ATP dependent DEAD-box helicase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP dependent DEAD-box helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X7R6_LEIDO

TriTrypDb:

LdBPK_341650.1 , LdCL_340022800 , LDHU3_34.2490

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000313	organellar ribosome	6	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005761	mitochondrial ribosome	7	1
GO:0005840	ribosome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X7R6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7R6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:0005488	binding	1	4
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0043022	ribosome binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0000166	nucleotide binding	3	3
GO:0003676	nucleic acid binding	3	3
GO:0005524	ATP binding	5	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.677
CLV_C14_Caspase3-7	225	229	PF00656	0.698
CLV_C14_Caspase3-7	618	622	PF00656	0.373
CLV_NRD_NRD_1	326	328	PF00675	0.492
CLV_NRD_NRD_1	361	363	PF00675	0.474
CLV_NRD_NRD_1	365	367	PF00675	0.510
CLV_NRD_NRD_1	399	401	PF00675	0.354
CLV_NRD_NRD_1	62	64	PF00675	0.560
CLV_NRD_NRD_1	686	688	PF00675	0.644
CLV_NRD_NRD_1	713	715	PF00675	0.490
CLV_NRD_NRD_1	770	772	PF00675	0.683
CLV_NRD_NRD_1	773	775	PF00675	0.716
CLV_PCSK_FUR_1	60	64	PF00082	0.602
CLV_PCSK_FUR_1	771	775	PF00082	0.644
CLV_PCSK_KEX2_1	154	156	PF00082	0.498
CLV_PCSK_KEX2_1	326	328	PF00082	0.579
CLV_PCSK_KEX2_1	361	363	PF00082	0.451
CLV_PCSK_KEX2_1	365	367	PF00082	0.489
CLV_PCSK_KEX2_1	399	401	PF00082	0.354
CLV_PCSK_KEX2_1	62	64	PF00082	0.586
CLV_PCSK_KEX2_1	688	690	PF00082	0.644
CLV_PCSK_KEX2_1	713	715	PF00082	0.476
CLV_PCSK_KEX2_1	737	739	PF00082	0.549
CLV_PCSK_KEX2_1	752	754	PF00082	0.488
CLV_PCSK_KEX2_1	772	774	PF00082	0.710
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.498
CLV_PCSK_PC1ET2_1	688	690	PF00082	0.670
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.549
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.494
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.710
CLV_PCSK_PC7_1	361	367	PF00082	0.533
CLV_PCSK_SKI1_1	110	114	PF00082	0.673
CLV_PCSK_SKI1_1	178	182	PF00082	0.556
CLV_PCSK_SKI1_1	198	202	PF00082	0.363
CLV_PCSK_SKI1_1	365	369	PF00082	0.443
CLV_PCSK_SKI1_1	448	452	PF00082	0.404
CLV_PCSK_SKI1_1	46	50	PF00082	0.572
CLV_PCSK_SKI1_1	523	527	PF00082	0.515
CLV_PCSK_SKI1_1	565	569	PF00082	0.331
CLV_PCSK_SKI1_1	689	693	PF00082	0.540
CLV_PCSK_SKI1_1	738	742	PF00082	0.451
CLV_PCSK_SKI1_1	749	753	PF00082	0.386
CLV_PCSK_SKI1_1	85	89	PF00082	0.509
DEG_APCC_DBOX_1	537	545	PF00400	0.390
DEG_MDM2_SWIB_1	560	568	PF02201	0.376
DEG_SPOP_SBC_1	4	8	PF00917	0.550
DOC_CYCLIN_RxL_1	735	742	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.501
DOC_MAPK_gen_1	326	334	PF00069	0.500
DOC_MAPK_gen_1	502	512	PF00069	0.363
DOC_MAPK_gen_1	71	78	PF00069	0.501
