Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7S0_LEIDO

TriTrypDb:

LdBPK_341560.1 , LdCL_340021900 , LDHU3_34.2390

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	668	672	PF00656	0.555
CLV_NRD_NRD_1	107	109	PF00675	0.602
CLV_NRD_NRD_1	13	15	PF00675	0.717
CLV_NRD_NRD_1	137	139	PF00675	0.563
CLV_NRD_NRD_1	248	250	PF00675	0.561
CLV_NRD_NRD_1	479	481	PF00675	0.517
CLV_NRD_NRD_1	534	536	PF00675	0.362
CLV_NRD_NRD_1	552	554	PF00675	0.327
CLV_NRD_NRD_1	658	660	PF00675	0.591
CLV_NRD_NRD_1	68	70	PF00675	0.473
CLV_NRD_NRD_1	685	687	PF00675	0.518
CLV_NRD_NRD_1	82	84	PF00675	0.453
CLV_PCSK_KEX2_1	107	109	PF00082	0.581
CLV_PCSK_KEX2_1	13	15	PF00082	0.746
CLV_PCSK_KEX2_1	137	139	PF00082	0.593
CLV_PCSK_KEX2_1	248	250	PF00082	0.541
CLV_PCSK_KEX2_1	311	313	PF00082	0.535
CLV_PCSK_KEX2_1	479	481	PF00082	0.519
CLV_PCSK_KEX2_1	497	499	PF00082	0.740
CLV_PCSK_KEX2_1	534	536	PF00082	0.345
CLV_PCSK_KEX2_1	563	565	PF00082	0.427
CLV_PCSK_KEX2_1	68	70	PF00082	0.473
CLV_PCSK_KEX2_1	685	687	PF00082	0.518
CLV_PCSK_KEX2_1	82	84	PF00082	0.444
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.535
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.784
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.427
CLV_PCSK_SKI1_1	107	111	PF00082	0.530
CLV_PCSK_SKI1_1	137	141	PF00082	0.525
CLV_PCSK_SKI1_1	186	190	PF00082	0.437
CLV_PCSK_SKI1_1	311	315	PF00082	0.509
CLV_PCSK_SKI1_1	376	380	PF00082	0.452
CLV_PCSK_SKI1_1	429	433	PF00082	0.530
CLV_PCSK_SKI1_1	69	73	PF00082	0.530
DEG_APCC_DBOX_1	185	193	PF00400	0.445
DEG_SCF_FBW7_2	593	600	PF00400	0.554
DEG_SPOP_SBC_1	43	47	PF00917	0.780
DOC_CKS1_1	130	135	PF01111	0.371
DOC_CKS1_1	594	599	PF01111	0.543
DOC_CYCLIN_RxL_1	104	112	PF00134	0.581
DOC_CYCLIN_yCln2_LP_2	674	680	PF00134	0.635
DOC_MAPK_gen_1	13	21	PF00069	0.671
DOC_MAPK_gen_1	563	569	PF00069	0.471
DOC_MAPK_MEF2A_6	180	189	PF00069	0.483
DOC_MAPK_MEF2A_6	563	571	PF00069	0.382
DOC_MAPK_MEF2A_6	620	628	PF00069	0.531
DOC_PP1_RVXF_1	310	317	PF00149	0.497
DOC_PP2B_LxvP_1	469	472	PF13499	0.420
DOC_PP2B_LxvP_1	674	677	PF13499	0.544
DOC_USP7_MATH_1	116	120	PF00917	0.743
DOC_USP7_MATH_1	150	154	PF00917	0.625
DOC_USP7_MATH_1	200	204	PF00917	0.510
DOC_USP7_MATH_1	230	234	PF00917	0.754
DOC_USP7_MATH_1	273	277	PF00917	0.665
DOC_USP7_MATH_1	30	34	PF00917	0.664
DOC_USP7_MATH_1	322	326	PF00917	0.681
DOC_USP7_MATH_1	488	492	PF00917	0.690
DOC_USP7_MATH_1	666	670	PF00917	0.622
DOC_WW_Pin1_4	109	114	PF00397	0.538
DOC_WW_Pin1_4	129	134	PF00397	0.441
