HLA0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	99%
Q5HLU4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q6DB24	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	32%	100%
Q6F943	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	30%	92%
Q6G6F1	Staphylococcus aureus (strain MSSA476)	27%	99%
Q6GDS2	Staphylococcus aureus (strain MRSA252)	26%	99%
Q83PR3	Shigella flexneri	32%	100%
Q88VJ2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	28%	98%
Q8CN22	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	99%
Q8CNB8	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q8D2P6	Wigglesworthia glossinidia brevipalpis	28%	86%
Q8FCF1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	30%	100%
Q8NUT2	Staphylococcus aureus (strain MW2)	27%	99%
Q8U3Y2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	27%	97%
Q91Z53	Mus musculus	32%	99%
Q9C4M5	Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)	27%	98%
Q9CA90	Arabidopsis thaliana	26%	100%
Q9UBQ7	Homo sapiens	32%	99%
Q9YAW4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	29%	97%
V5B3E2	Trypanosoma cruzi	49%	100%
V5BIV9	Trypanosoma cruzi	45%	93%