Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X7R3_LEIDO

TriTrypDb:

LdBPK_341260.1 , LdCL_340018600 , LDHU3_34.1990

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X7R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X7R3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.617
CLV_C14_Caspase3-7	457	461	PF00656	0.610
CLV_NRD_NRD_1	191	193	PF00675	0.568
CLV_NRD_NRD_1	213	215	PF00675	0.420
CLV_NRD_NRD_1	300	302	PF00675	0.565
CLV_NRD_NRD_1	359	361	PF00675	0.568
CLV_NRD_NRD_1	408	410	PF00675	0.605
CLV_PCSK_KEX2_1	191	193	PF00082	0.546
CLV_PCSK_KEX2_1	300	302	PF00082	0.593
CLV_PCSK_KEX2_1	359	361	PF00082	0.568
CLV_PCSK_KEX2_1	416	418	PF00082	0.582
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.590
CLV_PCSK_SKI1_1	136	140	PF00082	0.532
CLV_PCSK_SKI1_1	208	212	PF00082	0.631
CLV_PCSK_SKI1_1	315	319	PF00082	0.585
CLV_PCSK_SKI1_1	394	398	PF00082	0.561
CLV_PCSK_SKI1_1	416	420	PF00082	0.574
CLV_PCSK_SKI1_1	592	596	PF00082	0.796
DEG_APCC_DBOX_1	103	111	PF00400	0.645
DEG_Nend_UBRbox_3	1	3	PF02207	0.708
DEG_SCF_FBW7_1	1	7	PF00400	0.705
DEG_SPOP_SBC_1	461	465	PF00917	0.686
DOC_CKS1_1	1	6	PF01111	0.775
DOC_PP2B_LxvP_1	278	281	PF13499	0.771
DOC_USP7_MATH_1	13	17	PF00917	0.543
DOC_USP7_MATH_1	249	253	PF00917	0.631
DOC_USP7_MATH_1	4	8	PF00917	0.638
DOC_USP7_MATH_1	445	449	PF00917	0.674
DOC_USP7_MATH_1	461	465	PF00917	0.730
DOC_USP7_MATH_1	536	540	PF00917	0.719
DOC_USP7_MATH_1	624	628	PF00917	0.764
DOC_WW_Pin1_4	476	481	PF00397	0.794
DOC_WW_Pin1_4	490	495	PF00397	0.624
DOC_WW_Pin1_4	521	526	PF00397	0.691
DOC_WW_Pin1_4	549	554	PF00397	0.720
LIG_14-3-3_CanoR_1	141	145	PF00244	0.522
LIG_14-3-3_CanoR_1	161	169	PF00244	0.543
LIG_14-3-3_CanoR_1	177	187	PF00244	0.401
LIG_14-3-3_CanoR_1	214	223	PF00244	0.479
LIG_14-3-3_CanoR_1	343	347	PF00244	0.639
LIG_14-3-3_CanoR_1	354	358	PF00244	0.546
LIG_14-3-3_CanoR_1	592	597	PF00244	0.712
LIG_14-3-3_CanoR_1	66	76	PF00244	0.579
LIG_Actin_WH2_2	121	138	PF00022	0.573
LIG_Actin_WH2_2	166	181	PF00022	0.514
LIG_Actin_WH2_2	240	257	PF00022	0.556
LIG_CaM_IQ_9	184	199	PF13499	0.615
LIG_Clathr_ClatBox_1	45	49	PF01394	0.567
LIG_FHA_1	123	129	PF00498	0.499
LIG_FHA_1	173	179	PF00498	0.590
LIG_FHA_1	3	9	PF00498	0.638
LIG_FHA_1	308	314	PF00498	0.585
LIG_FHA_1	393	399	PF00498	0.591
LIG_FHA_1	41	47	PF00498	0.574
LIG_FHA_1	469	475	PF00498	0.750
LIG_FHA_1	497	503	PF00498	0.522
LIG_FHA_1	569	575	PF00498	0.813
LIG_FHA_1	659	665	PF00498	0.641
LIG_FHA_2	111	117	PF00498	0.561
LIG_FHA_2	387	393	PF00498	0.637
LIG_LIR_Apic_2	552	557	PF02991	0.773
LIG_LIR_Apic_2	603	608	PF02991	0.719
LIG_LIR_Gen_1	513	521	PF02991	0.734
LIG_LIR_Gen_1	84	93	PF02991	0.501
LIG_LIR_Nem_3	513	518	PF02991	0.732
LIG_LIR_Nem_3	84	89	PF02991	0.503
LIG_NRBOX	92	98	PF00104	0.569
LIG_PCNA_yPIPBox_3	354	365	PF02747	0.574
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.547
LIG_SH2_CRK	487	491	PF00017	0.738
LIG_SH2_CRK	515	519	PF00017	0.737
LIG_SH2_CRK	545	549	PF00017	0.678
LIG_SH2_CRK	554	558	PF00017	0.573
LIG_SH2_CRK	605	609	PF00017	0.775
LIG_SH2_GRB2like	24	27	PF00017	0.563
LIG_SH2_NCK_1	601	605	PF00017	0.646
LIG_SH2_SRC	601	604	PF00017	0.708
LIG_SH2_STAP1	24	28	PF00017	0.536
LIG_SH2_STAT5	570	573	PF00017	0.742
LIG_SH3_3	499	505	PF00018	0.761
LIG_SH3_3	560	566	PF00018	0.638
LIG_SH3_3	576	582	PF00018	0.515
LIG_SH3_3	618	624	PF00018	0.793
LIG_SH3_3	636	642	PF00018	0.572
LIG_SH3_4	615	622	PF00018	0.740
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.623
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.590
LIG_SUMO_SIM_par_1	395	401	PF11976	0.509
LIG_TRAF2_1	145	148	PF00917	0.532
LIG_TRAF2_1	180	183	PF00917	0.509
LIG_TRAF2_1	389	392	PF00917	0.630
LIG_UBA3_1	237	243	PF00899	0.449
LIG_UBA3_1	396	400	PF00899	0.592
MOD_CK1_1	143	149	PF00069	0.625
MOD_CK1_1	17	23	PF00069	0.535
MOD_CK1_1	311	317	PF00069	0.613
MOD_CK1_1	323	329	PF00069	0.710
MOD_CK1_1	454	460	PF00069	0.753
MOD_CK1_1	514	520	PF00069	0.827
MOD_CK2_1	110	116	PF00069	0.552
MOD_CK2_1	177	183	PF00069	0.527
MOD_CK2_1	197	203	PF00069	0.618
MOD_CK2_1	32	38	PF00069	0.577
MOD_CK2_1	363	369	PF00069	0.629
MOD_CK2_1	386	392	PF00069	0.638
MOD_CK2_1	624	630	PF00069	0.751
MOD_CK2_1	89	95	PF00069	0.536
MOD_GlcNHglycan	152	155	PF01048	0.604
MOD_GlcNHglycan	199	202	PF01048	0.630
MOD_GlcNHglycan	267	270	PF01048	0.645
MOD_GlcNHglycan	447	450	PF01048	0.771
MOD_GlcNHglycan	455	459	PF01048	0.787
MOD_GlcNHglycan	476	479	PF01048	0.722
MOD_GlcNHglycan	626	629	PF01048	0.792
MOD_GSK3_1	13	20	PF00069	0.521
MOD_GSK3_1	136	143	PF00069	0.586
MOD_GSK3_1	307	314	PF00069	0.586
MOD_GSK3_1	320	327	PF00069	0.662
MOD_GSK3_1	450	457	PF00069	0.699
MOD_GSK3_1	510	517	PF00069	0.812
MOD_N-GLC_1	308	313	PF02516	0.602
MOD_N-GLC_1	392	397	PF02516	0.589
MOD_N-GLC_1	421	426	PF02516	0.583
MOD_N-GLC_1	445	450	PF02516	0.727
MOD_N-GLC_1	511	516	PF02516	0.781
MOD_N-GLC_1	54	59	PF02516	0.531
MOD_N-GLC_1	89	94	PF02516	0.545
MOD_NEK2_1	110	115	PF00069	0.631
MOD_NEK2_1	40	45	PF00069	0.585
MOD_NEK2_1	489	494	PF00069	0.798
MOD_NEK2_1	511	516	PF00069	0.753
MOD_PIKK_1	136	142	PF00454	0.607
MOD_PIKK_1	161	167	PF00454	0.552
MOD_PIKK_1	17	23	PF00454	0.631
MOD_PIKK_1	178	184	PF00454	0.349
MOD_PIKK_1	215	221	PF00454	0.484
MOD_PIKK_1	249	255	PF00454	0.584
MOD_PIKK_1	270	276	PF00454	0.701
MOD_PIKK_1	331	337	PF00454	0.627
MOD_PIKK_1	536	542	PF00454	0.742
MOD_PIKK_1	95	101	PF00454	0.566
MOD_PKA_1	150	156	PF00069	0.519
MOD_PKA_2	140	146	PF00069	0.542
MOD_PKA_2	226	232	PF00069	0.618
MOD_PKA_2	323	329	PF00069	0.750
MOD_PKA_2	342	348	PF00069	0.637
MOD_PKA_2	353	359	PF00069	0.550
MOD_PKA_2	580	586	PF00069	0.702
MOD_PKA_2	624	630	PF00069	0.826
MOD_PKA_2	634	640	PF00069	0.447
MOD_PKA_2	79	85	PF00069	0.589
MOD_Plk_1	14	20	PF00069	0.528
MOD_Plk_1	249	255	PF00069	0.584
MOD_Plk_1	308	314	PF00069	0.590
MOD_Plk_1	386	392	PF00069	0.599
MOD_Plk_1	421	427	PF00069	0.584
MOD_Plk_1	511	517	PF00069	0.736
MOD_Plk_1	54	60	PF00069	0.532
MOD_Plk_1	89	95	PF00069	0.539
MOD_Plk_2-3	32	38	PF00069	0.631
MOD_Plk_2-3	401	407	PF00069	0.633
MOD_Plk_4	14	20	PF00069	0.490
MOD_Plk_4	308	314	PF00069	0.609
MOD_Plk_4	342	348	PF00069	0.570
MOD_Plk_4	4	10	PF00069	0.646
MOD_Plk_4	421	427	PF00069	0.537
MOD_Plk_4	592	598	PF00069	0.632
MOD_ProDKin_1	476	482	PF00069	0.795
MOD_ProDKin_1	490	496	PF00069	0.626
MOD_ProDKin_1	521	527	PF00069	0.690
MOD_ProDKin_1	549	555	PF00069	0.724
MOD_SUMO_for_1	169	172	PF00179	0.508
MOD_SUMO_for_1	242	245	PF00179	0.616
MOD_SUMO_for_1	247	250	PF00179	0.495
MOD_SUMO_for_1	29	32	PF00179	0.619
MOD_SUMO_for_1	418	421	PF00179	0.589
MOD_SUMO_for_1	497	500	PF00179	0.693
MOD_SUMO_for_1	58	61	PF00179	0.608
MOD_SUMO_rev_2	106	113	PF00179	0.645
MOD_SUMO_rev_2	143	152	PF00179	0.563
MOD_SUMO_rev_2	277	285	PF00179	0.590
MOD_SUMO_rev_2	403	411	PF00179	0.521
TRG_DiLeu_BaEn_1	392	397	PF01217	0.589
TRG_DiLeu_BaEn_1	41	46	PF01217	0.646
TRG_DiLeu_BaEn_1	421	426	PF01217	0.535
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.508
TRG_ENDOCYTIC_2	487	490	PF00928	0.698
TRG_ENDOCYTIC_2	515	518	PF00928	0.736
TRG_ER_diArg_1	300	303	PF00400	0.611
TRG_ER_diArg_1	359	361	PF00400	0.576
TRG_NES_CRM1_1	235	250	PF08389	0.546
TRG_NES_CRM1_1	56	71	PF08389	0.560
TRG_NLS_MonoExtC_3	415	421	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H0	Leptomonas seymouri	46%	100%
A0A3R7KMJ4	Trypanosoma rangeli	26%	100%
A4HAN5	Leishmania braziliensis	59%	100%
A4I9S8	Leishmania infantum	100%	100%
E9B4T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q387	Leishmania major	87%	100%
V5B3B6	Trypanosoma cruzi	29%	100%