DOC_WW_Pin1_4	233	238	PF00397	0.707
DOC_WW_Pin1_4	403	408	PF00397	0.447
DOC_WW_Pin1_4	44	49	PF00397	0.713
DOC_WW_Pin1_4	447	452	PF00397	0.563
DOC_WW_Pin1_4	481	486	PF00397	0.498
DOC_WW_Pin1_4	593	598	PF00397	0.509
LIG_14-3-3_CanoR_1	13	21	PF00244	0.684
LIG_14-3-3_CanoR_1	193	200	PF00244	0.511
LIG_14-3-3_CanoR_1	248	252	PF00244	0.469
LIG_14-3-3_CanoR_1	327	331	PF00244	0.490
LIG_14-3-3_CanoR_1	376	381	PF00244	0.458
LIG_14-3-3_CanoR_1	479	485	PF00244	0.579
LIG_14-3-3_CanoR_1	553	559	PF00244	0.420
LIG_14-3-3_CanoR_1	572	578	PF00244	0.418
LIG_14-3-3_CanoR_1	68	78	PF00244	0.430
LIG_APCC_ABBA_1	624	629	PF00400	0.532
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_deltaCOP1_diTrp_1	287	293	PF00928	0.388
LIG_deltaCOP1_diTrp_1	307	316	PF00928	0.203
LIG_eIF4E_1	86	92	PF01652	0.534
LIG_FHA_1	16	22	PF00498	0.700
LIG_FHA_1	193	199	PF00498	0.585
LIG_FHA_1	234	240	PF00498	0.681
LIG_FHA_1	286	292	PF00498	0.445
LIG_FHA_1	426	432	PF00498	0.543
LIG_FHA_1	52	58	PF00498	0.595
LIG_FHA_1	636	642	PF00498	0.564
LIG_FHA_1	699	705	PF00498	0.570
LIG_FHA_1	74	80	PF00498	0.430
LIG_FHA_2	179	185	PF00498	0.529
LIG_FHA_2	491	497	PF00498	0.716
LIG_FHA_2	514	520	PF00498	0.733
LIG_FHA_2	557	563	PF00498	0.539
LIG_FHA_2	96	102	PF00498	0.344
LIG_GBD_Chelix_1	57	65	PF00786	0.490
LIG_LIR_Apic_2	452	458	PF02991	0.551
LIG_LIR_Gen_1	141	150	PF02991	0.497
LIG_LIR_Gen_1	168	178	PF02991	0.394
LIG_LIR_Gen_1	203	212	PF02991	0.374
LIG_LIR_Gen_1	287	297	PF02991	0.428
LIG_LIR_Gen_1	456	467	PF02991	0.487
LIG_LIR_Gen_1	546	556	PF02991	0.396
LIG_LIR_Gen_1	639	646	PF02991	0.495
LIG_LIR_Nem_3	141	146	PF02991	0.577
LIG_LIR_Nem_3	168	173	PF02991	0.388
LIG_LIR_Nem_3	201	207	PF02991	0.384
LIG_LIR_Nem_3	287	292	PF02991	0.373
LIG_LIR_Nem_3	307	313	PF02991	0.208
LIG_LIR_Nem_3	456	462	PF02991	0.399
LIG_LIR_Nem_3	546	552	PF02991	0.383
LIG_LIR_Nem_3	607	613	PF02991	0.333
LIG_LIR_Nem_3	639	645	PF02991	0.475
LIG_LIR_Nem_3	648	654	PF02991	0.550
LIG_LIR_Nem_3	72	78	PF02991	0.516
LIG_LYPXL_SIV_4	346	354	PF13949	0.377
LIG_NRBOX	105	111	PF00104	0.494
LIG_NRBOX	608	614	PF00104	0.481
LIG_Pex14_1	289	293	PF04695	0.383
LIG_Pex14_2	209	213	PF04695	0.466
LIG_RPA_C_Fungi	681	693	PF08784	0.542
LIG_SH2_CRK	170	174	PF00017	0.408
LIG_SH2_CRK	610	614	PF00017	0.378
LIG_SH2_CRK	651	655	PF00017	0.700
LIG_SH2_CRK	75	79	PF00017	0.463
LIG_SH2_GRB2like	369	372	PF00017	0.517
LIG_SH2_STAP1	170	174	PF00017	0.472
LIG_SH2_STAP1	205	209	PF00017	0.427
LIG_SH2_STAT3	67	70	PF00017	0.448
