LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X7R9_LEIDO
TriTrypDb:
LdBPK_341590.1 , LdCL_340022200 , LDHU3_34.2420
Length:
352

Annotations

Annotations by Jardim et al.

Phosphatase, phosphatase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7X7R9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7R9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 193 195 PF00675 0.717
CLV_NRD_NRD_1 266 268 PF00675 0.611
CLV_NRD_NRD_1 33 35 PF00675 0.501
CLV_NRD_NRD_1 56 58 PF00675 0.796
CLV_NRD_NRD_1 63 65 PF00675 0.693
CLV_PCSK_KEX2_1 266 268 PF00082 0.675
CLV_PCSK_KEX2_1 33 35 PF00082 0.501
CLV_PCSK_SKI1_1 195 199 PF00082 0.706
CLV_PCSK_SKI1_1 24 28 PF00082 0.525
CLV_PCSK_SKI1_1 259 263 PF00082 0.623
CLV_PCSK_SKI1_1 34 38 PF00082 0.354
DEG_SPOP_SBC_1 131 135 PF00917 0.521
DOC_MAPK_gen_1 30 38 PF00069 0.693
DOC_MAPK_gen_1 64 72 PF00069 0.394
DOC_MAPK_gen_1 86 95 PF00069 0.493
DOC_MAPK_HePTP_8 106 118 PF00069 0.400
DOC_MAPK_MEF2A_6 109 118 PF00069 0.424
DOC_USP7_MATH_1 107 111 PF00917 0.516
DOC_USP7_MATH_1 150 154 PF00917 0.422
DOC_USP7_MATH_1 50 54 PF00917 0.423
DOC_USP7_MATH_1 84 88 PF00917 0.437
DOC_USP7_UBL2_3 141 145 PF12436 0.433
DOC_USP7_UBL2_3 322 326 PF12436 0.387
DOC_WW_Pin1_4 161 166 PF00397 0.473
DOC_WW_Pin1_4 74 79 PF00397 0.476
DOC_WW_Pin1_4 87 92 PF00397 0.526
LIG_14-3-3_CanoR_1 266 275 PF00244 0.385
LIG_14-3-3_CanoR_1 33 37 PF00244 0.635
LIG_14-3-3_CanoR_1 57 61 PF00244 0.529
LIG_Actin_WH2_2 20 35 PF00022 0.768
LIG_Clathr_ClatBox_1 211 215 PF01394 0.414
LIG_eIF4E_1 206 212 PF01652 0.421
LIG_eIF4E_1 297 303 PF01652 0.363
LIG_FHA_1 131 137 PF00498 0.443
LIG_FHA_1 312 318 PF00498 0.418
LIG_FHA_1 33 39 PF00498 0.544
LIG_FHA_1 330 336 PF00498 0.522
LIG_FHA_2 17 23 PF00498 0.838
LIG_FHA_2 196 202 PF00498 0.513
LIG_FHA_2 266 272 PF00498 0.485
LIG_FHA_2 296 302 PF00498 0.444
LIG_FHA_2 338 344 PF00498 0.506
LIG_FHA_2 57 63 PF00498 0.519
LIG_GBD_Chelix_1 41 49 PF00786 0.411
LIG_LIR_Gen_1 273 279 PF02991 0.398
LIG_LIR_Gen_1 90 99 PF02991 0.476
LIG_LIR_Nem_3 153 158 PF02991 0.424
LIG_LIR_Nem_3 223 229 PF02991 0.435
LIG_LIR_Nem_3 273 278 PF02991 0.463
LIG_LIR_Nem_3 90 95 PF02991 0.484
LIG_SH2_STAT5 189 192 PF00017 0.416
LIG_SH2_STAT5 196 199 PF00017 0.406
LIG_SH2_STAT5 226 229 PF00017 0.412
LIG_SH2_STAT5 297 300 PF00017 0.420
LIG_SH3_1 6 12 PF00018 0.819
LIG_SH3_2 2 7 PF14604 0.724
LIG_SH3_3 146 152 PF00018 0.422
LIG_SH3_3 234 240 PF00018 0.539
LIG_SH3_3 5 11 PF00018 0.779