DOC_MAPK_gen_1	749	757	PF00069	0.508
DOC_MAPK_MEF2A_6	284	292	PF00069	0.375
DOC_MAPK_MEF2A_6	448	455	PF00069	0.384
DOC_MAPK_MEF2A_6	727	735	PF00069	0.450
DOC_MAPK_NFAT4_5	448	456	PF00069	0.382
DOC_PP1_RVXF_1	509	515	PF00149	0.348
DOC_PP1_RVXF_1	521	528	PF00149	0.352
DOC_PP2B_LxvP_1	526	529	PF13499	0.391
DOC_PP4_FxxP_1	692	695	PF00568	0.534
DOC_USP7_MATH_1	134	138	PF00917	0.709
DOC_USP7_MATH_1	144	148	PF00917	0.702
DOC_USP7_MATH_1	150	154	PF00917	0.603
DOC_USP7_MATH_1	158	162	PF00917	0.510
DOC_USP7_MATH_1	171	175	PF00917	0.591
DOC_USP7_MATH_1	212	216	PF00917	0.592
DOC_USP7_MATH_1	223	227	PF00917	0.705
DOC_USP7_MATH_1	230	234	PF00917	0.592
DOC_USP7_MATH_1	580	584	PF00917	0.349
DOC_USP7_MATH_2	337	343	PF00917	0.327
DOC_USP7_UBL2_3	561	565	PF12436	0.533
DOC_USP7_UBL2_3	619	623	PF12436	0.415
DOC_USP7_UBL2_3	694	698	PF12436	0.512
DOC_WW_Pin1_4	105	110	PF00397	0.544
DOC_WW_Pin1_4	137	142	PF00397	0.714
DOC_WW_Pin1_4	210	215	PF00397	0.607
DOC_WW_Pin1_4	90	95	PF00397	0.561
LIG_14-3-3_CanoR_1	132	141	PF00244	0.778
LIG_14-3-3_CanoR_1	14	18	PF00244	0.615
LIG_14-3-3_CanoR_1	3	12	PF00244	0.726
LIG_14-3-3_CanoR_1	372	381	PF00244	0.381
LIG_14-3-3_CanoR_1	486	492	PF00244	0.530
LIG_14-3-3_CanoR_1	505	509	PF00244	0.427
LIG_14-3-3_CanoR_1	672	678	PF00244	0.579
LIG_Actin_WH2_2	383	401	PF00022	0.408
LIG_AP2alpha_2	765	767	PF02296	0.631
LIG_APCC_ABBA_1	548	553	PF00400	0.379
LIG_BIR_III_4	228	232	PF00653	0.651
LIG_BRCT_BRCA1_1	160	164	PF00533	0.632
LIG_BRCT_BRCA1_1	191	195	PF00533	0.514
LIG_BRCT_BRCA1_1	341	345	PF00533	0.511
LIG_BRCT_BRCA1_1	571	575	PF00533	0.390
LIG_BRCT_BRCA1_1	582	586	PF00533	0.323
LIG_BRCT_BRCA1_1	632	636	PF00533	0.533
LIG_deltaCOP1_diTrp_1	339	345	PF00928	0.419
LIG_deltaCOP1_diTrp_1	563	566	PF00928	0.384
LIG_FHA_1	119	125	PF00498	0.510
LIG_FHA_1	283	289	PF00498	0.382
LIG_FHA_1	307	313	PF00498	0.513
LIG_FHA_1	31	37	PF00498	0.659
LIG_FHA_1	375	381	PF00498	0.448
LIG_FHA_1	40	46	PF00498	0.698
LIG_FHA_1	477	483	PF00498	0.416
LIG_FHA_1	52	58	PF00498	0.522
LIG_FHA_1	746	752	PF00498	0.454
LIG_FHA_2	179	185	PF00498	0.535
LIG_FHA_2	186	192	PF00498	0.522
LIG_FHA_2	346	352	PF00498	0.517
LIG_FHA_2	374	380	PF00498	0.342
LIG_FHA_2	757	763	PF00498	0.512
LIG_Integrin_RGDW_4	561	564	PF00362	0.381
LIG_LIR_Apic_2	690	695	PF02991	0.536
LIG_LIR_Gen_1	232	242	PF02991	0.457
LIG_LIR_Gen_1	24	31	PF02991	0.615
LIG_LIR_Gen_1	339	349	PF02991	0.390
LIG_LIR_Gen_1	354	364	PF02991	0.408
LIG_LIR_Gen_1	391	398	PF02991	0.433
LIG_LIR_Gen_1	503	513	PF02991	0.362
LIG_LIR_Gen_1	563	574	PF02991	0.412
LIG_LIR_Gen_1	583	591	PF02991	0.332
LIG_LIR_Gen_1	592	600	PF02991	0.402
LIG_LIR_Gen_1	703	710	PF02991	0.543
LIG_LIR_Nem_3	232	237	PF02991	0.466
LIG_LIR_Nem_3	24	29	PF02991	0.578
LIG_LIR_Nem_3	248	254	PF02991	0.536
LIG_LIR_Nem_3	273	279	PF02991	0.389
LIG_LIR_Nem_3	339	344	PF02991	0.390
LIG_LIR_Nem_3	351	356	PF02991	0.414
LIG_LIR_Nem_3	391	395	PF02991	0.436
LIG_LIR_Nem_3	503	509	PF02991	0.342
LIG_LIR_Nem_3	563	569	PF02991	0.360
LIG_LIR_Nem_3	583	589	PF02991	0.337
LIG_LIR_Nem_3	592	597	PF02991	0.413
LIG_LIR_Nem_3	703	708	PF02991	0.571
LIG_LIR_Nem_3	89	95	PF02991	0.623
LIG_NRBOX	508	514	PF00104	0.330
LIG_PCNA_PIPBox_1	668	677	PF02747	0.505
LIG_Pex14_2	560	564	PF04695	0.408
LIG_REV1ctd_RIR_1	689	694	PF16727	0.559
LIG_RPA_C_Fungi	189	201	PF08784	0.619
LIG_SH2_CRK	251	255	PF00017	0.497
LIG_SH2_CRK	705	709	PF00017	0.550
LIG_SH2_NCK_1	705	709	PF00017	0.550
LIG_SH2_NCK_1	92	96	PF00017	0.679
LIG_SH2_STAP1	341	345	PF00017	0.434
LIG_SH2_STAP1	353	357	PF00017	0.345
LIG_SH2_STAP1	675	679	PF00017	0.634
LIG_SH2_STAT3	10	13	PF00017	0.489
LIG_SH2_STAT3	675	678	PF00017	0.502
LIG_SH2_STAT5	397	400	PF00017	0.381
LIG_SH2_STAT5	402	405	PF00017	0.356
LIG_SH2_STAT5	498	501	PF00017	0.385
LIG_SH2_STAT5	508	511	PF00017	0.338
LIG_SH2_STAT5	614	617	PF00017	0.364
LIG_SH2_STAT5	675	678	PF00017	0.521
LIG_SH2_STAT5	705	708	PF00017	0.532
LIG_SH3_3	331	337	PF00018	0.445
LIG_SH3_3	408	414	PF00018	0.461
LIG_SH3_3	482	488	PF00018	0.436
LIG_SH3_3	574	580	PF00018	0.444
LIG_SH3_4	474	481	PF00018	0.545
LIG_SH3_4	694	701	PF00018	0.511
LIG_SH3_5	337	341	PF00018	0.556
LIG_TRFH_1	100	104	PF08558	0.570
LIG_TRFH_1	663	667	PF08558	0.495
LIG_TYR_ITIM	90	95	PF00017	0.637
LIG_WRC_WIRS_1	494	499	PF05994	0.345
LIG_WRC_WIRS_1	586	591	PF05994	0.285
MOD_CDK_SPK_2	105	110	PF00069	0.624
MOD_CDK_SPxxK_3	90	97	PF00069	0.587
MOD_CK1_1	137	143	PF00069	0.705
MOD_CK1_1	174	180	PF00069	0.644
MOD_CK1_1	203	209	PF00069	0.577
MOD_CK1_1	213	219	PF00069	0.590
MOD_CK1_1	24	30	PF00069	0.597
MOD_CK1_1	282	288	PF00069	0.385
MOD_CK1_1	39	45	PF00069	0.537
MOD_CK2_1	132	138	PF00069	0.604
MOD_CK2_1	185	191	PF00069	0.531
MOD_CK2_1	242	248	PF00069	0.404
MOD_CK2_1	345	351	PF00069	0.507
MOD_CK2_1	352	358	PF00069	0.506
MOD_CK2_1	756	762	PF00069	0.509
MOD_CK2_1	90	96	PF00069	0.572
MOD_GlcNHglycan	134	137	PF01048	0.761
MOD_GlcNHglycan	191	194	PF01048	0.578
MOD_GlcNHglycan	234	237	PF01048	0.443
MOD_GlcNHglycan	244	247	PF01048	0.421
MOD_GlcNHglycan	281	284	PF01048	0.372
MOD_GlcNHglycan	285	288	PF01048	0.365
MOD_GlcNHglycan	415	418	PF01048	0.499
MOD_GlcNHglycan	442	445	PF01048	0.439
MOD_GlcNHglycan	456	459	PF01048	0.389
MOD_GlcNHglycan	7	10	PF01048	0.697
MOD_GSK3_1	132	139	PF00069	0.660
MOD_GSK3_1	174	181	PF00069	0.561
MOD_GSK3_1	185	192	PF00069	0.508
MOD_GSK3_1	210	217	PF00069	0.606
MOD_GSK3_1	279	286	PF00069	0.423
MOD_GSK3_1	32	39	PF00069	0.632
MOD_GSK3_1	476	483	PF00069	0.422
MOD_GSK3_1	585	592	PF00069	0.412
MOD_LATS_1	717	723	PF00433	0.544
MOD_N-GLC_1	158	163	PF02516	0.516
MOD_N-GLC_1	39	44	PF02516	0.642
MOD_NEK2_1	12	17	PF00069	0.674
MOD_NEK2_1	164	169	PF00069	0.525
MOD_NEK2_1	242	247	PF00069	0.355
MOD_NEK2_1	29	34	PF00069	0.425
MOD_NEK2_1	306	311	PF00069	0.452
MOD_NEK2_1	317	322	PF00069	0.395
MOD_NEK2_1	345	350	PF00069	0.472