LIG_SH2_STAT5	162	165	PF00017	0.529
LIG_SH2_STAT5	369	372	PF00017	0.484
LIG_SH2_STAT5	455	458	PF00017	0.522
LIG_SH2_STAT5	574	577	PF00017	0.510
LIG_SH2_STAT5	75	78	PF00017	0.505
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.381
LIG_SUMO_SIM_anti_2	59	66	PF11976	0.275
LIG_SUMO_SIM_par_1	16	23	PF11976	0.470
LIG_TYR_ITIM	608	613	PF00017	0.517
LIG_TYR_ITSM	647	654	PF00017	0.603
LIG_UBA3_1	305	311	PF00899	0.534
LIG_UBA3_1	420	429	PF00899	0.398
LIG_UBA3_1	548	555	PF00899	0.457
MOD_CDK_SPK_2	44	49	PF00069	0.579
MOD_CK1_1	17	23	PF00069	0.691
MOD_CK1_1	233	239	PF00069	0.663
MOD_CK1_1	325	331	PF00069	0.612
MOD_CK1_1	33	39	PF00069	0.596
MOD_CK1_1	406	412	PF00069	0.596
MOD_CK1_1	42	48	PF00069	0.715
MOD_CK1_1	427	433	PF00069	0.509
MOD_CK1_1	470	476	PF00069	0.420
MOD_CK1_1	492	498	PF00069	0.742
MOD_CK1_1	73	79	PF00069	0.463
MOD_CK1_1	94	100	PF00069	0.479
MOD_CK2_1	109	115	PF00069	0.577
MOD_CK2_1	178	184	PF00069	0.515
MOD_CK2_1	200	206	PF00069	0.481
MOD_CK2_1	47	53	PF00069	0.720
MOD_CK2_1	490	496	PF00069	0.711
MOD_CK2_1	513	519	PF00069	0.660
MOD_CK2_1	556	562	PF00069	0.546
MOD_CK2_1	57	63	PF00069	0.503
MOD_GlcNHglycan	118	121	PF01048	0.630
MOD_GlcNHglycan	175	178	PF01048	0.396
MOD_GlcNHglycan	275	278	PF01048	0.746
MOD_GlcNHglycan	324	327	PF01048	0.633
MOD_GlcNHglycan	337	340	PF01048	0.661
MOD_GlcNHglycan	38	41	PF01048	0.772
MOD_GlcNHglycan	472	475	PF01048	0.447
MOD_GlcNHglycan	513	516	PF01048	0.769
MOD_GlcNHglycan	583	586	PF01048	0.405
MOD_GSK3_1	13	20	PF00069	0.705
MOD_GSK3_1	169	176	PF00069	0.392
MOD_GSK3_1	218	225	PF00069	0.677
MOD_GSK3_1	29	36	PF00069	0.708
MOD_GSK3_1	292	299	PF00069	0.454
MOD_GSK3_1	322	329	PF00069	0.635
MOD_GSK3_1	376	383	PF00069	0.509
MOD_GSK3_1	39	46	PF00069	0.772
MOD_GSK3_1	402	409	PF00069	0.496
MOD_GSK3_1	47	54	PF00069	0.685
MOD_GSK3_1	486	493	PF00069	0.676
MOD_GSK3_1	554	561	PF00069	0.596
MOD_GSK3_1	646	653	PF00069	0.550
MOD_GSK3_1	69	76	PF00069	0.454
MOD_GSK3_1	90	97	PF00069	0.540
MOD_NEK2_1	139	144	PF00069	0.554
MOD_NEK2_1	173	178	PF00069	0.412
MOD_NEK2_1	247	252	PF00069	0.496
MOD_NEK2_1	267	272	PF00069	0.620
MOD_NEK2_1	292	297	PF00069	0.436
MOD_NEK2_1	380	385	PF00069	0.516
MOD_NEK2_1	424	429	PF00069	0.399
MOD_NEK2_1	556	561	PF00069	0.509
MOD_NEK2_1	57	62	PF00069	0.564
MOD_NEK2_1	573	578	PF00069	0.347
MOD_NEK2_1	645	650	PF00069	0.574
MOD_NEK2_1	697	702	PF00069	0.595
MOD_NEK2_1	90	95	PF00069	0.519
MOD_NEK2_2	200	205	PF00069	0.486
MOD_PIKK_1	118	124	PF00454	0.677
MOD_PIKK_1	296	302	PF00454	0.452