LIG_SUMO_SIM_par_1 34 39 PF11976 0.567
LIG_TRAF2_1 243 246 PF00917 0.479
LIG_TRAF2_1 268 271 PF00917 0.355
LIG_UBA3_1 136 145 PF00899 0.438
MOD_CDK_SPxxK_3 87 94 PF00069 0.447
MOD_CK1_1 126 132 PF00069 0.544
MOD_CK1_1 265 271 PF00069 0.451
MOD_CK1_1 77 83 PF00069 0.495
MOD_CK1_1 87 93 PF00069 0.461
MOD_CK2_1 16 22 PF00069 0.830
MOD_CK2_1 265 271 PF00069 0.495
MOD_CK2_1 295 301 PF00069 0.459
MOD_CK2_1 337 343 PF00069 0.464
MOD_GlcNHglycan 121 124 PF01048 0.683
MOD_GlcNHglycan 125 128 PF01048 0.710
MOD_GlcNHglycan 152 155 PF01048 0.617
MOD_GlcNHglycan 175 179 PF01048 0.659
MOD_GlcNHglycan 186 189 PF01048 0.696
MOD_GlcNHglycan 220 223 PF01048 0.659
MOD_GSK3_1 117 124 PF00069 0.506
MOD_GSK3_1 126 133 PF00069 0.505
MOD_GSK3_1 150 157 PF00069 0.413
MOD_GSK3_1 262 269 PF00069 0.441
MOD_GSK3_1 32 39 PF00069 0.581
MOD_GSK3_1 325 332 PF00069 0.424
MOD_GSK3_1 52 59 PF00069 0.770
MOD_N-GLC_1 131 136 PF02516 0.707
MOD_N-GLC_1 218 223 PF02516 0.665
MOD_N-GLC_1 330 335 PF02516 0.637
MOD_N-GLC_1 87 92 PF02516 0.736
MOD_NEK2_1 119 124 PF00069 0.448
MOD_NEK2_1 130 135 PF00069 0.463
MOD_NEK2_1 227 232 PF00069 0.435
MOD_NEK2_1 252 257 PF00069 0.438
MOD_NEK2_1 262 267 PF00069 0.443
MOD_NEK2_1 32 37 PF00069 0.654
MOD_NEK2_1 325 330 PF00069 0.484
MOD_PIKK_1 139 145 PF00454 0.472
MOD_PKA_1 266 272 PF00069 0.441
MOD_PKA_2 265 271 PF00069 0.429
MOD_PKA_2 32 38 PF00069 0.602
MOD_PKA_2 56 62 PF00069 0.521
MOD_Plk_1 131 137 PF00069 0.515
MOD_Plk_1 253 259 PF00069 0.367
MOD_Plk_1 330 336 PF00069 0.432
MOD_Plk_4 126 132 PF00069 0.478
MOD_Plk_4 144 150 PF00069 0.446
MOD_ProDKin_1 161 167 PF00069 0.475
MOD_ProDKin_1 74 80 PF00069 0.474
MOD_ProDKin_1 87 93 PF00069 0.520
MOD_SUMO_rev_2 177 187 PF00179 0.543
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.458
TRG_DiLeu_BaLyEn_6 331 336 PF01217 0.491
TRG_DiLeu_BaLyEn_6 91 96 PF01217 0.499
TRG_ENDOCYTIC_2 155 158 PF00928 0.419
TRG_ENDOCYTIC_2 226 229 PF00928 0.413
TRG_ER_diArg_1 32 34 PF00400 0.724
TRG_NLS_MonoCore_2 63 68 PF00514 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAP6 Leptomonas seymouri 65% 100%
A0A0S4IM03 Bodo saltans 29% 96%
A0A1X0PAG1 Trypanosomatidae 38% 98%
A0A422N0E3 Trypanosoma rangeli 40% 99%
A4H7S5 Leishmania braziliensis 82% 100%
A4I9W1 Leishmania infantum 100% 100%
C9ZMS1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9B4X4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q353 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS