PTP1-interacting protein, 39 kDa, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI-interacting factor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7S3_LEIDO

TriTrypDb:

LdBPK_341360.1 , LdCL_340019600 , LDHU3_34.2120

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005829	cytosol	2	1

Expansion

Sequence features

A0A3S7X7S3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7S3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004721	phosphoprotein phosphatase activity	3	3
GO:0004725	protein tyrosine phosphatase activity	4	2
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.425
CLV_NRD_NRD_1	227	229	PF00675	0.438
CLV_NRD_NRD_1	320	322	PF00675	0.397
CLV_PCSK_KEX2_1	227	229	PF00082	0.438
CLV_PCSK_KEX2_1	320	322	PF00082	0.393
CLV_PCSK_SKI1_1	221	225	PF00082	0.399
CLV_PCSK_SKI1_1	259	263	PF00082	0.472
CLV_PCSK_SKI1_1	4	8	PF00082	0.697
CLV_PCSK_SKI1_1	98	102	PF00082	0.351
DEG_APCC_DBOX_1	258	266	PF00400	0.465
DOC_CDC14_PxL_1	176	184	PF14671	0.268
DOC_CDC14_PxL_1	262	270	PF14671	0.337
DOC_CKS1_1	200	205	PF01111	0.382
DOC_CYCLIN_RxL_1	1	11	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.533
DOC_MAPK_gen_1	184	192	PF00069	0.407
DOC_MAPK_gen_1	254	264	PF00069	0.478
DOC_MAPK_gen_1	47	56	PF00069	0.295
DOC_MAPK_MEF2A_6	20	27	PF00069	0.463
DOC_MAPK_MEF2A_6	309	317	PF00069	0.522
DOC_MAPK_MEF2A_6	47	56	PF00069	0.271
DOC_MAPK_NFAT4_5	49	57	PF00069	0.314
DOC_PP1_RVXF_1	327	333	PF00149	0.621
DOC_PP2B_LxvP_1	37	40	PF13499	0.440
DOC_USP7_MATH_1	146	150	PF00917	0.452
DOC_USP7_MATH_1	18	22	PF00917	0.521
DOC_USP7_MATH_1	353	357	PF00917	0.633
DOC_USP7_UBL2_3	147	151	PF12436	0.331
DOC_WW_Pin1_4	199	204	PF00397	0.355
DOC_WW_Pin1_4	320	325	PF00397	0.492
LIG_14-3-3_CanoR_1	137	145	PF00244	0.408
LIG_14-3-3_CanoR_1	166	171	PF00244	0.292
LIG_14-3-3_CanoR_1	184	190	PF00244	0.473
LIG_14-3-3_CanoR_1	320	324	PF00244	0.510
LIG_14-3-3_CanoR_1	8	18	PF00244	0.504
LIG_Actin_RPEL_3	68	87	PF02755	0.198
LIG_APCC_ABBA_1	66	71	PF00400	0.258
LIG_EVH1_1	37	41	PF00568	0.470
LIG_FHA_1	165	171	PF00498	0.328
LIG_FHA_1	279	285	PF00498	0.437
LIG_FHA_1	299	305	PF00498	0.422
LIG_FHA_1	49	55	PF00498	0.268
LIG_FHA_2	314	320	PF00498	0.578
LIG_GBD_Chelix_1	52	60	PF00786	0.268
LIG_LIR_Apic_2	32	38	PF02991	0.461
LIG_LIR_Gen_1	138	146	PF02991	0.450
LIG_LIR_Gen_1	88	97	PF02991	0.343
LIG_LIR_Nem_3	138	143	PF02991	0.304
LIG_LIR_Nem_3	159	164	PF02991	0.403
LIG_LIR_Nem_3	285	290	PF02991	0.511
LIG_LIR_Nem_3	88	92	PF02991	0.295
LIG_PDZ_Class_1	353	358	PF00595	0.603
LIG_Pex14_2	108	112	PF04695	0.449
LIG_Pex14_2	31	35	PF04695	0.497
LIG_PTB_Apo_2	331	338	PF02174	0.455
LIG_SH2_CRK	89	93	PF00017	0.428
LIG_SH2_NCK_1	140	144	PF00017	0.222
LIG_SH2_STAT5	120	123	PF00017	0.318
LIG_SH2_STAT5	178	181	PF00017	0.361
LIG_SH2_STAT5	292	295	PF00017	0.322
LIG_SH3_1	197	203	PF00018	0.273
LIG_SH3_3	197	203	PF00018	0.273
LIG_SH3_3	30	36	PF00018	0.367
LIG_SH3_3	312	318	PF00018	0.426
LIG_SH3_3	38	44	PF00018	0.376
LIG_SUMO_SIM_par_1	187	194	PF11976	0.264
LIG_SUMO_SIM_par_1	50	55	PF11976	0.255
LIG_SxIP_EBH_1	320	331	PF03271	0.568
LIG_TRFH_1	199	203	PF08558	0.268
LIG_TYR_ITIM	87	92	PF00017	0.331
LIG_WW_2	41	44	PF00397	0.562
MOD_CDK_SPK_2	199	204	PF00069	0.361
MOD_CK1_1	138	144	PF00069	0.404
MOD_CK1_1	154	160	PF00069	0.438
MOD_CK2_1	138	144	PF00069	0.423
MOD_CK2_1	313	319	PF00069	0.568
MOD_Cter_Amidation	182	185	PF01082	0.438
MOD_GlcNHglycan	11	14	PF01048	0.654
MOD_GlcNHglycan	305	308	PF01048	0.494
MOD_GlcNHglycan	334	337	PF01048	0.452
MOD_GlcNHglycan	339	342	PF01048	0.477
MOD_GlcNHglycan	351	354	PF01048	0.641
MOD_GSK3_1	152	159	PF00069	0.446
MOD_GSK3_1	162	169	PF00069	0.275
MOD_GSK3_1	195	202	PF00069	0.355
MOD_GSK3_1	328	335	PF00069	0.483
MOD_GSK3_1	343	350	PF00069	0.454
MOD_GSK3_1	56	63	PF00069	0.353
MOD_GSK3_1	69	76	PF00069	0.353
MOD_NEK2_1	152	157	PF00069	0.331
MOD_NEK2_1	164	169	PF00069	0.285
MOD_NEK2_1	298	303	PF00069	0.399
MOD_NEK2_1	313	318	PF00069	0.408
MOD_NEK2_1	332	337	PF00069	0.239
MOD_NEK2_1	347	352	PF00069	0.493
MOD_NEK2_1	60	65	PF00069	0.346
MOD_NEK2_2	343	348	PF00069	0.450
MOD_PIKK_1	164	170	PF00454	0.293
MOD_PK_1	185	191	PF00069	0.331
MOD_PKA_1	184	190	PF00069	0.438
MOD_PKA_2	319	325	PF00069	0.462
MOD_Plk_1	343	349	PF00069	0.577
MOD_Plk_1	56	62	PF00069	0.255
MOD_Plk_4	185	191	PF00069	0.319
MOD_Plk_4	328	334	PF00069	0.590
MOD_Plk_4	48	54	PF00069	0.282
MOD_Plk_4	56	62	PF00069	0.313
MOD_Plk_4	82	88	PF00069	0.462
MOD_ProDKin_1	199	205	PF00069	0.355
MOD_ProDKin_1	320	326	PF00069	0.494
TRG_ENDOCYTIC_2	140	143	PF00928	0.331
TRG_ENDOCYTIC_2	178	181	PF00928	0.303
TRG_ENDOCYTIC_2	89	92	PF00928	0.407
TRG_ER_diArg_1	226	228	PF00400	0.438
TRG_NES_CRM1_1	134	148	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.552
TRG_PTS1	355	358	PF00515	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D2	Leptomonas seymouri	75%	100%
A0A0S4IR87	Bodo saltans	28%	80%
A0A0S4IXS3	Bodo saltans	33%	92%
A0A0S4J698	Bodo saltans	33%	76%
A0A0S4J952	Bodo saltans	35%	100%
A0A0S4JFL1	Bodo saltans	35%	100%
A0A0S4JIG1	Bodo saltans	28%	98%
A0A0S4JJI6	Bodo saltans	44%	95%
A0A0S4JU68	Bodo saltans	36%	100%
A0A1X0NUJ8	Trypanosomatidae	53%	98%
A0A422N4T2	Trypanosoma rangeli	54%	100%
A4HAP2	Leishmania braziliensis	87%	100%
A4I9T8	Leishmania infantum	100%	100%
C9ZXU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZXU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B4U9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q377	Leishmania major	97%	100%
V5B4L5	Trypanosoma cruzi	55%	100%