MOD_NEK2_1	373	378	PF00069	0.381
MOD_NEK2_1	435	440	PF00069	0.371
MOD_NEK2_2	493	498	PF00069	0.330
MOD_NEK2_2	747	752	PF00069	0.612
MOD_PIKK_1	719	725	PF00454	0.542
MOD_PIKK_1	76	82	PF00454	0.663
MOD_PK_1	727	733	PF00069	0.460
MOD_PKA_1	365	371	PF00069	0.520
MOD_PKA_2	13	19	PF00069	0.674
MOD_PKA_2	365	371	PF00069	0.535
MOD_PKA_2	4	10	PF00069	0.785
MOD_PKA_2	504	510	PF00069	0.464
MOD_PKA_2	516	522	PF00069	0.384
MOD_PKA_2	654	660	PF00069	0.450
MOD_PKB_1	3	11	PF00069	0.574
MOD_Plk_1	158	164	PF00069	0.622
MOD_Plk_1	171	177	PF00069	0.568
MOD_Plk_1	339	345	PF00069	0.400
MOD_Plk_1	703	709	PF00069	0.550
MOD_Plk_1	88	94	PF00069	0.533
MOD_Plk_2-3	352	358	PF00069	0.409
MOD_Plk_2-3	621	627	PF00069	0.472
MOD_Plk_2-3	630	636	PF00069	0.474
MOD_Plk_4	118	124	PF00069	0.664
MOD_Plk_4	13	19	PF00069	0.622
MOD_Plk_4	144	150	PF00069	0.706
MOD_Plk_4	164	170	PF00069	0.600
MOD_Plk_4	185	191	PF00069	0.543
MOD_Plk_4	21	27	PF00069	0.644
MOD_Plk_4	339	345	PF00069	0.453
MOD_Plk_4	352	358	PF00069	0.392
MOD_Plk_4	477	483	PF00069	0.418
MOD_Plk_4	727	733	PF00069	0.539
MOD_ProDKin_1	105	111	PF00069	0.545
MOD_ProDKin_1	137	143	PF00069	0.710
MOD_ProDKin_1	210	216	PF00069	0.614
MOD_ProDKin_1	90	96	PF00069	0.565
MOD_SUMO_rev_2	457	464	PF00179	0.516
MOD_SUMO_rev_2	559	567	PF00179	0.426
MOD_SUMO_rev_2	617	625	PF00179	0.408
TRG_DiLeu_BaEn_1	53	58	PF01217	0.570
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.438
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.317
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.401
TRG_DiLeu_BaLyEn_6	508	513	PF01217	0.323
TRG_ENDOCYTIC_2	251	254	PF00928	0.509
TRG_ENDOCYTIC_2	341	344	PF00928	0.460
TRG_ENDOCYTIC_2	357	360	PF00928	0.322
TRG_ENDOCYTIC_2	69	72	PF00928	0.585
TRG_ENDOCYTIC_2	705	708	PF00928	0.557
TRG_ENDOCYTIC_2	754	757	PF00928	0.549
TRG_ENDOCYTIC_2	92	95	PF00928	0.627
TRG_ER_diArg_1	195	198	PF00400	0.484
TRG_ER_diArg_1	2	5	PF00400	0.656
TRG_ER_diArg_1	360	362	PF00400	0.475
TRG_ER_diArg_1	364	366	PF00400	0.483
TRG_ER_diArg_1	398	400	PF00400	0.363
TRG_ER_diArg_1	535	538	PF00400	0.502
TRG_ER_diArg_1	539	542	PF00400	0.499
TRG_ER_diArg_1	60	63	PF00400	0.631
TRG_ER_diArg_1	686	689	PF00400	0.547
TRG_ER_diArg_1	713	715	PF00400	0.481
TRG_ER_diArg_1	771	774	PF00400	0.570
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.696
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	719	723	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC11	Leptomonas seymouri	72%	100%
A0A0S4IWL5	Bodo saltans	38%	87%
A0A1X0P9H1	Trypanosomatidae	55%	100%
A0A3R7MZ37	Trypanosoma rangeli	57%	100%
A4HAM5	Leishmania braziliensis	83%	100%
A4HAQ8	Leishmania braziliensis	72%	100%
C9ZMR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AHT4	Leishmania infantum	99%	100%
E9B4X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q347	Leishmania major	94%	100%
V5BT32	Trypanosoma cruzi	57%	100%