MOD_PIKK_1	646	652	PF00454	0.640
MOD_PIKK_1	95	101	PF00454	0.442
MOD_PK_1	554	560	PF00069	0.407
MOD_PKA_1	13	19	PF00069	0.741
MOD_PKA_1	479	485	PF00069	0.567
MOD_PKA_1	497	503	PF00069	0.742
MOD_PKA_1	554	560	PF00069	0.516
MOD_PKA_2	13	19	PF00069	0.739
MOD_PKA_2	192	198	PF00069	0.499
MOD_PKA_2	218	224	PF00069	0.614
MOD_PKA_2	247	253	PF00069	0.463
MOD_PKA_2	326	332	PF00069	0.528
MOD_PKA_2	36	42	PF00069	0.690
MOD_PKA_2	479	485	PF00069	0.567
MOD_PKA_2	497	503	PF00069	0.742
MOD_Plk_1	200	206	PF00069	0.486
MOD_Plk_1	219	225	PF00069	0.621
MOD_Plk_1	508	514	PF00069	0.668
MOD_Plk_4	169	175	PF00069	0.465
MOD_Plk_4	200	206	PF00069	0.389
MOD_Plk_4	528	534	PF00069	0.379
MOD_Plk_4	544	550	PF00069	0.212
MOD_Plk_4	57	63	PF00069	0.526
MOD_Plk_4	604	610	PF00069	0.395
MOD_Plk_4	70	76	PF00069	0.409
MOD_ProDKin_1	109	115	PF00069	0.553
MOD_ProDKin_1	129	135	PF00069	0.432
MOD_ProDKin_1	233	239	PF00069	0.698
MOD_ProDKin_1	403	409	PF00069	0.456
MOD_ProDKin_1	44	50	PF00069	0.703
MOD_ProDKin_1	447	453	PF00069	0.558
MOD_ProDKin_1	481	487	PF00069	0.503
MOD_ProDKin_1	593	599	PF00069	0.517
TRG_DiLeu_BaEn_1	562	567	PF01217	0.471
TRG_DiLeu_BaEn_2	522	528	PF01217	0.545
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.502
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.513
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.447
TRG_ENDOCYTIC_2	170	173	PF00928	0.366
TRG_ENDOCYTIC_2	205	208	PF00928	0.368
TRG_ENDOCYTIC_2	574	577	PF00928	0.532
TRG_ENDOCYTIC_2	610	613	PF00928	0.393
TRG_ENDOCYTIC_2	651	654	PF00928	0.699
TRG_ENDOCYTIC_2	75	78	PF00928	0.544
TRG_ER_diArg_1	106	108	PF00400	0.516
TRG_ER_diArg_1	136	138	PF00400	0.581
TRG_ER_diArg_1	247	249	PF00400	0.543
TRG_ER_diArg_1	478	480	PF00400	0.546
TRG_ER_diArg_1	533	535	PF00400	0.371
TRG_ER_diArg_1	67	69	PF00400	0.463
TRG_ER_diArg_1	684	686	PF00400	0.518
TRG_ER_diArg_1	690	693	PF00400	0.537
TRG_ER_diArg_1	82	84	PF00400	0.451
TRG_NES_CRM1_1	546	562	PF08389	0.450
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	311	315	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	564	568	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA97	Leptomonas seymouri	56%	100%
A0A0S4IIE1	Bodo saltans	33%	100%
A0A1X0P9G0	Trypanosomatidae	37%	100%
A0A3R7MA99	Trypanosoma rangeli	39%	100%
A4H7S8	Leishmania braziliensis	77%	100%
A4I9V8	Leishmania infantum	99%	100%
C9ZMS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q356	Leishmania major	93%	100%
V5BT29	Trypanosoma cruzi	38%	100%